1,279 research outputs found
Thermodynamics of SU(3) gauge theory on anisotropic lattices
Finite temperature SU(3) gauge theory is studied on anisotropic lattices
using the standard plaquette gauge action. The equation of state is calculated
on , and lattices with
the anisotropy , where and are the
spatial and temporal lattice spacings. Unlike the case of the isotropic lattice
on which data deviate significantly from the leading scaling behavior,
the pressure and energy density on an anisotropic lattice are found to satisfy
well the leading scaling from our coarsest lattice, . With
three data points at , 5 and 6, we perform a well controlled
continuum extrapolation of the equation of state. Our results in the continuum
limit agree with a previous result from isotropic lattices using the same
action, but have smaller and more reliable errors.Comment: RevTeX, 21 pages, 17 PS figures. A quantitative test about the
benefit of anisotropic lattices added, minor errors corrected. Final version
for PR
Factors Influencing the Participation of Older People in Clinical Trials : Data Analysis from the MAVIS Trial
Peer reviewedPostprin
Exact Solution for the Critical State in Thin Superconductor Strips with Field Dependent or Anisotropic Pinning
An exact analytical solution is given for the critical state problem in long
thin superconductor strips in a perpendicular magnetic field, when the critical
current density j_c(B) depends on the local induction B according to a simple
three-parameter model. This model describes both isotropic superconductors with
this j_c(B) dependence, but also superconductors with anisotropic pinning
described by a dependence j_c(theta) where theta is the tilt angle of the flux
lines away from the normal to the specimen plane
Development of a tight-binding potential for bcc-Zr. Application to the study of vibrational properties
We present a tight-binding potential based on the moment expansion of the
density of states, which includes up to the fifth moment. The potential is
fitted to bcc and hcp Zr and it is applied to the computation of vibrational
properties of bcc-Zr. In particular, we compute the isothermal elastic
constants in the temperature range 1200K < T < 2000K by means of standard Monte
Carlo simulation techniques. The agreement with experimental results is
satisfactory, especially in the case of the stability of the lattice with
respect to the shear associated with C'. However, the temperature decrease of
the Cauchy pressure is not reproduced. The T=0K phonon frequencies of bcc-Zr
are also computed. The potential predicts several instabilities of the bcc
structure, and a crossing of the longitudinal and transverse modes in the (001)
direction. This is in agreement with recent ab initio calculations in Sc, Ti,
Hf, and La.Comment: 14 pages, 6 tables, 4 figures, revtex; the kinetic term of the
isothermal elastic constants has been corrected (Eq. (4.1), Table VI and
Figure 4
Associations of Hair Dye and Relaxer Use with Breast Tumor Clinicopathologic Features: Findings from the Women’s Circle of Health Study
Background Building upon our earlier findings of significant associations between hair dye and relaxer use with increased breast cancer risk, we evaluated associations of select characteristics of use with breast tumor clinicopathology. Methods Using multivariable-adjusted models we examined the associations of interest in a case-only study of 2998 women with breast cancer, overall and stratified by race and estrogen receptor (ER) status, addressing multiple comparisons using Bonferroni correction. Results Compared to salon application of permanent hair dye, home kit and combination application (both salon and home kit application) were associated with increased odds of poorly differentiated tumors in the overall sample. This association was consistent among Black (home kit: OR 2.22, 95 % CI: 1.21–5.00; combination: OR 2.46, 95 % CI: 1.21–5.00), but not White women, and among ER+ (home kit: OR 1.47, 95 % CI: 0.82–2.63; combination: OR 2.98, 95 % CI: 1.62–5.49) but not ER-cases. Combination application of relaxers was associated with increased odds of tumors \u3e2.0 cm vs. \u3c1.0 cm (OR = 1.82, 95 % CI: 1.23–2.69). Longer duration and earlier use of relaxers and combination application of permanent hair dyes and relaxers were associated with breast tumor features including higher tumor grade and larger tumor size, which often denote more aggressive phenotypes, although the findings did not maintain significance with Bonferroni correction. Conclusions These novel data support reported associations between hair dye and relaxer use with breast cancer, showing for the first time, associations with breast tumor clinicopathologic features. Improved hair product exposure measurement is essential for fully understanding the impact of these environmental exposure with breast cancer and to guide risk reduction strategies in the future
Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors
We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discover
COVID-19: how has a global pandemic changed manual therapy technique education in chiropractic programs around the world?
Background
Manual therapy is a cornerstone of chiropractic education, whereby students work towards a level of skill and expertise that is regarded as competent to work within the field of chiropractic. Due to the COVID-19 pandemic, chiropractic programs in every region around the world had to make rapid changes to the delivery of manual therapy technique education, however what those changes looked like was unknown.
Aims
The aims of this study were to describe the immediate actions made by chiropractic programs to deliver education for manual therapy techniques and to summarise the experience of academics who teach manual therapy techniques during the initial outbreak of COVID-19 pandemic.
Methods
A qualitative descriptive approach was used to describe the immediate actions made by chiropractic programs to deliver manual therapy technique education during the COVID-19 pandemic. Chiropractic programs were identified from the webpages of the Councils on Chiropractic Education International and the Council on Chiropractic Education – USA. Between May and June 2020, a convenience sample of academics who lead or teach in manual therapy technique in those programs were invited via email to participate in an online survey with open-ended questions. Responses were entered into the NVivo software program and analysed using a reflexive thematic analysis by a qualitative researcher independent to the data collection.
Results
Data from 16 academics in 13 separate chiropractic programs revealed five, interconnected themes: Immediate response; Move to online delivery; Impact on learning and teaching; Additional challenges faced by educators; and Ongoing challenges post lockdown.
Conclusion
This study used a qualitative descriptive approach to describe how some chiropractic programs immediately responded to the initial outbreak of the COVID-19 pandemic in their teaching of manual therapy techniques. Chiropractic programs around the world provided their students with rapid, innovative learning strategies, in an attempt to maintain high standards of chiropractic education; however, challenges included maintaining student engagement in an online teaching environment, psychomotor skills acquisition and staff workload
Implementation of a pharmacogenomics consult service to support the INGENIOUS trial
Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding
Gravitational stability and dynamical overheating of stellar disks of galaxies
We use the marginal stability condition for galactic disks and the stellar
velocity dispersion data published by different authors to place upper limits
on the disk local surface density at two radial scalelengths .
Extrapolating these estimates, we constrain the total mass of the disks and
compare these estimates to those based on the photometry and color of stellar
populations. The comparison reveals that the stellar disks of most of spiral
galaxies in our sample cannot be substantially overheated and are therefore
unlikely to have experienced a significant merging event in their history. The
same conclusion applies to some, but not all of the S0 galaxies we consider.
However, a substantial part of the early type galaxies do show the stellar
velocity dispersion well in excess of the gravitational stability threshold
suggesting a major merger event in the past. We find dynamically overheated
disks among both seemingly isolated galaxies and those forming pairs. The ratio
of the marginal stability disk mass estimate to the total galaxy mass within
four radial scalelengths remains within a range of 0.4---0.8. We see no
evidence for a noticeable running of this ratio with either the morphological
type or color index.Comment: 25 pages, 5 figures, accepted to Astronomy Letter
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