95 research outputs found
Structure determination of Split-soret Cytochrome from a Desulfovibrio species isolated from a human abdominal abcess
The determined structure of the split-soret cytochrome (SSC) isolated from Desulfovibrio desulfuricans ATCC 27774 (D.d.) revealed a new Heme arrangement, which suggests that this protein constitutes a new cytochrome class.. SSC is a 52.6kDa homodimer containing four hemes at one end of the molecule. In each monomer the two hemes have their edges overlapped within van der Waals contacts. The polypeptide chain of each monomer supplies the sixth ligand to the heme-iron of the other monomer. A similar protein was recently purified from a homologous Desulfovibrio clinical strain isolated from an abdominal wall abscess in human patient2. Crystals of this SSC were grown using vapour diffusion method in the presence of agarose gel. Diffraction data were collected using X-ray synchrotron radiation at the ESRF, beamline, ID 14-1. The structure will be solved by molecular replacement using the structure of the D.d. as a starting model
BMJ Open
Objective To compare the effectiveness of the mobile e-Tabac Info Service (e-TIS) application (app) for helping adult smokers quit smoking with current practices. Design Pragmatic randomised controlled trial with a 1-year follow-up (2017â2018). Setting France, population-wide level. Participants 2806 adult smokers who wished to quit smoking were recruited via the website of the French National Mandatory Health Insurance fund. Of them, 1400 were randomised to the e-TIS app arm and 1406 were randomised to the current practices arm (control). Intervention The app involved personalised interactive contacts that included questionnaires, advice, activities and text messages. All contacts were individually tailored and based on each smokerâs progress. In the control group, recommended practices for quitting smoking were described on a non-interactive website. Primary and secondary outcomes measures The primary outcome was 7-day point prevalence abstinence (PPA) at 6 months. The secondary outcomes included continuous abstinence rates at 6 and 12 months, minimum 24-hour point abstinence at 3 months, minimum 30-day point abstinence at 12 months and number and duration of quit attempts. Results There was no difference between the e-TIS and control arms for the primary outcome (12.6% vs 13.7% for 7-day PPA at 6 months, p=0.3949, intention-to-treat analysis). However, e-TIS participants with high levels of exposure to the app, which was defined by the completion of at least eight activities or questionnaires, showed higher rates of smoking cessation than the control participants (17.6% vs 12.9% for 7-day PPA at 6 months, p=0.0169, per-protocol analysis). Conclusion Use of the e-TIS app was not associated with a higher rate of smoking cessation. However, high level of exposure to the e-TIS app may have been more effective than current practices
Behavior of the giant-dipole resonance in Sn and Pb at high excitation energ
The properties of the giant-dipole resonance (GDR) are calculated as a
function of excitation energy, angular momentum, and the compound nucleus
particle decay width in the nuclei Sn and Pb, and are compared
with recent experimental data. Differences observed in the behavior of the
full-width-at-half-maximum of the GDR for Sn and Pb are
attributed to the fact that shell corrections in Pb are stronger than
in Sn, and favor the spherical shape at low temperatures. The effects
shell corrections have on both the free energy and the moments of inertia are
discussed in detail. At high temperature, the FWHM in Sn exhibits
effects due to the evaporation width of the compound nucleus, while these
effects are predicted for Pb.Comment: 28 pages in RevTeX plus eight postscript figures. Submitted to Nucl.
Phys.
Orbital stability: analysis meets geometry
We present an introduction to the orbital stability of relative equilibria of
Hamiltonian dynamical systems on (finite and infinite dimensional) Banach
spaces. A convenient formulation of the theory of Hamiltonian dynamics with
symmetry and the corresponding momentum maps is proposed that allows us to
highlight the interplay between (symplectic) geometry and (functional) analysis
in the proofs of orbital stability of relative equilibria via the so-called
energy-momentum method. The theory is illustrated with examples from finite
dimensional systems, as well as from Hamiltonian PDE's, such as solitons,
standing and plane waves for the nonlinear Schr{\"o}dinger equation, for the
wave equation, and for the Manakov system
Compilation of Giant Electric Dipole Resonances Built on Excited States
Giant Electric Dipole Resonance (GDR) parameters for gamma decay to excited
states with finite spin and temperature are compiled. Over 100 original works
have been reviewed and from some 70 of which more than 300 parameter sets of
hot GDR parameters for different isotopes, excitation energies, and spin
regions have been extracted. All parameter sets have been brought onto a common
footing by calculating the equivalent Lorentzian parameters. The current
compilation is complementary to an earlier compilation by Samuel S. Dietrich
and Barry L. Berman (At. Data Nucl. Data Tables 38(1988)199-338) on
ground-state photo-neutron and photo-absorption cross sections and their
Lorentzian parameters. A comparison of the two may help shed light on the
evolution of GDR parameters with temperature and spin. The present compilation
is current as of January 2006.Comment: 31 pages including 1 tabl
The prevalence of hepatitis B virus markers in a cohort of students in Bangui, Central African Republic
Incidence of Neisseria gonorrhoeae and Chlamydia trachomatis infections in Strasbourg over 8 years.
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