Influence of Climate on Malaria in China

Malaria is the fifth leading cause of death from infectious diseases worldwide, after respiratory infections, HIV/AIDS, diarrheal diseases, and tuberculosis. With half the world’s population living in areas at risk of malaria transmission, it remains a public health issue in many countries, including China. To understand the epidemiology of the disease, it is important to study the climate and environmental factors such as temperature, precipitation, relative humidity, and altitude, because these factors influence the life cycles and development of both the malaria parasite and mosquito vector. Global warming and climate change can increase the areas at risk of malaria incidence and affect transmission rates. As temperatures get warmer, incubation periods for the parasite and mosquito development can shorten, and malaria transmission can occur at higher elevations, infecting populations that have not been exposed to the disease. While control measures and efforts have been undertaken to eliminate malaria in China, the disease still exists in concentrated areas. Changes in temperatures and rainfall could reverse control efforts if the disease spreads from the seven provinces in which it has been concentrated

Masks of Folly: Portrait of the Idiot

Masks of Folly: Portrait of the Idiot is an MFA thesis exhibit by Grace An that creates a portrait of the Idiot or, fool. The Idiot is an exception, one who interrupts and blurs boundaries in the refusal of rationality. Using folly and profanation to ask questions. The mask as a concealment of intellect, ironically unmasks. Drawing from the concepts of Mikhail Bakhtin, the exhibit functions as polyphonic utterances by way of the multitude. Multi-voicedness and the cyclical nature of the carnivalized folk, removes the concept of the individual. The site of the Idiot, the carnival, is a space where power structures are temporarily suspended. Offering the character of the Idiot as an unfinalizable being

Evaluation of Magnetic Materials for Very High Frequency Power Applications

This paper investigates the loss characteristics of RF magnetic materials for power conversion applications in the 10 to 100 MHz range. A measurement method is proposed that provides a direct measurement of an inductor quality factor QL as a function of inductor current at RF frequencies, and enables indirect calculation of core loss as a function of flux density. Possible sources of error in measurement and calculation are evaluated and addressed. The proposed method is used to identify loss characteristics of several commercial RF magnetic-core materials. The loss characteristics of these materials, which have not previously been available, are illustrated and compared in tables and figures. The use of the method and data is demonstrated in the design of a magnetic-core inductor, which is applied in a 30-MHz inverter. The results of this paper are thus useful for the design of magnetic components for very high frequency applications.Sheila and Emanuel Landsman FoundationInterconnect Focus Center (United States. Defense Advanced Research Projects Agency and Semiconductor Research Corporation

Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior.

An improved understanding of glycosylation will provide new insights into many biological processes. In the analysis of oligosaccharides from biological samples, a strict regime is typically followed to ensure sample integrity. However, the fate of glycans that have been exposed to environmental conditions over millennia has not yet been investigated. This is also true for understanding the evolution of the glycosylation machinery in humans as well as in any other biological systems. In this study, we examined the glycosylation of tissue samples derived from four mummies which have been naturally preserved: - the 5,300 year old "Iceman called Oetzi", found in the Tyrolean Alps; the 2,400 year old "Scythian warrior" and "Scythian Princess", found in the Altai Mountains; and a 4 year old apartment mummy, found in Vienna/Austria. The number of N-glycans that were identified varied both with the age and the preservation status of the mummies. More glycan structures were discovered in the contemporary sample, as expected, however it is significant that glycan still exists in the ancient tissue samples. This discovery clearly shows that glycans persist for thousands of years, and these samples provide a vital insight into ancient glycosylation, offering us a window into the distant past

WangLab at MEDIQA-Chat 2023: Clinical Note Generation from Doctor-Patient Conversations using Large Language Models

This paper describes our submission to the MEDIQA-Chat 2023 shared task for automatic clinical note generation from doctor-patient conversations. We report results for two approaches: the first fine-tunes a pre-trained language model (PLM) on the shared task data, and the second uses few-shot in-context learning (ICL) with a large language model (LLM). Both achieve high performance as measured by automatic metrics (e.g. ROUGE, BERTScore) and ranked second and first, respectively, of all submissions to the shared task. Expert human scrutiny indicates that notes generated via the ICL-based approach with GPT-4 are preferred about as often as human-written notes, making it a promising path toward automated note generation from doctor-patient conversations.Comment: Camera-ready submission to ClinicalNLP @ ACL 202

Comprehensive native glycan profiling with isomer separation and quantitation for the discovery of cancer biomarkers

Glycosylation is highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Glycan compositional profiling of human serum with mass spectrometry has already identified potential biomarkers for several types of cancer and diseases; however, composition alone does not fully describe glycan stereo-and regioisomeric diversity. The vast structural heterogeneity of glycans presents a formidable analytical challenge. We have developed a method to identify and quantify isomeric native glycans using nanoflow liquid chromatography (nano-LC)/mass spectrometry. A microfluidic chip packed with graphitized carbon was used to chromatographically separate the glycans. To determine the utility of this method for structure-specific biomarker discovery, we analyzed serum samples from two groups of prostate cancer patients with different prognoses. More than 300 N-glycan species (including isomeric structures) were identified, corresponding to over 100 N-glycan compositions. Statistical tests established significant differences in glycan abundances between patient groups. This method provides comprehensive, selective, and quantitative glycan profiling

The Iowa Homemaker vol.1, no.8

Table of Contents An Appreciation of the Life of Dean MacKay compiled by Clara Jordan, page 1 Iowa Members of W. C. T. U. Meet by Helen Paschal, page 2 What Shall We Have for Thanksgiving Dinner? by Beth Bailey, page 3 Things to Know About the School Lunch Basket by Millie Lerdall and Grace McIlrath, page 4 Do You Know What’s In a Can? by Blanche Ingersoll, page 5 “La Chambre D’Ami” in An Iowa Home by Eda Lord Murphy, page 6 “Looking In” on Home Economics at Iowa State by An Alumna, page 6 Pumpkin Pies They Don’t Forget by Viola M. Bell, page

BigO: A public health decision support system for measuring obesogenic behaviors of children in relation to their local environment

Obesity is a complex disease and its prevalence depends on multiple factors related to the local socioeconomic, cultural and urban context of individuals. Many obesity prevention strategies and policies, however, are horizontal measures that do not depend on context-specific evidence. In this paper we present an overview of BigO (http://bigoprogram.eu), a system designed to collect objective behavioral data from children and adolescent populations as well as their environment in order to support public health authorities in formulating effective, context-specific policies and interventions addressing childhood obesity. We present an overview of the data acquisition, indicator extraction, data exploration and analysis components of the BigO system, as well as an account of its preliminary pilot application in 33 schools and 2 clinics in four European countries, involving over 4,200 participants.Comment: Accepted version to be published in 2020, 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Montreal, Canad

The SCottish Alcoholic Liver disease Evaluation: a population-level matched cohort study of hospital-based costs, 1991-2011

Studies assessing the costs of alcoholic liver disease are lacking. We aimed to calculate the costs of hospitalisations before and after diagnosis compared to population controls matched by age, sex and socio-economic deprivation. We aimed to use population level data to identify a cohort of individuals hospitalised for the first time with alcoholic liver disease in Scotland between 1991 and 2011.Incident cases were classified by disease severity, sex, age group, socio-economic deprivation and year of index admission. 5 matched controls for every incident case were identified from the Scottish population level primary care database. Hospital costs were calculated for both cases and controls using length of stay from morbidity records and hospital-specific daily rates by specialty. Remaining lifetime costs were estimated using parametric survival models and predicted annual costs. 35,208 incident alcoholic liver disease hospitalisations were identified. Mean annual hospital costs for cases were 2.3 times that of controls pre diagnosis (£804 higher) and 10.2 times (£12,774 higher) post diagnosis. Mean incident admission cost was £6,663. Remaining lifetime cost for a male, 50-59 years old, living in the most deprived area diagnosed with acoholic liver disease was estimated to be £65,999 higher than the matched controls (£12,474 for 7.43 years remaining life compared to £1,224 for 21.8 years). In Scotland, alcoholic liver disease diagnosis is associated with significant increases in admissions to hospital both before and after diagnosis. Our results provide robust population level estimates of costs of alcoholic liver disease for the purposes of health-care delivery, planning and future cost-effectiveness analyses

Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior

Midbrain dopamine neurons are crucial for many behavioral and cognitive functions. As the major excitatory input, glutamatergic afferents are important for control of the activity and plasticity of dopamine neurons. However, the role of glutamatergic input as a whole onto dopamine neurons remains unclear. Here we developed a mouse line in which glutamatergic inputs onto dopamine neurons are specifically impaired, and utilized this genetic model to directly test the role of glutamatergic inputs in dopamine-related functions. We found that while motor coordination and reward learning were largely unchanged, these animals showed prominent deficits in effort-related behavioral tasks. These results provide genetic evidence that glutamatergic transmission onto dopaminergic neurons underlies incentive motivation, a willingness to exert high levels of effort to obtain reinforcers, and have important implications for understanding the normal function of the midbrain dopamine system.Fil: Hutchison, M. A.. National Institutes of Health; Estados UnidosFil: Gu, X.. National Institutes of Health; Estados UnidosFil: Adrover, Martín Federico. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Lee, M. R.. National Institutes of Health; Estados UnidosFil: Hnasko, T. S.. University of California at San Diego; Estados UnidosFil: Alvarez, V. A.. National Institutes of Health; Estados UnidosFil: Lu, W.. National Institutes of Health; Estados Unido