A longitudinal examination of the relationship between trauma-related cognitive factors and internalising and externalising psychopathology in physically injured children

Cognitive models of posttraumatic stress disorder (PTSD) highlight maladaptive posttrauma appraisals, trauma memory qualities, and coping strategies, such as rumination or thought suppression, as key processes that maintain PTSD symptoms. Anxiety, depression and externalising symptoms can also present in children in the aftermath of trauma, yet there has been little empirical investigation of the potential relevance of posttrauma cognitive processes for such difficulties. Here, we examined whether: a) acute maladaptive cognitive processes (specifically, maladaptive appraisals, memory qualities, and cognitive coping) were associated with symptoms of PTSD, internalising, and externalising at 1-month posttrauma (T1); and b) changes in these cognitive processes predicted symptom change at a follow-up assessment 6 months later (T2). We recruited 132 6–13 year old children and their parents from emergency departments following the child’s experience of an acute trauma. Children self-reported on their maladaptive appraisals, trauma-memory and cognitive coping strategies, along with symptoms of PTSD, anxiety and depression. Parents also rated children’s internalising and externalising symptoms. We found each cognitive process to be robustly associated with PTSD and non-PTSD internalising symptoms at T1, and change in each predicted change in symptoms to T2. Maladaptive appraisals and cognitive coping were unique predictors of children’s posttrauma internalising. Effects were partially retained even controlling for co-occurring PTSD symptoms. There was less evidence that trauma-specific cognitive processes were associated with externalising symptoms. Findings suggest aspects of cognitive models of PTSD are applicable to broader posttrauma psychopathology, and have implications for how we understand and target children’s posttrauma psychological adjustment

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Background and aims Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to use a Mendelian randomisation approach to test the hypothesis that proinsulin plays a causal role in subclinical vascular remodelling. Methods We studied the high CVD-risk IMPROVE cohort (n = 3345), which has detailed biochemical phenotyping and repeated, state-of-the-art, high-resolution carotid ultrasound examinations. Genotyping was performed using Illumina Cardio-Metabo and Immuno arrays, which include reported proinsulin-associated loci. Participants with type 2 diabetes (n = 904) were omitted from the analysis. Linear regression was used to identify proinsulin-associated genetic variants. Results We identified a proinsulin locus on chromosome 15 (rs8029765) and replicated it in data from 20,003 additional individuals. An 11-SNP score, including the previously identified and the chromosome 15 proinsulin-associated loci, was significantly and negatively associated with baseline IMTmean and IMTmax (the primary cIMT phenotypes) but not with progression measures. However, MR-Eggers refuted any significant effect of the proinsulin-associated 11-SNP score, and a non-pleiotropic SNP score of three variants (including rs8029765) demonstrated no effect on baseline or progression cIMT measures. Conclusions We identified a novel proinsulin-associated locus and demonstrated that whilst proinsulin levels are associated with cIMT measures, proinsulin per se is unlikely to have a causative effect on cIMT

Grupoterapia cognitivo-comportamental para crianças e adolescentes vítimas de abuso sexual Terapia de grupo congnitivo-comportamental para niñas y adolescentes víctimas de abuso sexual Cognitive behavioral group therapy for sexually abused girls

OBJETIVO: Avaliar os efeitos do modelo de grupoterapia cognitivo-comportamental para crianças e adolescentes do sexo feminino vítimas de abuso sexual. MÉTODOS: Foi utilizado delineamento não-randomizado intragrupos de séries temporais. Crianças e adolescentes do sexo feminino com idade entre nove e 16 anos (N=40) da região metropolitana de Porto Alegre (RS), foram clinicamente avaliadas em três encontros individuais, de 2006 a 2008. A grupoterapia consistiu de 16 sessões semi-estruturadas. Instrumentos psicológicos investigaram sintomas de ansiedade, depressão, transtorno do estresse pós-traumático, stress infantil e crenças e percepções da criança em relação à experiência abusiva antes, durante e após a intervenção. Os resultados foram analisados por meio de testes estatísticos para medidas repetidas. Foi realizada uma análise comparativa dos resultados do pré-teste entre os grupos que receberam atendimento psicológico em grupo imediato após a denúncia do abuso e aquelas que aguardaram por atendimento. RESULTADOS: A análise do impacto da intervenção revelou que a grupoterapia cognitivo-comportamental reduziu significativamente sintomas de depressão, ansiedade, stress infantil e transtorno do estresse pós-traumático. Além disso, a intervenção contribuiu para a reestruturação de crenças de culpa, baixa confiança e credibilidade, sendo efetivo para a redução de sintomas psicológicos e alteração de crenças e percepções distorcidas sobre o abuso. CONCLUSÕES: A grupoterapia cognitivo-comportamental mostrou ser efetiva para a redução de sintomas psicológicos de crianças e adolescentes vítimas de abuso sexual.<br>OBJETIVO: Evaluar los efectos del modelo de terapia de grupo cognitivo-comportamental para niñas y adolescentes del sexo femenino víctimas de abuso sexual. MÉTODOS: Fue utilizado delineamiento no aleatorio intragrupos de series temporales. Niños y adolescentes del sexo femenino con edad entre nueve y 16 años (N=40) de la región metropolitana de Porto Alegre (Sur de Brasil), fueron clínicamente evaluadas en tres encuentros individuales, de 2006 a 2008. La terapia de grupo consistió de 16 sesiones semi-estructuradas. Instrumentos psicológicos investigaron síntomas de ansiedad, depresión, trastorno del estrés post-traumático, estrés infantil y creencias y percepciones del niño con relación a la experiencia abusiva antes, durante y posterior a la intervención. Los resultados fueron analizados por medio de pruebas estadísticas para medidas repetidas. Fue realizado un análisis comparativo de los resultados de la pre-evaluación entre los grupos que recibieron atención psicológica en grupo inmediato posterior a la denuncia del abuso y aquellas que aguardaron por atención. RESULTADOS: El análisis del impacto de la intervención reveló que la terapia de grupo cognitivo-comportamental redujo significativamente síntomas de depresión, ansiedad, estrés infantil y trastorno del estrés post-traumático. Adicionalmente, la intervención contribuyó para la reestructuración de creencias de culpa, baja confianza y credibilidad, siendo efectivo para la reducción de síntomas psicológicos y alteración de creencias y percepciones distorsionadas sobre el abuso. CONCLUSIONES: La terapia de grupo cognitivo-comportamental mostró ser efectiva para la reducción de síntomas psicológicos de niños y adolescentes víctimas de abuso sexual.<br>OBJECTIVE: To assess the effects of a cognitive behavioral group therapy model among female children and adolescents victims of sexual abuse. METHODS: A non-randomized study with intragroup comparisons over time was carried out. Female children and teenagers from nine to 16 years of age (N=40) were clinically assessed in three individual meetings in the metropolitan area of Porto Alegre, Southern Brazil, between 2006 and 2008. The group therapy comprised 16 semi-structured sessions. Psychological instruments were applied to investigate symptoms of anxiety, depression, post-traumatic stress disorder, child stress, beliefs and perception of the abuse experience before, during and after the intervention. The results were analyzed through statistical tests for repeated measures. A comparative analysis was carried out with the results of the pretest between the groups that received group psychotherapy immediately after the sexual abuse was reported and those who were waiting for psychological support. RESULTS: The assessment of the impact of the intervention revealed that cognitive behavioral group therapy significantly reduced symptoms of depression, anxiety, child stress and post-traumatic stress disorder. In addition, the intervention enabled the participants to modify beliefs of guilt, low degrees of trust and credibility, and was effective in reducing psychological symptoms and changing distorted beliefs and perception in regard to the abuse. CONCLUSIONS: Cognitive behavioral group therapy was effective in reducing psychological symptoms in sexually abused girls