Ajjan, RA

Alobaid, AM

Birch, KM

Campbell, MD

Ho, P

Holmes, M

Mappa, G

O'Mahoney, LL

Orsi, NM

Price, OJ

Stavropoulos-Kalinoglou, A

Leeds Beckett Repository

Citation:O’Mahoney, LL and Alobaid, AM and Ajjan, RA and Birch, KM and Orsi, NM and Mappa, G andHolmes, M and Ho, P and Stavropoulos-Kalinoglou, A and Price, OJ and Campbell, MD (2020)Effects of omega-3 polyunsaturated fatty acid supplementation on parameters of glycaemic control inpeople with type 1 diabetes: A double-blind, randomised, placebo-controlled trial. Proceedings of theNutrition Society, 79 (OCE3). ISSN 0029-6651 DOI: https://doi.org/10.1017/S002966512000734XLink to Leeds Beckett Repository record:https://eprints.leedsbeckett.ac.uk/id/eprint/7254/Document Version:Article (Published Version)Published abstractCopyright c© The Authors 2020The aim of the Leeds Beckett Repository is to provide open access to our research, as required byfunder policies and permitted by publishers and copyright law.The Leeds Beckett repository holds a wide range of publications, each of which has beenchecked for copyright and the relevant embargo period has been applied by the Research Servicesteam.We operate on a standard take-down policy. If you are the author or publisher of an outputand you would like it removed from the repository, please contact us and we will investigate on acase-by-case basis.Each thesis in the repository has been cleared where necessary by the author for third partycopyright. If you would like a thesis to be removed from the repository or believe there is an issuewith copyright, please contact us on openaccess@leedsbeckett.ac.uk and we will investigate on acase-by-case basis.Citation:O’Mahoney, LL and Alobaid, AM and Ajjan, RA and Birch, KM and Orsi, NM and Mappa, G andHolmes, M and Ho, P and Stavropoulos-Kalinoglou, A and Price, OJ and Campbell, MD (2020)Effects of omega-3 polyunsaturated fatty acid supplementation on parameters of glycaemic controlin people with type 1 diabetes: A double-blind, randomised, placebo-controlled trial. Proceedings ofthe Nutrition Society. ISSN 0029-6651 DOI: https://doi.org/10.1017/S002966512000734XLink to Leeds Beckett Repository record:http://eprints.leedsbeckett.ac.uk/id/eprint/7254/Document Version:ArticleThe aim of the Leeds Beckett Repository is to provide open access to our research, as required byfunder policies and permitted by publishers and copyright law.The Leeds Beckett repository holds a wide range of publications, each of which has beenchecked for copyright and the relevant embargo period has been applied by the Research Servicesteam.We operate on a standard take-down policy. If you are the author or publisher of an outputand you would like it removed from the repository, please contact us and we will investigate on acase-by-case basis.Each thesis in the repository has been cleared where necessary by the author for third partycopyright. If you would like a thesis to be removed from the repository or believe there is an issuewith copyright, please contact us on openaccess@leedsbeckett.ac.uk and we will investigate on acase-by-case basis.Nutrition Society Live 2020, 14–15th July 2020Effects of omega-3 polyunsaturated fatty acid supplementation onparameters of glycaemic control in people with type 1 diabetes:a double-blind, randomised, placebo-controlled trialL.L. O’Mahoney1, A.M. Alobaid2, R.A. Ajjan3, K.M. Birch4, N.M. Orsi5, G. Mappa5,M. Holmes2, P. Ho2, A. Stavropoulos-Kalinoglou1, O.J. Price1 and M.D. Campbell21Carnegie School of Sport, Leeds Beckett University, Leeds, UK,2School of Food Science a Nutrition, University of Leeds, Leeds, UK,3School of Medicine, University of Leeds, Leeds, UK,4School of Biomedical Sciences, University of Leeds, Leeds, UK and5Leeds Institute of Cancer & Pathology, St James’s University Hospital, Leeds, UKThe effect of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on glycaemic control in T1D remains unclear(1).Additionally, the effects of n-3 PUFA on postprandial glucose control in T1D are unknown. Here, we report the effect of6-month supplementation with a daily high-dose-bolus of n-3 PUFA on parameters of glycaemic control in people with T1D.For this double-blind, randomized, placebo-controlled trial, individuals with T1D (n = 18; males: 14; 35 ± 15 years; BMI: 26.6 ±5.2 kg/m2; glycated haemoglobin (HbA1c): 59 ± 13mmol/mol-1 [7.5 ± 3.3%]), were randomly allocated in a 1:1 ratio to receive either3.3 g/day of encapsulated n-3 PUFA or placebo (PLA) consisting of an encapsulated dose of 3.0 g/day corn oil for 6-months. Venousblood samples were obtained at baseline, and 6-months, to determine HbA1c, fasting plasma glucose (FPG), and postprandial glucoseresponses (PPGR) to a standardised mixed-meal tolerance test assessed by area under the curve over a 4-hour period. Fatty acids weremeasured in erythrocyte membranes by gas chromatography with n-3 PUFA index (O3I) calculated as eicosapentaenoic acid plusdocosahexaenoic acid. Paired-samples t tests were used to compare intragroup mean differences with statistical significance set atp≤ 0.05. Data are presented as mean ± SD.In the n-3 PUFA group, baseline O3I increased from 4.97 ± 0.98% to 8.24 ± 1.52% after 6-months (p < 0.001). O3I in PLA did notchange (baseline: 4.31 ± 1.22% vs. 6-months: 4.58 ± 1.59%, p = 0.256). In the n-3 PUFA group, the mean difference between baselineand 6-months for HbA1c (-3.89 ± 6.05 mmol/mol-1; p = 0.090), FPG (-1.04 ± 2.82 mmol/L-1; p = 0.301), and PPGR (-607.03 ± 2014.63mmol/L-1/min-1; p = 0.392) did not significantly differ. Similar findings were observed in the PLA group; HbA1c (p = 0.208), FPG (p =0.624), and PPGR (p = 0.966). Overall, no safety issues arose during administration of n-3 PUFA or PLA.Supplementation with a daily high-dose-bolus of n-3 PUFA for 6-months did not modulate HbA1c, FPG, or PPGR to a mixed-meal tolerance test in people with T1D. These findings do not support the use of n-3 PUFA supplementation as an adjunct therapyin the management of T1D.1. De Caterina R, Madonna R, Bertolotto A et al. (2007) Diabetes Care 30, 1012–1026.Proceedings of the Nutrition Society (2020), 79 (OCE3), E748 doi:10.1017/S002966512000734XProceedingsoftheNutritionSocietyhttps://www.cambridge.org/core/terms. https://doi.org/10.1017/S002966512000734XDownloaded from https://www.cambridge.org/core. IP address: 86.173.114.46, on 20 Nov 2020 at 12:10:59, subject to the Cambridge Core terms of use, available at

Effects of omega-3 polyunsaturated fatty acid supplementation on parameters of glycaemic control in people with type 1 diabetes: A double-blind, randomised, placebo-controlled trial

https://eprints.leedsbeckett.ac.uk/id/eprint/7254/7/EffectsOfOmega-3PolyunsaturatedFattyAcidSupplementationOnParametersOfGlycaemicControlnPeopleWithType1DiabetesPV-PRICE.pdf

Effects of omega-3 polyunsaturated fatty acid supplementation on parameters of glycaemic control in people with type 1 diabetes: A double-blind, randomised, placebo-controlled trial

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