Esthésioneuroblastome nasosinusien: Nouvelles modalités thérapeutiques

Introduction : L’esthésioneuroblastome est une tumeur maligne rare des cavités nasosinusiennes. La chirurgie par voie externe et la radiothérapie ont été le traitement de référence. L’utilisation ces dernières années de la chirurgie endoscopique endonasale et de la chimiothérapie parait prometteuse.Observations : Nous présentons deux cas cliniques de patients traités pour esthésioneuroblastome nasosinusien : Le premier par une chirurgie endoscopique endonasale et une radiothérapie, le second par une chimio-radiothérapie. L’évolution a été favorable respectivement à 39 mois et à 49 mois.Discussion : A travers une revue de la littérature, nous discuterons les différentes modalités thérapeutiques de cette tumeur.Mots clés : esthésioneuroblastome, sinus, traitement

Malakoplakie pseudotumorale du sein

La malakoplakie est une maladie inflammatoire granulomateuse chronique, qui affecte généralement le tractus génito-urinaire et exceptionnellement la glande mammaire. Il faut savoir évoquer ce diagnostic devant une mastite pseudotumorale. Sa définition est anatomopathologique. Nous rapportons un cas inhabituel de malakoplakie mammaire chez une patiente ayant des antécédents de tuberculose. L'imagerie était en faveur d'une mastite carcinomateuse. L'analyse histologique de la biopsie mammaire révélait une inflammation granulomateuse faite d'histiocytes renfermant des granulations pathognomoniques de Michaelis-Gutmann. La patiente était mise sous traitement médical à base de ciprofloxacine avec bonne évolution clinique et radiologique après un recul d'un mois

Comparative study on some biochemical characteristics of surimi from common carp and silver carp and proteins recovered using an acid-alkaline process

Some biochemical characteristics of common carp (Cyprinus carpio) and silver carp (Hypophthalmichthys molitrix) surimi prepared by a conventional washing method and protein isolated using alkaline-acid-aided processes were investigated. Solubility of protein in silver carp and common carp were found to be highest by using the conventional washing method. Decreases in myoglobin and lipid contents in both fish were found in the alkaline- or acid-aided process when compared to the conventional process (p0.05). In protein patterns of Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), the lowest intensity of the myosin heavy chains (MHC) band was found in silver carp by the conventional washing process

Comparative Study of Chemical Composition and the biological effect of essential oils for two plants; Lavandula Stoechas et Laurus Nobilis.

For both plants, the aerial parts used of Lavandula Stoechas (LS) and Laurus Nobilis (LN) are leaves harvested during the flowering period. They give respectively (0.12%; 0.45%) and (0.326% 0.623%) by hydrodistillation essence. The constituents of the chemical composition have been identified by gas chromatography coupled to mass spectrometry (GC-MS). The essential oils leaves of LN and LN for two areas, "Zinat" and "Hallila" are very rich in oxygenated monoterpenes. Moreover, the biological effect, for essential oils of LS and LN possess an antibacterial activity against a bacteria Bacillus subtilis, except for LN has also the effect against Escherichia coli K12 and other bacteria don’t  have  the effect against Porteus sp, Staphylococcus aureus and Escherichia coli K12 LS of our species

Variétés Chifaa et Bounejmate : Caractérisation et Etude de leur effet sur la structure alvéolaire du pain par analyse d’image numérique

The alveolar structure of bread products is one of the factors that the bakery industry seeks to control. The objective of this work is to elucidate the effect of this parameter through the evaluation of the alveolar structure of bread by image analysis. The naked barley variety "Chifaà" and the naked oat variety "Bounejmate" were used for this purpose. The work consists on the characterisation of the physical and chemical criteria regarding these two varieties followed by the constitution of mixtures from a commercial flour of soft wheat and complete flours of barley and oat, respectively, as follows: (100% wheat), (barley or oats/wheat) : (10/90), (20/80) and (30/70). Seven loaves of bread (6 mixed loaves and the control loaf) were made using a bread machine. Slices of the obtained loaves were then analysed by image analysis for the following criteria (crumb development, total area of the alveoli, % alveoli in the crumb, number of alveoli). The results showed variability in the composition of the studied varieties. The variety "Chifaà" is marked by a high content of β-glucan (7.9%) and the variety "Bounejmate" is marked by a high content of protein (17.6%) and fat (10.4%). The addition of oat induced a 44.7% decrease in crumb development from 10% addition, whereas barley showed a similar effect at 30% addition. Moreover, barley at 30% addition had more negative effect on the crumb alveoli which decrease until disappearance of the majority.La structure alvéolaire des produits de panification constitue un des facteurs que la profession cherche à maitriser. L’objectif de ce travail est d’élucider l’effet de cet ajout à travers l’évaluation de la structure alvéolaire du pain par analyse d’image. La variété d’orge à grains nus « Chifaa » et la variété d’avoine à grains nus « Bounejmate » ont été utilisées à cet effet. Le travail consiste à une caractérisation des critères physico-chimiques des deux variétés suivi de la constitution des mélanges à partir d’une farine commerciale de blé tendre et des farines complètes d’orge et d’avoine, respectivement, comme suit ; (100% blé), (orge ou avoine/blé) : (10/90), (20/80) et (30/70). Sept pains (6 pains mélanges et le pain contrôle) ont été fabriqués à l’aide d’une machine à pain. Des tranches des pains obtenus ont subies par la suite une analyse d’image pour les critères suivants (développement de la mie, aire total des alvéoles, % d’alvéoles dans la mie, nombre d’alvéoles). Les résultats ont montré une variabilité dans la composition des variétés utilisées, en effet la variété « Chifaa» est marquée par une forte teneur en β-glucane (7,9%) et la variété « Bounejmate » est marquée par une forte teneur en protéine (17,6%) et en lipides (10,4%). L’ajout d’avoine a induit une diminution de 44.7% du développement de la mie à partir de 10% d’ajout alors que l’orge n’a montré un effet similaire qu’à partir de 30% d’ajout. En outre, l’orge à 30% d’ajout a montré plus d’effet négatif sur les alvéoles de la mie qui diminuent jusqu’à disparition de la majorité

Transient up- and down-regulation of expression of myosin light chain 2 and myostatin mRNA mark the changes from stratified hyperplasia to muscle fiber hypertrophy in larvae of gilthead sea bream (Sparus aurata L.)

Hyperplasia and hypertrophy are the two mechanisms by which muscle develops and grows. We study these two mechanisms, during the early development of white muscle in Sparus aurata, by means of histology and the expression of structural and regulatory genes. A clear stage of stratified hyperplasia was identified early in the development of gilthead sea bream but ceased by 35 dph when hypertrophy took over. Mosaic recruitment of new white fibers began as soon as 60 dph. The genes mlc2a and mlc2b were expressed at various levels during the main phases of hyperplasia and hypertrophy. The genes myog and mlc2a were significantly up-regulated during the intensive stratified formation of new fibers and their expression was significantly correlated. Expression of mstn1 and igf1 increased at 35 dph, appeared to regulate the hyperplasia-to-hypertrophy transition, and may have stimulated the expression of mlc2a, mlc2b and col1a1 at the onset of mosaic hyperplasia. The up-regulation of mstn1 at transitional phases in muscle development indicates a dual regulatory role of myostatin in fish larval muscle growth

The fodder legume Chamaecytisus albidus establishes functional symbiosis with different Bradyrhizobial symbiovars in Morocco

In this work, we analyzed the symbiotic performance and diversity of rhizobial strains isolated from the endemic shrubby legume Chamaecytisus albidus grown in soils of three different agroforestry ecosystems representing arid and semi-arid forest areas in Morocco. The analysis of the rrs gene sequences from twenty-four representative strains selected after REP-PCR fingerprinting showed that all the strains belong to the genus Bradyrhizobium. Following multi-locus sequence analysis (MLSA) using the rrs, gyrB, recA, glnII, and rpoB housekeeping genes, five representative strains, CA20, CA61, CJ2, CB10, and CB61 were selected for further molecular studies. Phylogenetic analysis of the concatenated glnII, gyrB, recA, and rpoB genes showed that the strain CJ2 isolated from Sahel Doukkala soil is close to Bradyrhizobium canariense BTA-1 (96.95%); that strains CA20 and CA61 isolated from the Amhach site are more related to Bradyrhizobium valentinum LmjM3, with 96.40 and 94.57% similarity values; and that the strains CB10 and CB60 isolated from soil in the Bounaga site are more related to Bradyrhizobium murdochi CNPSo 4020 and Bradyrhizobium. retamae Ro19, with which they showed 95.45 and 97.34% similarity values, respectively. The phylogenetic analysis of the symbiotic genes showed that the strains belong to symbiovars lupini, genistearum, and retamae. All the five strains are able to nodulate Lupinus luteus, Retama monosperma, and Cytisus monspessilanus, but they do not nodulate Glycine max and Phaseolus vulgaris. The inoculation tests showed that the strains isolated from the 3 regions improve significantly the plant yield as compared to uninoculated plants. However, the strains of Bradyrhizobium sp. sv. retamae isolated from the site of Amhach were the most performing. The phenotypic analysis showed that the strains are able to use a wide range of carbohydrates and amino acids as sole carbon and nitrogen source. The strains isolated from the arid areas of Bounaga and Amhach were more tolerant to salinity and drought stress than strains isolated in the semi-arid area of Sahel Doukkala.Financial support was obtained from Académie Hassan II des Sciences et Techniques (in Morocco). Mr Omar Bouhnik received a grant from the Hassan II Academy of Science and Technolog