Adiabatic quantum pumping in graphene NIS junctions

We investigate adiabatic quantum pumping through a normal metal-insulator-superconductor (NIS) junction in a monolayer of graphene. The pumped current is generated by periodic modulation of two gate voltages, applied to the insulating and superconducting regions respectively. In the bilinear response regime and in the limit of a thin high insulating barrier, we find that the presence of the superconductor enhances the pumped current per mode by a factor of 4 at resonance. Compared to the pumped current in an analogous semiconductor NIS junction, the resonances have a $\pi/2$ phase difference. We also predict experimentally distinguishable differences between the pumped current and the tunneling conductance in graphene NIS junctions.Comment: 4 pages, 3 figure

An evaluation of sampling methodology for assessing settlement of temperate fish in seagrass meadows

All demersal fish with planktonic larvae settle at some point early in life, generally around the transformation from larvae to juveniles or soon after. Sampling pre-settlement or very young, settled fish is challenging due to spatial concretions within the habitat and the pulsed, rapid nature of the settlement process. There is a lack of robust methods that enable this sampling, but information on the settlement, that represents a mortality bottleneck, is crucial for the follow-up of populations for fisheries and conservation purposes. An empirical evaluation of sampling methods has not been conducted in temperate habitats. Here, we compare six different sampling methods to collect pre- and post-settlement stages of fish to determine the best combination of techniques to utilise in Posidonia oceanica, an endemic Mediterranean seagrass that provides a key nursery habitat for coastal fish. We considered three types of pelagic nets (bongo net, neuston net and ring net), two types of light-traps (Quatrefoil and Ecocean CARE®) to sample pre-settled stages and a low-impact epibenthic trawl for recent settlers. Our results show a significantly different size-spectrum for each method, with a continuous range of sizes from 2 mm to 200 mm. The smallest sizes were collected by the bongo net, followed by the ring net, the neuston net, the Quatrefoil, the Ecocean and finally the epibenthic trawl. Our results suggest that an appropriate strategy for collecting and estimating the abundance of key littoral fish species around settlement size is the combination of the Ecocean light trap and the epibenthic trawl

Valencia bridge fire tests: Validation of simplified and advanced numerical approaches to model bridge fire scenarios

[EN] Bridge fires are a major concern and the subject of many studies that use numerical models. However, experimental studies are still required to test the validity of these numerical models and improve their accuracy. This paper uses temperature results of the Valencia bridge fire tests carried out at the Universitat Politecnica de Valencia, in Valencia (Spain) to calibrate the fire models that constitute the first step in modeling any bridge fire event. The calibration is carried out by both a simplified approach (Heskestad and Hamada's correlation) and advanced numerical models (Computational Fluid Dynamics models built with the Fire Dynamics Simulator -FDS- software). The Valencia bridge fire tests involved four fire scenarios under a composite bridge with Heat Release Rate (HRR) values between 361 and 1352 kW. The results show that applying Heskestad and Hamada's correlation gave good results when used within its limits of application (HRR < 0.764 MW) but did not work well beyond them, which means it would be suitable for planning reduced scale bridge fire tests but not in the analysis of real bridge fires. On the other hand, FDS provides good predictions of the temperatures and can be used to study bridge fire responses. This work is therefore an important step forward in the study of bridge fires and towards the improvement of the resilience of infrastructure networks vis-a-vis fire hazards. It also highlights the problems that can arise in fire tests in the open air, the influence of the wind being of critical importance.Funding for this research was provided by the Spanish Ministry of Science and Innovation (Research Project BIA 2011-27104). The authors are grateful to the Infrastructure and Safety departments of the Universitat Politecnica de Valencia and the City of Valencia Fire Department (Cuerpo de Bomberos de Valencia), which provided crucial support in conducting the tests.Alós-Moya, J.; Paya-Zaforteza, I.; Hospitaler Pérez, A.; Loma-Ossorio, E. (2019). Valencia bridge fire tests: Validation of simplified and advanced numerical approaches to model bridge fire scenarios. Advances in Engineering Software (Online). 128:55-68. https://doi.org/10.1016/j.advengsoft.2018.11.003S556812

Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients

Electrical impedance spectroscopy has clinical relevance in diagnosing malignancy in melanocytic lesions. Sixty-eight lesions with changes during digital follow-up of patients at very high risk of developing melanoma were prospectively included in this study from February to December 2016. Electrical impedance spectroscopy and reflectance confocal microscopy were performed to evaluate their performance in this subset of difficult lesions. Forty-six lesions were considered suspicious on reflectance confocal microscopy and were excised, 19 were diagnosed as melanoma. Fifteen melanomas were detected by electrical impedance spectroscopy, while 4 received a score lower than 4, which suggested no malignancy. The addition of reflectance confocal microscopy improves accuracy while maintaining the same sensitivity. In the case of electrical impedance spectroscopy scores <4, lesions exhibiting changes in follow-up may need short-term monitoring or excision if dermoscopy shows criteria for melanoma. Results of electrical impedance spectroscopy in this subset of very early lesions should be carefully considered due to the risk of false negatives

Refining the phenotype associated with biallelic DNAJC21 mutations

Accepted manuscriptInherited bone marrow failure syndromes (IBMFS) are caused by mutations in genes involved in genomic stability. Although they may be recognized by the association of typical clinical features, variable penetrance and expressivity are common, and clinical diagnosis is often challenging. DNAJC21, which is involved in ribosome biogenesis, was recently linked to bone marrow failure. However, the specific phenotype and natural history remain to be defined. We correlate molecular data, phenotype, and clinical history of 5 unreported affected children and all individuals reported in the literature. All patients present features consistent with IBMFS: bone marrow failure, growth retardation, failure to thrive, developmental delay, recurrent infections, and skin, teeth or hair abnormalities. Additional features present in some individuals include retinal abnormalities, pancreatic insufficiency, liver cirrhosis, skeletal abnormalities, congenital hip dysplasia, joint hypermobility, and cryptorchidism. We suggest that DNAJC21-related diseases constitute a distinct IBMFS, with features overlapping Shwachman-Diamond syndrome and Dyskeratosis congenita, and additional characteristics that are specific to DNAJC21 mutations. The full phenotypic spectrum, natural history, and optimal management will require more reports. Considering the aplastic anemia, the possible increased risk for leukemia, and the multisystemic features, we provide a checklist for clinical evaluation at diagnosis and regular follow-up.FCT—Fundação para a Ciência e a Tecnologia (SFRH/BD/84650/2010)info:eu-repo/semantics/publishedVersio

Analysis of a bridge failure due to fire using computational fluid dynamics and finite element models

Bridge fires are a major concern because of the consequences that these kind of events have and because they are a real threat. However, bridge fire response is under researched and not covered in the codes. This paper studies the capabilities of numerical models to predict the fire response of a bridge and provides modeling guidelines useful for improving bridge design. To reach this goal, a numerical analysis of the fire of the I-65 overpass in Birmingham, Alabama, USA in 2002 is carried out. The analyses are based on computational fluid dynamics (CFD) for creating the fire model, and finite element (FE) software for obtaining the thermo-mechanical response of the bridge. The models are validated with parametric studies that consider heat release rate of the spilled fuel, discretization of the fire temperature in the transition from CFD to FE modeling, and boundary conditions. The validated model is used in a study to evaluate the influence of fire scenario (CFD versus standard fires), and live load. Results show that numerical models are able to simulate the response of the bridge and can be used as a basis for a performance-based approach for the design of bridges under fire. Additionally, it is found that applying the Eurocode standard and hydrocarbon fires along the full length of the bridge does not adequately represent a real bridge fire response for medium-long span bridges such as this case study. The study also shows that live loads essentially do not influence the response of the bridge. (C) 2014 Elsevier Ltd. All rights reserved.Funding for this research has been provided by the Spanish Ministry of Science and Innovation (research project BIA 2011-27104) and the Universitat Politecnica de Valencia (Research and Development Support Program PAID-06-11). Funding has also been provided to Dr. Maria Garlock by the National Science Foundation (NSF) under award number CMMI-1068252. The authors are grateful to R. King from the Federal Highway Administration of the USA, J. Black and T. Colquett from the Alabama Department of Transportation, J. Glassman from Princeton University, J.V. Aguado from Ecole Centrale de Nantes and to J. Hidalgo from the University of Edinburgh for all the information and support provided. All opinions expressed in this paper are the authors' and do not necessarily reflect the policies and views of the sponsors.Alós Moya, J.; Paya-Zaforteza, I.; Garlock, ME.; Loma-Ossorio, E.; Schiffner, D.; Hospitaler Pérez, A. (2014). Analysis of a bridge failure due to fire using computational fluid dynamics and finite element models. Engineering Structures. 68:96-110. https://doi.org/10.1016/j.engstruct.2014.02.022S961106

Clustering of antibiotic resistance of E. coli in couples: suggestion for a major role of conjugal transmission

BACKGROUND: Spread of antibiotic resistance in hospitals is a well-known problem, but studies investigating the importance of factors potentially related to the spread of resistant bacteria in outpatients are sparse. METHODS: Stool samples were obtained from 206 healthy couples in a community setting in Southern Germany in 2002–2003. E. coli was cultured and minimal inhibition concentrations were tested. Prevalences of E. coli resistance to commonly prescribed antibiotics according to potential risk factors were ascertained. RESULTS: Prevalences of ampicillin resistance were 15.7% and 19.4% for women and men, respectively. About ten percent and 15% of all isolates were resistant to cotrimoxazole and doxycycline, respectively. A partner carrying resistance was the main risk factor for being colonized with resistant E. coli. Odds ratios (95% CI) for ampicillin and cotrimoxazole resistance given carriage of resistant isolates by the partner were 6.9 (3.1–15.5) and 3.3 (1.5–18.0), respectively. CONCLUSION: Our data suggest that conjugal transmission may be more important for the spread of antibiotic resistance in the community setting than commonly suspected risk factors such as previous antibiotic intake or hospital contacts

Mapping and assessment of ecosystems and their services. Urban ecosystems

Action 5 of the EU Biodiversity Strategy to 2020 requires member states to Map and Assess the state of Ecosystems and their Services (MAES). This report provides guidance for mapping and assessment of urban ecosystems. The MAES urban pilot is a collaboration between the European Commission, the European Environment Agency, volunteering Member States and cities, and stakeholders. Its ultimate goal is to deliver a knowledge base for policy and management of urban ecosystems by analysing urban green infrastructure, condition of urban ecosystems and ecosystem services. This report presents guidance for mapping urban ecosystems and includes an indicator framework to assess the condition of urban ecosystems and urban ecosystem services. The scientific framework of mapping and assessment is designed to support in particular urban planning policy and policy on green infrastructure at urban, metropolitan and regional scales. The results are based on the following different sources of information: a literature survey of 54 scientific articles, an online-survey (on urban ecosystems, related policies and planning instruments and with participation of 42 cities), ten case studies (Portugal: Cascais, Oeiras, Lisbon; Italy: Padua, Trento, Rome; The Netherlands: Utrecht; Poland: Poznań; Spain: Barcelona; Norway: Oslo), and a two-day expert workshop. The case studies constituted the core of the MAES urban pilot. They provided real examples and applications of how mapping and assessment can be organized to support policy; on top, they provided the necessary expertise to select a set of final indicators for condition and ecosystem services. Urban ecosystems or cities are defined here as socio-ecological systems which are composed of green infrastructure and built infrastructure. Urban green infrastructure (GI) is understood in this report as the multi-functional network of urban green spaces situated within the boundary of the urban ecosystem. Urban green spaces are the structural components of urban GI. This study has shown that there is a large scope for urban ecosystem assessments. Firstly, urban policies increasingly use urban green infrastructure and nature-based solutions in their planning process. Secondly, an increasing amount of data at multiple spatial scales is becoming available to support these policies, to provide a baseline, and to compare or benchmark cities with respect to the extent and management of the urban ecosystem. Concrete examples are given on how to delineate urban ecosystems, how to choose an appropriate spatial scale, and how to map urban ecosystems based on a combination of national or European datasets (including Urban Atlas) and locally collected information (e.g., location of trees). Also examples of typologies for urban green spaces are presented. This report presents an indicator framework which is composed of indicators to assess for urban ecosystem condition and for urban ecosystem services. These are the result of a rigorous selection process and ensure consistent mapping and assessment across Europe. The MAES urban pilot will continue with work on the interface between research and policy. The framework presented in this report needs to be tested and validated across Europe, e.g. on its applicability at city scale, on how far the methodology for measuring ecosystem condition and ecosystem service delivery in urban areas can be used to assess urban green infrastructure and nature-based solutions