Genomics and epidemiology for gastric adenocarcinomas (GE4GAC): a Brazilian initiative to study gastric cancer

Abstract Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large research centers from developed countries. The need for further understanding of this complex disease, including the local importance of epidemiological factors and the rich ancestral admixture found in Brazil, stimulated the implementation of the GE4GAC project. GE4GAC aims to embrace epidemiological, clinical, molecular and microbiological data from Brazilian controls and patients with malignant and pre-malignant gastric disease. In this letter, we summarize the main goals of the project, including subject and sample accrual and current findings

A conservation roadmap for the subterranean biome

The 15th UN Convention on Biological Diversity (CBD) (COP15) will be held in Kunming, China in October 2021. Historically, CBDs and other multilateral treaties have either alluded to or entirely overlooked the subterranean biome. A multilateral effort to robustly examine, monitor, and incorporate the subterranean biome into future conservation targets will enable the CBD to further improve the ecological effectiveness of protected areas by including groundwater resources, subterranean ecosystem services, and the profoundly endemic subsurface biodiversity. To this end, we proffer a conservation roadmap that embodies five conceptual areas: (1) science gaps and data management needs; (2) anthropogenic stressors; (3) socioeconomic analysis and conflict resolution; (4) environmental education; and (5) national policies and multilateral agreements.Peer reviewe

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Ciclos longos e cenários contemporâneos da sociedade internacional Long cycles of the international society

A despeito da anarquia que resulta da ausência uma autoridade legítima comum, as relações internacionais pós-Westphalia têm elementos de ordem que são suficientes para caracterizá-las como uma forma de "associação prática". Esses elementos são a (igual) soberania nacional, a diplomacia, o direito internacional e o equilíbrio de poder. Discute-se, neste artigo, em que medida esses pilares da ordem mundial pós-Westphalia ainda se prestam para pensar as relações internacionais no pós-Guerra Fria. Trata-se de saber em que medida essas relações hoje se afastam do modelo de "associação prática" em direção a um modelo, normativamente mais exigente, de "associação de objetivos".<br>Despite the lack of a common legitimate authority the international relations after Westphalia share enough elements of order for being characterized as a form of "practical association": (equal) national sovereignty, diplomacy, international law and the balance of power. The fit-ness of those pilars of the post-Westphalian world order for thinking the international relations after the Cold War is discussed. It is asked how far those relations are leaving the model of a practical association towards another normatively more demanding model, of "goals association"

A visão brasileira da futura ordem global Brazil's vision of the future global order

Este artigo visa desdobrar a concepção brasileira da futura ordem global localizada entre os polos extremos de um concerto de grandes potências e de uma ordem mundial multirregional. O autor demonstra como os formuladores de política externa brasileira contribuem para um tipo de ordem global que oferece espaço de manobra para a potência emergente. As opções de política externa do Brasil são limitadas, diante do superior poder material (hard power) das grandes potências estabelecidas. A estratégia de soft balancing do Brasil envolve estratégias institucionais, como a formação de coalizões diplomáticas limitadas ou alianças para restringir o poder das grandes potências estabelecidas. O Brasil tem estado entre os mais poderosos condutores de mudança incremental na diplomacia mundial e é beneficiado em grande parte pelas conectadas mudanças de poder global. Em uma ordem global moldada por grandes potências por meio de arranjos e instituições internacionais, esses jogadores que efetivamente operam em ambos como inovadores, construtores de coalizões e porta-vozes, ao mesmo tempo em que preservam grande parcela de soberania e autonomia, têm o potencial de influenciar substancialmente os resultados da futura política global.<br>This article aims to unfold the Brazilian conception of the future global order located between the extreme poles of a concert of great powers and a multiregional world order. The author demonstrates how Brazilian foreign policy makers contribute to the kind of global order, which offers most room to manoeuvre to the rising power. The foreign policy options of Brazil are limited in view of the superior hard power of the established great powers. Brazil's soft balancing strategy involves institutional strategies such as the formation of limited diplomatic coalitions or ententes to constrain the power of the established great powers. Brazil has been amongst the most powerful drivers of incremental change in world diplomacy and it benefits most from the connected global power shifts. In a global order shaped by great powers through international groupings and institutions, those players who effectively operate within them as innovators, coalition builders and spokesmen while preserving great amounts of sovereignty and autonomy have the potential to substantially influence the outcomes of future global politics