A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect

We conducted a preregistered multilaboratory project (k = 36; N = 3,531) to assess the size and robustness of ego-depletion effects using a novel replication method, termed the paradigmatic replication approach. Each laboratory implemented one of two procedures that was intended to manipulate self-control and tested performance on a subsequent measure of self-control. Confirmatory tests found a nonsignificant result (d = 0.06). Confirmatory Bayesian meta-analyses using an informed-prior hypothesis (δ = 0.30, SD = 0.15) found that the data were 4 times more likely under the null than the alternative hypothesis. Hence, preregistered analyses did not find evidence for a depletion effect. Exploratory analyses on the full sample (i.e., ignoring exclusion criteria) found a statistically significant effect (d = 0.08); Bayesian analyses showed that the data were about equally likely under the null and informed-prior hypotheses. Exploratory moderator tests suggested that the depletion effect was larger for participants who reported more fatigue but was not moderated by trait self-control, willpower beliefs, or action orientation.</p

Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists

Some effects of relative reinforcement rate and changeover delay in response-independent concurrent schedules of reinforcement

Reinforcements were arranged independently of the pigeon's behavior by concurrent variable-interval schedules. The reinforcements arranged by one of the schedules occurred when the chamber was illuminated with amber light, and the reinforcements arranged by the other schedule occurred when the chamber was illuminated with blue light. Both schedules functioned concurrently, but reinforcers were delivered by each only in the presence of the appropriate stimulus condition. A response on a white key, the only key in the chamber, alternated the stimulus condition and the effective schedule. The results of this procedure were similar to those obtained with concurrent response-dependent variable-interval schedules of reinforcement. The proportion of the total session time spent in the presence of a schedule component approximated the proportion of the total number of reinforcements in the component. Changeover rate was a decreasing function of the changeover delay and of the difference between the relative rates of reinforcement for each pair of concurrent schedules

Time allocation on concurrent schedules with asymmetrical response requirements

Pigeons were trained on concurrent schedules in which key pecking was required by both schedules (concurrent variable-interval variable-interval schedules) and on concurrent schedules in which key pecking was required by only one of the schedules (concurrent variable-interval variable-time schedules). The distribution of reinforcements was systematically varied with both types of concurrent schedules. The distribution of time between the schedules depended on the reinforcement distribution and was independent of the symmetry of the response requirement. The relation between time and reinforcement distributions appears to be invariant over a wide range of manipulations of responding maintained by concurrent schedules

West at al. Manuscript Data &amp; Analyses

Data files and scripts for analyses in CTRA change REV manuscrip

Cold Spring Harb Perspect Med Fungal Biofilms, Drug Resistance, and Recurrent Infection Subject Collection Human Fungal Pathogens Loss of Heterozygosity Diversity: Whole Ploidy Shifts, Aneuploidy, and Rapid Mechanisms for Generating Genome Pathogenic Spec

Metabolism in Fungal Pathogenesis et al

Health Reform Redux: Learning From Experience and Politics

The 2008 presidential campaign season featured health care reform proposals. I discuss 3 approaches to health care reform and the tools for bringing about reform, such as insurance market reforms, tax credits, subsidies, individual and employer mandates, and public program expansions. I also discuss the politics of past and current health care reform efforts