A BIM-based PSS approach for the management of maintenance operations of building equipment

The service-centered economy has grown considerably in the last few years, shifting from product-based solutions towards service centered offerings, i.e., Product-Service System (PSS) solutions. Such an approach is also emerging in the context of building equipment, where maintenance activities play a fundamental role in facility management. In this field, Building Information Modeling (BIM) based tools are diffusely used to improve the performances of facility management. However, few studies have addressed the above issues while considering a shift from product-based approaches in favor of more advanced servitization models. The study aims at integrating BIM based approaches in a PSS context for the improvement of the management of maintenance operations of building equipment. A general framework for maintenance management has been developed, merging the implementation of the PSS components in a BIM model for the definition of maintenance management. A first application of this methodology to a real case study concerning the elevators of an existing building has shown the efficacy of the proposed approach. The study highlighted the benefits that can be achieved, especially in terms of reduced periods of equipment unavailability, reduced costs and augmented customer satisfaction, while enhancing the information exchange between the PSS actors. Hence, although further research is still needed for its validation, the proposed approach can offer practical insights for the development of promising BIM-based PSS solutions for facility management in the construction industry

Spatial Analysis ofLobesia botrana(Lepidoptera: Tortricidae) Male Population in a Mediterranean Agricultural Landscape in Central Italy

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Optimal Ecodriving Control: Energy-Efficient Driving of Road Vehicles as an Optimal Control Problem

International audienceTransportation is responsible for a substantial fraction of worldwide energy consumption and greenhouse gas emissions and is the largest sector after energy production. However, while emissions from other sectors are generally decreasing, those from transportation have increased since 1990. Reducing the impact of transportation is a task that is inherently associated with the improvement of energy efficiency, particularly for passenger cars that contribute to almost half of the whole sector

Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis

The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to JNK1 and TRAF2. We recently demonstrated that, unlike its parent compound, the benzoyl ester of 1 (compound 3) exhibits negligible reactivity towards GSH, and has a different mode of interaction with GSTP1-1. Unfortunately, 3 is susceptible to rapid metabolic hydrolysis. In an effort to improve the metabolic stability of 3, its ester group has been replaced by an amide, leading to N-(6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexyl)benzamide (4). Unlike 3, compound 4 was stable to human liver microsomal carboxylesterases, but retained the ability to disrupt the interaction between GSTP1-1 and TRAF2 regardless of GSH levels. Moreover, 4 exhibited both a higher stability in the presence of GSH and a greater cytotoxicity towards cultured A375 melanoma cells, in comparison with 1 and its analog 2. These findings suggest that 4 deserves further preclinical testing

Cerebrovascular complications and infective endocarditis. impact of available evidence on clinical outcome

Infective endocarditis (IE) is a life-threatening disease. Its epidemiological profile has substantially changed in recent years although 1-year mortality is still high. Despite advances in medical therapy and surgical technique, there is still uncertainty on the best management and on the timing of surgical intervention. The objective of this review is to produce further insight intothe short- and long-term outcomes of patients with IE, with a focus on those presenting cerebrovascular complications

Feel My Pain: Design and Evaluation of Painpad, a Tangible Device for Supporting Inpatient Self-Logging of Pain

Monitoring patients' pain is a critical issue for clinical caregivers, particularly among staff responsible for providing analgesic relief. However, collecting regularly scheduled pain readings from patients can be difficult and time-consuming for clinicians. In this paper we present Painpad, a tangible device that was developed to allow patients to engage in self-logging of their pain. We report findings from two hospital-based field studies in which Painpad was deployed to a total of 78 inpatients recovering from ambulatory surgery. We find that Painpad results in improved frequency and compliance with pain logging, and that self-logged scores may be more faithful to patients' experienced pain than corresponding scores reported to nurses. We also show that older adults may prefer tangible interfaces over tablet-based alternatives for reporting their pain, and we contribute design lessons for pain logging devices intended for use in hospital settings

Note faunistiche su alcuni interessanti Tortricidi dell’Italia meridionale (Lepidoptera)

FAUNISTIC NOTES ON SOME INTERESTING TORTRICID MOTHS FROM SOUTHERN ITALY (LEPIDOPTERA) Studies on the Lepidoptera Tortricidae Collection at the Agricultural Entomology Institute of Bari University are reported. Cydia johanssoni Aarvik Karsholt, 1993, was found for the first time in Italy; Diceratura rhodograpta Djakonov, 1929, was a new record for the mainland; 25 species are new for Southern Italy. Key words: Lepidoptera Tortricidae, faunistic reports, Southern Italy. Lo studio della collezione di Lepidotteri Tortricidi presente presso l’Istituto di Entomologia agraria dell’Università degli Studi di Bari ha permesso il rinvenimento di Cydia johanssoni Aarvik Karsholt, 1993, specie nuova per la fauna italiana e di Diceratura rhodograpta Djakonov, 1929, entità trovata per la prima volta sul continente. A queste si aggiungono ulteriori 25 specie, mai segnalate nelle regioni meridionali del nostro Paese. Parole chiave: Lepidotteri, Tortricidi, faunistica, Italia meridionale

Can a Mendelian Randomization Study Predict the Results of a Clinical Trial? Yes and No

Randomized controlled trials are considered at the top of the evidence hierarchy. However, in several cases randomized trials cannot be conducted or have not yet been completed. In such settings observational studies may provide important inference, yet traditional statistical adjustment methods fall short of controlling for all potential confounders, as unknown confounders cannot be taken care of by even the most sophisticated statistical tools. The mendelian randomization study is a type of research design which simultaneously exploits random transmission of genes and genetic linkage to obtain inferential estimates from the association between specific genetic variants known to modulate given risk factors and the corresponding outcomes of interests. Despite several developments in this field, there remain several areas of further research, and discrepancies between mendelian randomization studies and the corresponding randomized trials have already been recognized. Nonetheless, it is likely that this novel type of study will be used more commonly in the future, and a working knowledge of its pros, cons, and range of validity is crucial for conscientious interpretation and application. We thus aimed to concisely yet poignantly introduce the scholarly reader to this novel type of research design, notwithstanding that complementarity prevails in most cases over overlap between mendelian randomization studies and randomized trials

Human Adaptability for Deep Space Missions: An Exploratory Study

The present qualitative study conducts in-depth interviews with astronauts and other subject matter experts in order to shed light on human adaptability in extreme environments. Deep space travel will entail a range of highly stressful conditions to which astronauts must adapt. Feelings of isolation will be increased, as the space traveler is farther from Earth for longer periods of time. Daily life will take place in small and confined areas, for durations extending into years. The dangers of the extreme environment of space are ever-present, and failure of critical equipment or components can lead to death. Astronauts will need to function more autonomously, with diminished support from Earth. It is thus important to select and train future astronauts who are able to adapt to such extreme and variable conditions and continue to function effectively. Subject matter experts identify the central adaptive challenges faced by crewmembers, and what are the key individual attributes associated with human adaptability. Results also point to organizational factors, as well as several coping and resource strategies that can be applied to improve human adaptability to extreme environments and missions. These results can be used to inform selection and training programs, as well as the design of space vehicles, systems, and habitats in order to enhance astronaut adaptive task performance