2,120 research outputs found
Evaluation of a strict protocol approach in managing women with severe disease due to abortion
No Abstract
Maternal near miss and maternal death in the Pretoria Academic Complex, South Africa: A population-based study
Background. In order to reduce maternal mortality in South Africa (SA), it is important to understand the process of obstetric care, identify weaknesses within the system, and implement interventions for improving care.Objective. To determine the spectrum of maternal morbidity and mortality in the Pretoria Academic Complex (PAC), SA.Methods. A descriptive population-based study that included all women delivering in the PAC. The World Health Organization definition, criteria and indicators of near miss and maternal death were used to identify women with severe complications in pregnancy.Results. Between 1 August 2013 and 31 July 2014, there were 26 614 deliveries in the PAC. The institutional maternal mortality ratio was 71.4/100 000 live births. The HIV infection rate was 19.9%, and 2.7% of women had unknown HIV status. Of the women, 1 120 (4.2%) developed potentially life-threatening conditions and 136 (0.5%) life-threatening conditions. The mortality index was 14.0% overall, 30.0% for non-pregnancy-related infections, 2.0% for obstetric haemorrhage and 13.6% for hypertension. Of the women with life-threatening conditions, 39.3% were referred from the primary level of care. Vascular, uterine and coagulation dysfunctions were the most frequent organ dysfunctions in women with life-threatening conditions. The perinatal mortality rate was 26.9/1 000 births overall, 23.1/1 000 for women with non-life-threatening conditions, and 198.0/1 000 for women with life-threatening conditions.Conclusion. About one in 20 pregnant women in the PAC had a potentially life-threatening condition; 39.3% of women presented to a primary level facility as an acute emergency and had to be transferred for tertiary care. All healthcare professionals involved in maternity care must have knowledge and skills that equip them to manage obstetric emergencies. Review of the basic antenatal care protocol may be necessary
Silent cold-sensing neurons contribute to cold allodynia in neuropathic pain.
Neuropathic pain patients often experience innocuous cooling as excruciating pain. The cell and molecular basis of this cold allodynia is little understood. We used in vivo calcium imaging of sensory ganglia to investigate how the activity of peripheral cold-sensing neurons was altered in three mouse models of neuropathic pain: Oxaliplatin-induced neuropathy, partial sciatic nerve ligation and ciguatera poisoning. In control mice, cold-sensing neurons were few in number and small in size. In neuropathic animals with cold allodynia, a set of normally silent large-diameter neurons became sensitive to cooling. Many of these silent cold-sensing neurons responded to noxious mechanical stimuli and expressed the nociceptor markers NaV1.8 and CGRPα. Ablating neurons expressing NaV1.8 resulted in diminished cold allodynia. The silent cold-sensing neurons could also be activated by cooling in control mice through blockade of KV1 voltage-gated potassium channels. Thus silent cold-sensing neurons are unmasked in diverse neuropathic pain states and cold allodynia results from peripheral sensitization caused by altered nociceptor excitability
Influences of Excluded Volume of Molecules on Signaling Processes on Biomembrane
We investigate the influences of the excluded volume of molecules on
biochemical reaction processes on 2-dimensional surfaces using a model of
signal transduction processes on biomembranes. We perform simulations of the
2-dimensional cell-based model, which describes the reactions and diffusion of
the receptors, signaling proteins, target proteins, and crowders on the cell
membrane. The signaling proteins are activated by receptors, and these
activated signaling proteins activate target proteins that bind autonomously
from the cytoplasm to the membrane, and unbind from the membrane if activated.
If the target proteins bind frequently, the volume fraction of molecules on the
membrane becomes so large that the excluded volume of the molecules for the
reaction and diffusion dynamics cannot be negligible. We find that such
excluded volume effects of the molecules induce non-trivial variations of the
signal flow, defined as the activation frequency of target proteins, as
follows. With an increase in the binding rate of target proteins, the signal
flow varies by i) monotonically increasing; ii) increasing then decreasing in a
bell-shaped curve; or iii) increasing, decreasing, then increasing in an
S-shaped curve. We further demonstrate that the excluded volume of molecules
influences the hierarchical molecular distributions throughout the reaction
processes. In particular, when the system exhibits a large signal flow, the
signaling proteins tend to surround the receptors to form receptor-signaling
protein clusters, and the target proteins tend to become distributed around
such clusters. To explain these phenomena, we analyze the stochastic model of
the local motions of molecules around the receptor.Comment: 31 pages, 10 figure
First measurement of the T-violating muon polarization in the decay K^+ --> mu^+ nu gamma
We present the result of the first measurement of the T-violating muon
polarization P_T in the decay K^+ --> mu^+ nu gamma. This polarization is
sensitive to new sources of CP-violation in the Higgs sector. Using data
accumulated in the period 1996-98 we have obtained P_T = (-0.64 +- 1.85(stat)
+- 0.10(syst))x10^{-2} which is consistent with no T-violation in this decay.Comment: 11 pages, 8 figure
High Resolution Spectroscopy of Two-Dimensional Electron Systems
Spectroscopic methods involving the sudden injection or ejection of electrons
in materials are a powerful probe of electronic structure and interactions.
These techniques, such as photoemission and tunneling, yield measurements of
the "single particle" density of states (SPDOS) spectrum of a system. The SPDOS
is proportional to the probability of successfully injecting or ejecting an
electron in these experiments. It is equal to the number of electronic states
in the system able to accept an injected electron as a function of its energy
and is among the most fundamental and directly calculable quantities in
theories of highly interacting systems. However, the two-dimensional electron
system (2DES), host to remarkable correlated electron states such as the
fractional quantum Hall effect, has proven difficult to probe
spectroscopically. Here we present an improved version of time domain
capacitance spectroscopy (TDCS) that now allows us to measure the SPDOS of a
2DES with unprecedented fidelity and resolution. Using TDCS, we perform
measurements of a cold 2DES, providing the first direct measurements of the
single-particle exchange-enhanced spin gap and single particle lifetimes in the
quantum Hall system, as well as the first observations of exchange splitting of
Landau levels not at the Fermi surface. The measurements reveal the difficult
to reach and beautiful structure present in this highly correlated system far
from the Fermi surface.Comment: There are formatting and minor textual differences between this
version and the published version in Nature (follow the DOI link below
Improved measurement of the K+->pi+nu(nu)over-bar branching ratio
An additional event near the upper kinematic limit for K+-->pi(+)nu(nu) over bar has been observed by experiment E949 at Brookhaven National Laboratory. Combining previously reported and new data, the branching ratio is B(K+-->pi(+)nu(nu) over bar)=(1.47(-0.89)(+1.30))x10(-10) based on three events observed in the pion momentum region 211<P<229 MeV/c. At the measured central value of the branching ratio, the additional event had a signal-to-background ratio of 0.9
A novel fluorescent imaging technique for assessment of cerebral vasospasm after experimental subarachnoid hemorrhage
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