Interhemispheric communication during haptic self-perception

During the haptic exploration of a planar surface, slight resistances against the hand's movement are illusorily perceived as asperities (bumps) in the surface. If the surface being touched is one's own skin, an actual bump would also produce increased tactile pressure from the moving finger onto the skin. We investigated how kinaesthetic and tactile signals combine to produce haptic perceptions during self-touch. Participants performed two successive movements with the right hand. A haptic force-control robot applied resistances to both movements, and participants judged which movement was felt to contain the larger bump. An additional robot delivered simultaneous but task-irrelevant tactile stroking to the left forearm. These strokes contained either increased or decreased tactile pressure synchronized with the resistance-induced illusory bump encountered by the right hand. We found that the size of bumps perceived by the right hand was enhanced by an increase in left tactile pressure, but also by a decrease. Tactile event detection was thus transferred interhemispherically, but the sign of the tactile information was not respected. Randomizing (rather than blocking) the presentation order of left tactile stimuli abolished these interhemispheric enhancement effects. Thus, interhemispheric transfer during bimanual self-touch requires a stable model of temporally synchronized events, but does not require geometric consistency between hemispheric information, nor between tactile and kinaesthetic representations of a single common object

Microstructure of the Local Interstellar Cloud and the Identification of the Hyades Cloud

We analyze high-resolution UV spectra of the Mg II h and k lines for 18 members of the Hyades Cluster to study inhomogeneity along these proximate lines of sight. The observations were taken by the Space Telescope Imaging Spectrograph (STIS) instrument on board the Hubble Space Telescope (HST). Three distinct velocity components are observed. All 18 lines of sight show absorption by the Local Interstellar Cloud (LIC), ten stars show absorption by an additional cloud, which we name the Hyades Cloud, and one star exhibits a third absorption component. The LIC absorption is observed at a lower radial velocity than predicted by the LIC velocity vector derived by Lallement & Bertin (1992) and Lallement et al. (1995), (v(predicted LIC) - v(observed LIC) = 2.9 +/- 0.7 km/s), which may indicate a compression or deceleration at the leading edge of the LIC. We propose an extention of the Hyades Cloud boundary based on previous HST observations of other stars in the general vicinity of the Hyades, as well as ground-based Ca II observations. We present our fits of the interstellar parameters for each absorption component. The availability of 18 similar lines of sight provides an excellent opportunity to study the inhomogeneity of the warm, partially ionized local interstellar medium (LISM). We find that these structures are roughly homogeneous. The measured Mg II column densities do not vary by more than a factor of 2 for angular separations of < 8 degrees, which at the outer edge of the LIC correspond to physical separations of < 0.6 pc.Comment: 35 pages, 11 figures, AASTEX v.5.0 plus EPSF extensions in mkfig.sty; accepted by Ap

Capillary filling with wall corrugations] Capillary filling in microchannels with wall corrugations: A comparative study of the Concus-Finn criterion by continuum, kinetic and atomistic approaches

We study the impact of wall corrugations in microchannels on the process of capillary filling by means of three broadly used methods - Computational Fluid Dynamics (CFD), Lattice-Boltzmann Equations (LBE) and Molecular Dynamics (MD). The numerical results of these approaches are compared and tested against the Concus-Finn (CF) criterion, which predicts pinning of the contact line at rectangular ridges perpendicular to flow for contact angles theta > 45. While for theta = 30, theta = 40 (no flow) and theta = 60 (flow) all methods are found to produce data consistent with the CF criterion, at theta = 50 the numerical experiments provide different results. Whilst pinning of the liquid front is observed both in the LB and CFD simulations, MD simulations show that molecular fluctuations allow front propagation even above the critical value predicted by the deterministic CF criterion, thereby introducing a sensitivity to the obstacle heigth.Comment: 25 pages, 8 figures, Langmuir in pres

Dynamics of Fluid Vesicles in Oscillatory Shear Flow

The dynamics of fluid vesicles in oscillatory shear flow was studied using differential equations of two variables: the Taylor deformation parameter and inclination angle $\theta$. In a steady shear flow with a low viscosity $\eta_{\rm {in}}$ of internal fluid, the vesicles exhibit steady tank-treading motion with a constant inclination angle $\theta_0$. In the oscillatory flow with a low shear frequency, $\theta$ oscillates between $\pm \theta_0$ or around $\theta_0$ for zero or finite mean shear rate $\dot\gamma_{\rm m}$, respectively. As shear frequency $f_{\gamma}$ increases, the vesicle oscillation becomes delayed with respect to the shear oscillation, and the oscillation amplitude decreases. At high $f_{\gamma}$ with $\dot\gamma_{\rm m}=0$, another limit-cycle oscillation between $\theta_0-\pi$ and $-\theta_0$ is found to appear. In the steady flow, $\theta$ periodically rotates (tumbling) at high $\eta_{\rm {in}}$, and $\theta$ and the vesicle shape oscillate (swinging) at middle $\eta_{\rm {in}}$ and high shear rate. In the oscillatory flow, the coexistence of two or more limit-cycle oscillations can occur for low $f_{\gamma}$ in these phases. For the vesicle with a fixed shape, the angle $\theta$ rotates back to the original position after an oscillation period. However, it is found that a preferred angle can be induced by small thermal fluctuations.Comment: 11 pages, 13 figure

Combined genetic approaches yield a 48% diagnostic rate in a large cohort of French hearing-impaired patients

International audienceHearing loss is the most common sensory disorder and because of its high genetic heterogeneity, implementation of Massively Parallel Sequencing (MPS) in diagnostic laboratories is greatly improving the possibilities of offering optimal care to patients. We present the results of a two-year period of molecular diagnosis that included 207 French families referred for non-syndromic hearing loss. Our multi-step strategy involved (i) DFNB1 locus analysis, (ii) MPS of 74 genes, and (iii) additional approaches including Copy Number Variations, in silico analyses, minigene studies coupled when appropriate with complete gene sequencing, and a specific assay for STRC. This comprehensive screening yielded an overall diagnostic rate of 48%, equally distributed between DFNB1 (24%) and the other genes (24%). Pathogenic genotypes were identified in 19 different genes, with a high prevalence of GJB2, STRC, MYO15A, OTOF, TMC1, MYO7A and USH2A. Involvement of an Usher gene was reported in 16% of the genotyped cohort. Four de novo variants were identified. This study highlights the need to develop several molecular approaches for efficient molecular diagnosis of hearing loss, as this is crucial for genetic counselling, audiological rehabilitation and the detection of syndromic forms

Antitumour necrosis factor-α therapy for hidradenitis suppurativa: results from a national cohort study between 2000 and 2013

International audienceHidradenitis suppurativa (HS) is a frequent chronic inflammatory skin disease typically characterized by recurrent painful, deep inflammatory nodules of the axillary, breast, groin and gluteal areas. European recommendations are mainly based on expert opinion. Drug treatments are heterogenous (e.g., antibiotics, corticosteroids, retinoids) and lack consensus among expert centres. The most severe disease forms or those failing to respond to conventional drugs may be associated with worsened functional prognosis. Anti-tumor necrosis factor α (anti-TNFα) drugs have been prescribed in these cases. The results of randomized controlled trials (RCTs) are discordant. Three RCTs concluded to the efficacy of adalimumab (ADA), and two others did not detect any difference between infliximab (IFX) or etanercept (ETA) and placebo. Finally, data from the literature and reported experiences do not conclude on the efficacy of anti-TNFα drugs for HS. This article is protected by copyright. All rights reserve

Modelling the sigma phase

39th Edition of the Joint European Days on Equilibrium between Phases (JEEP), Nancy, FRANCE, MAR 19-21, 2013International audienceno abstrac

Multi-Particle Collision Dynamics -- a Particle-Based Mesoscale Simulation Approach to the Hydrodynamics of Complex Fluids

In this review, we describe and analyze a mesoscale simulation method for fluid flow, which was introduced by Malevanets and Kapral in 1999, and is now called multi-particle collision dynamics (MPC) or stochastic rotation dynamics (SRD). The method consists of alternating streaming and collision steps in an ensemble of point particles. The multi-particle collisions are performed by grouping particles in collision cells, and mass, momentum, and energy are locally conserved. This simulation technique captures both full hydrodynamic interactions and thermal fluctuations. The first part of the review begins with a description of several widely used MPC algorithms and then discusses important features of the original SRD algorithm and frequently used variations. Two complementary approaches for deriving the hydrodynamic equations and evaluating the transport coefficients are reviewed. It is then shown how MPC algorithms can be generalized to model non-ideal fluids, and binary mixtures with a consolute point. The importance of angular-momentum conservation for systems like phase-separated liquids with different viscosities is discussed. The second part of the review describes a number of recent applications of MPC algorithms to study colloid and polymer dynamics, the behavior of vesicles and cells in hydrodynamic flows, and the dynamics of viscoelastic fluids

Performances de systèmes viticoles à faible niveau d’intrants phytopharmaceutiques dans le vignoble bordelais

Afin de répondre aux exigences de réduction de l'usage des produits phytosanitaires, ce projet vise à concevoir et à évaluer des systèmes viticoles qui en sont très économes. Ces systèmes, menés en agriculture conventionnelle ou biologique, sont basés essentiellement sur des leviers d'efficience de la lutte chimique pour la gestion des maladies et des ravageurs (règles de décision de traitement), et de substitution pour la maîtrise des adventices (travail du sol, couverts végétaux). Un autre type de système teste aussi le levier de la résistance variétale contre le mildiou et l'oïdium. Une évaluation multicritères de ces systèmes est effectuée pendant 5 ans au vignoble (réduction d’IFT, présence de résidus, maîtrise des bioagresseurs, atteinte des objectifs de rendement, coûts de production, temps de travail). Les résultats montrent que des systèmes basés essentiellement sur l'efficience permettent de réduire significativement l'IFT en maintenant des performances agronomiques et économiques satisfaisantes. Néanmoins, compte tenu d'une certaine prise de risque engendrée par ces systèmes, la diffusion des règles de décisions doit impliquer les viticulteurs. En viticulture biologique, il apparaît difficile de réduire les doses de cuivre et de soufre par rapport aux pratiques actuelles en maintenant des performances agronomiques stables. La mise en œuvre de variétés résistantes au mildiou et à l'oïdium permet de réduire l’IFT de 90 % par rapport aux références régionales