19 research outputs found
A systematic review of the use of an expertise-based randomised controlled trial design
Acknowledgements JAC held a Medical Research Council UK methodology (G1002292) fellowship, which supported this research. The Health Services Research Unit, Institute of Applied Health Sciences (University of Aberdeen), is core-funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. Views express are those of the authors and do not necessarily reflect the views of the funders.Peer reviewedPublisher PD
Barriers to Exercise in Adults with Type 1 Diabetes and Insulin Resistance
Objective
To explore attitudes to exercise and quality of life (QoL) in adults with type 1 diabetes (T1D) with and without insulin resistance (IR).
Design
We pooled baseline pre-treatment data from a subset of T1D individuals from two randomised controlled trials (RCT). Estimated glucose disposal rate (eGDR), a validated surrogate marker of IR, was calculated using an established formula to classify individuals according to IR status with a cut-point of <6mg/kg/min for the determination of IR. Self-reported barriers to exercise were obtained using a validated questionnaire, the Barriers to Physical Activity in T1D (BAPAD-1). In addition, QoL was determined using the 36-item short form (SF-36) questionnaire. Differences between dichotomised variables were assessed using independent t-tests, Mann-Whitney U tests or Fisherâs exact tests. Linear regression was employed to explore the association of eGDR with BAPAD-1 and QoL scores, with sequential adjustment for potential confounders.
Results
Of 85 individuals included, n=39 were classified as having IR. The mean BAPAD-1 total score was higher for individuals with IR (IR 3.87±0.61 vs. non-IR 2.83±0.55; P0.05).
Conclusions
Risk of hypoglycaemia was the greatest barrier to exercise in T1D individuals with IR, whereas non-diabetes related barriers to exercise were more salient in T1D individuals without IR
Reducing sitting time in type 1 diabetes: considerations and implications
Sedentary behaviours are ubiquitous in modern society with western populations spending approximately âŒ50% of their waking hours expending low levels of energy expenditure. This behaviour is associated with cardiometabolic derangements and increased morbidity and mortality. In individuals living with, or at risk of developing type 2 diabetes (T2D), âbreaking upâ sedentariness, by interrupting prolonged periods of sitting has been shown to acutely improve glucose control and cardiometabolic risk factors related to diabetes complications. As such, current guidelines recommend interrupting prolonged periods of sitting with short, frequent activity breaks. However, the evidence underpinning these recommendations remain preliminary and are focused on those with or at risk of developing T2D, with little information regarding whether and how reducing sedentariness may be effective and safe in those living with type 1 diabetes (T1D). In this review, we discuss the potential application of interventions that target prolonged sitting time in T2D within the context of T1D
Interrupting prolonged sitting with frequent short bouts of light-intensity activity in people with type 1 diabetes improves glycaemic control without increasing hypoglycaemia: The SIT-LESS randomised controlled trial
Aim
To examine the impact of interrupting prolonged sitting with frequent short bouts of light-intensity activity on glycaemic control in people with type 1 diabetes (T1D).
Materials and Methods
In total, 32 inactive adults with T1D [aged 27.9â±â4.7âyears, 15 men, diabetes duration 16.0â±â6.9âyears and glycated haemoglobin 8.4â±â1.4% (68â±â2.3âmmol/mol)] underwent two 7-h experimental conditions in a randomised crossover fashion with >7-day washout consisting of: uninterrupted sitting (SIT), or, interrupted sitting with 3-min bouts of self-paced walking at 30-min intervals (SIT-LESS). Standardised mixed-macronutrient meals were administered 3.5âh apart during each condition. Blinded continuous glucose monitoring captured interstitial glucose responses during the 7-h experimental period and for a further 48-h under free-living conditions.
Results
SIT-LESS reduced total mean glucose (SIT 8.2â±â2.6 vs. SIT-LESS 6.9â±â1.7âmmol/L, pâ=â.001) and increased time in range (3.9-10.0âmmol/L) by 13.7% (SIT 71.5â±â9.5 vs. SIT-LESS 85.1â±â7.1%, pâ=â.002). Hyperglycaemia (>10.0âmmol/L) was reduced by 15.0% under SIT-LESS (SIT 24.2â±â10.8 vs. SIT-LESS 9.2â±â6.4%, pâ=â.002), whereas hypoglycaemia exposure (
Conclusions
Interrupting prolonged sitting with frequent short bouts of light-intensity activity improves acute postprandial and 48-h glycaemia in adults with T1D. This pragmatic strategy is an efficacious approach to reducing sedentariness and increasing physical activity levels without increasing risk of hypoglycaemia in T1D.</p