Freins et incitations au développement de l’agriculture biologique en France : une analyse à plusieurs niveaux

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Homogenization of a model for the propagation of sound in the lungs

International audienceIn this paper, we are interested in the mathematical modeling of the propagation of sound waves in the lung parenchyma, which is a foam-like elastic material containing millions of air-filled alveoli. In this study, the parenchyma is governed by the linearized elasticity equations, and the air by the acoustic wave equations. The geometric arrangement of the alveoli is assumed to be periodic with a small period ε > 0. We consider the time-harmonic regime forced by vibrations induced by volumic forces. We use the two-scale convergence theory to study the asymptotic behavior as ε goes to zero and prove the convergence of the solutions of the coupled fluid-structure problem to the solution of a linear-elasticity boundary value problem

Dermatite atopique canine et homéopathie

LYON1-BU Santé (693882101) / SudocSudocFranceF

The Future of the High Technologies World Market (Anatoly Belorusov, Vsevolod Vovchenko)

Раздел - "Международные экономические отношения"Development of new technologies will determine the future economic progress. It is the innovations that are the main constituent of the production efficiency growth, therefore they can usher in a new era in the economic development of any country. The study of the relevant literature resources showed gaps in the exploration of this problem despite its relevance. In this connection, the article aims to research the basic trends in high technologies world market development. A number of important aspects are pointed out in the basic trends of the above-mentioned development. Information technologies play a key role in the high tech sphere. Progress in the area of the information technologies creates the products that allow to get the most prompt and complete information on any subject. Today one should be able to orient oneself in the flow of incoming information and pick out the most important data for maintaining one's personal professional competitiveness. The establishment and improvement of technopark and technopolis systems is an important factor in the development of high tech sector in world economy. Special foundations are required to finance scientific technical projects, creation of consulting structures that give assistance to the innovation companies in finding and dealing with foreign partners. The databases on new projects could also assist sellers and customers in making connection. Authors believe that further worldwide improvement of the educational system is laying down the basis for the innovation sphere development. Today the concept of continuing education and retraining of labour force is becoming popular. Authors outline three most prominent centres of high technologies (the USA, Japan, Western Europe) that have emerged and mainly compete in the high tech sphere thus stimulating the economic progress

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Dossier La justification de l’engagement dans un mode de production ou de consommation en agriculture biologique repose sur les dimensions transversales de cette activité. Les motivations obéissent généralement à plusieurs finalités ou conduites, tout autant économiques qu’éthiques et politiques. Les pratiques traversent des territoires sociaux très divers, tant au plan individuel que collectif. Mais la recherche n’a pas encore suffisamment pris en compte cette réalité dans la construction d’outils méthodologiques et théoriques appropriés à l’étude et au développement du bio. Dans la suite d’un colloque qui a réuni des intervenants d’horizons très différents et peu habitués à dialoguer, ce numéro d’Économie Rurale propose des pistes de réflexion à partir des enjeux économiques, des pratiques et discours, et de l’identité de l’agriculture biologique. Dépassant les clivages institutionnels et disciplinaires traditionnels, les articles proposés augurent de nouvelles passerelles scientifiques. Note de lecture Innovation et patrimoine alimentaire en espace rura

Nestin as a Diagnostic and Prognostic Marker for Combined Hepatocellular-Cholangiocarcinoma.

International audienceBACKGROUND AND AIMS: Combined Hepatocellular-Cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer (PLC) associated with a poor prognosis. Given the challenges in its identification and its clinical implications, biomarkers are critically needed. We aimed to investigate the diagnostic and prognostic value of the immunohistochemical expression of Nestin, a progenitor cell marker, in a large multicentric series of PLC. METHODS: We collected 461 cHCC-CCA samples from 32 different clinical centers. Control cases included 368 hepatocellular carcinomas (HCC) and 221 intrahepatic cholangiocarcinomas (ICCA). Nestin immunohistochemistry was performed on whole tumor sections. Diagnostic and prognostic performances of Nestin expression were determined using receiver operating characteristic curves and cox regression modeling. RESULTS: Nestin was able to distinguish cHCC-CCA from HCC with AUC of 0.85 and 0.86 on surgical and biopsy samples, respectively. Performance was lower for the distinction of cHCC-CCA from ICCA (AUC of 0.59 and 0.60). Nestin, however, showed a high prognostic value, allowing identification of the subset of cHCC-CCA ("Nestin High", >30% neoplastic cells with positive staining) associated with the worst clinical outcome (shorter disease-free and overall survival) after surgical resection and liver transplantation, as well as when assessment was performed on biopsies. CONCLUSION: We show in different clinical settings that Nestin has a diagnostic value and that it is a useful biomarker to identify the subset of cHCC-CCA associated with the worst clinical outcome. Nestin immunohistochemistry may be used to refine risk stratification and improve treatment allocation for patients with this highly aggressive malignancy. LAY SUMMARY: Combined Hepatocellular-Cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer (PLC) that lacks robust tissue biomarkers. We show in different clinical settings that Nestin immunohistochemical staining has a diagnostic value and is a useful biomarker to identify the subset of cHCC-CCA associated with the worst clinical outcome. Nestin immunohistochemistry may be used to refine risk stratification and improve treatment allocation for patients with this highly aggressive malignancy

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

International audienceAbstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal or mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping of multiple cohorts of patients. We show that deep learning can reproduce the diagnosis of HCC vs. CCA with a high performance. We analyze a series of 405 cHCC-CCA patients and demonstrate that the model can reclassify the tumors as HCC or ICCA, and that the predictions are consistent with clinical outcomes, genetic alterations and in situ spatial gene expression profiling. This type of approach could improve treatment decisions and ultimately clinical outcome for patients with rare and biphenotypic cancers such as cHCC-CCA