Rediscovering Braverman?: Political Economy, Skill, and Skill Shortages

The debate over skill and skill shortages is full of complexity and contradiction. For example, just what is meant by skill and skill shortages is, at the very least, open to debate (Shah and Burke 2005). Furthermore, at the same time as Grugulis and Lloyd (2010, p. 92) point to a shift away from attempts to locate skill within a broader analysis of capitalist development and towards a narrower explanation of particular trends and concepts, theories are emerging about the changing nature of the economy - the knowledge economy, for example - which have major implications for the nature of skill and skill formation. Skill shortages are used to justify importing skilled labour from outside the state and country, echoing more generally a disproportionate focus on supply side issues in the debate (Hall 2011), at the same time as skill itself, once seen as a driver of prosperity, is placed alongside productivity as the driver of prosperity (Keep and Mayhew 2010). Internationally, this is reflected in policy documents which are 'couched in terms that ring with evangelical zeal' about the competitive and social importance of the supply of skills (Hayward and James 2004, p. 1)

A review of studies on information systems and SMEs in high ranked IS journals (2000-2014)

This paper identifies novel approaches to future small and medium enterprise (SME) research from a review of articles, and then introduces the papers in this AJIS special section which evidence these approaches. More specifically, the paper makes an important contribution by reviewing 61 articles in high ranked IS journals (2000-2014) and introducing three new facets which are used to analyse research on SME adoption/use of IS (units of analysis, SME sizes and SME types) not considered in previous literature review studies. These facets provide the basis for proposing various future research opportunities. The editorial then introduces the four papers in this special section covering the research theme on SMEs, and highlights the contributions they make using the three facets

A review of studies on information systems and SMEs in high ranked IS journals (2000-2014)

This paper identifies novel approaches to future small and medium enterprise (SME) research from a review of articles, and then introduces the papers in this AJIS special section which evidence these approaches. More specifically, the paper makes an important contribution by reviewing 61 articles in high ranked IS journals (2000-2014) and introducing three new facets which are used to analyse research on SME adoption/use of IS (units of analysis, SME sizes and SME types) not considered in previous literature review studies. These facets provide thebasis for proposing various future research opportunities. The editorial then introduces the four papers in this special section covering the research theme on SMEs, and highlights the contributions they make using the three facets

Whole genome sequence analysis of ESBL-producing Escherichia coli recovered from New Zealand freshwater sites.

CAUL read and publish agreement 2023Extended-spectrum beta lactamase (ESBL)-producing Escherichia coli are often isolated from humans with urinary tract infections and may display a multidrug-resistant phenotype. These pathogens represent a target for a One Health surveillance approach to investigate transmission between humans, animals and the environment. This study examines the multidrug-resistant phenotype and whole genome sequence data of four ESBL-producing E. coli isolated from freshwater in New Zealand. All four isolates were obtained from a catchment with a mixed urban and pastoral farming land-use. Three isolates were sequence type (ST) 131 (CTX-M-27-positive) and the other ST69 (CTX-M-15-positive); a phylogenetic comparison with other locally isolated strains demonstrated a close relationship with New Zealand clinical isolates. Genes associated with resistance to antifolates, tetracyclines, aminoglycosides and macrolides were identified in all four isolates, together with fluoroquinolone resistance in two isolates. The ST69 isolate harboured the bla CTX-M-15 gene on a IncHI2A plasmid, and two of the three ST131 isolates harboured the bla CTX-M-27 genes on IncF plasmids. The last ST131 isolate harboured bla CTX-M-27 on the chromosome in a unique site between gspC and gspD. These data highlight a probable human origin of the isolates with subsequent transmission from urban centres through wastewater to the wider environment.Publishe

The development of marine biotechnology in Oman: Potential for capacity building through open innovation

This study examines the current state of the art in the emerging and strategically important marine biotechnology sector in Oman, which has a long coastline, rich marine heritage and strong fishing industry. In a knowledge-based economy, the ability to innovate is a key factor for increasing organisational competitiveness and this may be achieved using open innovation. This is the use by firms of external knowledge, ideas and technology to innovate. In this study, the extent of open innovation in Omani marine bioindustry companies has been studied by examining data from the top sixteen companies ranked by number of employees. The results indicate that the extent of openness in these companies is higher towards market side activities. In addition, the use of open innovation to increase collaboration between companies, Universities and government research institutes needs to be significantly strengthened

Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.

(c) The Author/sAntimicrobial resistance (AMR) is a global threat to human and animal health, with the misuse and overuse of antimicrobials being suggested as the main driver of resistance. In a global context, New Zealand (NZ) is a relatively low user of antimicrobials in animal production. However, the role antimicrobial usage on pasture-based dairy farms, such as those in NZ, plays in driving the spread of AMR within the dairy farm environment remains equivocal. Culture-based methods were used to determine the prevalence and distribution of extended-spectrum β-lactamase (ESBL)- and AmpC-producing Escherichia coli from farm environmental samples collected over a 15-month period from two NZ dairy farms with contrasting management practices. Whole genome sequencing was utilised to understand the genomic epidemiology and antimicrobial resistance gene repertoire of a subset of third-generation cephalosporin resistant E. coli isolated in this study. There was a low sample level prevalence of ESBL-producing E. coli (faeces 1.7%; farm dairy effluent, 6.7% from Dairy 4 and none from Dairy 1) but AmpC-producing E. coli were more frequently isolated across both farms (faeces 3.3% and 8.3%; farm dairy effluent 38.4%, 6.7% from Dairy 1 and Dairy 4, respectively). ESBL- and AmpC-producing E. coli were isolated from faeces and farm dairy effluent in spring and summer, during months with varying levels of antimicrobial use, but no ESBL- or AmpC-producing E. coli were isolated from bulk tank milk or soil from recently grazed paddocks. Hybrid assemblies using short- and long-read sequence data from a subset of ESBL- and AmpC-producing E. coli enabled the assembly and annotation of nine plasmids from six E. coli, including one plasmid co-harbouring 12 antimicrobial resistance genes. ESBL-producing E. coli were infrequently identified from faeces and farm dairy effluent on the two NZ dairy farms, suggesting they are present at a low prevalence on these farms. Plasmids harbouring several antimicrobial resistance genes were identified, and bacteria carrying such plasmids are a concern for both animal and public health. AMR is a burden for human, animal and environmental health and requires a holistic "One Health" approach to address.Published onlin

Macrophages as determinants and regulators of fibrosis in systemic sclerosis

SSc is a multiphase autoimmune disease with a well-known triad of clinical manifestations including vasculopathy, inflammation and fibrosis. Although a plethora of drugs has been suggested as potential candidates to halt SSc progression, nothing has proven clinically efficient. In SSc, both innate and adaptive immune systems are abnormally activated fuelling fibrosis of the skin and other vital organs. Macrophages have been implicated in the pathogenesis of SSc and are thought to be a major source of immune dysregulation. Due to their plasticity, macrophages can initiate and sustain chronic inflammation when classically activated while, simultaneously or parallelly, when alternatively activated they are also capable of secreting fibrotic factors. Here, we briefly explain the polarization process of macrophages. Subsequently, we link the activation of macrophages and monocytes to the molecular pathology of SSc, and illustrate the interplay between macrophages and fibroblasts. Finally, we present recent/near-future clinical trials and discuss novel targets related to macrophages/monocytes activation in SSc

Molybdenum Complexes of Chiral C2-symmetric Picchxn-type Ligands: Synthesis, Characterization, and Structural Studies

A series of molybdenum complexes based on chiral C2-symmetric picchxn-type ligands (N4 ligands, defined as trans-N,N′-bis(heterocycl-2-ylmethyl)-1,2-diaminocyclohexanes) has been synthesized and characterized. Reported and novel picchxn-type ligands form (κ3-N4)Mo(CO)3, [(κ4-N4)Mo(NO)(CO)]PF6, and [(κ4-N4)Mo(NO)X]PF6 (X = Br, I) compounds. Multiple tridentate (κ3) and tetradentate (κ4) ligand configurations were observed, and the favored κ4 configuration was found to vary with N4 heterocycle identity. Heterocycle variation allowed for directed modification of the molybdenum electronic characteristics, but none of the studied {(κ4-N4)Mo(NO)}+ fragments was found to be a suitable π-base for dearomatization chemistry. The crystal structures of eight molybdenum complexes with picchxn-type ligands were determined

An analytical approach to modelling shear panels in steel beams at elevated temperatures

Shear buckling of beam webs in the vicinity of beam-to-column connections has been observed in many full-scale fire tests. This phenomenon can lead to force redistribution within the adjacent connections, and even influence the performance-based analysis of full-scale structures in fire. However, beam-web shear buckling for Class 1 beams at either ambient or elevated temperatures has not been well studied previously. In this work an analytical model has been created to predict the shear buckling behaviour of Class 1 beams in the vicinity of beam-to-column connections at ambient and elevated temperatures. The model considers the reduction of resistance of the beam after web shear buckling has occurred. It is capable of predicting the shear resistance and transverse drift of the shear panel from its initial loading to final failure. Several 3D finite element models have been created using the ABAQUS software, in order to validate the analytical model over a range of geometries. Comparisons between the theoretical and FE models have shown that the proposed method provides sufficient accuracy to be implemented and used in performance-based global modelling

Solution NMR assignment of the C-terminal domain of human chTOG

The microtubule regulatory protein colonic and hepatic tumor overexpressed gene (chTOG), also known as cytoskeleleton associated protein 5 (CKAP5) plays an important role in organizing the cytoskeleton and in particular in the assembly of k-fibres in mitosis. Recently, we dissected the hitherto poorly understood C-terminus of this protein by discovering two new domains—a cryptic TOG domain (TOG6) and a smaller, helical domain at the very C-terminus. It was shown that the C-terminal domain is important for the interaction with the TACC domain in TACC3 during the assembly of k-fibres in a ternary complex that also includes clathrin. Here we now present the solution NMR assignment of the chTOG C-terminal domain which confirms our earlier prediction that it is mainly made of α-helices. However, the appearance of the 1H–15N HSQC spectrum is indicative of the presence of a considerable amount of unstructured and possibly flexible portions of protein in the domain