Educação formal e não formal em ciências

Apresenta-se uma estratégia de formação contínua de professores que se desenvolveu no âmbito dum estudo de caso sobre a planificação, concepção e avaliação de um Ambiente Integrado de Educação em Ciências (AIEC) na futura escola 1º CEB de Vila Nova da Barquinha (VNB). Esta escola que irá ser construída de raiz, é um projecto inovador que conta com a colaboração protocolada da Universidade de Aveiro, através de uma equipa de docentes do Departamento de Didáctica e Tecnologia Educativa, da qual a primeira autora faz parte como investigadora. Com este estudo pretende-se, assim perspectivar uma nova forma de organizar o ensino e aprendizagem formal e não-formal das ciências, integrando-os. Tal anseio exige uma formação adequada dos professores que irão leccionar nessa escola, pois serão eles a implementar, com as suas crianças, as actividades Integradas de Educação em Ciencias

Hepatic Artery Thrombosis in Live Liver Donor Transplantation: How to Solve - a Case Report

The decrease in the number of cadaveric donors has proved a limiting factor in the number of liver transplants, leading to the death of many patients on the waiting list. The living donor liver transplantation is an option that allows, in selected cases, increase the number of donors. One of the most serious complications in liver transplantation is hepatic artery thrombosis, in the past considered potentially fatal without urgent re-transplantation. A white male patient, 48 years old, diagnosed with hepatocellular carcinoma in chronic liver failure caused by hepatitis B virus, underwent living donor liver transplantation (right lobe). Doppler echocardiography performed in the immediate postoperative period did not identify arterial flow in the right branch, having been confirmed thrombosis of the right hepatic artery in CT angiography. Urgent re-laparotomy was performed, which consisted of thrombectomy and re-anastomosis of the hepatic artery with segmental splenic artery allograft interposition. The patient started anticoagulation and antiplatelet therapy with acetylsalicylic acid. Serial evaluation with Doppler echocardiography showed hepatic artery patency. At present, the patient is asymptomatic. One of the most devastating complications in liver transplantation, and particularly in living liver donor, is thrombosis of the hepatic artery; thus, early diagnosis and treatment is vital. The rapid intervention for revascularization of the graft avoids irreversible ischemia of the bile ducts and hepatic parenchyma, thus avoiding the need for re-transplantation

Desenvolvimento de um laboratório de ciências para os primeiros anos de escolaridade

A presente comunicação visa apresentar uma proposta de laboratório de ciências para os primeiros anos de escolaridade. Assim, pretende-se: (i) fundamentar a relevância de infraestruturas, equipamentos e recursos de suporte ao ensino das ciências e apresentar princípios orientadores apontados pela literatura para o desenvolvimento de laboratórios escolares e (ii) descrever o processo de concepção, validação e implementação inerente ao desenvolvimento de um laboratório de ciências numa escola do 1.º Ciclo do Ensino Básico (CEB), tendo por base o marco teórico de suporte ao desenvolvimento do mesmo

Sclerosing encapsulating peritonitis: a case successfully treated with immunosuppression.

Perit Dial Int. 1999 Sep-Oct;19(5):478-81. Sclerosing encapsulating peritonitis: a case successfully treated with immunosuppression. Martins LS, Rodrigues AS, Cabrita AN, Guimaraes S. SourceDepartment of Nephrology, Hospital de Santo António, Porto, Portugal

Spatiotemporal variation of taxi demand

The growth of urban areas has made taxi service become increasingly more popular due to its ubiquity and flexibility when compared with, more rigid, public transportation modes. However, in big cities taxi service is still unbalanced, resulting in inefficiencies such as long waiting times and excessive vacant trips. This paper presents an exploratory taxi fleet service analysis and compares two forecast models aimed at predicting the spatiotemporal variation of short-term taxi demand. For this paper, we used a large sample with more than 1 million trips between 2014 and 2017, representing roughly 10% of Lisbon’s fleet. We analysed the spatiotemporal variation between pick-up and drop-off locations and how they are affected by weather conditions and points of interest. More, based on historic data, we built two models to predict the demand, ARIMA and Artificial Neural Network (ANN), and evaluated and compared the performance of both models. This study not only allows the direct comparison of a linear statistical model with a machine learning one, but also leads to a better comprehension of complex interactions surrounding different urban data sources using the taxi service as a probe to better understand urban mobility-on-demand and its needs.info:eu-repo/semantics/publishedVersio

Manifestação Incomum de uma Entidade Rara: Doença de Erdheim-Chester

A 69-year-old woman presented with sudden left hemiparesis. Computed tomography (CT) scan excluded acute brain injuries. Patient was admitted with acute ischemic stroke of right hemisphere. There was full recovery within 24 hours and etiologic studies were normal. There was a concomitant history of ingestion of 6 litres of water per day over the previous 2 years. Water deprivation test followed by the administration of desmopressin confirmed central diabetes insipidus diagnosis. Brain magnetic resonance imaging (MRI) was normal. Full body CT scan showed arterial wall thickening suggestive of large and medium vessels vasculitis, retroperitoneal fibrosis, perinephric infiltration, pleural and pericardial thickening and diffuse densification of greater omentum. Angio-MRI showed occlusive micro-arterial injuries. Laparoscopic biopsy of greater omentum revealed multinucleated giant Touton CD68+, CD1A- cells. This finding is pathognomonic of Erdheim-Chester Disease, a rare non-Langerhans histiocytosis.info:eu-repo/semantics/publishedVersio

The prognostic value of abnormal coagulation times in dogs that are at the risk of developing sepsis

Introduction: Sepsis is a hard to define syndrome associated with a deleterious systemic inflammatory response that ultimately leads to coagulopathy, organ dysfunction, and death. The primary aim of this prospective study was to evaluate if coagulation times can be predictive of disease severity and outcome in patients at risk of developing sepsis.A secondary objective was to correlate activated partial thromboplastin time (aPTT) and prothrombin time (PT) with the quick sequential organ failure assessment (qSOFA) scoring system at the moment of admission to the intensive care unit (ICU) and evaluate their combined prognostic value. The main hypothesis of the study was: Are aPTT and PT correlated with disease severity and outcome, when associated with the qSOFA score, at the moment of admission to the ICU? Methods: A total of 43 dogs were prospectively enrolled in the study between September 2016 and March 2017. Patients that were hemodynamically altered with clinical signs of coagulopathy, infection, shock, or SIRS were included, as well as those affected by polytrauma, organ dysfunction, or neoplasia, upon presentation. These patients had at least one of these clinical signs but some had more than one. Regarding the presence of coagulopathies, all alterations in coagulation times were included. All these patients were susceptible to subclinical infections and bacterial translocation, therefore being at risk of developing sepsis. Coagulation testing and qSOFA scoring were performed at the time of admission to the ICU and were statistically analyzed using tests such as Chi-square tests, T-tests, ANOVA, HSD tests, and Pearson correlation coefficient tests. Other variables such as signalment, diagnosis, duration of hospitalization and post-discharge treatment and outcome were also recorded and analyzed. Results: Mortality rate was 34.9%. Mortality increased with the number of qSOFA points (0 points: 10%; 1 point: 30.8%; 2 points: 47.1%; 3 points: 66.7%). The aPTT was significantly higher (p = 0.029) in patients with a qSOFA score of 2 points in comparison to those with 1 point. A positive correlation was found between aPTT and PT (r = 0.406, n = 43, p = 0.005). Mean values for aPTT and PT were similar between surviving and non-surviving patients. Ten out of 15 patients (66.7%) that died did so between the first and fifth day of treatment, and 3 of the remaining 5 deaths (60%) were caused by neoplastic disease. Causes of dead included gastrointestinal disease, infectious disease,urinary tract disease, trauma, autoimmune disease, neurological disorder and neoplasia. Conclusions: The results of this study suggest the existence of hemostatic dysfunction amongst patients with a qSOFA score of 2 points. In isolation, however, prolonged coagulation times at ICU admission were not predictive of outcome

Molecular Evaluation of exons 8 and 22 of the SHANK3 gene in Autism Spectrum Disorders

Autism spectrum disorders are a group of neurodevelopmental disorders with a complex and heterogeneous etiology. Studies have shown that genetic factors play an important role in the aetiology of these diseases. Recently, de novo mutations, frameshifts and deletions have been described in the SHANK3 gene, also known as ProSAP2 gene, which encodes a synaptic scaffolding protein. All the participants of this study had normal karyotypes and underwent screening for Fragile-X syndrome. Subsequently, they were analyzed by direct sequencing of different points of exons 8 and 22 of the SHANK3 gene. None of the study participants presented with changes in these regions. These findings may be due to the fact that mutations, deletions and duplications of the SHANK3 gene are rare