From Psychiatry to Law

Após uma breve introdução, é feito um enquadramento jurídico-penal da doença mental, bem como uma descrição sumária do conceito de inimputabilidade. É ainda considerada a questão da aplicação das medidas de segurança, citando-se a contribuição dos autores que mais se têm salientado neste campo e as actuais perspectivas sobre o tema

Da Doença Mental à Violência

Resumo: Os comportamentos violentos no âmbito da doença mental têm sido motivo de intenso debate e crescente investigação. A complexidade da questão e a sua importância clínica e social moveram-nos na elaboração do presente artigo, com o qual pretendemos, a partir de uma revisão da literatura existente, a contextualização daquela relação à luz dos actuais conhecimentos científicos

Rna Sequencing Reveals Region-specific Molecular Mechanisms Associated With Epileptogenesis In A Model Of Classical Hippocampal Sclerosis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)We report here the first complete transcriptome analysis of the dorsal (dDG) and ventral dentate gyrus (vDG) of a rat epilepsy model presenting a hippocampal lesion with a strict resemblance to classical hippocampal sclerosis (HS). We collected the dDG and vDG by laser microdissection 15 days after electrical stimulation and performed high-throughput RNA-sequencing. There were many differentially regulated genes, some of which were specific to either of the two sub-regions in stimulated animals. Gene ontology analysis indicated an enrichment of inflammation-related processes in both subregions and of axonal guidance and calcium signaling processes exclusively in the vDG. There was also a differential regulation of genes encoding molecules involved in synaptic function, neural electrical activity and neuropeptides in stimulated rats. The data presented here suggests, in the time point analyzed, a remarkable interaction among several molecular components which takes place in the damaged hippocampi. Furthermore, even though similar mechanisms may function in different regions of the DG, the molecular components involved seem to be region specific.6Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), SP, BRAZILFAPESPCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), BRAZILConselho Nacional de Pesquisa (CNPq), BrazilFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

CDH3 (Cadherin 3, Type 1, P-Cadherin (Placental))

Review on CDH3 (Cadherin 3, Type 1, P-Cadherin (Placental)), with data on DNA, on the protein encoded, and where the gene is implicated

A new method to quantify and compare the multiple components of fitness-A study case with kelp niche partition by divergent microstage adaptations to Temperature

Point 1 Management of crops, commercialized or protected species, plagues or life-cycle evolution are subjects requiring comparisons among different demographic strategies. The simpler methods fail in relating changes in vital rates with changes in population viability whereas more complex methods lack accuracy by neglecting interactions among vital rates. Point 2 The difference between the fitness (evaluated by the population growth rate.) of two alternative demographies is decomposed into the contributions of the differences between the pair-wised vital rates and their interactions. This is achieved through a full Taylor expansion (i.e. remainder = 0) of the demographic model. The significance of each term is determined by permutation tests under the null hypothesis that all demographies come from the same pool. Point 3 An example is given with periodic demographic matrices of the microscopic haploid phase of two kelp cryptic species observed to partition their niche occupation along the Chilean coast. The method provided clear and synthetic results showing conditional differentiation of reproduction is an important driver for their differences in fitness along the latitudinal temperature gradient. But it also demonstrated that interactions among vital rates cannot be neglected as they compose a significant part of the differences between demographies. Point 4 This method allows researchers to access the effects of multiple effective changes in a life-cycle from only two experiments. Evolutionists can determine with confidence the effective causes for changes in fitness whereas population managers can determine best strategies from simpler experimental designs.CONICYT-FRENCH EMBASSADY Ph.D. gran

Using K-Means Algorithm for Description Analysis of Text in RSS News Format

This article shows the use of different techniques for the extraction of information through text mining. Through this implementation, the performance of each of the techniques in the dataset analysis process can be identified, which allows the reader to recommend the most appropriate technique for the processing of this type of data. This article shows the implementation of the K-means algorithm to determine the location of the news described in RSS format and the results of this type of grouping through a descriptive analysis of the resulting clusters