Three-dimensional imaging of aquifer and aquitard heterogeneity via transient hydraulic tomography at a highly heterogeneous field site

The final publication is available at Elsevier via http://dx.doi.org/10.1016/j.jhydrol.2018.02.024 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/Previous studies have shown that geostatistics-based transient hydraulic tomography (THT) is robust for subsurface heterogeneity characterization through the joint inverse modeling of multiple pumping tests. However, the hydraulic conductivity (K) and specific storage (Ss) estimates can be smooth or even erroneous for areas where pumping/observation densities are low. This renders the imaging of interlayer and intralayer heterogeneity of highly contrasting materials including their unit boundaries difficult. In this study, we further test the performance of THT by utilizing existing and newly collected pumping test data of longer durations that showed drawdown responses in both aquifer and aquitard units at a field site underlain by a highly heterogeneous glaciofluvial deposit. The robust performance of the THT is highlighted through the comparison of different degrees of model parameterization including: (1) the effective parameter approach; (2) the geological zonation approach relying on borehole logs; and (3) the geostatistical inversion approach considering different prior information (with/without geological data). Results reveal that the simultaneous analysis of eight pumping tests with the geostatistical inverse model yields the best results in terms of model calibration and validation. We also find that the joint interpretation of long-term drawdown data from aquifer and aquitard units is necessary in mapping their full heterogeneous patterns including intralayer variabilities. Moreover, as geological data are included as prior information in the geostatistics-based THT analysis, the estimated K values increasingly reflect the vertical distribution patterns of permeameter-estimated K in both aquifer and aquitard units. Finally, the comparison of various THT approaches reveals that differences in the estimated K and Ss tomograms result in significantly different transient drawdown predictions at observation ports.Environmental Security and Technology Certification Program (ESTCP) under grant ER201212China Scholarship CouncilDiscovery and Collaborative Research and Development Grants from the Natural Sciences and Engineering Research Council of Canada (NSERC)Ontario Research Foundation (ORF)Canada Foundation for Innovation (CFI

Review of temporary crating of farrowing and lactating sows

Temporary crating (TC) provides lactating sows with the opportunity to move more freely after crate opening a few days after parturition. The aim of this paper was to evaluate whether TC gives overall welfare improvement when compared to permanent crating or free farrowing. This review shows that when pens with TC allow the sows to turn during the majority of time in the farrowing unit, it is the pen design and period of confinement in a crate within it that influence the extent to which different functional and motivated behaviors can be fulfilled. This review also indicates that there are at least short-term benefits to sows when confinement is reduced, as shown by reported increases in motivated behaviors such as exploration and interactions with piglets when not permanently crated. It remains unclear whether there are any longer-term beneficial effects (until or beyond weaning) due to the paucity of studies. Furthermore, it is uncertain whether the observed short-term benefits translate to other welfare indicators. Research findings indicate no reduction in the frequency of stereotypies or body lesions and do not provide a clear answer regarding sow stress response when released from confinement. Compared to free farrowing, TC appears beneficial for reducing piglet mortality. The impact of the time of onset of TC on the farrowing process and piglet mortality have been inconsistent. While confinement before farrowing prevents nest building behavior, consequences of this for sow physiology have been ambiguous. Confining the sow briefly after farrowing may be the best compromise, allowing the sow to perform motivated nest-building behavior, but the risks of crushing during the unconfined farrowing period may increase. Subsequent crate reopening seems to increase piglet mortality but only if done earlier than 3–5 days after farrowing. The review also provides methodological considerations, a proposal for consistent and accurate terminology when describing systems and highlights gaps of knowledge. In conclusion, TC is a step forward to better pig welfare compared to the farrowing crate, as it allows some freedom of movement for sows without impairing piglet welfare. However, more comprehensive research is needed to draw sound conclusions as to whether TC is a viable transition from permanent crating to free farrowing

Automatic estimation of aquifer parameters using long-term water supply pumping and injection records

Analyses are presented of long-term hydrographs perturbed by variable pumping/injection events in a confined aquifer at a municipal water-supply well field in the Region of Waterloo, Ontario (Canada). Such records are typically not considered for aquifer test analysis. Here, the water-level variations are fingerprinted to pumping/injection rate changes using the Theis model implemented in the WELLS code coupled with PEST. Analyses of these records yield a set of transmissivity (T) and storativity (S) estimates between each monitoring and production borehole. These individual estimates are found to poorly predict water-level variations at nearby monitoring boreholes not used in the calibration effort. On the other hand, the geometric means of the individual T and S estimates are similar to those obtained from previous pumping tests conducted at the same site and adequately predict water-level variations in other boreholes. The analyses reveal that long-term municipal water-level records are amenable to analyses using a simple analytical solution to estimate aquifer parameters. However, uniform parameters estimated with analytical solutions should be considered as first rough estimates. More accurate hydraulic parameters should be obtained by calibrating a three-dimensional numerical model that rigorously captures the complexities of the site with these data.Grant from the Region of Waterloo to the University of WaterlooDiscovery grant - Natural Sciences & Engineering Research Council of Canada (NSERC

Optimization of the hydrodynamic characteristics of a karst conduit with CFPv2 coupled to OSTRICH

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.jhydrol.2018.10.050 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/In order to better define the characteristics of a karst conduit, an integrated hydrogeological study including numerical modeling using CFPv2 is conducted at a karst aquifer in the Zagros Mountain Region of Iran. The Sarvak limestone aquifer in the Nil Anticline is the main karst aquifer of the study area with major groundwater discharge taking place at Sarkur spring. An annual water balance and a dye tracing test confirmed that the karst system is mainly recharged through rainfall and the Maroon River. Several depressions are observed along the banks of the river with a major one classified as a sinkhole used for dye injection. A groundwater flow model was developed based on the available hydrogeological information. A probable direct conduit flow path with an estimated groundwater flow velocity of 96 m/h is estimated between the injection point and the Sarkur spring. Four scenarios are assumed to simulate the probable conduit flow path using the CFPv2 code. As one of the first attempts in regional groundwater flow modeling of a karst aquifer, CFPv2 is automatically calibrated with field measurements of spring discharge and a dye breakthrough curve through a parameter estimation code OSTRICH to optimize the characteristics of the conduit through the minimization of the weighted sum of square error. Simulated results reveal that a conduit with a diameter of 2.9 m is required to adequately simulate spring discharge and dye tracer migration between the injection and discharge points. Our new approach (linking of CFPv2 and OSTRICH) provides a deeper understanding of groundwater flow and solute transport in karst terrains even when available data are limited and the approach should be applicable to other areas.Shiraz UniversityUniversity of Waterlo

Theoretical interpretation of a pronounced permeability scale effect in unsaturated fractured tuff

Numerous single‐hole and cross‐hole pneumatic injection tests have been conducted in unsaturated fractured tuff at the Apache Leap Research Site (ALRS) near Superior, Arizona. Single‐hole tests have yielded values of air permeability at various locations throughout the tested rock volume on a nominal scale of ∼1 m. Cross‐hole tests have yielded equivalent air permeabilities (and air‐filled porosities) for a rock volume characterized by a length scale of several tens of meters. Cross‐hole tests have also provided high‐resolution tomographic estimates of how air permeability (and air‐filled porosity), defined over grid blocks having a length scale of 1 m, vary throughout a similar rock volume. The results have revealed a highly pronounced scale effect in permeability (and porosity) at the ALRS. We examine the extent to which the permeability scale effect is amenable to interpretation by a recent stochastic scaling theory, which treats the rock as a truncated random fractal

Equivariant Lefschetz maps for simplicial complexes and smooth manifolds

Let X be a locally compact space with a continuous proper action of a locally compact group G. Assuming that X satisfies a certain kind of duality in equivariant bivariant Kasparov theory, we can enrich the classical construction of Lefschetz numbers to equivariant K-homology classes. We compute the Lefschetz invariants for self-maps of finite-dimensional simplicial complexes and of self-maps of smooth manifolds. The resulting invariants are independent of the extra structure used to compute them. Since smooth manifolds can be triangulated, we get two formulas for the same Lefschetz invariant in these cases. The resulting identity is closely related to the equivariant Lefschetz Fixed Point Theorem of Luck and Rosenberg.Comment: Minor revisions, affecting some theorem number

Comparative study of transient hydraulic tomography with varying parameterizations and zonations: Laboratory sandbox investigation

The final publication is available at Elsevier via http://dx.doi.org/10.1016/j.jhydrol.2017.09.045 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Transient hydraulic tomography (THT) is a robust method of aquifer characterization to estimate the spatial distributions (or tomograms) of both hydraulic conductivity (K) and specific storage (Ss). However, the highly-parameterized nature of the geostatistical inversion approach renders it computationally intensive for large-scale investigations. In addition, geostatistics-based THT may produce overly smooth tomograms when head data used to constrain the inversion is limited. Therefore, alternative model conceptualizations for THT need to be examined. To investigate this, we simultaneously calibrated different groundwater models with varying parameterizations and zonations using two cases of different pumping and monitoring data densities from a laboratory sandbox. Specifically, one effective parameter model, four geology-based zonation models with varying accuracy and resolution, and five geostatistical models with different prior information are calibrated. Model performance is quantitatively assessed by examining the calibration and validation results. Our study reveals that highly parameterized geostatistical models perform the best among the models compared, while the zonation model with excellent knowledge of stratigraphy also yields comparable results. When few pumping tests with sparse monitoring intervals are available, the incorporation of accurate or simplified geological information into geostatistical models reveals more details in heterogeneity and yields more robust validation results. However, results deteriorate when inaccurate geological information are incorporated. Finally, our study reveals that transient inversions are necessary to obtain reliable K and Ss estimates for making accurate predictions of transient drawdown events.Discovery grant - Natural Sciences & Engineering Research Council of Canada (NSERC)China Scholarship Counci

The Baum-Connes Conjecture via Localisation of Categories

We redefine the Baum-Connes assembly map using simplicial approximation in the equivariant Kasparov category. This new interpretation is ideal for studying functorial properties and gives analogues of the assembly maps for all equivariant homology theories, not just for the K-theory of the crossed product. We extend many of the known techniques for proving the Baum-Connes conjecture to this more general setting

MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer

Background\ud The purpose of this study was to investigate invasion and metastasis related genes in gastric cancer.\ud \ud Methods\ud The transwell migration assay was used to select a highly invasive sub-line from minimally invasive parent gastric cancer cells, and gene expression was compared using a microarray. MMP28 upregulation was confirmed using qRT-PCR. MMP28 immunohistochemistry was performed in normal and gastric cancer specimens. Invasiveness and tumor formation of stable cells overexpressing MMP28 were tested in vitro and in vivo.\ud \ud Results\ud MMP28 was overexpressed in the highly invasive sub-cell line. Immunohistochemistry revealed MMP28 expression was markedly increased in gastric carcinoma relative to normal epithelia, and was significantly associated with depth of tumor invasion, lymph node metastasis and poorer overall survival. Ectopic expression of MMP28 indicated MMP28 promoted tumor cell invasion in vitro and increased gastric carcinoma metastasis in vivo.\ud \ud Conclusions\ud This study indicates MMP28 is frequently overexpressed during progression of gastric carcinoma, and contributes to tumor cell invasion and metastasis. MMP28 may be a novel therapeutic target for prevention and treatment of metastases in gastric cancer

Persistent psychogenic déjà vu: a case report

Introduction: Déjà vu is typically a transient mental state in which a novel experience feels highly familiar. Although extensively studied in relation to temporal lobe epilepsy as part of simple partial seizures, déjà vu has been less studied in other clinical populations. A recent review of temporal lobe epilepsy suggested a possible link between clinical levels of anxiety and debilitating déjà vu, indicating further research is required. Here, for the first time in the literature, we present a case study of a young man with anxiety and depersonalisation who reported experiencing persistent and debilitating déjà vu. This report therefore adds to the limited literature on the relationship between anxiety and déjà vu. Case presentation: A 23-year-old White British man presented with a form of persistent déjà vu in 2010, approximately 3 years since symptom onset. He reported a history of anxiety and experiencing feelings of depersonalisation. Neurological assessment (electroencephalogram and magnetic resonance imaging) did not indicate any abnormalities. We assessed his recognition memory with a task used in patients with dementia who report similar experiences but lack awareness of their falseness. Conclusions: Our case' s memory performance was more conservative than controls but did not indicate a memory deficit. Unlike other patients with chronic déjà vu (for example, in dementia), he is fully aware of the false nature of his déjà vu and this presumably leads to his intact recognition memory performance. We suggest that his persistent déjà vu is psychogenic and conclude that déjà vu should be further studied in psychiatric disorders.</p