Appendix : 1820 Treaty Negotiation between the Penobscot Indian Nation and Maine from Wabanaki Homeland and the New State of Maine: The 1820 Journal and Plans of Survey of Joseph Treat

In late September 1820, hoping to lay claim to territory then under dispute between Great Britain and the United States, Governor William King of the newly founded state of Maine dispatched Major Joseph Treat to survey public lands on the Penobscot and Saint John Rivers. Traveling well beyond the limits of colonial settlement, Treat relied heavily on the cultural knowledge and expertise of John Neptune, lieutenant governor of the Penobscot tribe, to guide him across the Wabanaki homeland... The groundwork for cooperation between Treat and Neptune [was] laid during the 1820 treaty negotiations in which both men participated and which were successfully concluded just over a month before their expedition departed from Bangor, Maine. -- Description adapted from University of Massachusetts Press Edited with an introduction by Micah A. Pawling, Ph.D., Assistant Professor of History and Native American Studies, University of Maine. Appendix : 1820 Treaty Negotiation between the Penobscot Indian Nation and Maine posted in DigitalCommons@UMaine with permission of the author and of University of Massachusetts Press, Amherst.https://digitalcommons.library.umaine.edu/mainebicentennial/1078/thumbnail.jp

An interactive layout exploration and optimisation method for early stage ship design

This paper presents a novel, highly interactive genetic algorithm-based layout exploration and optimisation method for generating spatial configurations of ships in the early stages of the design process. The method draws upon the principles of design-driven architecturally centred ship design processes by enabling the naval architects to make important decisions in a hybrid design process. The method utilises a genetic algorithm-based optimisation tool to rapidly generate and evaluate a diverse set of general arrangement options. It is approached in stages where each stage comprises two steps (manual and automatic). The new genetic algorithm-based layout optimisation tool is demonstrated by being applied to an Offshore Patrol Vessel test case. The advantages and disadvantages of the proposed tool are discussed, as well as the current limitations of the overall approach and future work

Ship impact model for technical assessment and selection of Carbon dioxide Reducing Technologies (CRTs)

It is not unreasonable to imagine that the future may herald higher energy prices and greater regulation of shipping׳s Greenhouse Gas (GHG) emissions. With the introduction of the Energy Efficiency Design Index (EEDI) into MARPOL Annex VI, tools are needed to assist Naval Architects and Marine Engineers to select the best solutions to meet evolving requirements for reduced fuel consumption and associated carbon dioxide emissions. To that end, a concept design tool, the Ship Impact Model (SIM), has been developed for quickly calculating the technical performance of a vessel with one or more Carbon dioxide Reducing Technologies (CRTs) at an early design stage. The underlying basis for this model is the calculation of changes from known ‘baseline ships’. The Ship Impact Model has been used in two projects to assess which selection (individual or combination) of Carbon dioxide Reducing Technologies (CRTs) have the most potential, in terms of cost-effectiveness and under other technical, operational and regulatory influences

Congenital Anosmia and Facial Emotion Recognition

Major functions of the olfactory system include guiding ingestion and avoidance of environmental hazards. People with anosmia report reliance on others, for example to check the edibility of food, as their primary coping strategy. Facial expressions are a major source of non-verbal social information that can be used to guide approach and avoidance behaviour. Thus, it is of interest to explore whether a life-long absence of the sense of smell heightens sensitivity to others' facial emotions, particularly those depicting threat. In the present, online study 28 people with congenital anosmia (mean age 43.46) and 24 people reporting no olfactory dysfunction (mean age 42.75) completed a facial emotion recognition task whereby emotionally neutral faces (6 different identities) morphed, over 40 stages, to express one of 5 basic emotions: anger, disgust, fear, happiness, or sadness. Results showed that, while the groups did not differ in their ability to identify the final, full-strength emotional expressions, nor in the accuracy of their first response, the congenital anosmia group successfully identified the emotions at significantly lower intensity (i.e. an earlier stage of the morph) than the control group. Exploratory analysis showed this main effect was primarily driven by an advantage in detecting anger and disgust. These findings indicate the absence of a functioning sense of smell during development leads to compensatory changes in visual, social cognition. Future work should explore the neural and behavioural basis for this advantage

The role of emotion in the learning of trustworthiness from eye-gaze : Evidence from facial electromyography.

When perception of gaze direction is congruent with the location of a target, attention is facilitated and responses are faster compared to when incongruent. Faces that consistently gaze congruently are also judged trustworthier than faces that consistently gaze incongruently. However, it’s unclear how gaze-cues elicit changes in trust. We measured facial electromyography (EMG) during an identity-contingent gaze-cueing task to examine whether embodied emotional reactions to gaze-cues mediate trust learning. Gaze-cueing effects were found to be equivalent regardless of whether participants showed learning of trust in the expected direction or did not. In contrast, we found distinctly different patterns of EMG activity in these two populations. In a further experiment we showed the learning effects were specific to viewing faces, as no changes in liking were detected when viewing arrows that evoked similar attentional orienting responses. These findings implicate embodied emotion in learning trust from identity-contingent gaze-cueing, possibly due to the social value of shared attention or deception rather than domain-general attentional orienting

Plasma membrane domain organization regulates EGFR signaling in tumor cells

Macromolecular complexes exhibit reduced diffusion in biological membranes; however, the physiological consequences of this characteristic of plasma membrane domain organization remain elusive. We report that competition between the galectin lattice and oligomerized caveolin-1 microdomains for epidermal growth factor (EGF) receptor (EGFR) recruitment regulates EGFR signaling in tumor cells. In mammary tumor cells deficient for Golgi β1,6N-acetylglucosaminyltransferase V (Mgat5), a reduction in EGFR binding to the galectin lattice allows an increased association with stable caveolin-1 cell surface microdomains that suppresses EGFR signaling. Depletion of caveolin-1 enhances EGFR diffusion, responsiveness to EGF, and relieves Mgat5 deficiency–imposed restrictions on tumor cell growth. In Mgat5+/+ tumor cells, EGFR association with the galectin lattice reduces first-order EGFR diffusion rates and promotes receptor interaction with the actin cytoskeleton. Importantly, EGFR association with the lattice opposes sequestration by caveolin-1, overriding its negative regulation of EGFR diffusion and signaling. Therefore, caveolin-1 is a conditional tumor suppressor whose loss is advantageous when β1,6GlcNAc-branched N-glycans are below a threshold for optimal galectin lattice formation

N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation

Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of re-myelination promotes permanent neuro-axonal damage.  Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling and endocytosis. N-acetylglucosamine (GlcNAc) is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting PDGF receptor-α cell endocytosis. Supplying oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk, while genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone) induced demyelination, oral GlcNAc prevents neuro-axonal damage by driving myelin repair. In MS patients, endogenous serum GlcNAc levels inversely correlated with imaging measures of demyelination and microstructural damage.   Our data identifies N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggests oral GlcNAc may be neuro-protective in demyelinating diseases like MS

An architectural framework for distributed naval ship systems

This paper introduces a framework for analyzing distributed ship systems. The increase in interconnected and interdependent systems aboard modern naval vessels has significantly increased their complexity, making them more vulnerable to cascading failures and emergent behavior that arise only once the system is complete and in operation. There is a need for a systematic approach to describe and analyze distributed systems at the conceptual stage for naval vessels. Understanding the relationships between various aspects of these distributed systems is crucial for uninterrupted naval operations and vessel survivability. The framework introduced in this paper decomposes information about an individual system into three views: the physical, logical, and operational architectural representations. These representations describe the spatial and functional relationships of the system, together with their temporal behavior characteristics. This paper defines how these primary architectural representations are used to describe a system, the interrelations between the architectural blocks, and how those blocks fit together. A list of defined terms is presented, and a preliminary set of requirements for specific design tools to model these architectures is discussed. A practical application is introduced to illustrate how the framework can be used to describe the delivery of power to a high energy weapon

C-tactile afferent stimulating touch carries a positive affective value

The rewarding sensation of touch in affiliative interactions is hypothesized to be underpinned by a specialized system of nerve fibers called C-Tactile afferents (CTs), which respond optimally to slowly moving, gentle touch, typical of a caress. However, empirical evidence to support the theory that CTs encode socially relevant, rewarding tactile information in humans is currently limited. While in healthy participants, touch applied at CT optimal velocities (1-10cm/sec) is reliably rated as subjectively pleasant, neuronopathy patients lacking large myelinated afferents, but with intact C-fibres, report that the conscious sensation elicited by stimulation of CTs is rather vague. Given this weak perceptual impact the value of self-report measures for assessing the specific affective value of CT activating touch appears limited. Therefore, we combined subjective ratings of touch pleasantness with implicit measures of affective state (facial electromyography) and autonomic arousal (heart rate) to determine whether CT activation carries a positive affective value. We recorded the activity of two key emotion-relevant facial muscle sites (zygomaticus major—smile muscle, positive affect & corrugator supercilii—frown muscle, negative affect) while participants evaluated the pleasantness of experimenter administered stroking touch, delivered using a soft brush, at two velocities (CT optimal 3cm/sec & CT non-optimal 30cm/sec), on two skin sites (CT innervated forearm & non-CT innervated palm). On both sites, 3cm/sec stroking touch was rated as more pleasant and produced greater heart rate deceleration than 30cm/sec stimulation. However, neither self-report ratings nor heart rate responses discriminated stimulation on the CT innervated arm from stroking of the non-CT innervated palm. In contrast, significantly greater activation of the zygomaticus major (smiling muscle) was seen specifically to CT optimal, 3cm/sec, stroking on the forearm in comparison to all other stimuli. These results offer the first empirical evidence in humans that tactile stimulation that optimally activates CTs carries a positive affective valence that can be measured implicitly