Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Effects of olive oil-based propolis, caffeic acid phenethyl ester, and methylprednisolone on differentiation of human acute myeloid leukemia cells

Leukemia, originating from the hematopoietic system, is a malignant disease for the treatment of which various glucocorticoids are used. The use of natural products alongside conventional therapy has focused on increasing drug-drug interactions and reducing potential side effects. Based on the idea that propolis and caffeic acid phenethyl ester (CAPE) can stimulate cancer cells to differentiation and enhance the effect of chemotherapeutic drugs, we conducted this study. In this study, we investigated whether the synergistic effect of olive oil-based propolis and CAPE is effective with metylprednisolone (MP), which is used for supportive therapy in AML. In the study, OEP (Olive Oil- Based Propolis), CAPE, MP and their combinations were applied to HL -60 cells for 1-3 days. Then, CD11b, CD14 and CD68 antigens were detected on HL -60 cells using flow cytometry techniques to determine the cellular differentiations. As a result, HL -60 cells were found to be significantly directed to CD11b differentiation. OEP and CAPE will enhance the effect of chemotherapy by differentiating cells and ensure treatment completion by minimizing damage to normal tissues and cells

Investigation of Bovine viral diarrhea virus (BVDV) infection clinically, serologically and virologically in a dairy management with repeat breeding problem

Burdur ilinde, Repeat Breeding (döl tutmama) problemine sahip bir süt sığırı işletmesinde Bovine Viral Diarrhea Virus (BVDV) enfeksiyonu klinik, serolojik ve virolojik yönden araştırıldı. Bu amaçla, sürüde bulunan 25 inek ve 8 buzağıdan alınan kan serumu örnekleri BVDV'ye karşı antikor (Ab) ve lökosit örnekleri BVDV antijen (Ag) varlığı yönünden ELISA ile incelendi. Çalışmada, 7 buzağıdan alınan kan serum örneklerinde BVDV (Ab) ve lökosit örneklerinde BVDV (Ag) varlığı belirlenmedi. Bu buzağıların annelerine ait kan serumu ve lökosit örneklerinde de BVDV (Ab) ve BVDV (Ag) varlığı tespit edilmedi. Ancak, 1 buzağının kan serum örneğinde BVDV (Ab) varlığı tespit edilmezken, lökosit örneğinde BVDV (Ag) varlığı bulundu. Bu buzağının annesine ait kan serumlarında BVDV (Ab) varlığı tespit edilmezken ve lökosit örneklerinde BVDV (Ag) varlığı belirlendi. Bu anne ve buzağısının 45 gün sonraki ikinci kan örneklemelerinde de aynı sonuçların elde edilmesine bağlı olarak, hayvanların persiste enfekte (Pl) olduğuna karar verildi (%6.06). Bununla birlikte, 7 adet BVDV (Ab-/Ag+) ve 4 adet BVDV (Ab+/Ag+) tespit edilen ineklerden 45 gün sonra tekrar alınan kan örneklerinde de aynı sonuçlar tespit edildi. Bu hayvanlarında persiste enfekte (Pl) olduğuna karar verildi.In Burdur province, the infection of Bovine Viral Diarrhea Virus (BVDV) was investigated clinically, serologically and virologically in a dairy herd having the problems of the Repeat Breeding. For this purpose, serum and leucocyte samples from 25 cattle and 8 calves were collected. Serum samples for the presence of antibody (Ab) and leucocyte samples for the presence of antigen (Ag) were examined by ELISA. In the study, the presence of BVDV-Ab in serum samples, obtained from 7 calves and the presence of BVDV-Ag in leucocyte samples obtained from these calves were not detected. The presence of Ab and Ag in serum and leucocyte samples belonging to the dams of these calves were not detected. But, the presence of Ag in leucocyte samples of the same animal was detected while the presence of Ab in sera sample of a calf was not detected. The dam of this calf was negative serologicaliy and was positive virologically. The leucocyte samples obtained from this cow and its calf after 45 days were retested They were described as persistent infected (PI) animals (6.06%). However, the presence of Ag in leucocyte samples obtained again from cattle found 7 BVDV (Ab-/Ag+) and 4 BVDV (Ab+/Ag+) after 45 days was detected and these animals were also decided to be PI

Serological and Virological Investigation of Bovine Viral Diarrhea Virus (BVDV) infection in Candidate Bulls before taken in Artifical Insemination Centers by Enzyme Linked Immunosorbent Assay (ELISA)

Bovine Viral Diarrhea (BVD) is a common infection all over the world. It causes important economical losses in cattle breeding. In this study, a total of 46 blood samples were examined taken into tubes with and without EDTA from bulls in Artifical Insemination Centers. Blood serum samples were tested to detect for antibodies against Bovine Viral Diarrhea Virus (BVDV) and leukocyte samples were tested for BVDV antigens by ELISA methods.  Eight (17.3%) out of 46 serum samples were found as positive by the means of antibodies against BVDV while 3 (6.5%) out of 46 leukocyte samples were detected as positive for BVD antigens. One (2.1%) of the seropositive bulls was detected as positive for BVD antigen. Two (4.3%) of the seronegative bulls were detected as positive for BVD antigens

Natural Fiber Reinforced Polyurethane Rigid Foam

WOS: 000405869900007The main objective of this study was to prepare polyurethane foam reinforced with local Turkish natural resources. In this work, olive kernel and nutshell fibers were used for reinforcing the polyurethane foam. In order to characterize reinforced polyurethane samples, mechanical, chemical, thermal, and morphological methods were used. Mechanical properties of polyurethane foam were measured by compression test. With compression test, it was observed that compressive strength of polyurethane foam was increased with 2.5 wt % olive kernel. Functional groups of polyurethane foams were determined by Fourier Transform Infrared Spectroscopy. Thermal behavior of polyurethane foam was analyzed with thermogravimetric analyzer device. Among biocomposites, polyurethane foam filled with nutshell indicated higher thermal degradation than polyurethane foam filled with olive kernel. Scanning electron microscopy observations revealed that foam structure was formed with biofiber addition