2,279 research outputs found

    Potentialities of remote teams in the innovation process in an organization through the design management

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    Design management and innovation give companies competitive advantages. In this scenario, the involvement of employees for generation of innovation is an important factor to be developed within the organization. Therefore, this research aims to identify the potentialities of employees from Sales and Technical Assistance areas for the innovation process. These remote teams work outside the organization in touch with the market and know the necessities of the market and consumers. This survey of the potential is motivated by the possibility of integration of employees who work in the field to participate and get involved with innovation in the organization. The research was conducted through a bibliographical research and application in a case study in a construction consumer goods company, based on design management and human centered design. The case study is divided in two steps: mapping and diagnosis, to easily collect information. As a result, in this paper, we will demonstrate the requirements and potential correlation of these teams that allow the creation of an innovation process focused on the routine and life of these employees.Keywords: design management, innovation, remote teams, employee

    Magnetic Resonance Image In The Diagnosis And Evaluation Of Extra-prostatic Extension And Involvement Of Seminal Vesicles Of Prostate Cancer: A Systematic Review Of Literature And Meta-analysis.

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    Systematic review of literature and meta-analysis to evaluate the results of magnetic resonance image 1.5T with endorectal coil in the diagnosis and evaluation of extra-prostatic extension and involvement of seminal vesicles of prostate cancer, compared to the histopathological results of the radical prostatectomy specimen. It was conducted a systematic review of literature and meta-analyses of all studies data published after 2008. In those studies, the patients with prostate cancer with indication to radical prostatectomy were submitted to magnetic resonance image (MRI) at pre-operatory period and the results were compared to those of histopathological studies after the surgery. The selected terms for research included prostate cancer, magnetic resonance, radical prostatectomy, and prostate cancer diagnosis, in the databases EMBASE, LILACS, PUBMED/MEDLINE and Cochrane Library. The data were collected using a specific qualitative instrument and the meta-analysis data were presented in the forest plot graphics, homogeneity test and sROC curves and funnel plot. A total of seven studies were included, with a total of 603 patients. Among these studies, six evaluated the value of MRI for the detection of prostate cancer, and the median sensitivity of meta-analysis was 0.6 and specificity 0.58, but with heterogeneity among the studies. Three studies evaluated extra-prostatic extension with a median sensitivity of 0.49, specificity 0.82 and heterogeneity only for sensitivity. Three studies evaluated invasion of seminal vesicles, with median sensitivity of 0.45 and specificity 0.96, with heterogeneity in both analysis. Magnetic resonance of 1.5T with endocoil showed low values of sensitivity and specificity for the diagnosis and staging of prostate cancer. The reviewed studies showed a significant heterogeneity among them. The best observed result was MRI specificity for invasion of seminal vesicles. More studies are necessary to evaluate new techniques and parameters before recommending the routine use of MRI in clinical practice.39215516

    Etnomatemåtica Do Sistema De Contagem Guarani Das Aldeias Itaty, Do Morro Dos Cavalos, E M'biguaçu

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    The Guarani are one of several indigenous Brazilian tribes. Since the first Portuguese colonizers arrived to Brazil, the culture and costumes - including mathematical knowledge - and practices of Guarani and other indigenous people were considered inferior and unworthy. Considering this panorama and taking into account the multicultural features of Brazilian school, we present this article with the objective of analyzing the counting system and some graphical symbols of two Guarani tribes, the Itaty tribe, settled at the "Morro dos Cavalos" and M'Biguaçu tribe, located between the cities Palhoça and Biguaçu in Santa Catarina State, Brazil. This ethnographic case study was carried out through interviews with leaders of the Guarani tribes mentioned above. The present study is based on the theoretical principles of the "Ethnomatematics Program". The results of our analyses made evident that the counting system as well as the symbols employed are strongly correlated to these people's culture, thus playing roles both in quantification and in what we call in this paper as qualitative function.3056992101

    Observation of Vortex Matching Phenomena in Antidot Array of NbN Thin Film

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    We report vortex matching phenomenon in rectangular antidot array fabricated on epitaxial NbN thin film. The antidot array was fabricated using Focussed Ion Beam milling technique. The magneto-transport measurements points to a period doubling transition at higher magnetic field for rectangular lattices. The results are discussed within the light of several models including the multi-vortex model, the matched lattice model and the super-matched lattice model.Comment: Added references, modified abstract and discussions and corrected typo-graphic errors. Accepted for proceedings of M2S-IX 2009, Tokyo (Physica C

    Differential gene expression and immunolocalization of platelet-derived growth factors and their receptors in caprine ovaries

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    AbstractThis study evaluated the messenger RNA (mRNA) expression and immunolocalization of all members of the platelet-derived growth factor (PDGF) family in caprine ovaries by quantitative PCR and immunohistochemistry, respectively. Detectable levels of PDGF-A mRNA were not observed in primordial follicles. Higher levels of PDGF-B mRNA were observed in primary follicles than in primordial follicles (P < 0.05). PDGF-D mRNA levels were higher in secondary follicles than in the other preantral follicle categories (P < 0.05). PDGF-B mRNA expression was higher than PDGF-C mRNA expression in primary follicles (P < 0.05). In antral follicles, PDGF-A mRNA expression was higher in cumulus-oocyte complexes (COCs) from small antral follicles than in those from large antral follicles and their respective granulosa/theca (GT) cells (P < 0.05). Furthermore, in COCs from small and large antral follicles, PDGF-A mRNA expression was higher than that of the other PDGF isoforms (P < 0.05). The mRNA levels of PDGF-B and PDGF-D and PDGFR-α and PDGFR-ÎČ were higher in GT cells from large antral follicles than in GT cells from small antral follicles and in their respective COCs (P < 0.05). In COCs and GT cells from small antral follicles, the mRNA levels of PDGFR-α were higher than those of PDGFR-ÎČ (P < 0.05). All proteins were observed in the cytoplasm of oocytes from all follicular categories. In granulosa cells, all PDGFs and PDGFR-ÎČ were detected from starting at the secondary stage, and in theca cells, all proteins, except PDGF-C, were detected starting at the antral stage. In conclusion, PDGF and its receptors are differentially expressed in the oocytes and ovarian cells according to the stage of follicular development, suggesting their role in the regulation of folliculogenesis in goats

    Quantum-wave evolution in a step potential barrier

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    By using an exact solution to the time-dependent Schr\"{o}dinger equation with a point source initial condition, we investigate both the time and spatial dependence of quantum waves in a step potential barrier. We find that for a source with energy below the barrier height, and for distances larger than the penetration length, the probability density exhibits a {\it forerunner} associated with a non-tunneling process, which propagates in space at exactly the semiclassical group velocity. We show that the time of arrival of the maximum of the {\it forerunner} at a given fixed position inside the potential is exactly the traversal time, τ\tau. We also show that the spatial evolution of this transient pulse exhibits an invariant behavior under a rescaling process. This analytic property is used to characterize the evolution of the {\it forerunner}, and to analyze the role played by the time of arrival, 3−1/2τ3^{-1/2}\tau, found recently by Muga and B\"{u}ttiker [Phys. Rev. A {\bf 62}, 023808 (2000)].Comment: To be published in Phys. Rev. A (2002

    Potentialities of remote teams in the innovation process in an organization through the design management

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    Design management and innovation give companies competitive advantages. In this scenario, the involvement of employees for generation of innovation is an important factor to be developed within the organization. Therefore, this research aims to identify the potentialities of employees from Sales and Technical Assistance areas for the innovation process. These remote teams work outside the organization in touch with the market and know the necessities of the market and consumers. This survey of the potential is motivated by the possibility of integration of employees who work in the field to participate and get involved with innovation in the organization. The research was conducted through a bibliographical research and application in a case study in a construction consumer goods company, based on design management and human centered design. The case study is divided in two steps: mapping and diagnosis, to easily collect information. As a result, in this paper, we will demonstrate the requirements and potential correlation of these teams that allow the creation of an innovation process focused on the routine and life of these employees.Keywords: design management, innovation, remote teams, employee

    Beam test evaluation of electromagnetic calorimeter modules made from proton-damaged PbWO4_4 crystals

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    The performance of electromagnetic calorimeter modules made of proton-irradiated PbWO(4) crystals has been studied in beam tests. The modules, similar to those used in the Endcaps of the CMS electromagnetic calorimeter (ECAL), were formed from 5×5 matrices of PbWO(4) crystals, which had previously been exposed to 24 GeV protons up to integrated fluences between 2.1× 10(13) and 1.3× 10(14) cm(−)(2). These correspond to the predicted charged-hadron fluences in the ECAL Endcaps at pseudorapidity η = 2.6 after about 500 fb(−)(1) and 3000 fb(−)(1) respectively, corresponding to the end of the LHC and High Luminosity LHC operation periods. The irradiated crystals have a lower light transmission for wavelengths corresponding to the scintillation light, and a correspondingly reduced light output. A comparison with four crystals irradiated in situ in CMS showed no significant rate dependence of hadron-induced damage. A degradation of the energy resolution and a non-linear response to electron showers are observed in damaged crystals. Direct measurements of the light output from the crystals show the amplitude decreasing and pulse becoming faster as the fluence increases. The latter is interpreted, through comparison with simulation, as a side-effect of the degradation in light transmission. The experimental results obtained can be used to estimate the long term performance of the CMS ECAL.Peer Reviewe

    Field Evaluation Of Safety During Gestation And Horizontal Spread Of A Recombinant Differential Bovine Herpesvirus 1 (bohv-1) Vaccine

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    Bovine herpesvirus type 1 (BoHV-1) is recognized as a major cause of respiratory, reproductive disease and abortion in cattle. Vaccination is widely applied to minimize losses induced by BoHV-1 infections; however, vaccination of dams during pregnancy with modified live virus (MLV) vaccines has been occasionally associated to abortions. We have previously reported the development of a BoHV-1 recombinant virus, constructed with basis on a Brazilian BoHV-1 (Franco et al. 2002a) from which the gene coding for glycoprotein E (gE) was deleted (gE-) by genetic manipulation. Such recombinant has been previously evaluated in its potential as a differential vaccine (gE-vaccine) that allows differentiation between vaccinated and infected animals. Here, in the first part of the present study, the safety of the gE-vaccine during pregnancy was evaluated by the intramuscular inoculation of 107.4 tissue culture 50% infective doses (TCID50) of the virus into 22 pregnant dams (14 BoHV-1 seronegative; 8 seropositive), at different stages of gestation. Other 15 pregnant dams were kept as non-vaccinated controls. No abortions, stillbirths or fetal abnormalities were seen after vaccination. Seroconversion was observed in both groups of previously seronegative vaccinated animals. In the second part of the study, the potential of the gE-vaccine virus to spread among beef cattle under field conditions was examined. Four heifers were inoculated intranasally with a larger amount (107.6TCID50) of the gE-vaccine (to increase chances of transmission) and mixed with other sixteen animals at the same age and body condition, in the same grazing area, at a population density equal to the average cattle farming density within the region (one cattle head per 10,000 m2), for 180 days. All animals were monitored daily for clinical signs. Serum samples were collected on days 0, 30, 60 and 180 post-vaccination. Seroconversion was observed only in vaccinated heifers. These results indicate that, under the conditions of the present study, the gE-vaccine virus did not cause any noticeable harmful effect on pregnant dams and on its offspring and did not spread horizontally among cattle.2515458Belknap, E.B., Walters, L.M., Kelling, C., Ayers, V.K., Norris, J., McMillend, J., Hayhowe, C., Collins, J.K., Immunogenicity and protective efficacy of a gE, gG and US2 gene-deleted bovine herpesvirus-1 (BHV-1) vaccine (1999) Vaccine, 17, pp. 2297-2305Bouma, A., De Jong, M.C.M., Kimman, T.G., Transmission of pseudorabies virus within pig populations is independent of the size of the population (1995) Prev. Vet. Med., 23, pp. 163-172Casal, J., Planasdemunt, L., Varo, J.A., Martín, M., The use of different vaccination schedules for sows to protect piglets against Aujeszky's disease (2004) Vet. Med. B, 51, pp. 8-11D'Arce, R.C.F., Almeida, R.S., Silva, T.C., Franco, A.C., Spilki, F., Roehe, P.M., Arns, C.W., Restriction endonuclease and monoclonal antibody characterization of Brazilian isolates of bovine herpesviruses types 1 and 5 (2002) Vet. Microbiol., 88, pp. 315-324Ellis, J.A., Hassard, L.E., Cortese, V.S., Morley, P.S., Effects of perinatal vaccination on humoral and cellular immune responses in dams and young calves (1996) J. Am. Vet. Med. Assoc., 208, pp. 393-400Flores, E.F., Donis, R.O., Isolation of a mutant MDBK cell line resistant to bovine viral diarrhea virus infection due to a block in viral entry (1995) Virology, 208, pp. 565-575Flores, E.F., Osorio, F.A., Zanella, E.L., Kit, S., Kit, M., Efficacy of a deletion mutant bovine herpesvirus-1 (BHV-1) vaccine that allows serologic differentiation of vaccinated from naturally infected animals (1993) J. Vet. Diagn. Invest., 5, pp. 534-540Franco, A.C., Rijsewijk, F.A.M., Flores, E.F., Weiblen, R., Roehe, P.M., Construction and characterization of a glycoprotein E deletion of bovine herpesvirus type 1.2 strain isolated in Brazil (2002) Braz. J. Microbiol., 33, pp. 274-278Franco, A.C., Spilki, F.R., Esteves, P.A., Lima, M., Weiblen, R., Flores, E.F., Rijsewijk, F.A.M., Roehe, P.M., A Brazilian glycoprotein E-negative bovine herpesvirus type 1.2a (BHV-1.2a) mutant is attenuated for cattle and induces protection against wild-type virus challenge (2002) Pesq. Vet. Bras., 22, pp. 135-140Hage, J.J., Schukken, Y.H., Barkema, H.W., Benedictus, G., Rijsewijk, F.A.M., Wentink, G.H., Population dynamics of bovine herpesvirus infection a dairy herd (1996) Vet. Microbiol., 53, pp. 169-180Guy, J.S., Potgieter, L.N., Bovine herpesvirus-1 infection of cattle: Kinetics of antibody formation after intranasal exposure and abortion induced by the virus (1985) Am. J. Vet. Res., 46, pp. 893-898Kaashoek, M., (1995) Marker Vaccines Against Bovine Herpesvirus 1 Infections, 155p. , Ph.D. Thesis, Utrecht University, NetherlandsKleiboeker, S.B., Lee, S.M., Jones, C.A., Estes, D.M., Evaluation of shedding of bovine herpesvirus 1, bovine viral diarrhea virus 1, and bovine viral diarrhea virus 2 after vaccination of calves with a multivalent modified-live virus vaccine (2003) J. Am. Vet. Med Assoc., 222, pp. 1399-1403Lomba, F., Vascoboinic, E., Zygraich, N., Immunization of pregnant dams with a temperature-sensitive mutant of the IBR Virus (1976) 6th Int. Congr. Diseases of Cattle, pp. 395-399. , ParisMars, M.H., De Jong, M.C.M., Van Oirschot, J.T., A gE-negative BHV-1 vaccine virus strain cannot perpetuate in cattle populations (2000) Vaccine, 18, pp. 2120-2124McFelly, R.A., Merrit, A.M., Stearly, E.L., Abortion in a dairy herd vaccinated for infectious bovine rhinotracheitis (1964) Vet. Path., 1, pp. 7-17Miller, J.M., Whetstone, C.A., Van Der Maaten, M.J., Abortfacient property of bovine herpesvirus type 1 isolates that represent three subtypes determined by restriction endonuclease analysis of viral DNA (1991) Am. J. Vet. Res., 52, pp. 458-461Miller, J.M., Whetstone, C.A., Bello, L.J., Lawrence, W.C., Whitbeck, J.C., Abortions in heifers inoculated with a thymidine kinase-negative recombinant of bovine herpesvirus 1 (1995) Am. J. Vet. Res., 56, pp. 870-874Mitchell, D., An outbreak of abortion in a dairy herd following inoculation with an intramuscular infectious bovine rhinotracheitis virus (1964) Can. Vet. J., 26, pp. 8-14Odde, K.G., Survival of the neonatal calf. Factors influencing colostral and calf serum immunoglobulin levels (1988) Vet. Clin. North Am. Food Anim. Pract., 4, pp. 501-508Pastoret, P.P., Babiuk, L.A., Misra, V., Griebel, P., Reactivation of temperature sensitive and non-temperature-sensitive infectious bovine rhinotracheitis vaccine virus with dexamethasone (1980) Infect. Immun., 29, pp. 483-488Roehe, P.M., (1991) Studies on the Comparative Virology of Pestiviruses, 361p. , Ph.D. thesis. University of Surrey, Guildford, UKSiebert, S., Auer, S., Heinem, E., Kretzdom, D., Strube, W., Marker vaccines - Opportunities for IBR control. Part I: BHV-1 infections - The problem (1995) TierÀrztl. Umschau, 50, pp. 530-533Siebert, S., Auer, S., Heinem, E., Kretzdom, D., Strube, W., Marker vaccines - Opportunities for IBR control. Part II: Safety and efficacy of the gE-deleted Bayovac IBR marker vaccines (1995) TierÀrztl. Umschau, 50, pp. 582-584Strube, W., Abar, B., Bergle, R.D., Safety aspects in the development of an infectious bovine rhinotracheitis marker vaccine. Non-target effects of live vaccines (1995) Dev. Biol. Stand., 84, pp. 75-81Turin, L., Russo, S., Poli, G., BHV-1: New molecular approaches to control a common and widespread infection (1999) Mol. Med., 5, pp. 261-284Van Drunen Littel-van Den Hurk, S., Parker, M.D., Massie, B., Van Den Hurk, J.V., Harland, R., Babiuk, L.A., Zamb, T.J., Protection of cattle from BHV-1 infection by immunization with recombinant glycoprotein gIV (1993) Vaccine, 11, pp. 25-35Van Engelenburg, F.A.C., Kaashoek, M.J., Van Oirschot, J.T., Rijsewijk, F.A.M., A glycoprotein E deletion mutant of bovine herpesvirus 1 infects the same limited number of tissues in calves as wild-type virus, but for a shorter period (1995) J. Gen. Virol., 76, pp. 2387-2392Wentink, G.H., Van Oirschot, J.T., Verhoeff, J., Risk of infection with bovine herpes virus 1 (BHV-1): A review (1993) Vet. Quarterly, 15, pp. 30-33Whetstone, C.A., Wheeler, J.G., Reed, D.E., Investigation of possible vaccine-induced epizootics of infectious bovine rhinotracheitis, using restriction endonuclease analysis of viral DNA (1986) Am. J. Vet. Res., 47, pp. 1789-1795Zuckermann, F.A., Husmann, R.J., Schwartz, R., Brandt, J., Mateu De Antonio, E., Martin, S., Interleukin-12 enhances the virus-specific interferon gamma response of pigs to an inactivated pseudorabies virus vaccine (1998) Vet. Immunol. Immunopath., 63, pp. 57-6

    Do Uso E Cobertura Da Terra Ă  ExperiĂȘncia EtnogrĂĄfica: Croquis E Imagens De SatĂ©lite Na AmazĂŽnia Rural Brasileira

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    The objective of this work is to explore two perspectives on land use and land cover change (LULC) in agricultural settlements of the Amazon region within an ethnographic experience: a “technical-scientific” view that defines LULC from afar using remote sensing techniques (classification and analysis of satellite imagery), and a “local” perspective that defines LULC by local farmers and residents using participatory sketch maps. This paper summarizes research results and the ethnographic experiences through which these perspectives may be formed, especially similarities and differences among the two. The analysis and results are divided into three views: one in which these perspectives are given equivalency across LULC studies; another describing the ethnographic experience according to an affective-intellectual intersectionality; and, finally, one that identifies a diagonally-shifting perspective, described as an expression of the spatial understanding of farmers produced through the ethnographic experience. © 2016, Centro em Rede de Investigacao em Antropologia. All rights reserved.20358360
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