Covid-19 in Peru: From supervised walks for children to the first case of Kawasaki-like syndrome

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Determination of free radical scavenging activity, phenolic and flavonoid content of seven corn cultivars from the Southwest Maluku District, Indonesia

Sinay H, Mahulette F, YáñezJA. 2022. Determination of free radical scavenging activity, phenolicand flavonoid content of seven corn cultivars from the Southwest Maluku District, Indonesia.Biodiversitas 23:5974-5981.The variation of corn (Zea maysL.) kernel might be considered as a surrogate indicator of the phytochemical and bioactive content. This study aimed to determine the phenolics, flavonoids, and free radical scavenging activity of seven local corn cultivars from Kisar Island, Southwest Maluku District in Indonesia. Sample extraction was done by the maceration method. Flavonoid content wasdetermined using the Dowd method, and total phenolic content was performed using the Folin-Ciocalteu method. Free radical scavenging activity was determined using the DPPH radical scavenging method. One-way ANOVA was performed with Duncan multiple range tests to assess the differences between corn seed cultivars, and p < 0.05 were regarded as statistically significant. The results show that the total flavonoid content varied from 8.463 mg QE/mg (Putihcultivar) to 40.075 mg QE/mg (Kuning Dalamcultivar). Total polyphenol content also varied between 105.63 mg GAE/mg (Merah Delima Tongkol Putihcultivar) and 136.41 mg GAE/mg (Pulutcultivar). The antioxidant activity by DPPH assay determined that the seven local corn cultivars had IC50values that were similar to quercetin (used as control), some were even lower. The IC50value of the seven local corn cultivars ranged from 5.56 to 16.96 μg/mL, while quercetinhad an IC50value of 11.97 μg/mL. It was observed that theMerah Delima Tongkol Cokelat, Merah Delima Tongkol Putih,andPutihcultivars had comparable antioxidant activity to the control quercetin. TheMerah Darah, Kuning Genjah, andKuning Dalamcultivars exhibited a statistically significant higher antioxidant capacity than quercetin. These results can contribute to the selection of corn cultivars to harvest for commercial purposes and potential nutraceutical applications

Influence of technostress on academic performance of university medicine students in peru during the covid-19 pandemic

The current study aims to validate and apply an instrument to assess the relationship between communication overload, social overload, technostress, exhaustion and academic performance. We performed a cross-sectional, analytical study of 2286 university medical students to assess the influence of technostress as a mediator of social media overload, communication overload and mental exhaustion and its detrimental effect on the academic performance of university students in Peru during the COVID-19 pandemic. The research model was validated using partial least square structural equation modeling (PLS-SEM) to establish the influence of variables on the model. Communication and social overload were found to positively influence technostress by correlations of 0.284 and 0.557, respectively. Technostress positively influenced exhaustion by 0.898, while exhaustion negatively influenced academic performance by-0.439. Bootstrapping demonstrated that the path coefficients of the research model were statistically significant. The research outcomes may help university managers understand students’ technostress and develop strategies to improve the balanced use of technology for their daily academic activities.Revisión por pare

Anxiety, distress, and turnover intention of healthcare workers in Peru by their distance to the epicenter during the COVID-19 crisis

We conducted a cross-sectional survey to assess the anxiety, distress, and turnover intention (likelihood to leave their current job) of healthcare workers in Peru during the COVID-19 pandemic. Our results reported that 21.7% healthcare workers in Peru experienced severe anxiety, whereas 26.1% of them experienced severe mental distress. A higher level of education related with a lower level of anxiety. Younger workers had a higher level of turnover intention than their older colleagues did. Healthcare workers in the private sector had a higher turnover intention than those in the public sector. Most importantly, people who were geographically far from Lima, the epicenter in Peru, during the outbreak experienced less anxiety and mental distress, corroborating the ripple effect and disconfirming the typhoon eye theory. However, the direction of these relationships can change depending on the type of institutions (public versus private) and the type of employees' contract (full time versus part time). Our research helps provide insights for clinical professionals in identifying the vulnerable groups to mental disorders in Peru. This is the first study to assess anxiety, mental distress, and turnover intention in healthcare workers in Peru during the COVID-19 pandemic. Copyrigh

A Cremophor-Free Formulation for Tanespimycin (17-AAG) using PEO-b-PDLLA Micelles: Characterization and Pharmacokinetics in Rats

Tanespimycin (17-allylamino-17-demethoxygeldanamycin or 17-AAG) is a promising heat shock protein 90 inhibitor currently undergoing clinical trials for the treatment of cancer. Despite its selective mechanism of action on cancer cells, 17-AAG faces challenging issues due to its poor aqueous solubility, requiring formulation with Cremophor EL (CrEL) or ethanol (EtOH). Therefore, a CrEL-free formulation of 17-AAG was prepared using amphiphilic diblock micelles of poly(ethylene oxide)-b-poly(D,L-lactide) (PEO-b-PDLLA). Dynamic light scattering revealed PEO-b-PDLLA (12:6 kDa) micelles with average sizes of 257 nm and critical micelle concentrations of 350 nM, solubilizing up to 1.5 mg/mL of 17-AAG. The area under the curve (AUC) of PEO-b-PDLLA micelles was 1.3-fold that of the standard formulation. The renal clearance (CLrenal) increased and the hepatic clearance (CLhepatic) decreased with the micelle formulation, as compared to the standard vehicle. The micellar formulation showed a 1.3-fold increase in the half-life (t1/2) of the drug in serum and 1.2-fold increase in t1/2 of urine. As expected, because it circulated longer in the blood, we also observed a 1.7-fold increase in the volume of distribution (Vd) with this micelle formulation compared to the standard formulation. Overall, the new formulation of 17-AAG in PEO-b-PDLLA (12:6 kDa) micelles resulted in a favorable 150-fold increase in solubility over 17-AAG alone, while retaining similar properties to the standard formulation. Our data indicates that the nanocarrier system can retain the pharmacokinetic disposition of 17-AAG without the need for toxic agents such as CrEL and EtOH

Study of strawberry flavored milk under pulsed electric field processing

Few studies exist on flavored milk processed by pulsed electric fields (PEF). The main concern is product stability. This study aimed to analyze the degradation of coloring agent Allura Red in strawberry milk under PEF. Four systems were tested containing Allura Red: two commercial milks and two model systems. PEF conditions were 40 kV/cm, 48 pulses (2.5 μs), and 55 °C; coloring agent was quantified via RP-HPLC. After processing, only minor changes were observed in color, Allura Red concentration, and pH. During storage (32 d) at refrigerated conditions (4 °C) commercial samples maintained pH above 6. Model systems dropped below pH 6 after 10 days of storage. Color of samples showed important decrease in a⁎; hue angle and chroma changed during storage. HPLC analysis reported a bi-phasic effect in Allura Red concentrations versus time. Concentration changed, reaching a maximum value during the middle of storage, possibly attributed to microbial growth, pH reduction, or interaction of proteins. However, PEF affected the stability of Allura Red in milk when additional ingredients were not added to the product

Study of strawberry flavored milk under pulsed electric field processing

Few studies exist on flavored milk processed by pulsed electric fields (PEF). The main concern is product stability. This study aimed to analyze the degradation of coloring agent Allura Red in strawberry milk under PEF. Four systems were tested containing Allura Red: two commercial milks and two model systems. PEF conditions were 40 kV/cm, 48 pulses (2.5 μs), and 55 °C; coloring agent was quantified via RP-HPLC. After processing, only minor changes were observed in color, Allura Red concentration, and pH. During storage (32 d) at refrigerated conditions (4 °C) commercial samples maintained pH above 6. Model systems dropped below pH 6 after 10 days of storage. Color of samples showed important decrease in a⁎; hue angle and chroma changed during storage. HPLC analysis reported a bi-phasic effect in Allura Red concentrations versus time. Concentration changed, reaching a maximum value during the middle of storage, possibly attributed to microbial growth, pH reduction, or interaction of proteins. However, PEF affected the stability of Allura Red in milk when additional ingredients were not added to the product

COVID-19, mental health and its relationship with workplace accidents

The general objective of this article is to show the relationship that exists in the COVID-19 pandemic, the mental health of people and the propensity for work-related accidents in companies. Various results are shown that detail how COVID-19 has generated and is generating mental alterations in people such as post-traumatic stress disorder, PTSD for its acronym in English. Likewise, data are presented that report the influence of mental health as a precursor to workplace accidents in different industries, with which it can be concluded that COVID-19 needs a comprehensive approach in companies to prevent it from negatively impacting workers and they end up accident during their daily work. Some concrete actions are proposed to promote and avoid in companies so that workers can be better managed in times of a COVID-19 pandemic.Campus Lima Centr