Lateral cephalometric analysis of asymptomatic volunteers and symptomatic patients with and without bilateral temporomandibular joint disk displacement

Few studies of dentofacial and orthodontic structural relationships relative to temporomandibular joint (TMJ) dysfunction have been reported. We undertook this investigation to determine any correlation of orthodontic and dentofacial characteristics with TMJ bilateral disc displacement. The population of patients was selected from a TMJ clinic where a control group of asymptomatic volunteers had been previously established and standardized. Differences in skeletal structural features were determined among three study groups: (1) asymptomatic volunteers with no TMJ disk displacement, (2) symptomatic patients with no TMJ disc displacement, and (3) symptomatic patients with bilateral TMJ disk displacement. Thirty-two asymptomatic volunteers without disk displacement (25 female, 7 male) were compared with the same number each of symptomatic patients without TMJ disk displacement and symptomatic patients with bilateral TMJ disk displacement. All subjects had undergone a standardized clinical examination, bilateral TMJ magnetic resonance imaging, and lateral cephalometric radiographic analysis. The groups were matched according to sex, TMJ status, age, and Angle classification of malocclusion. Seventeen lateral cephalometric radiographic cranial base, maxillomandibular, and vertical dimension variables were evaluated and compared among the study groups. The mean angle of SNB, or the intersection of the sella-nasion plane and the nasion–point B line (indicating mandibular retrognathism relative to cranial base), of the symptomatic patients-with-displacement group was significantly smaller than that in the asymptomatic volunteers and symptomatic patients without bilateral disk displacement (p \u3c 0.05). Female subjects showed smaller linear measurements of mandibular length, lower facial height, and total anterior facial height than male subjects in all three groups (p \u3c 0.05). The mean angle of ANB, or the intersection of the nasion–point A and nasion–point B planes (indicating retrognathism of mandible relative to maxilla), was significantly greater in female than in male subjects, in all groups (p \u3c 0.05). Symptomatic patients with bilateral disk displacement had a retropositioned mandible, indicated by a smaller mean SNB angle compared with that in asymptomatic volunteers and symptomatic patients with no disk displacement on either side. Lateral cephalometric radiographic assessment may improve predictability of TMJ disk displacement in orthodontic patients but is not diagnostic; nor does the assessment explain any cause-and-effect relationship. (Am J Orthod Dentofacial Orthop 1998;114:248-55.

Efficient Neural Network Approximation via Bayesian Reasoning

Approximate Computing (AxC) trades off between the accuracy required by the user and the precision provided by the computing system to achieve several optimizations such as performance improvement, energy, and area reduction. Several AxC techniques have been proposed so far in the literature. They work at different abstraction levels and propose both hardware and software implementations. The standard issue of all existing approaches is the lack of a methodology to estimate the impact of a given AxC technique on the application-level accuracy. This paper proposes a probabilistic approach based on Bayesian networks to quickly estimate the impact of a given approximation technique on application-level accuracy. Moreover, we have also shown how Bayesian networks allow a backtrack analysis that automatically identifies the most sensitive components. That influence analysis dramatically reduces the space exploration for approximation techniques. Preliminary results on a simple artificial neural network shown the efficiency of the proposed approach

A Genetic-algorithm-based Approach to the Design of DCT Hardware Accelerators

As modern applications demand an unprecedented level of computational resources, traditional computing system design paradigms are no longer adequate to guarantee significant performance enhancement at an affordable cost. Approximate Computing (AxC) has been introduced as a potential candidate to achieve better computational performances by relaxing non-critical functional system specifications. In this article, we propose a systematic and high-abstraction-level approach allowing the automatic generation of near Pareto-optimal approximate configurations for a Discrete Cosine Transform (DCT) hardware accelerator. We obtain the approximate variants by using approximate operations, having configurable approximation degree, rather than full-precise ones. We use a genetic searching algorithm to find the appropriate tuning of the approximation degree, leading to optimal tradeoffs between accuracy and gains. Finally, to evaluate the actual HW gains, we synthesize non-dominated approximate DCT variants for two different target technologies, namely, Field Programmable Gate Arrays (FPGAs) and Application Specific Integrated Circuits (ASICs). Experimental results show that the proposed approach allows performing a meaningful exploration of the design space to find the best tradeoffs in a reasonable time. Indeed, compared to the state-of-the-art work on approximate DCT, the proposed approach allows an 18% average energy improvement while providing at the same time image quality improvement

Computational drug discovery under RNA times

RNA molecules play many functional and regulatory roles in cells, and hence, have gained considerable traction in recent times as therapeutic interventions. Within drug discovery, structure-based approaches have successfully identified potent and selective small-molecule modulators of pharmaceutically relevant protein targets. Here, we embrace the perspective of computational chemists who use these traditional approaches, and we discuss the challenges of extending these methods to target RNA molecules. In particular, we focus on recognition between RNA and small-molecule binders, on selectivity, and on the expected properties of RNA ligands

Surface Induced Order in Liquid Metals and Binary Alloys

Measurements of the surface x-ray scattering from several pure liquid metals (Hg, Ga, and In) and from three alloys (Ga-Bi, Bi-In, and K-Na) with different heteroatomic chemical interactions in the bulk phase are reviewed. Surface-induced layering is found for each elemental liquid metal. The surface structure of the K-Na alloy resembles that of an elemental liquid metal. Bi-In displays pair formation at the surface. Surface segregation and a wetting film are found for Ga-Bi.Comment: 10 pages, 3 fig, published in Journal of Physics: Condensed Matte

The preparation period in basketball: Training load and neuromuscular adaptations

© 2018 Human Kinetics, Inc. Purpose: To investigate the effect of the preparation period on neuromuscular characteristics of 12 professional (PRO) and 16 semiprofessional (SEMIPRO) basketball players and relationships between training-load indices and changes in neuromuscular physical performance. Methods: Before and after the preparation period, players underwent a countermovement jump (CMJ) test followed by a repeated change-of-direction (COD) test consisting of 4 levels with increasing intensities. The peripheral neuromuscular functions of the knee extensors (peak torque [PT]) were measured using electrical stimulations after each level (PT1, PT2, PT3, and PT4). Furthermore, PT Max (the highest value of PT) and PT Dec (PT decrement from PT Max to PT4) were calculated. Results: Trivial to small (effect size [ES] = -0.17 to 0.46) improvements were found in CMJ variables, regardless of competitive level. After the preparation period, peripheral fatigue induced by a COD test was similarly reduced in both PRO (PT Dec: from 27.8% [21.3%] to 11.4% [13.7%]; ES = -0.71; 90% confidence interval [CI], ±0.30) and SEMIPRO (PT Dec: from 26.1% [21.9%] to 10.2% [8.2%]; ES = -0.69; 90% CI, ±0.32). Moderate to large relationships were found between session rating of perceived exertion training load and changes in peak power output (PPO) measured during the CMJs (rs [90% confidence interval]: PPOabs, -.46 [±.26]; PPOrel, -.53 [±.23]) and in some PTs measured during the COD test (PT1, -.45 [±.26]; PT2, -.44 [±.26]; PT3, -.40 [±.27]; and PT Max, -.38 [±.28]). Conclusions: The preparation period induced minimal changes in the CMJ, while the ability to sustain repeated COD efforts was improved. Reaching high session rating of perceived exertion training loads might partially and negatively affect the ability to produce strength and power

Morning Priming Exercise Strategy to Enhance Afternoon Performance in Young Elite Soccer Players.

PURPOSE: To compare the effects of different modalities of morning priming exercise on afternoon physical performance with the associated hormonal and psychophysiological responses in young soccer players. METHODS: In a randomized counterbalanced crossover design, 12 young soccer players completed 3 different morning conditions on 3 different days: repeated-sprint running (6 × 40 m), easy exercise (4 × 12 fast half squats, 6 speed ladder drills, and 20-m sprints), and control (no exercise). Blood testosterone and cortisol concentrations were assessed upon arrival (approximately 8:30AM) and approximately 5 hours and 30 minutes later. Body temperature, self-reported mood, quadriceps neuromuscular function (maximal voluntary contraction, voluntary activation, rate of torque development, and twitch contractile properties), jump, and sprint performance were evaluated twice per day, while rating of perceived exertion, motivation, and the Yo-Yo Intermittent Recovery level 2 (IR2) tests were assessed once per day. RESULTS: Compared with the control, repeated-sprint running induced a possible positive effect on testosterone (+11.6%) but a possible to very likely negative effect on twitch contractile properties (-13.0%), jump height (-1.4%), and Yo-Yo IR2 (-7.1%). On the other hand, easy exercise had an unclear effect on testosterone (-3.3%), resulted in lower self-reported fatigue (-31.0%) and cortisol (-12.9%), and had a possible positive effect on the rate of torque development (+4.3%) and Yo-Yo IR2 (+6.5%) compared with the control. CONCLUSIONS: Players' testosterone levels were positively influenced by repeated-sprint running, but this did not translate into better physical function, as both muscular and endurance performance were reduced. Easy exercise seemed to be suitable to optimize the physical performance and psychophysiological state of young soccer players

Circuit training during physical education classes to prepare cadets for military academies tests: Analysis of an educational project

Background: The aim of this study was to test the efficacy of an eight-week physical education program based on circuit training to better improve the overall physical and military-specific performance compared to a conventional physical education program in military high school students. Methods: Sixty-four students were enrolled in this study and randomly assigned to an experimental (EG, circuit training) or a control group (CG, traditional physical education program). Immediately before and after the eight-week training period, participants were tested on strength and endurance performance, circuit training tests, and military tests. Moreover, the acquisition of the educational objectives and the pleasantness of the experimental intervention were tested using a qualitative approach. Results: Despite the higher workload in EG than CG during the training period, the effect of the experimental intervention compared to the control was only possibly to likely positive for a few strength and endurance performances and circuit training tests, respectively. A trivial effect was shown in the military tests. On the contrary, the high percentage of motivation (76%), understanding (78%) and collaboration (86%) showed by the students suggests the achievement of acquisition of the educational objectives and a fair pleasantness of the lessons. Conclusions: A lack of clear and marked effect of the experimental intervention could be ascribed to an insufficient exposure time to the training and a high subjective overall workload encountered in military high school students

Bilateral asymmetry of skin temperature is not related to bilateral asymmetry of crank torque during an incremental cycling exercise to exhaustion

© 2018 Trecroci et al. Although moderate relationships (|r|~0:5) were reported between skin temperature and performance-related variables (e.g., kinetic), it remains unclear whether skin temperature asymmetry reflects muscle force imbalance in cycling. Therefore, the aim of this study was to assess whether a relationship exists between kinetic and thermal asymmetry during a fatiguing exercise. Ten elite cyclists were enrolled and tested on a maximal incremental cycling test. Peak crank torques of both legs were obtained at the initial and final workload. Likewise, bilateral skin temperatures were recorded before and after exercise. Asymmetric indexes were also calculated for kinetic (AIK) and skin temperature (AIT) outcomes. The bilateral peak crank torques showed a larger difference at the final compared to the initial workload (p0:05). Additionally, trivial relationships were reported between AIK and AIT (-0:3<r<0:2) at the initial and final workload. The obtained results showed that changes in bilateral kinetic values did not reflect concurrent changes in bilateral skin temperatures. This finding emphasizes the difficulty of associating the asymmetry of skin temperature with those of muscle effort in elite cyclists. Lastly, our study also provided further insights on thermal skin responses during exhaustive cycling exercise in very highly-trained athletes

On the existence of star products on quotient spaces of linear Hamiltonian torus actions

We discuss BFV deformation quantization of singular symplectic quotient spaces in the special case of linear Hamiltonian torus actions. In particular, we show that the Koszul complex on the moment map of an effective linear Hamiltonian torus action is acyclic. We rephrase the nonpositivity condition of Arms, Gotay and Jennings for linear Hamiltonian torus actions. It follows that reduced spaces of such actions admit continuous star products.Comment: 9 pages, 4 figures, uses psfra