232 research outputs found

    Capturing variability in Model Based Systems Engineering

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    International audienceAutomotive model-based systems engineering needs to be dapted to the industry specific needs, in particular by implementing appropriate means of representing and operating with variability. We rely on existing modeling techniques as an opportunity to provide a description of variability adapted to a systems en- gineering model. However, we also need to take into account requirements related to backwards compatibility with current practices, given the industry experience in mass customization. We propose to adopt the product line paradigm in model-based systems engineering by extending the orthogonal variability model, and adapting it to our specific needs. This brings us to an expression closer to a description of constraints, related to both orthogonal variability, and to SysML system models. We introduce our approach through a discussion on the different aspects that need to be covered for expressing variability in systems engineering. We explore these aspects by observing an automotive case study, and relate them to a list of contextual requirements for variability management

    Relative Reactivity of the Metal-Amido versus Metal-Imido Bond in Linked Cp-Amido and Half-Sandwich Complexes of Vanadium

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    Treatment of (η5-C5H4C2H4NR)V(N-t-Bu)Me (R = Me, i-Pr) and CpV(N-p-Tol)(N-i-Pr2)Me (Cp = η5-C5H5) with B(C6F5)3 or [Ph3C][B(C6F5)4] results in formation of the corresponding cations, [(η5-C5H4C2H4NR)V(N-t-Bu)]+ and [CpV(N-p-Tol)(N-i-Pr2)]+. The latter could also be generated as its N,N-dimethylaniline adduct by treatment of the methyl complex with [PhNMe2H][BAr4] (Ar = Ph, C6F5). Instead, the analogous reaction with the linked Cp-amido precursor results in protonation of the imido-nitrogen atom. Sequential cyclometalation of the amide substituents gave cationic imine complexes [(η5-C5H4C2H4NCR'2)V(NH-t-Bu)]+ (R' = H, Me) and methane. Reaction of cationic [(η5-C5H4C2H4NR)V(N-t-Bu)]+ with olefins affords the corresponding olefin adducts, whereas treatment with 1 or 2 equiv of 2-butyne results in insertion of the alkyne into the vanadium-nitrogen single bond, affording the mono- and bis-insertion products [(η5-C5H4C2H4N(i-Pr)C2Me2)V(N-t-Bu)]+ and [(η5-C5H4C2H4N(i-Pr)C4Me4)V(N-t-Bu)]+. The same reaction with the half-sandwich compound [CpV(N-p-Tol)(N-i-Pr2)]+ results in a paramagnetic compound that, upon alcoholysis, affords sec-butylidene-p-tolylamine, suggesting an initial [2+2] cycloaddition reaction. The difference in reactivity between the V-N bond versus the V=N bond was further studied using computational methods. Results were compared to the isoelectronic titanium system CpTi(NH)(NH2). These studies indicate that the kinetic product in each system is derived from a [2+2] cycloaddition reaction. For titanium, this was found as the thermodynamic product as well, whereas the insertion reaction was found to be thermodynamically more favorable in the case of vanadium.

    Automated reasoning on feature models

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    Software Product Line (SPL) Engineering has proved to be an effective method for software production. However, in the SPL community it is well recognized that variability in SPLs is increasing by the thousands. Hence, an automatic support is needed to deal with variability in SPL. Most of the current proposals for automatic reasoning on SPL are not devised to cope with extra– functional features. In this paper we introduce a proposal to model and reason on an SPL using constraint programming. We take into account functional and extra–functional features, improve current proposals and present a running, yet feasible implementation

    Curriculum is - or should be - at the heart of educational practice

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    First paragraph: We write our first Editorial as Lead Editors of The Curriculum Journal against the political backdrop of turbulent scenes in the UK Parliament. On 12 March 2019, Members of Parliament voted (for a second time) to categorically reject the Prime Minister’s ‘deal’ for exiting the European Union. The following day, they voted almost as decisively to reject a ‘no deal’ exit from the EU. Despite this, at the time of writing it is still quite possible that the UK is spiralling inexorably towards a chaotic (some would say catastrophic) no deal Brexit, with long term effects on the prosperity and wellbeing of its citizens, on its future trading relations with the rest of the world, and ultimately upon its international standing and reputation.Editoria

    School-based curriculum development in Scotland: Curriculum policy and enactment

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    Recent worldwide trends in curriculum policy have re-emphasised the role of teachers in school-based curriculum development. Scotland’s Curriculum for Excellence is typical of these trends, stressing that teachers are agents of change. This paper draws upon empirical data to explore school-based curriculum development in response to Curriculum for Excellence. We focus on two case studies – secondary schools within a single Scottish local education authority. In the paper we argue that the nature and extent of innovation in schools is dependent upon teachers being able to make sense of often complex and confusing curriculum policy, including the articulation of a clear vision about what such policy means for education within each school

    Automated Analysis in Feature Modelling and Product Configuration

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    The automated analysis of feature models is one of the thriving topics of research in the software product line and variability management communities that has attracted more attention in the last years. A recent literature review reported that more than 30 analysis operations have been identi ed and di erent analysis mechanisms have been proposed. Product con guration is a well established research eld with more than 30 years of successful applications in di erent industrial domains. Our hypothesis, that is not really new, is that these two independent areas of research have interesting synergies that have not been fully explored. To try to explore the potential synergies systematically, in this paper we provide a rapid review to bring together these previously disparate streams of work. We de ne a set of research questions and give a preliminary answer to some of them. We conclude that there are many research opportunities in the synergy of these independent areas.Ministerio de Ciencia e Innovación TIN2009- 07366Junta de Andalucía TIC-590

    Establishing the phenotypic spectrum of ZTTK syndrome by analysis of 52 individuals with variants in SON

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    Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome, an intellectual disability syndrome first described in 2016, is caused by heterozygous loss-of-function variants in SON. Its encoded protein promotes pre-mRNA splicing of many genes essential for development. Whereas individual phenotypic traits have previously been linked to erroneous splicing of SON target genes, the phenotypic spectrum and the pathogenicity of missense variants have not been further evaluated. We present the phenotypic abnormalities in 52 individuals, including 17 individuals who have not been reported before. In total, loss-of-function variants were detected in 49 individuals (de novo in 47, inheritance unknown in 2), and in 3, a missense variant was observed (2 de novo, 1 inheritance unknown). Phenotypic abnormalities, systematically collected and analyzed in Human Phenotype Ontology, were found in all organ systems. Significant inter-individual phenotypic variability was observed, even in individuals with the same recurrent variant (n = 13). SON haploinsufficiency was previously shown to lead to downregulation of downstream genes, contributing to specific phenotypic features. Similar functional analysis for one missense variant, however, suggests a different mechanism than for heterozygous loss-of-function. Although small in numbers and while pathogenicity of these variants is not certain, these data allow for speculation whether de novo missense variants cause ZTTK syndrome via another mechanism, or a separate overlapping syndrome. In conclusion, heterozygous loss-of-function variants in SON define a recognizable syndrome, ZTTK, associated with a broad, severe phenotypic spectrum, characterized by a large inter-individual variability. These observations provide essential information for affected individuals, parents, and healthcare professionals to ensure appropriate clinical management
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