Collider design issues based on proton-driven plasma wakefield acceleration

Recent simulations have shown that a high-energy proton bunch can excite strong plasma wakefields and accelerate a bunch of electrons to the energy frontier in a single stage of acceleration. It therefore paves the way towards a compact future collider design using the proton beams from existing high-energy proton machines, e.g. Tevatron or the LHC. This paper addresses some key issues in designing a compact electron-positron linear collider and an electron-proton collider based on existing CERN accelerator infrastructure

Readapting macroeconomic management to a globalized economy: How to handle the accountability on the current account balance

Current account imbalances that have been a component of the globalization process threaten overall macroeconomic management, jeopardize financial stability and exacerbate effects of financial turmoil. Despite its detrimental effects, however, current account imbalances are overlooked by policy makers. In this paper we argue that assigning the responsibility to monitor and be accountable on the current account balance to an appropriate public institution would improve macroeconomic management not only in terms of soothing external balance but would also make internal balance concerns less troublesome and mitigate risks of economic and financial crises. Considering the developments particularly in the aftermath of the global financial crisis, we propose the central bank as a plausible candidate

Disease associated with equine coronavirus infection and high case fatality rate.

BackgroundEquine coronavirus (ECoV) is associated with clinical disease in adult horses. Outbreaks are associated with a low case fatality rate and a small number of animals with signs of encephalopathic disease are described.ObjectivesThe aim of this study is to describe the epidemiological and clinical features of two outbreaks of ECoV infection that were associated with an high case fatality rate.Animals14 miniature horses and 1 miniature donkey testing fecal positive for ECoV from two related disease outbreaks.MethodsRetrospective study describing the epidemiological findings, clinicopathological findings, and fecal viral load from affected horses.ResultsIn EcoV positive horses, 27% (4/15) of the animals died or were euthanized. Severe hyperammonemia (677 μmol/L, reference range ≤ 60 μmol/L) was identified in one animal with signs of encephalopathic disease that subsequently died. Fecal viral load (ECoV genome equivalents per gram of feces) was significantly higher in the nonsurvivors compared to animals that survived (P = .02).Conclusions and clinical importanceEquine coronavirus had a higher case fatality rate in this group of miniature horses than previously reported in other outbreaks of varying breeds. Hyperammonemia could contribute to signs of encephalopathic disease, and the fecal viral load might be of prognostic value in affected horses

Potential effects of logistics clusters: The case of Turkish Freight Villages

Freight Villages (FV) are logistics clusters in which all activities related with freight transportation are realized. Various operators conduct business under one roof in FVs. Coordination and collaboration are the essential part for creating harmony to achieve sustainability. The establishment of such facilities in Turkey has been realized in late 2000s. In this paper, the aim is to provide a broad overview of the FVs in Turkey and shed light into their potential for the future. To do so site visits to all existing operational public FVs and a private FV have been made, where interviews with the management units have been conducted and comparisons to global counterparts have been made. As a result of these, it has been observed that currently, FVs in Turkey are overwhelmed due to lack of coordination and collaboration. However, also light has been shed into possible alternative working principles for Turkish FVs, and it has been showed that if coordination and collaboration could be realized, significant positive effects can be achieved in terms of different aspects regarding sustainability and social equity

Handbook for the Post-Earthquake Safety Evaluation of Bridges and Roads

It is acknowledged that the most damaging earthquake within the state took place on September 27, 1909 near the Illinois border between Vincennes and Terre Haute. Both nonstructural and structural damage occurred to the buildings in this area, and it was felt strongly in the southwest of Indiana including Indianapolis. Unfortunately, due to the long recurrence interval of strong earthquakes in Mid-America, a large inventory of structures has accumulated without explicit consideration of seismic resistance. Highway bridges are a significant component of this inventory. The seismic vulnerability of highway bridges constructed within the state, especially in southwestern portion of Indiana, presents a problem of serious consequences. The main purpose of this handbook is to provide INDOT personnel of various backgrounds with a rapid and effective methodology for the post-earthquake safety inspection of bridges and roads in Indiana. This methodology is intended to promote and maintain the uniformity of the inspection as much as possible while assessing and rating bridge and road damage. This handbook contains the material necessary for a systematic safety evaluation of bridge structures and roads for a wide range of INDOT personnel. In the handbook, the necessary material is arranged according to two inspection levels. Level 1 inspection consists of the rapid visual evaluation of the bridges and roads in the affected area to establish obviously unsafe structures and roads. The Level 1 section of the handbook is intended for INDOT personnel with a broad range of backgrounds. Level 2 inspection consists of a more in-depth safety evaluation of bridges and roads, as well as temporary repair and long-term monitoring techniques. This segment is designed specifically for INDOT engineers. The Level 2 inspection team will be expected to make a more detailed structural and geotechnical post-earthquake condition assessment of the bridge. The organization and the management of the post-earthquake inspections are under the jurisdiction of INDOT, unless declared a State Disaster by the Governor and taken over by SEMA, and it is outside the scope of this handbook