ABA increased soybean yield by enhancing production of carbohydrates and their allocation in seed

Soybean is the most expanding crop worldwide, and in the last 30 years it has doubled the cultivated area (FAO, 2002). Argentina is one of the main producers, where soybean production increased from 11 millions of tons in the campaign 1990-1991 to 55 millions of tons in the campaign 2009- 2010, with a planted area that reached 18.7 million hectares (GEA, 2010). Soybean expansion in Argentina has been so significant that the crop is now located in areas that were previously considered “marginal” or “not suitable for the crop” due to environmental conditions (Qaim & Traxler, 2005; Monti, 2008; Zak et al., 2008). In the last five years, this crop has moved approximately 4.6 millions of hectares of other crops and pasture lands (Pengue, 2009). The same as in other countries in Latin America such as Brazil, Bolivia and Paraguay, soybean culture has been the main cause of deforestation during the last years (Kaimowitz & Smith 2001; Steininger et al., 2001; Pengue, 2009). Several technological advances have allowed the development of a new agricultural model that having less input is able to increase yields therefore generating an intensive system that in turn increases the financial profit (Monti, 2008). The use of practices such as direct sowing, fertilization, and genetically modified materials resistant to glyphosate that allow easy weed control and with high yield potential, have permitted yield increases and consolidated the new agricultural model. This agricultural model, based in monoculture, has made soybean production very economic to crop growers allowing an interesting income in a short period with low investment of resources. Argentina’s economy is greatly dependent on the currency generated by exportation of primary products and it is one of the top three producers and exporters of vegetable oils, and the biggest worldwide exporter of soybean oil (FAO, 2008). Due to the country’s size and geographical diversity, soybean has a high potential to satisfy the increasing international demand of bio-fuels (Tomei & Upham, 2009). Therefore it is possible to think in a future of increasing soybean production.Fil: Reinoso, Herminda Elmira. Universidad Nacional de Río Cuarto; ArgentinaFil: Travaglia, Claudia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto; ArgentinaFil: Bottini, Ambrosio Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentin

Estrategias docentes para el desarrollo de la creatividad desde el lenguaje gráf́ico-plástico en un aula de 5 años de una institución educativa privada de Surco

La creatividad es una habilidad que posee toda persona de manera innata, y que se refleja en los diferentes ámbitos, desde las formas de aprendizaje, interacción y la relación con el mundo. No obstante, en muchas ocasiones, no se le da la importancia necesaria, a pesar de tener múltiples beneficios en las diferentes dimensiones. Es por ello que, el presente trabajo de tesis tiene como principal objetivo analizar las estrategias docentes para el desarrollo de la creatividad desde el lenguaje gráfico-plástico de los niños de cinco años de una institución educativa privada del distrito de Surco. Es una investigación de enfoque cualitativo y nivel descriptivo, la cual se redacta partiendo del recojo de información de las fuentes; como las revistas académicas, libros y tesis. Los sujetos informantes son dos docentes de las aulas de 5 años de una institución educativa privada. La técnica empleada para el recojo y procesamiento de la información es la entrevista semiestructurada y la observación no participante. Los resultados obtenidos denotan las definiciones que los docentes tienen sobre la creatividad y la gráfico-plástica, las cuales permiten constatar e identificar aquellas estrategias docentes empleadas en las sesiones de aprendizaje. Por último, se brindan recomendaciones para seguir fomentando estrategias gráfico-plásticas, llevándolo, además, a un trabajo colaborativo con los padres de familia.Creativity is an ability that every person innately possesses, and that is reflected in different areas, from the ways of learning, interaction and relationship with the world. However, in many occasions, it is not given the necessary importance, despite having multiple benefits in children. That is why, in the present thesis work, its main objective is to analyze the teaching strategies for the development of creativity from the plastic graphic language of five-year-old children of a private educational institution in the district of Surco. It is a research of qualitative approach and descriptive level, which is written based on the collection of information from sources such as academic journals, books and theses. The informant subjects are two teachers of the 5-year classrooms of a private educational institution. The technique used for the collection and processing of information is the semi-structured interview and non-participant observation. The results obtained denote the definitions that teachers have about creativity and plastic graphics, which allow us to verify and identify those teaching strategies used in the learning sessions. Finally, recommendations are offered to continue promoting graphic-plastic strategies, also leading to a collaborative work with parents

Indole-3-acetic acid attenuates the fungal lesions in infected potato tubers

In this report, we demonstrated that potato tubers pre-treated with 100 μM of indole-3-acetic acid (IAA) and then inoculated with Fusarium solani f. sp. eumartii (F. eumartii) showed a decrease in the fungal lesion compared with non-IAA pre-treated and inoculated tubers. Consequently, we tested the addition of different concentrations of IAA on the fungal growth and on the proteolytic activity when the fungus was grown in liquid culture medium. Fungal growth did not change under different phytohormone concentrations, but the activity of Fusarium extracellular serine protease (FESP) clearly decreased. The inhibition of FESP activity by IAA was dose dependent. Moreover, FESP as well as others extracellular pectinolytic activities detected in IAA pre-treated and inoculated tubers decreased compared with controls. In addition, the ability of IAA production by F. eumartii was tested, and the role of IAA on potato-F. eumartii interaction is discussed.Fil: Terrile, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Olivieri, Florencia Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Bottini, Ambrosio Ruben. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Economía, Política y Administración Rural.; ArgentinaFil: Casalongue, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentin

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells

The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the release of danger signals that induce the recruitment of various cells, including innate immune cells such as macrophages (Mo), dendritic cells (DCs), eosinophils, basophils, and mast cells. In this scenario, these cells are able to secrete soluble factors, which orchestrate immune effector mechanisms that depend on the different niches these parasites inhabit. Here, we focus on recent advances in the knowledge of excretory-secretory products (ESP), resulting from helminth recognition by DCs and Mo. Phagocytes and other cells types such as innate lymphocyte T cells 2 (ILC2), when activated by ESP, participate in an intricate cytokine network to generate innate and adaptive Th2 responses. In this review, we also discuss the mechanisms of innate immune cell-induced parasite killing and the tissue repair necessary to assure helminth survival over long periods of time.Fil: Motran, Claudia Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Silvane, Leonardo Micael. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Chiapello, Laura Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; ArgentinaFil: Theumer, Martín Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Ambrosio, Laura Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Volpini, Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; ArgentinaFil: Celias, Daiana Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; ArgentinaFil: Cervi, Laura Alejandra. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentin

CONSIDERAÇÕES SOBRE O CONCEITO DE EQUAÇÃO PRESENTE NOS CADERNOS DO PROFESSOR E AS ZONAS DE PERFIL CONCEITUAL DE EQUAÇÃO

Neste artigo, trazemos uma análise da noção de equação presente nos Cadernos do Professor (Matemática) que compõem a Proposta Curricular de Matemática do Estado de São Paulo. Esta análise constitui elemento essencial, uma vez que buscamos compreender a maneira com que o currículo oficial e o material didático utilizado pela rede estadual de ensino tece e/ou abre possibilidades de desenvolvimento de zonas de perfil conceitual de equação e de que modo pode contribuir para a aprendizagem eficaz do conteúdo de equação. Em seguida, discorremos sobre os termos utilizados para nomear e/ou qualificar as questões de Matemática presentes nos Cadernos do Professor, fazendo uma diferenciação e de que forma podem contribuir para o desenvolvimento das zonas de equação, além de trazer reflexões sobre a prova do SARESP do Ensino Médio. Os resultados constataram que o material relativo ao conteúdo de equação embora apresente alguns equívocos de abordagem na parte introdutória, as questões, contudo, possibilitam o desenvolvimento de diversas zonas de perfil conceitual de equação, uma vez que são de tipos variados que possibilitam manifestarvárias formas de resolução

Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Their Intracellular Replication in Macrophages

During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling pathways could modulate macrophages response to restrict parasite replication and instruct an appropriate adaptive response. Recently, it has become evident that Wnt signaling has immunomodulatory functions during inflammation and infection. Here, we tested the hypothesis that during T. cruzi infection, the activation of Wnt signaling pathway in macrophages plays a role in modulating the inflammatory/tolerogenic response and therefore regulating the control of parasite replication. In this report, we show that early after T. cruzi infection of bone marrow-derived macrophages (BMM), β-catenin was activated and Wnt3a, Wnt5a, and some Frizzled receptors as well as Wnt/β-catenin pathway's target genes were upregulated, with Wnt proteins signaling sustaining the activation of Wnt/β-catenin pathway and then activating the Wnt/Ca+2 pathway. Wnt signaling pathway activation was critical to sustain the parasite's replication in BMM; since the treatments with specific inhibitors of β-catenin transcriptional activation or Wnt proteins secretion limited the parasite replication. Mechanistically, inhibition of Wnt signaling pathway armed BMM to fight against T. cruzi by inducing the production of pro-inflammatory cytokines and indoleamine 2,3-dioxygenase activity and by downregulating arginase activity. Likewise, in vivo pharmacological inhibition of the Wnts' interaction with its receptors controlled the parasite replication and improved the survival of lethally infected mice. It is well established that T. cruzi infection activates a plethora of signaling pathways that ultimately regulate immune mediators to determine the modulation of a defined set of effector functions in macrophages. In this study, we have revealed a new signaling pathway that is activated by the interaction between protozoan parasites and host innate immunity, establishing a new conceptual framework for the development of new therapies.Fil: Volpini, Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Ambrosio, Laura Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Fozzatti, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Insfran, Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Stempin, Cinthia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Cervi, Laura Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Motran, Claudia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentin

In vitro cultures of Vitis vinifera L. cv. Chardonnay synthesize the phytoalexin nerolidol upon infection by Phaeoacremonium parasiticum

This study investigated terpene synthase (TPS) activity and terpene antifungal metabolites in calluses and cell suspension cultures of Vitis vinifera cv. Chardonnay infected with Phaecremonium parasiticum, one of the fungi associated with the grapevine diseases known as “hoja de malvón” and young vine decline. The highest TPS activity, assessed as tritiated farnesyl pyrophosphate ([1-3H]-FPP) transformed into hexane-soluble radioactive products, was observed in both inoculated calluses and cell suspension cultures (CSC). When tested in inoculated cell suspension cultures the TPS activity was maximal at 8 h after [1-3H]-FPP application and then declined; this was associated with a temporary increase of the sesquiterpene nerolidol. Grape calluses produced: α-pinene, nerolidol and squalene whether or not they were inoculated with Pm. parasiticum. As fungal amount raised the relative concentration of α-pinene and nerolidol increased in respect to squalene in calluses. The TPS activity and nerolidol and α-pinene accumulation was correlated with the increase in the amount of inoculated fungus. Of the mentioned metabolites mainly squalene was identified from extracts of fungal cultures. The results suggest that the response of grapevine tissues to Pm. parasiticum is dependent on the pathogen concentration and is characterized by increasing TPS activity through de novo synthesis.Fil: Escoriaza, Maria Georgina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza. Laboratorio de Fitopatología; ArgentinaFil: Sansberro, Pedro. Universidad Nacional del Nordeste-Consejo Nacional de Investigaciones Científicas y Técnicas.Instituto de Botánica del Nordeste; ArgentinaFil: Garcia Lampasona, Sandra Claudia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina. Universidad Nacional de Cuyo-Consejo Nacional de Investigaciones Científicas y Técnicas. Laboratorio de Biología Molecular; ArgentinaFil: Gatica, Marta Elcira. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza. Laboratorio de Fitopatología; ArgentinaFil: Bottini, Rubén. Universidad Nacional de Cuyo-Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Piccoli, Patricia Noemí. Universidad Nacional de Cuyo-Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Agrícola de Mendoza; Argentin

Exogenous ABA increases yield in field-grown wheat with moderate water restriction

Water stress is one of the most important environmental factors that regulate a plant's growth and development. In agronomic practice the effects of water stress are translated into low yield and/or reduced quality. Abscisic acid (ABA) sprays (1 mM) were applied to wheat plants at different phenological stages and the effects on several physiological variables and on yield were evaluated under field conditions at different water regimes. Studies were conducted in the field across three consecutive winter-spring seasons. ABA treatments were applied at the beginning of shoot enlargement and repeated at anthesis. Exogenous ABA increased shoot dry weight and maintained a high concentration of photosynthetic pigments for a longer period of time during grain growth and maturation. Although ABA applications increased stomatal closure immediately after its application, the longer-term effect was to allow for a greater ostiolar opening of the stomatal pore which resulted in increased conductance of gases and water vapor. ABA also improved the transport of photoassimilates from the leaves and stem to the developing grains, that is, it effectively increased the sink strength of the grains. This correlated with a yield increase without significantly changing the protein quality in the grains. Thus, elevated ABA levels from exogenous application or genetic selection could help improve agricultural production of grains in arid areas where irrigation is not possible.Fil: Travaglia, Claudia Noemi. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Ciencias Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reinoso, Herminda Elmira. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Cohen, Ana Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Luna, Celina Mercedes. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Fitopatología y Fisiología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tommasino, Exequiel Arturo. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Fitopatología y Fisiología Vegetal; ArgentinaFil: Castillo, Carlos. Universidad Nacional de Río Cuarto; ArgentinaFil: Bottini, Ambrosio Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentin

Propuesta de lineamientos para la mejora del proceso de selección de personal en el Programa Integral Nacional para Bienestar Familiar - Inabif

La presente investigación tiene como objetivo proponer lineamientos para mejorar el proceso de selección de personal en el Programa Integral Nacional para el Bienestar Familiar (Inabif), que cubran las necesidades de requerimiento de personal idóneo de sus Unidades de Servicio y de Desarrollo. Para tal fin, se revisaron y analizaron las fuentes secundarias contenidas en la documentación entregada por el Inabif, así como la recabada de los portales web institucionales de la referida institución, y del Ministerio de la Mujer y Poblaciones Vulnerables. A continuación, se recogió información de fuentes primarias relacionadas con el proceso de selección en la institución a través de entrevistas iniciales y entrevistas semiestructuradas. Posteriormente, se efectuó un estudio de benchmarking con instituciones públicas reconocidas con la mejor reputación en el país, y entrevistas a expertos y a personal de organizaciones que atienden a similar público objeto que el Inabif

Role of aryl hydrocarbon receptor (AhR) in the regulation of immunity and immunopathology during trypanosoma cruzi infection

Resistance to Trypanosoma cruzi infection is dependent on a rapid induction of Th1-type and CD8+ T cell responses that should be promptly balanced to prevent immunopathology. T. cruzi-infected B6 mice are able to control parasite replication but show a limited expansion of Foxp3+regulatory T (Treg) cells that results in the accumulation of effector immune cells and the development of acute liver pathology. AhR is a ligand-activated transcription factor that promotes Treg cell development and suppression of pro-inflammatory cytokine production in dendritic cells, altering the course of adaptive immune response and the development of immunopathology. Here, we used different AhR-dependent activation strategies aiming to improve the Treg response, and B6 congenic mice carrying a mutant AhR variant with low affinity for its ligands (AhRd) to evaluate the role of AhR activation by natural ligands during experimental T. cruzi infection. The outcome of TCDD or 3-HK plus ITE treatments indicated that strong or weak AhR activation before or during T. cruzi infection was effective to regulate inflammation improving the Treg cell response and regularizing the ratio between CD4+ CD25- to Treg cells. However, AhR activation shifted the host-parasite balance to the parasite replication. Weak AhR activation resulted in Treg promotion while strong activation differentially modulated the susceptibility and resistance of cell death in activated T and Treg cells and the increase in TGF-β-producing Treg cells. Of note, T. cruzi-infected AhRd mice showed low levels of Treg cells associated with strong Th1-type response, low parasite burden and absence of liver pathology. These mice developed a Treg- and Tr1-independent mechanism of Th1 constriction showing increased levels of systemic IL-10 and IL-10-secreting CD4+ splenocytes. In addition, AhR activation induced by exogenous ligands had negative effects on the development of memory CD8+ T cell subsets while the lack/very weak activation in AhRd mice showed opposite results, suggesting that AhR ligation restricts the differentiation of memory CD8+T cell subsets. We propose a model in which a threshold of AhR activation exists and may explain how activation or inhibition of AhR-derived signals by infection/inflammation-induced ligands, therapeutic interventions or exposure to pollutants can modulate infections/diseases outcomes or vaccination efficacy.Fil: Ambrosio, Laura Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Insfran, Constanza. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Volpini, Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Acosta Rodriguez, Eva Virginia. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Quintana, Francisco Javier. The Broad Institute of MIT and Harvard; Estados Unidos. Harvard Medical School; Estados UnidosFil: Cervi, Laura Alejandra. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Motran, Claudia Cristina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentin