A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep

Chronic gonadotropin-releasing hormone agonist (GnRHa) administration is used where suppression of hypothalamic-pituitary-gonadal axis activity is beneficial, such as steroid-dependent cancers, early onset gender dysphoria, central precocious puberty and as a reversible contraceptive in veterinary medicine. GnRH receptors, however, are expressed outside the reproductive axis, e.g. brain areas such as the hippocampus which is crucial for learning and memory processes. Previous work, using an ovine model, has demonstrated that long-term spatial memory is reduced in adult rams (45 weeks of age), following peripubertal blockade of GnRH signaling (GnRHa: goserelin acetate), and this was independent of the associated loss of gonadal steroid signaling. The current study investigated whether this effect is reversed after discontinuation of GnRHa-treatment. The results demonstrate that peripubertal GnRHa-treatment suppressed reproductive function in rams, which was restored after cessation of GnRHa-treatment at 44 weeks of age, as indicated by similar testes size (relative to body weight) in both GnRHa-Recovery and Control rams at 81 weeks of age. Rams in which GnRHa-treatment was discontinued (GnRHa-Recovery) had comparable spatial maze traverse times to Controls, during spatial orientation and learning assessments at 85 and 99 weeks of age. Former GnRHa-treatment altered how quickly the rams progressed beyond a specific point in the spatial maze at 83 and 99 weeks of age, and the direction of this effect depended on gonadal steroid exposure, i.e. GnRHa-Recovery rams progressed quicker during breeding season and slower during non-breeding season, compared to Controls. The long-term spatial memory performance of GnRHa-Recovery rams remained reduced (P < 0.05, 1.5-fold slower) after discontinuation of GnRHa, compared to Controls. This result suggests that the time at which puberty normally occurs may represent a critical period of hippocampal plasticity. Perturbing normal hippocampal formation in this peripubertal period may also have long lasting effects on other brain areas and aspects of cognitive function

Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep

Chronic gonadotropin-releasing hormone agonist (GnRHa) is used therapeutically to block activity within the reproductive axis through down-regulation of GnRH receptors within the pituitary gland. GnRH receptors are also expressed in non-reproductive tissues, including areas of the brain such as the hippocampus and amygdala. The impact of long-term GnRHa-treatment on hippocampus-dependent cognitive functions, such as spatial orientation, learning and memory, is not well studied, particularly when treatment encompasses a critical window of development such as puberty. The current study used an ovine model to assess spatial maze performance and memory of rams that were untreated (Controls), had both GnRH and testosterone signaling blocked (GnRHa-treated), or specifically had GnRH signaling blocked (GnRHa-treated with testosterone replacement) during the peripubertal period (8, 27 and 41 weeks of age). The results demonstrate that emotional reactivity during spatial tasks was compromised by the blockade of gonadal steroid signaling, as seen by the restorative effects of testosterone replacement, while traverse times remained unchanged during assessment of spatial orientation and learning. The blockade of GnRH signaling alone was associated with impaired retention of long-term spatial memory and this effect was not restored with the replacement of testosterone signaling. These results indicate that GnRH signaling is involved in the retention and recollection of spatial information, potentially via alterations to spatial reference memory, and that therapeutic medical treatments using chronic GnRHa may have effects on this aspect of cognitive function

Effect of soil type on seismic demand

This paper investigates the validity of the soil considerations used in the determination of seismic demand as part of NZS1170.5, which currently specifies seismic design spectra corresponding to 5 different soil types. According to the current provisions stipulated in NZS1170.5, for all natural periods, the building demand for soft soil is either equal to or greater than that for hard soil. It is noted that this is opposite to the basic structural dynamics theory which suggests that an increase in stiffness of a system results in an increase in the acceleration response. In this pretext, a numerical parametric study is undertaken using a 1-D nonlinear site response analysis in order to capture the effect of soil characteristics on structural seismic demand and to scrutinize the validity of the current site specific seismic design spectra. It is identified that the level of input ground motion intensity and shear stiffness of the column (represented by its shear wave velocity, Vs) are the main parameters affecting the surface response. The study found some shortfalls in the way the current code defines seismic design demand, in particular the hierarchy of soil stiffness at low structural periods. It was found that stiff soils generally tend to have a higher spectral acceleration response in comparison to soft soils although this trend is less prominent for high intensity bed rock motions. It was also found that for medium to hard soil types the spectral acceleration response at short period is grossly underestimated by the current NZS1170.5 provisions. Based on the outcomes of the parametric numerical analyses, a revised strategy to determine seismic structural demand is proposed and demonstrated

Trajectory versus probability density entropy

We study the problem of entropy increase of the Bernoulli-shift map without recourse to the concept of trajectory and we discuss whether, and under which conditions if it does, the distribution density entropy coincides with the Kolmogorov-Sinai entropy, namely, with the trajectory entropy.Comment: 24 page

Exclusive Queueing Process with Discrete Time

In a recent study [C Arita, Phys. Rev. E 80, 051119 (2009)], an extension of the M/M/1 queueing process with the excluded-volume effect as in the totally asymmetric simple exclusion process (TASEP) was introduced. In this paper, we consider its discrete-time version. The update scheme we take is the parallel one. A stationary-state solution is obtained in a slightly arranged matrix product form of the discrete-time open TASEP with the parallel update. We find the phase diagram for the existence of the stationary state. The critical line which separates the parameter space into the regions with and without the stationary state can be written in terms of the stationary current of the open TASEP. We calculate the average length of the system and the average number of particles

Revisiting the potential of carbonized grain to preserve biogenic 87 Sr/86 Sr signatures within the burial environment

Strontium (Sr) isotope analysis of archaeological crops is a potential method of provenancing and identifying the movement of crops in the past, but there remains uncertainty about whether original 87Sr/86Sr values can be obtained from carbonized buried grains. We have determined that hydrochloric acid (HCl) leaching removes some, but not all, exogenous Sr from carbonized cereal grains buried in soil for up to one year. We conclude that while further work could refine the leaching method, Sr isotope analysis of archaeological cereal grains can distinguish crops sourced from outside a particular (e.g., local) area if it can be shown that leaching moves grain 87Sr/86Sr values significantly away from the expected Sr signature

Density-functional theory of quantum wires and dots in a strong magnetic field

We study the competition between the exchange and the direct Coulomb interaction near the edge of a two-dimensional electron gas in a strong magnetic field using density-functional theory in a local approximation for the exchange-energy functional. Exchange is shown to play a significant role in reducing the spatial extent of the compressible edge channel regions obtained from an electrostatic description. The transition from the incompressible edge channels of the Hartree-Fock picture to the broad, compressible strips predicted by electrostatics occurs within a narrow and experimentally accessible range of confinement strengths.Comment: 24 pages latex and 10 postscript figures in self extracting fil

Mass-Induced Crystalline Color Superconductivity

We demonstrate that crystalline color superconductivity may arise as a result of pairing between massless quarks and quarks with nonzero mass m_s. Previous analyses of this phase of cold dense quark matter have all utilized a chemical potential difference \delta\mu to favor crystalline color superconductivity over ordinary BCS pairing. In any context in which crystalline color superconductivity occurs in nature, however, it will be m_s-induced. The effect of m_s is qualitatively different from that of \delta\mu in one crucial respect: m_s depresses the value of the BCS gap \Delta_0 whereas \delta\mu leaves \Delta_0 unchanged. This effect in the BCS phase must be taken into account before m_s-induced and \delta\mu-induced crystalline color superconductivity can sensibly be compared.Comment: 12 pages, 4 figures. v2: very small change onl

Heat flow and calculus on metric measure spaces with Ricci curvature bounded below - the compact case

We provide a quick overview of various calculus tools and of the main results concerning the heat flow on compact metric measure spaces, with applications to spaces with lower Ricci curvature bounds. Topics include the Hopf-Lax semigroup and the Hamilton-Jacobi equation in metric spaces, a new approach to differentiation and to the theory of Sobolev spaces over metric measure spaces, the equivalence of the L^2-gradient flow of a suitably defined "Dirichlet energy" and the Wasserstein gradient flow of the relative entropy functional, a metric version of Brenier's Theorem, and a new (stronger) definition of Ricci curvature bound from below for metric measure spaces. This new notion is stable w.r.t. measured Gromov-Hausdorff convergence and it is strictly connected with the linearity of the heat flow.Comment: To the memory of Enrico Magenes, whose exemplar life, research and teaching shaped generations of mathematician

On the Exact Evaluation of Certain Instances of the Potts Partition Function by Quantum Computers

We present an efficient quantum algorithm for the exact evaluation of either the fully ferromagnetic or anti-ferromagnetic q-state Potts partition function Z for a family of graphs related to irreducible cyclic codes. This problem is related to the evaluation of the Jones and Tutte polynomials. We consider the connection between the weight enumerator polynomial from coding theory and Z and exploit the fact that there exists a quantum algorithm for efficiently estimating Gauss sums in order to obtain the weight enumerator for a certain class of linear codes. In this way we demonstrate that for a certain class of sparse graphs, which we call Irreducible Cyclic Cocycle Code (ICCC_\epsilon) graphs, quantum computers provide a polynomial speed up in the difference between the number of edges and vertices of the graph, and an exponential speed up in q, over the best classical algorithms known to date