Influência do estado nutricional no risco para transtornos alimentares em estudantes de nutrição

Avaliar a relação entre a alteração do comportamento alimentar, associado à insatisfação com a imagem corporal, e o estado nutricional de universitárias de Nutrição. Realizou-se um estudo transversal com 175 universitárias do Curso de Nutrição (ENUT/UFOP). Foram aplicados os questionários Eating Attitudes Test-26 (EAT-26) e o Body Shape Questionare (BSQ) e realizadas medidas antropométricas. 21,7% das estudantes apresentaram alto risco para transtornos alimentares e 13,7% apresentaram insatisfação com a imagem corporal. A maioria das estudantes com BSQ e EAT-26 positivos estava eutrófica. As estudantes com excesso de peso, aumento do percentual de gordura corporal (% GC) e do perímetro da cintura (PC) apresentaram risco 5 a 9 vezes maiores de alteração do comportamento alimentar. Houve associação positiva entre os parâmetros antropométricos com a pontuação dos questionários EAT-26 e BSQ. Futuras nutricionistas com excesso de peso apresentaram maior risco de estarem insatisfeitas com a sua imagem corporal e de desenvolverem transtornos alimentares. A utilização de outros parâmetros antropométricos, além do IMC, pode ser útil na triagem de indivíduos suscetíveis ao surgimento de preocupações excessivas com o peso corporal e a alimentação.The scope of this paper was to evaluate the relationship between changes in eating behavior associated with dissatisfaction with body image, and the nutritional status of female university students of nutrition. A cross-sectional study was conducted among 175 female students of nutrition (ENUT/UFOP). The Eating Attitudes Test-26 (EAT-26) and Body Shape Questionnaire (BSQ) were applied and anthropometric measurements were taken. 21.7% of the students were found to be high risk in terms of eating disorders, and 13.7% declared dissatisfaction with their body image. The majority of students with positive results in the BSQ and EAT-26 tests were eutrophic. The students who were overweight, with elevated body fat percentage (% BF) and waist circumference (WC) had a 5-9 times greater risk of change in eating habits. There was a positive association between the anthropometric parameters with high scores in the EAT-26 and BSQ questionnaires. The future dietitians who are overweight, with increased body fat and waist circumference were more likely to be dissatisfied with their body image and develop eating disorders. The use of other anthropometric parameters, in addition to BMI, may prove useful in screening individuals susceptible to the emergence of excessive concerns with weight and diet

Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin

The protective effect of a whey protein concentrate (WPC) was Studied in three models of stomach ulcerative lesions induction: Subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4degreesC, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive. or subchronic (10 days) administration of WPC prior to treatment with the Ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P .05) compared with saline (negative control).o TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.7330931

Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition

High plasma level of triglycerides (TGs) is a common feature in atherosclerosis, obesity, diabetes, alcoholism, stress, and infection. Since mitochondria have been implicated in cell death under a variety of metabolic disorders, we examined liver mitochondrial functions in hypertriglyceridemic transgenic mice. Hypertriglyceridemia increased resting respiration and predisposed to mitochondrial permeability transition (MPT). Ciprofibrate therapy reduced plasma TG levels, normalized respiration, and prevented MPT. The higher resting respiration in transgenic mitochondria remained in the presence of the adenine nucleotide carrier inhibitor, carboxyatractyloside, bovine serum albumin, and the uncoupling proteins (UCPs) inhibitor, GDP. UCP2 content was similar in both control and transgenic mitochondria. We propose that faster resting respiration represents a regulated adaptation to oxidize excess free fatty acid in the transgenic mice.35545145

Modelo etiológico dos comportamentos de risco para os transtornos alimentares em adolescentes brasileiros do sexo feminino

Resumo: O objetivo foi construir um modelo etiológico dos comportamentos de risco para os transtornos alimentares em adolescentes brasileiros do sexo feminino. Participaram 1.358 adolescentes de quatro cidades. Foram avaliados os comportamentos de risco para os transtornos alimentares, insatisfação corporal, pressões midiáticas, autoestima, estado de humor, sintomas depressivos e perfeccionismo por intermédio de escalas psicométricas. Peso, estatura e dobras cutâneas foram aferidos para calcular o índice de massa corporal (IMC) e o percentual de gordura (%G). O modelo de equação estrutural explanou 76% da variância dos comportamento de risco (F(9, 1.351) = 74,50; p = 0,001). Os achados indicaram que a insatisfação corporal mediou a relação entre as pressões midiáticas, autoestima, estado de humor, IMC, %G e os comportamentos de risco (F(9, 1.351) = 59,89; p = 0,001). Vale destacar que embora os sintomas depressivos não tenham se relacionado com a insatisfação corporal, o modelo indicou relação direta com os comportamentos de risco para os transtornos alimentares (F(2, 1.356) = 23,98; p = 0,001). Concluiu-se que somente o perfeccionismo não aderiu ao modelo etiológico dos comportamentos de risco para os transtornos alimentares em adolescentes brasileiras

Effects of a Mikania laevigata extract on bone resorption and RANKL expression during experimental periodontitis in rats

OBJECTIVES: The Mikania laevigata extract (MLE) (popularly known in Brazil as "guaco") possesses anti-inflammatory properties. In the present study we tested the effects of MLE in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying such effects. MATERIAL AND METHODS: Periodontal disease was induced by a ligature placed around the mandibular first molars of each animal. Male Wistar rats were divided into 4 groups: non-ligated animals treated with vehicle; non-ligated animals treated with MLE (10 mg/kg, daily); ligature-induced animals treated with vehicle and ligature-induced animals treated with MLE (10 mg/kg, daily). Thirty days after the induction of periodontal disease, the animals were euthanized and mandibles and gingival tissues removed for further analysis. RESULTS: Morphometric analysis of alveolar bone loss demonstrated that MLE-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-κB ligand (RANKL) measured by immunohistochemistry. Moreover, gingival tissues from the MLE-treated group showed decreased neutrophil migration myeloperoxidase (MPO) assay. CONCLUSIONS: These results indicate that MLE may be useful to control bone resorption during progression of experimental periodontitis in rats

Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats

<p>Abstract</p> <p>Background</p> <p>The leaves and root of <it>Flabellaria paniculata</it> (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic extracts from the leaves (FPL) and root (FPR) of <it>F. paniculata</it> on gastric ulcers in rats.</p> <p>Methods</p> <p>The effect of FPL and FPR (100, 200 and 400 mg/kg) was evaluated in ethanol and indomethacin gastric ulcer models. Control groups for FPL and FPR were orally treated with 3% Tween 20 and distilled water respectively. FPL was further investigated in pylorus ligation model. Misoprostol and cimetidine were used as reference.</p> <p>Results</p> <p>FPL significantly (P < 0.05) reduced gastric lesions by 82.22% and 67.32% in ethanol and indomethacin induced ulcer models at 100 mg/kg respectively while FPR (100, 200 and 400 mg/kg) did not exert significant effect in the two models. In pylorus ligation model, FPL exerted a significant preventive antiulcer effect as indicated by reduction in gastric volume at 200 and 400 mg/kg doses. Only 400 mg/kg of the extract exerted a significant reduction in ulcer index when compared with the control group. The oral route LD₅₀ of FPL was estimated to be 4570 mg/kg while that of FPR was 2754 mg/kg. The LD₅₀ in intraperitoneal injection was estimated to be 1202.26 and 1380.38 mg/kg for FPL and FPR respectively. The phytochemical investigation showed that both extracts possess triterpenoids and saponin, while the presence of flavonoid was detected only in FPL.</p> <p>Conclusions</p> <p>The results of this study indicated that FPL and not FPR is effective against experimentally induced gastric ulcers. The presence of varied phytochemical constituents probably influenced the pharmacological differences between the two extracts.</p