Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia

© 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present pioneer in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the levels of NO, nitrite, nitrate and S-nitroglutathione (GSNO) were determined. Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be dependent of the degree of band 3 phosphorylation. In presence of higher fibrinogen concentrations the NO efflux is reinforced when band 3 is phosphorylated (p < 0.001). Higher levels of nitrite, nitrate and GSNO were documented (p < 0.05). However, the mechanisms by which fibrinogen signalling modulates erythrocyte function remain to be clarified and are currently under study. These conditions may be considered an approach to be followed in blood storage for transfusions.This study was supported by grants from the FCT - Fundação para a Ciência e a Tecnologia (project reference PTDC/SAU-OSM/73449/2006

Semiclassical Evolution of Dissipative Markovian Systems

A semiclassical approximation for an evolving density operator, driven by a "closed" hamiltonian operator and "open" markovian Lindblad operators, is obtained. The theory is based on the chord function, i.e. the Fourier transform of the Wigner function. It reduces to an exact solution of the Lindblad master equation if the hamiltonian operator is a quadratic function and the Lindblad operators are linear functions of positions and momenta. Initially, the semiclassical formulae for the case of hermitian Lindblad operators are reinterpreted in terms of a (real) double phase space, generated by an appropriate classical double Hamiltonian. An extra "open" term is added to the double Hamiltonian by the non-hermitian part of the Lindblad operators in the general case of dissipative markovian evolution. The particular case of generic hamiltonian operators, but linear dissipative Lindblad operators, is studied in more detail. A Liouville-type equivariance still holds for the corresponding classical evolution in double phase, but the centre subspace, which supports the Wigner function, is compressed, along with expansion of its conjugate subspace, which supports the chord function. Decoherence narrows the relevant region of double phase space to the neighborhood of a caustic for both the Wigner function and the chord function. This difficulty is avoided by a propagator in a mixed representation, so that a further "small-chord" approximation leads to a simple generalization of the quadratic theory for evolving Wigner functions.Comment: 33 pages - accepted to J. Phys.

Reflectance spectrometry of rocks from the comstock lode (Virginia City, Nevada, USA) and its comparison with X-ray diffraction

This paper presents the results of mineralogical analysis of hydrothermal altered rocks from the Comstock Lode, near Virginia City, Nevada, USA, using two different techniques: reflectance spectrometry and X-ray diffraction. These results are discussed based on their quickness, accuracy and low costs. The applicability to mineral mapping using high spectral resolution remote sensing images is also briefly discussed. Comparison of the results obtained for both techniques have a good degree of correlation, showing that reflectance spectrometry represents an expedite, simple and relatively inexpensive technique, capable of mapping numerous minerals in the field or in laboratory.Este trabalho apresenta resultados de análises mineralógicas de rochas com alteração hidrotermal do Lode de Comstock, próximo a Virgínia City, Estado de Nevada, EUA, utilizando duas diferentes técnicas: espectrometria de reflexão e difração de raio-X. Os resultados são discutidos em função de sua rapidez e facilidade de obtenção e acuracidade. Discute-se ainda, brevemente, sua aplicabilidade ao mapeamento mineral utilizando imagens de sensoriamento remoto com alta resolução espectral. A título de ilustração, apresenta-se uma imagem TM-Landsat da região de estudo, na qual pode-se observar a característica resposta das áreas alteradas hidrotermalmente. A comparação dos resultados obtidos com as duas técnicas apresentou um razoável grau de correlação, mostrando que a espectrometria é uma ferramenta expedita, simples, relativamente barata e capaz de identificar no campo ou em laboratório minerais de interesse na prospecção de áreas com alteração hidrotermal

Resistivity of non-Fermi liquid U2Pt2In under pressure

Non-Fermi liquid behaviour in single-crystalline U2Pt2In has been studied by means of resistivity experiments (I||c) under hydrostatic pressure (P<1.5 GPa). At ambient pressure the resistivity rho(T) follows a power law rho~T^alpha with alpha~0.5. Upon applying pressure alpha increases. For P>1 GPa a minimum develops in rho(T). A study of the field dependence of the minimum confirms its magnetic origin. The ratio c/a is proposed as the effective control parameter, rather than the unit cell volume.Comment: 5 pages (incl. 2 figures), submitted to SCES'99, Nagan

Teleportation of entangled states without Bell-state measurement

In a recent paper [Phys. Rev. A 70, 025803 (2004)] we presented a scheme to teleport an entanglement of zero- and one-photon states from a bimodal cavity to another one, with 100% success probability. Here, inspired on recent results in the literature, we have modified our previous proposal to teleport the same entangled state without using Bell-state measurements. For comparison, the time spent, the fidelity, and the success probability for this teleportation are considered.Comment: 4 pages, 1 figure, published in Phys. Rev. A 72, 045802 (2005

Spin-glass behaviour on random lattices

The ground-state phase diagram of an Ising spin-glass model on a random graph with an arbitrary fraction $w$ of ferromagnetic interactions is analysed in the presence of an external field. Using the replica method, and performing an analysis of stability of the replica-symmetric solution, it is shown that $w=1/2$, correponding to an unbiased spin glass, is a singular point in the phase diagram, separating a region with a spin-glass phase ($w<1/2$) from a region with spin-glass, ferromagnetic, mixed, and paramagnetic phases ($w>1/2$)

Decoherence of Semiclassical Wigner Functions

The Lindblad equation governs general markovian evolution of the density operator in an open quantum system. An expression for the rate of change of the Wigner function as a sum of integrals is one of the forms of the Weyl representation for this equation. The semiclassical description of the Wigner function in terms of chords, each with its classically defined amplitude and phase, is thus inserted in the integrals, which leads to an explicit differential equation for the Wigner function. All the Lindblad operators are assumed to be represented by smooth phase space functions corresponding to classical variables. In the case that these are real, representing hermitian operators, the semiclassical Lindblad equation can be integrated. There results a simple extension of the unitary evolution of the semiclassical Wigner function, which does not affect the phase of each chord contribution, while dampening its amplitude. This decreases exponentially, as governed by the time integral of the square difference of the Lindblad functions along the classical trajectories of both tips of each chord. The decay of the amplitudes is shown to imply diffusion in energy for initial states that are nearly pure. Projecting the Wigner function onto an orthogonal position or momentum basis, the dampening of long chords emerges as the exponential decay of off-diagonal elements of the density matrix.Comment: 23 pg, 2 fi

Duality between quantum and classical dynamics for integrable billiards

We establish a duality between the quantum wave vector spectrum and the eigenmodes of the classical Liouvillian dynamics for integrable billiards. Signatures of the classical eigenmodes appear as peaks in the correlation function of the quantum wave vector spectrum. A semiclassical derivation and numerical calculations are presented in support of the results. These classical eigenmodes can be observed in physical experiments through the auto-correlation of the transmission coefficient of waves in quantum billiards. Exact classical trace formulas of the resolvent are derived for the rectangle, equilateral triangle, and circle billiards. We also establish a correspondence between the classical periodic orbit length spectrum and the quantum spectrum for integrable polygonal billiards.Comment: 12 pages, 4 figure