88 research outputs found
Precision constraints on radiative neutrino decay with CMB spectral distortion
We investigate the radiative decay of the cosmic neutrino background, and its
impact on the spectrum of the cosmic microwave background (CMB) that is known
to be a nearly perfect black body. We derive exact formulae for the decay of a
heavier neutrino into a lighter neutrino and a photon, , and of absorption as its inverse, , by
accounting for the precise form of the neutrino momentum distribution. Our
calculations show that if the neutrinos are heavier than eV,
the exact formulae give results that differ by 50%, compared with
approximate ones where neutrinos are assumed to be at rest. We also find that
spectral distortion due to absorption is more important for heavy neutrino
masses (by a factor of 10 going from a neutrino mass of 0.01 eV to 0.1
eV). By analyzing the CMB spectral data measured with COBE-FIRAS, we obtain
lower limits on the neutrino lifetime of s
(95% C.L.) for the smaller mass splitting and s for the larger mass splitting. These represent up to one order of
magnitude improvement over previous CMB constraints. With future CMB
experiments such as PIXIE, these limits will improve by roughly 4 orders of
magnitude. This translates to a projected upper limit on the neutrino magnetic
moment (for certain neutrino masses and decay modes) of , where is the Bohr magneton. Such constraints would
make future precision CMB measurements competitive with lab-based constraints
on neutrino magnetic moments.Comment: 14 pages, 9 figures. v2: Added a number of references and
clarifications. Matches version published in PR
Cocrystal structure of a class-I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase
Riboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis selective for the essential nucleobase preQ1 (7-aminomethyl-7-deazaguanine). These reveal a previously unrecognized pseudoknot fold, and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional anti-terminator
Rituals of World Politics: On (Visual) Practices Disordering Things
Rituals are customarily muted into predictable and boring routines aimed to stabilise social orders and limit conflict. As a result, their magic lure recedes into the background, and the unexpected, disruptive and disordered elements are downplayed. Our collaborative contribution counters this move by foregrounding rituals of world politics as social practices with notable disordering effects. The collective discussion recovers the disruptive work of a range of rituals designed to sustain the sovereign exercise of violence and war. We do so through engaging a series of ‘world pictures' (Mitchell 2007). We show the worlding enacted in rituals such as colonial treaty-making, state commemoration, military/service dog training, cyber-security podcasts,algorithmically generated maps, the visit of Prince Harry to a joint NATO exercise and border ceremonies in India, respectively. We do so highlighting rituals’ immanent potential for disruption of existing orders, the fissures, failures and unforeseen repercussions. Reappraising the disordering role of ritual practices sheds light on the place of rituals in rearticulating the boundaries of the political. It emphasises the role of rituals in generating dissensus and re-divisions of the sensible rather than in imposing a consensus by policing the boundaries of the political, as Rancière might phrase it. Our images are essential to the account. They help disinterring the fundamentals and ambiguities of the current worldings of security, capturing the affective atmosphere of rituals
An analysis of benign human prostrate offers insight into the mechanism of apocrine secretion and the origin of prostasomes
The structure and function of normal human prostate is still not fully understood. Herein, we concentrate on the different cell types present in normal prostate, describing some previously unreported types and provide evidence that prostasomes are primarily produced by apocrine secretion. Patients (n = 10) undergoing TURP were prospectively consented based on their having a low risk of harbouring CaP. Scanning electron microscopy and transmission electron microscopy was used to characterise cell types and modes of secretion. Zinc levels were determined using Inductively Coupled Plasma Mass Spectrometry. Although merocrine secretory cells were noted, the majority of secretory cells appear to be apocrine; for the first time, we clearly show high-resolution images of the stages of aposome secretion in human prostate. We also report a previously undescribed type of epithelial cell and the first ultrastructural image of wrapping cells in human prostate stroma. The zinc levels in the tissues examined were uniformly high and X-ray microanalysis detected zinc in merocrine cells but not in prostasomes. We conclude that a significant proportion of prostasomes, possibly the majority, are generated via apocrine secretion. This finding provides an explanation as to why so many large proteins, without a signal peptide sequence, are present in the prostatic fluid
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Relativistic klystrons for high-gradient accelerators
Experimental work is being performed by collaborators at LLNL, SLAC, and LBL to investigate relativistic klystrons as a possible rf power source for future high-gradient accelerators. We have learned how to overcome or previously reported problem of high power rf pulse shortening and have achieved peak rf power levels of 330 MW using an 11.4-GHz high-gain tube with multiple output structures. In these experiments the rf pulse is of the same duration as the beam current pulse. In addition, experiments have been performed on two short sections of a high-gradient accelerator using the rf power from a relativistic klystron. An average accelerating gradient of 84 MV/m has been achieved with 80-MW of rf power
Critical phenomena and universal dynamics in one-dimensional driven diffusive systems with two species of particles
Recent work on stochastic interacting particle systems with two particle
species (or single-species systems with kinematic constraints) has demonstrated
the existence of spontaneous symmetry breaking, long-range order and phase
coexistence in nonequilibrium steady states, even if translational invariance
is not broken by defects or open boundaries. If both particle species are
conserved, the temporal behaviour is largely unexplored, but first results of
current work on the transition from the microscopic to the macroscopic scale
yield exact coupled nonlinear hydrodynamic equations and indicate the emergence
of novel types of shock waves which are collective excitations stabilized by
the flow of microscopic fluctuations. We review the basic stationary and
dynamic properties of these systems, highlighting the role of conservation laws
and kinetic constraints for the hydrodynamic behaviour, the microscopic origin
of domain wall (shock) stability and the coarsening dynamics of domains during
phase separation.Comment: 72 pages, 6 figures, 201 references (topical review for J. Phys. A:
Math. Gen.
Coitus-Free Sexual Transmission of Zika Virus in a Mouse Model
Zika virus (ZIKV) is an arboviral infection that may be sexually transmitted. The present study aims to determine if accessory sex glands are a potential source of infectious virus and important in sexual transmission. Male interferon type I receptor knockout (Ifnar−/−) mice were challenged subcutaneously with a Puerto Rican ZIKV isolate. Reproductive tissues were harvested seven days after viral challenge and artificial insemination fluid derived from epididymis or homogenized accessory sex glands (seminal plasma) was obtained. Naïve interferon type I and II receptor knockout (AG129) females were pretreated with progesterone, and inoculated intravaginally with either epididymal flush or seminal plasma from ZIKV-infected males. ZIKV RNA was demonstrated in the artificial insemination fluid and ZIKV antigen was detected in epididymal epithelial cells but not within seminiferous tubules at the time of artificial insemination fluid collection. Peripheral viremia, demonstrated by ZIKV RNA in whole blood samples of females from each challenge group was observed. Infectious virus was present in both epididymal fluid and seminal plasma. These studies provide evidence of passage of virus from epididymal flush and seminal plasma to naïve females via artificial insemination and provides a model for the study of sexual transmission of ZIKV
Next-generation sequencing for diagnosis of thoracic aortic aneurysms and dissections: diagnostic yield, novel mutations and genotype phenotype correlations
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