Nonel approaches in the field of gastric cancer surgical treatment

The aim of the study: to estimate the impact of different cellular phenotype of gastric tumors on the survival of patients treated according to standard protocols. Object and methods of research.The work presents the results of a study conducted on the basis of two medical institutions - the National Cancer Institute and the abdominal oncology and surgery department of the Odessa Regional Oncology Center. 221 patients underwent surgery for gastric cancer (GC) in the period 2007-2013. The average age of patients was 60.88 ± 10.5 years, men - 180, women - 41. Of the total number of operated, 143 patients underwent surgery in the amount of gastrectomy, 78 - subtotal distal resection. Results. All patients included in the study underwent radical surgery. Tumors removed during surgery were examined using histological, cytological, immunohistochemical methods and genetic tests. The obtained results are monitored for the presence/absence of clinical parallels and mathematical correlations. It was concluded that some combinations of immunohistochemical (IHC) markers were effective in separating groups of patients with different biology of gastric cancer. Conclusions. Performing more advanced operations (including the use of D2 lymph dissections) is the most effective option for surgical treatment of microsatellite-unstable and Epstein-Barr virus-associated gastric cancer

The character of fracture of iron based thermal coating during fretting

The character of destruction of thermal coatings during fretting has been investigated. An iron based plasma coating has been tested with oscillation amplitude from 30 to 200 microns. The tests were conducted in air. It has been determined that the main factor influencing the rate of the wear of the coating during fretting corrosion is the size of the coating area involved into the wear process. The coating exhibits high wear resistance when the amplitude of the oscillation is commensurate with the size of the sprayed particles. During destruction of the coating the leading role belongs to fatigue-oxidation processes. The wear of the coating acquires a catastrophic character when coating macro defects - pores and interlayer boundaries - are involved into the wear process

Peculiarities of electronic heat capacity of thulium cuprates in pseudogap state

Precise calorimetric measurements have been carried out in the 7 - 300 K temperature range on two ceramic samples of thulium 123 cuprates TmBa2Cu3O6.92 and TmBa2Cu3O6.70. The temperature dependence of the heat capacity was analyzed in the region where the pseudogap state (PGS) takes place. The lattice contribution was subtracted from the experimental data. The PGS component has been obtained by comparing electronic heat capacities of two investigated samples because the PGS contribution for the 6.92 sample is negligible. The anomalous behavior of the electronic heat capacity near the temperature boundary of PGS was found. It is supposed that this anomaly is due to peculiarities in N(E) function where N is the density of electronic states and E is the energy of carriers of charge.Comment: 12 pages, 3 Postscript figure

РАЗРАБОТКА ПРИКЛАДНОГО ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ НА ПЛАТФОРМЕ.NET С ПРИМЕНЕНИЕМ АСПЕКТНО-ОРИЕНТИРОВАННОГО ПРОГРАММИРОВАНИЯ

The authors’ aim is to develop application software for building stable distributed applications. The objectives are to identify main issues in building distributed applications and to suggest effective methods to solve these problems. The proposed solution can be used in building distributed applications and it will allow to significantly reduce the time spent on supporting infrastructure code in such applications.Целью данной статьи является разработка модели для построения устойчивых распределенных приложений. Задачами данной статьи являются выявление основных проблем при разработке распределенных приложений и предложение методов по их решению. Предлагаемое решение может быть применено в распределенных системах и позволит существенно снизить время на поддержку инфраструктурного кода

Features of Medical Care Providing to Patients with Digestive Diseases in the Krasnodar Region during the COVID-19 Pandemic

The aim of the study: optimization the medical care provision to patients with diseases of the digestive system (DD) in the Krasnodar Region during the COVID-19 pandemic.Material and methods. The analysis of the features of the DD course in the Krasnodar Region was carried out according to the data of form C 51 “Distribution of the dead by sex, age groups and causes of death” of the Territorial Federal State Statistics Service in the Krasnodar Region, as well as monitoring the quality of medical care for patients with DD for the period from 2019 to 2021 years.Results. During the COVID-19 pandemic, the routing of gastroenterological patients, dispensary observation and preventive measures have undergone some changes. In the structure of total mortality in the Krasnodar Region, mortality from DD was 21.6 % in 2020 and 4.0 % in 2021. The decrease in the growth of mortality rate, including from DD, in the second year of the pandemic is associated with the completed healthcare systems reformatting. The increase in hospital mortality in patients with gastric and duodenal ulcers, ulcerative colitis, and diverticular disease had a significant impact on mortality rates from DD. The decreasing number of hospitalizations was explained due to the conversion of a number of hospitals into hospitals for the treatment of patients with COVID-19. The hospitalization was mainly carried out for emergency indications and patients with a more severe course of the disease. The pandemic has increased the need for telemedicine: 378 tele-consultations on the gastroenterological profile was carried out in the Krasnodar Region in 2021.Conclusion. Healthcare system workload in the Krasnodar Region increased significantly during the coronavirus pandemic that required a number of structural adjustments. In recent times, the regional health care is returning to the planned mode of providing medical care

Phase Composition and Microstructure of Ti-Nb Alloy Produced by Selective Laser Melting

The phase composition and microstructure of Ti-Nb alloy produced from composite titanium and niobium powder by selective laser melting (SLM) was studied. Produced monolayered Ti-Nb alloy enhanced the formation of fine-grained and medium-grained zones with homogeneous element composition of 36-38% Nb mass interval. Alloy phase composition responded to [beta]-alloy substrate phase (grain size was 5-7 pm) and non-equilibrium martensite [alpha]"- phase (grain size was 0.1-0.7 [mu]m). [alpha]"-phase grains were found along [beta]-phase grain boundaries and inside grains, including decreased niobium content. Alloy microhardness varied within 4200-5500 MPa

SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS

The рарег presents the results of measurements of cytokine levels in serum and conditioned medium of PBMC cultures from the patients with atopic dermatitis with the exacerbation and remission in comparison with the healthy donors. We have shown that the serum levels of the key cytokines IL-5 and IL-13, proinflammatory cytokines IL-1β and IL-6 and the main Th1 cytokine — IFNγ — were higher compared to healthy donors. In the conditioned media of peripheral blood mononuclear cells in contrast, we have found a significant decrease of the spontaneous secretion of key cytokines IL-10 and IL-17. We have shown that the stimulated secretion of IL-5 and IL-13, IL-12 and INF-γ is significantly reduced in comparison with the control level. Only IL-1β revealed a statistically significant higher level of stimulated secretion without exacerbation of atopic dermatitis. The contemporary therapy has no effect on cytokine production

Особенности синтеза порошков нитрида и карбида кремния

The paper shows that temperature, burning rate and content of main substance bear a relationship to nitrogen pressure in a reactor, charge density, blank diameter, specific surface of initial silicon powder at synthesis of Si3N4-SiC powder composition. It has been shown that control of synthesis conditions makes it possible to obtain Si3N4-SiC powder of the given composition and particle structure. During the synthesis process high-tensile disperse oc-SiC particles, a and p Si3N4 particles of hexahedral and octahedral shape with a size of 0.02...0.2 microns, P-Si3N4 particles of irregular shape and a-Si3N4 particles as fibres have been formed.Установлена зависимость температуры, скорости горения и содержания основного вещества при СВС-синтезе композиции порошков Si3N4-SiC от давления азота в реакторе, плотности шихты, диаметра заготовки, удельной поверхности исходного порошка кремния. Показано, что, управляя режимами синтеза, можно получать порошки композиции Si3N4-SiC заданного состава и строения частиц. В процессе синтеза образуются высокопрочные дисперсные частицы oc-SiC, аир частицы Si3N4 шести- и восьмигранной формы размерами 0,02...0,2 мкм, частицы p-Si3N4 неправильной формы и частицы a-Si3N4 в виде волокон

Atherosclerosis: new achievements and failures

The article presents current information on the leading causes of atherosclerosis and its underlying mechanisms of pathogenesis, examined predictors of early stages of atherosclerosis (ІL-1β, ІL-6, FNP-α, NO, MCP-1, Fres, endothelin-1, CRP, which can join and heparin). The prospects of a new enzyme inhibition and RSSK9, 33a mRNA in the treatment of cardiovascular disease. Analyzed the contradictions of using inhibitors cholesteryl ester transfer protein (CETP), new European and American recommendations in the management of patients with dyslipidemia.В статье представлены современные сведения о ведущих причинах атеросклероза и основных механизмах его патогенеза, рассмотрены предикторы ранних стадий развития атеросклероза (ІЛ-1β, ІЛ-6, ФНП-α, NO, MCP-1, ФРЕС, эндотелин-1, СРБ, к которым может присоединиться и гепарин). Показана перспектива нового ферменте РСSK9 и ингибирование mРНК 33а в лечение сердечнососудистой патологии. Проанализированы противоречиях использования ингибиторов белка переносчика эфиров холестерина (СЕТР), новые Европейские и Американские рекомендации при ведении больных с дислипидемиями