Constitutive Models Based on Compressible Plastic Flows

The need for describing materials under time or cycle dependent loading conditions has been emphasized in recent years by several investigators. In response to the need, various constitutive models describing the nonlinear behavior of materials under creep, fatigue, or other complex loading conditions were developed. The developed models for describing the fully dense (non-porous) materials were mostly based on uncoupled plasticity theory. The improved characterization of materials provides a better understanding of the structual response under complex loading conditions. The pesent studies demonstrate that the rate or time dependency of the response of a porous aggregate can be incorporated into the nonlinear constitutive behavior of a porous solid by appropriately modeling the incompressible matrix behavior. It is also sown that the yield function which wads determined by a continuum mechanics approach must be verified by appropriate experiments on void containing sintered materials in order to obtain meaningful numbers for the constants that appear in the yield function

New Measurements with Stopped Particles at the LHC

Metastable particles are common in many models of new physics at the TeV scale. If charged or colored, a reasonable fraction of all such particles produced at the LHC will stop in the detectors and give observable out of time decays. We demonstrate that significant information may be learned from such decays about the properties (e.g. charge or spin) of this particle and of any other particles to which it decays, for example a dark matter candidate. We discuss strategies for measuring the type of decay (two- vs three-body), the types of particles produced, and the angular distribution of the produced particles using the LHC detectors. We demonstrate that with O(10-100) observed decay events, not only can the properties of the new particles be measured but indeed even the Lorentz structure of the decay operator can be distinguished in the case of three-body decays. These measurements can not only reveal the correct model of new physics at the TeV scale, but also give information on physics giving rise to the decay at energy scales far above those the LHC can probe directly.Comment: 31 pages, 6 figures. References added, updated to reflect recent experimental results, version accepted for publication in Physical Review

Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection-Scotland, 2012-2013

Acknowledgements This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z. Data collection was supported by a grant from Pfizer. G. Ramage was also supported by a research fellowship grant from Gilead Sciences. We are grateful to microbiology colleagues throughout Scotland for submitting isolates.Peer reviewedPublisher PD

Multiple Mineralocorticoid Response Elements Localized in Different Introns Regulate Intermediate Conductance K+ (Kcnn4) Channel Expression in the Rat Distal Colon

An elevated plasma aldosterone and an increased expression of the intermediate conductance K+ (IK/Kcnn4) channels are linked in colon. This observation suggests that the expression of Kcnn4 gene is controlled through the action of aldosterone on its cognate receptor (i.e., mineralocorticoid receptor; MR). In order to establish this, we performed chromatin immunoprecipitation (ChIP) assay to identify the MR response elements (MREs) in a region that spanned 20 kb upstream and 10 kb downstream of the presumed transcription start site (TSS) using chromatin from the colonic epithelial cells of normal and aldosterone-treated rats. MREs were immunoprecipitated in an approximately 5 kb region that spanned the first and second introns in the aldosterone rats. These regions were individually cloned in luciferase-expression vector lacking enhancer activity. These clones were tested for enhancer activity in vitro by transfecting in HEK293T and CaCo2 cells with MR and aldosterone treatment. At least four regions were found to be responsive to the MR and aldosterone. Two regions were identified to contain MREs using bioinformatics tools. These clones lost their enhancer activity after mutation of the presumptive MREs, and thus, established the functionality of the MREs. The third and fourth clones did not contain any bioinformatically obvious MREs. Further, they lost their activity upon additional sub-cloning, which suggest cooperativity between the regions that were separated upon sub-cloning. These results demonstrate the presence of intronic MREs in Kcnn4 and suggest a highly cooperative interaction between multiple intronic response elements

Analysis of gamma rays induced variability in lentil (Lens culinaris Medik.)

ArticleIn this study, a lentil variety, Idlib-3, was subjected to 100 Gy (LD50) gamma-ray irradiation. At M2, mutant families were characterized for the most beneficial agronomic traits. High genotypic coefficient of variation, broad sense heritability and genetic advance of the traits such as seed yield per plant and hundred-seed weight indicated expression of additive gene action and confirmed the response at early generation selection. Total number of pods per plant had positive correlation and the highest positive direct effect on seed yield per plant and hence the preference should be given for this trait during selection. The novel mutant families identified with early flowering, early maturity (families 5 and 90) in cluster I, and more first pod height (families 10,70 and 82) in cluster II could be utilized to breed short duration lentil varieties suitable for machine harvest

Ornamental Chasmophytes of Urumbikkara Hills, Western Ghats Region of Idukki District, Kerala, India

The present study on the ornamental chasmophytes in the rocky habitats of Urumbikkara hills of Idukki district, Kerala reveals that, there are about 52 species of ornamental chasmophytic plants belonging to 46 genera and 29 families were collected because of their aesthetic value in both domestic and rock garden practices. These chasmophytes also possess certain biological peculiarities with different interesting adaptations and flower colour which can attract many people for making domestic or rock garden for ornamental purposes and psychological beneficial