279 research outputs found
The matrix model version of AGT conjecture and CIV-DV prepotential
Recently exact formulas were provided for partition function of conformal
(multi-Penner) beta-ensemble in the Dijkgraaf-Vafa phase, which, if interpreted
as Dotsenko-Fateev correlator of screenings and analytically continued in the
number of screening insertions, represents generic Virasoro conformal blocks.
Actually these formulas describe the lowest terms of the q_a-expansion, where
q_a parameterize the shape of the Penner potential, and are exact in the
filling numbers N_a. At the same time, the older theory of CIV-DV prepotential,
straightforwardly extended to arbitrary beta and to non-polynomial potentials,
provides an alternative expansion: in powers of N_a and exact in q_a. We check
that the two expansions coincide in the overlapping region, i.e. for the lowest
terms of expansions in both q_a and N_a. This coincidence is somewhat
non-trivial, since the two methods use different integration contours:
integrals in one case are of the B-function (Euler-Selberg) type, while in the
other case they are Gaussian integrals.Comment: 27 pages, 1 figur
Matrix Model Conjecture for Exact BS Periods and Nekrasov Functions
We give a concise summary of the impressive recent development unifying a
number of different fundamental subjects. The quiver Nekrasov functions
(generalized hypergeometric series) form a full basis for all conformal blocks
of the Virasoro algebra and are sufficient to provide the same for some
(special) conformal blocks of W-algebras. They can be described in terms of
Seiberg-Witten theory, with the SW differential given by the 1-point resolvent
in the DV phase of the quiver (discrete or conformal) matrix model
(\beta-ensemble), dS = ydz + O(\epsilon^2) = \sum_p \epsilon^{2p}
\rho_\beta^{(p|1)}(z), where \epsilon and \beta are related to the LNS
parameters \epsilon_1 and \epsilon_2. This provides explicit formulas for
conformal blocks in terms of analytically continued contour integrals and
resolves the old puzzle of the free-field description of generic conformal
blocks through the Dotsenko-Fateev integrals. Most important, this completes
the GKMMM description of SW theory in terms of integrability theory with the
help of exact BS integrals, and provides an extended manifestation of the basic
principle which states that the effective actions are the tau-functions of
integrable hierarchies.Comment: 14 page
Boundary operators in minimal Liouville gravity and matrix models
We interpret the matrix boundaries of the one matrix model (1MM) recently
constructed by two of the authors as an outcome of a relation among FZZT
branes. In the double scaling limit, the 1MM is described by the (2,2p+1)
minimal Liouville gravity. These matrix operators are shown to create a
boundary with matter boundary conditions given by the Cardy states. We also
demonstrate a recursion relation among the matrix disc correlator with two
different boundaries. This construction is then extended to the two matrix
model and the disc correlator with two boundaries is compared with the
Liouville boundary two point functions. In addition, the realization within the
matrix model of several symmetries among FZZT branes is discussed.Comment: 26 page
Perturbative quantum gravity with the Immirzi parameter
We study perturbative quantum gravity in the first-order tetrad formalism.
The lowest order action corresponds to Einstein-Cartan plus a parity-odd term,
and is known in the literature as the Holst action. The coupling constant of
the parity-odd term can be identified with the Immirzi parameter of loop
quantum gravity. We compute the quantum effective action in the one-loop
expansion. As in the metric second-order formulation, we find that in the case
of pure gravity the theory is on-shell finite, and the running of Newton's
constant and the Immirzi parameter is inessential. In the presence of fermions,
the situation changes in two fundamental aspects. First, non-renormalizable
logarithmic divergences appear, as usual. Second, the Immirzi parameter becomes
a priori observable, and we find that it is renormalized by a four-fermion
interaction generated by radiative corrections. We compute its beta function
and discuss possible implications. The sign of the beta function depends on
whether the Immirzi parameter is larger or smaller than one in absolute value,
and the values plus or minus one are UV fixed-points (we work in Euclidean
signature). Finally, we find that the Holst action is stable with respect to
radiative corrections in the case of minimal coupling, up to higher order
non-renormalizable interactions.Comment: v2 minor amendment
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors. Thus, assays to detect BRCA1/BRCA2-deficient tumors have been sought. Recently, somatic substitution, insertion/deletion and rearrangement patterns, or 'mutational signatures', were associated with BRCA1/BRCA2 dysfunction. Herein we used a lasso logistic regression model to identify six distinguishing mutational signatures predictive of BRCA1/BRCA2 deficiency. A weighted model called HRDetect was developed to accurately detect BRCA1/BRCA2-deficient samples. HRDetect identifies BRCA1/BRCA2-deficient tumors with 98.7% sensitivity (area under the curve (AUC) = 0.98). Application of this model in a cohort of 560 individuals with breast cancer, of whom 22 were known to carry a germline BRCA1 or BRCA2 mutation, allowed us to identify an additional 22 tumors with somatic loss of BRCA1 or BRCA2 and 47 tumors with functional BRCA1/BRCA2 deficiency where no mutation was detected. We validated HRDetect on independent cohorts of breast, ovarian and pancreatic cancers and demonstrated its efficacy in alternative sequencing strategies. Integrating all of the classes of mutational signatures thus reveals a larger proportion of individuals with breast cancer harboring BRCA1/BRCA2 deficiency (up to 22%) than hitherto appreciated (âŒ1-5%) who could have selective therapeutic sensitivity to PARP inhibition
The genomic evolution of human prostate cancer.
Prostate cancers are highly prevalent in the developed world, with inheritable risk contributing appreciably to tumour development. Genomic heterogeneity within individual prostate glands and between patients derives predominantly from structural variants and copy-number aberrations. Subtypes of prostate cancers are being delineated through the increasing use of next-generation sequencing, but these subtypes are yet to be used to guide the prognosis or therapeutic strategy. Herein, we review our current knowledge of the mutational landscape of human prostate cancer, describing what is known of the common mutations underpinning its development. We evaluate recurrent prostate-specific mutations prior to discussing the mutational events that are shared both in prostate cancer and across multiple cancer types. From these data, we construct a putative overview of the genomic evolution of human prostate cancer
Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+
The COMPASS experiment at the CERN SPS has studied the diffractive
dissociation of negative pions into the pi- pi- pi+ final state using a 190
GeV/c pion beam hitting a lead target. A partial wave analysis has been
performed on a sample of 420000 events taken at values of the squared
4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances
a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data
show a significant natural parity exchange production of a resonance with
spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The
resonant nature of this wave is evident from the mass-dependent phase
differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a
resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2
is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged;
version 3 updated authors, text shortened, data unchange
Seqping: gene prediction pipeline for plant genomes using self-training gene models and transcriptomic data
The Polarised Valence Quark Distribution from semi-inclusive DIS
The semi-inclusive difference asymmetry A^{h^{+}-h^{-}} for hadrons of
opposite charge has been measured by the COMPASS experiment at CERN. The data
were collected in the years 2002-2004 using a 160 GeV polarised muon beam
scattered off a large polarised ^6LiD target and cover the range 0.006 < x <
0.7 and 1 < Q^2 < 100 (GeV/c)^2. In leading order QCD (LO) the asymmetry
A_d^{h^{+}-h^{-}} measures the valence quark polarisation and provides an
evaluation of the first moment of Delta u_v + Delta d_v which is found to be
equal to 0.40 +- 0.07 (stat.) +- 0.05 (syst.) over the measured range of x at
Q^2 = 10 (GeV/c)^2. When combined with the first moment of g_1^d previously
measured on the same data, this result favours a non-symmetric polarisation of
light quarks Delta u-bar = - Delta d-bar at a confidence level of two standard
deviations, in contrast to the often assumed symmetric scenario Delta u-bar =
Delta d-bar = Delta s-bar = Delta s.Comment: 7 pages, 3 figures, COMPASS, revised: details added, author list
update
The Hubbard model within the equations of motion approach
The Hubbard model has a special role in Condensed Matter Theory as it is
considered as the simplest Hamiltonian model one can write in order to describe
anomalous physical properties of some class of real materials. Unfortunately,
this model is not exactly solved except for some limits and therefore one
should resort to analytical methods, like the Equations of Motion Approach, or
to numerical techniques in order to attain a description of its relevant
features in the whole range of physical parameters (interaction, filling and
temperature). In this manuscript, the Composite Operator Method, which exploits
the above mentioned analytical technique, is presented and systematically
applied in order to get information about the behavior of all relevant
properties of the model (local, thermodynamic, single- and two- particle ones)
in comparison with many other analytical techniques, the above cited known
limits and numerical simulations. Within this approach, the Hubbard model is
shown to be also capable to describe some anomalous behaviors of the cuprate
superconductors.Comment: 232 pages, more than 300 figures, more than 500 reference
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