689 research outputs found
External validation of the fatty liver index and lipid accumulation product indices, using H-1-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals
Background and Aims. Simple clinical algorithms including the Fatty Liver Index (FLI) and Lipid Accumulation Product (LAP) have been developed as a surrogate marker for Non-Alcoholic Fatty Liver Disease (NAFLD). These algorithms have been constructed using ultrasonography, a semi-quantitative method. This study aimed to validate FLI and LAP as measures of hepatic steatosis, as measured quantitatively by proton magnetic resonance spectroscopy (1H-MRS).
Methods. Data were collected from 168 patients with NAFLD and 168 controls who had undergone clinical, biochemical and anthropometric assessment in the course of research studies. Values of FLI and LAP were determined, and assessed both as predictors of the presence of hepatic steatosis (liver fat >5.5 %) and of actual liver fat content, as measured by 1H MRS. The discriminative ability of FLI and LAP was estimated using the area under the Receiver Operator Characteristic curve (AUROC). Since FLI can also be interpreted as a predictive probability of hepatic steatosis, we assessed how well calibrated it was in our cohort. Linear regression with prediction intervals was used to assess the ability of FLI and LAP to predict liver fat content.
Results. FLI and LAP discriminated between patients with and without hepatic steatosis with an AUROC of 0.79 (IQR= 0.74, 0.84) and 0.78 (IQR= 0.72, 0.83), although quantitative prediction of liver fat content was unsuccessful. Additionally, the algorithms accurately matched the observed percentages of patients with hepatic steatosis in our cohort.
Conclusions. FLI and LAP may be used clinically, and for metabolic and epidemiological research, to identify patients with hepatic steatosis, but not as surrogates for liver fat content
Local multi-channel RF surface coil versus body RF coil transmission for cardiac magnetic resonance at 3 Tesla: which configuration is winning the game?
INTRODUCTION: The purpose of this study was to demonstrate the feasibility and efficiency of cardiac MR at 3 Tesla using local four-channel RF coil transmission and benchmark it against large volume body RF coil excitation. METHODS: Electromagnetic field simulations are conducted to detail RF power deposition, transmission field uniformity and efficiency for local and body RF coil transmission. For both excitation regimes transmission field maps are acquired in a human torso phantom. For each transmission regime flip angle distributions and blood-myocardium contrast are examined in a volunteer study of 12 subjects. The feasibility of the local transceiver RF coil array for cardiac chamber quantification at 3 Tesla is demonstrated. RESULTS: Our simulations and experiments demonstrate that cardiac MR at 3 Tesla using four-channel surface RF coil transmission is competitive versus current clinical CMR practice of large volume body RF coil transmission. The efficiency advantage of the 4TX/4RX setup facilitates shorter repetition times governed by local SAR limits versus body RF coil transmission at whole-body SAR limit. No statistically significant difference was found for cardiac chamber quantification derived with body RF coil versus four-channel surface RF coil transmission. Our simulation also show that the body RF coil exceeds local SAR limits by a factor of ~2 when driven at maximum applicable input power to reach the whole-body SAR limit. CONCLUSION: Pursuing local surface RF coil arrays for transmission in cardiac MR is a conceptually appealing alternative to body RF coil transmission, especially for patients with implants
Nature of the vortex-glass order in strongly type-II superconductors
The stability and the critical properties of the three-dimensional
vortex-glass order in random type-II superconductors with point disorder is
investigated in the unscreened limit based on a lattice {\it XY} model with a
uniform field. By performing equilibrium Monte Carlo simulations for the system
with periodic boundary conditions, the existence of a stable vortex-glass order
is established in the unscreened limit. Estimated critical exponents are
compared with those of the gauge-glass model.Comment: Error in the reported value of the exponent eta is correcte
Edge reconstruction in the fractional quantum Hall regime
The interplay of electron-electron interaction and confining potential can
lead to the reconstruction of fractional quantum Hall edges. We have performed
exact diagonalization studies on microscopic models of fractional quantum Hall
liquids, in finite size systems with disk geometry, and found numerical
evidence of edge reconstruction under rather general conditions. In the present
work we have taken into account effects like layer thickness and Landau level
mixing, which are found to be of quantitative importance in edge physics. Due
to edge reconstruction, additional nonchiral edge modes arise for both
incompressible and compressible states. These additional modes couple to
electromagnetic fields and thus can be detected in microwave conductivity
measurements. They are also expected to affect the exponent of electron Green's
function, which has been measured in tunneling experiments. We have studied in
this work the electric dipole spectral function that is directly related to the
microwave conductivity measurement. Our results are consistent with the
enhanced microwave conductivity observed in experiments performed on samples
with an array of antidots at low temperatures, and its suppression at higher
temperatures. We also discuss the effects of the edge reconstruction on the
single electron spectral function at the edge.Comment: 19 pages, 12 figure
The Lazarus project: A pragmatic approach to binary black hole evolutions
We present a detailed description of techniques developed to combine 3D
numerical simulations and, subsequently, a single black hole close-limit
approximation. This method has made it possible to compute the first complete
waveforms covering the post-orbital dynamics of a binary black hole system with
the numerical simulation covering the essential non-linear interaction before
the close limit becomes applicable for the late time dynamics. To determine
when close-limit perturbation theory is applicable we apply a combination of
invariant a priori estimates and a posteriori consistency checks of the
robustness of our results against exchange of linear and non-linear treatments
near the interface. Once the numerically modeled binary system reaches a regime
that can be treated as perturbations of the Kerr spacetime, we must
approximately relate the numerical coordinates to the perturbative background
coordinates. We also perform a rotation of a numerically defined tetrad to
asymptotically reproduce the tetrad required in the perturbative treatment. We
can then produce numerical Cauchy data for the close-limit evolution in the
form of the Weyl scalar and its time derivative
with both objects being first order coordinate and tetrad invariant. The
Teukolsky equation in Boyer-Lindquist coordinates is adopted to further
continue the evolution. To illustrate the application of these techniques we
evolve a single Kerr hole and compute the spurious radiation as a measure of
the error of the whole procedure. We also briefly discuss the extension of the
project to make use of improved full numerical evolutions and outline the
approach to a full understanding of astrophysical black hole binary systems
which we can now pursue.Comment: New typos found in the version appeared in PRD. (Mostly found and
collected by Bernard Kelly
Interaction Corrections to Two-Dimensional Hole Transport in Large Limit
The metallic conductivity of dilute two-dimensional holes in a GaAs HIGFET
(Heterojunction Insulated-Gate Field-Effect Transistor) with extremely high
mobility and large is found to have a linear dependence on temperature,
consistent with the theory of interaction corrections in the ballistic regime.
Phonon scattering contributions are negligible in the temperature range of our
interest, allowing comparison between our measured data and theory without any
phonon subtraction. The magnitude of the Fermi liquid interaction parameter
determined from the experiment, however, decreases with
increasing for r_{s}\agt22, a behavior unexpected from existing
theoretical calculations valid for small .Comment: 6 pages, 4 figure
Improved numerical stability of stationary black hole evolution calculations
We experiment with modifications of the BSSN form of the Einstein field
equations (a reformulation of the ADM equations) and demonstrate how these
modifications affect the stability of numerical black hole evolution
calculations. We use excision to evolve both non-rotating and rotating
Kerr-Schild black holes in octant and equatorial symmetry, and without any
symmetry assumptions, and obtain accurate and stable simulations for specific
angular momenta J/M of up to about 0.9M.Comment: 13 pages, 11 figures, 1 typo in Eq. (20) correcte
National Beef Quality Audit-2016: Transportation, mobility, and harvest-floor assessments of targeted characteristics that affect quality and value of cattle, carcasses, and by-products
The National Beef Quality Audit-2016 (NBQA-2016) was conducted to assess current transportation, mobility, and quality characteristics of U.S. fed steers and heifers. Data were collected at 17 beef processing facilities between March and November 2016. About 8,000 live cattle were evaluated for transportation and mobility, and about 25,000 carcasses were evaluated on the slaughter floor. Cattle were in transit to the slaughter facility for a mean duration of 2.7 h from a mean distance of 218.5 km using trailers with dimensions ranging from 17.84 m2 to 59.09 m2. Area allotted per animal averaged 1.13 m2 and ranged from 0.85 m2 to 2.28 m2. A total of 96.8% of cattle received a mobility score of 1 (walks easily, no apparent lameness). Identification types (35.1% had multiple) were lot visual tags (61.5%), individual tags (55.0%), electronic tags (16.9%), metal-clip tags (9.2%), bar-coded tags (0.05%), wattles (0.01%), and other (2.6%). Cattle were black-hided (57.8%), Holstein (20.4%), red-hided (10.5%), yellow-hided (4.8%), gray-hided (2.9%), brown-hided (1.3%), and white-hided (1.1%). Unbranded hides were observed on 74.3% of cattle; 18.6% had brands located on the butt, 6.3% on the side, and 1.3% on the shoulder (values exceed 100% due to multiple brands). For hide-on carcasses, 37.7% displayed no mud or manure; specific locations for mud or manure were legs (40.8%), belly (33.0%), tail region (15.5%), side (6.8%), and top-line (3.9%). Cattle without horns represented 83.3% of the sample, and cattle that did have horns measured: \u3c 2.54 cm (5.5%), 2.54 to 12.7 cm (8.3%), and \u3e 12.7 cm (2.9%). Carcasses without bruises represented 61.1% of those sampled, whereas 28.2% had 1, 8.2% had 2, 2.1% had 3, and 0.3% had 4 bruises. Of those carcasses with a bruise, the bruise was located on the loin (29.7%), round (27.8%), chuck (16.4%), rib (14.4%), and brisket/plate/flank (11.6%). Frequencies of offal condemnations were livers (30.8%), lungs (18.2%), viscera (16.3%), hearts (11.1%), heads (2.7%), and tongues (2.0%). Compared to NBQA-2011, fewer cattle were identified for traceability, fewer were black-hided, a greater number were Holstein cattle, more with no brand and no horns, fewer without bruises, more liver, lung, and viscera condemnations, and fewer heads and tongues were condemned. The NBQA remains an influential survey for the U.S. beef industry to provide benchmarks and strategic plans for continued improvement of beef quality and consistency
Photoproduction of mesons off nuclei
Recent results for the photoproduction of mesons off nuclei are reviewed.
These experiments have been performed for two major lines of research related
to the properties of the strong interaction. The investigation of nucleon
resonances requires light nuclei as targets for the extraction of the isospin
composition of the electromagnetic excitations. This is done with quasi-free
meson photoproduction off the bound neutron and supplemented with the
measurement of coherent photoproduction reactions, serving as spin and/or
isospin filters. Furthermore, photoproduction from light and heavy nuclei is a
very efficient tool for the study of the interactions of mesons with nuclear
matter and the in-medium properties of hadrons. Experiments are currently
rapidly developing due to the combination of high quality tagged (and
polarized) photon beams with state-of-the-art 4pi detectors and polarized
targets
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
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