Морфофункциональные изменения в структуре зон коры надпочечников крыс под влиянием алкогольной интоксикации и антиоксиданта

Burdenko State Medical Academy of Voronezh, Voronezh, Russia, Conferinţa Știinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată сentenarului profesorului B.Z. Perlin, Chişinău, 20-22 septembrie 2012Studies have shown that prolonged involuntary alcohol intoxication causes significant structural and functional reorganization of the cortex of the adrenal glands. Natural antioxidant α-tocopherol has a modifying influence on changes in the cells of the adrenal glands cortex in case of alcoholization, with the intensity and direction of this effect depends on whether the use of alcohol is being continued. Исследования показали, что длительная непроизвольная алкогольная интоксикация приводит к значительной структурной и функциональной реорганизации коры надпочечников. Природный антиоксидант α-токоферол имеет модифицирующее влияние на изменения в клетках коры надпочечников железы в случае алкоголизации, интенсивность и направленность этого влияния зависит от того, продолжается ли употребление алкоголя

Direct observation of Levy flight of holes in bulk n-InP

We study the photoluminescence spectra excited at an edge side of n-InP slabs and observed from the broadside. In a moderately doped sample the intensity drops off as a power-law function of the distance from the excitation - up to several millimeters - with no change in the spectral shape.The hole distribution is described by a stationary Levy-flight process over more than two orders of magnitude in both the distance and hole concentration. For heavily-doped samples, the power law is truncated by free-carrier absorption. Our experiments are near-perfectly described by the Biberman-Holstein transport equation with parameters found from independent optical experiments.Comment: 4 pages, 3 figure

Validation of a questionnaire for young women to assess knowledge, attitudes and behaviors towards cervical screening and vaccination against HPV in Italy

Background: Despite knowledge about HPV may be an important determinant for vaccine acceptance and uptake, only few studies have assessed HPV-related knowledge in young females. The aim of this study was to assess the reliability and validity of the questionnaire, in Italian women ≥18 years old, as a tool to examine knowledge, attitudes and behaviors towards screening and vaccination against HPV and reliable source of information. Methods: The questionnaire was administered to 30 girls in anonymous, voluntary and self -administered form with close-ended type of questions, except for the socio-demographic characteristics. It was composed in 3 sections for a total of 69 items. Participation in the study was entirely voluntary and anonymous. Descriptive analyses were performed using frequencies, percentages, and frequency table for categorical variables. Reliability analysis was tested and content validity was evaluated using Cronbach's alpha to check internal consistency and avoid misinterpretation of the results. The study was conducted in 4 Italian cities: Ferrara, Rome, Cassino and Palermo, to represent the different Italian geographical areas and knowledge, attitudes and behaviors towards screening and vaccination against HPV and reliable source of information. Data were collected in October 2010. Statistical analysis was performed with the statistical software for Windows SPSS, version 19.0. Results: The highest value of Cronbach's alpha resulted on 24 items (alpha= 0,774); the addition of other items, one at a time, decreased the value. Cronbach's alpha on all the 3 sections together resulted in a value of 0, 059. Young women generally knew that HPV can cause cervical cancer (93.3%) and genital warts (16.7%) and 76.7% of them recognized Pap-test as a screening tool. The main sources of information about HPV vaccination are represented by magazines / books (33.3%), TV (26.7%), and gynecologists (23.3%). Conclusions: This pilot study demonstrated that a short version of the questionnaire has very good reliability properties in the study and this needs to be taken into account for future studies

Analysis of chromosome aberrations by FISH and Giemsa assays in lymphocytes of cancer patients undergoing whole-body irradiation: comparison of in vivo and in vitro irradiation

Abstract. Studies of the frequencies of chromosome exchange aberrations in peripheral lymphocytes provide useful Purpose : To study the cytogenetic eVects of fractionated radiobiodosimetric information (IAEA 1986, Darroudi therapy in peripheral blood lymphocytes of ve cancer patients. 2000). For individual dose estimation, a calibration In vitro experiments were performed in parallel using the same dose-response curve constructed for human lympho- patients undergoing protracted whole-body irradiGiemsa-stained preparations were used to score unstable ation at low doses before local radiotherapy at high aberrations following in vivo and in vitro exposure. dose. Results: A linear dose-response curve was determined for both dicentrics and translocations. The in vivo frequency of translocations was higher than for dicentrics. Dose-response curves Materials and methods generated for translocations following in vivo and in vitro irradiation yielded similar frequencies. In contrast, for dicentrics, in 2.1. Subjects vitro irradiation yielded a higher frequency when compared with data generated following in vivo exposure. The study was performed on ve patients aged Conclusions : For dose reconstruction purposes, translocations fre-23-70 years, one woman and four men, with quency seems to be a more adequate end-point than the scoring advanced cancers and distant metastases

PGI12 Organizational and Economic Issues Related to the Introduction of Boceprevir in the Treatment of Patients with Genotype 1 Chronic Hepatitis C in Italy

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Molecular Plasmonic Silver Forests for the Photocatalytic-Driven Sensing Platforms

Structural electronics, as well as flexible and wearable devices are applications that are possible by merging polymers with metal nanoparticles. However, using conventional technologies, it is challenging to fabricate plasmonic structures that remain flexible. We developed three-dimensional (3D) plasmonic nanostructures/polymer sensors via single-step laser processing and further functionalization with 4-nitrobenzenethiol (4-NBT) as a molecular probe. These sensors allow ultrasensitive detection with surface-enhanced Raman spectroscopy (SERS). We tracked the 4-NBT plasmonic enhancement and changes in its vibrational spectrum under the chemical environment perturbations. As a model system, we investigated the sensor’s performance when exposed to prostate cancer cells’ media over 7 days showing the possibility of identifying the cell death reflected in the environment through the effects on the 4-NBT probe. Thus, the fabricated sensor could have an impact on the monitoring of the cancer treatment process. Moreover, the laser-driven nanoparticles/polymer intermixing resulted in a free-form electrically conductive composite that withstands over 1000 bending cycles without losing electrical properties. Our results bridge the gap between plasmonic sensing with SERS and flexible electronics in a scalable, energy-efficient, inexpensive, and environmentally friendly way.</p

Особенности клинических проявлений отдаленных последствий закрытой черепно-мозговой травмы

The clinical characteristic of the remote consequences of the closed cranio-cerebral trauma оn the basis of complex neurological, psychophysiological, electrophysiological inspection 171 patients was given. The big variety of clinical symptoms is stacked in displays of a syndrome of intracranial hypertensia, vegetovascular and neurotic syndromes. Allocation of the specified syndromes was proved by results of laboratory researches of patients. It is established, that at younger age (25—35 years old) at patients after the closed craniocerebral trauma it is formed a syndrome of intracranial hypertensia, in more senior period of a life (35—45 years old) displays of vegetovascular and neurotic syndromes take place.На основании комплексного неврологического, психофизиологического, электрофизиологического обследования 171 больного дана клиническая характеристика отдаленных последствий закрытой черепно-мозговой травмы. Большое разнообразие клинических симптомов укладываются в проявления гипертензионно-гидроцефального, вегетативно-сосудистого и астеноневротического синдромов. Выделение указанных синдромов обосновывалось результатами лабораторных исследований больных (КТ, МРТ, РЭГ, ЭЭГ, офтальмоскопия, вегетативные пробы). Установлено, что в более молодом возрасте (25-35 лет) у больных после ЗЧМТ формируется гипертензионно-гидроцефальный синдром, в более старшем периоде жизни (35-45 лет) имеют место проявления вегетативно-сосудистого и астеноневротического синдромов

A comparative study on the health and well-being of adolescent immigrants in Spain and Portugal

The terms on which the integration of new generations of immigrants into Portuguese and Spanish societies happens will have a decisive influence in the future of both countries. Therefore, promoting their health, well-being, and psychosocial adaptation is a matter of strategic interest. This paper analyses psychosocial factors associated with well-being and psychological adjustment on a sample of 108 adolescents (55 males and 53 females), children of immigrants from Huelva (Spain) and Algarve (Portugal), aged between 10 and 17 years. Adolescents were assessed for demographic characteristics and perceived well-being. We used the "KIDSCREEN-5", a self-report questionnaire that yields detailed profile information for children aged 8 to 18 years for the following ten dimensions: Physical well-being, Psychological well-being, Moods and emotions, Self-perception, Autonomy, Parental relationships and home life, Financial resources, Social support and peers, School environment, and Social acceptance (Bullying). Overall, significant differences were found between the Spanish and Portuguese samples on physical well-being, psychological well-being, mood, financial resources and social acceptance (bullying). Boys perceived themselves as having a better physical well-being than girls. Mothers' educational level was associated with psychological well-being and mood. Also, results suggested that residence location and other socio-demographical variables were not associated with the adolescents' well-being and psychological adjustment

Пролиферация и апоптоз лимфоцитов в ответ на стимуляцию боррелиозным антигеном у больных иксодовым клещевым боррелиозом

The object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the cultures obtained from chronic patients induced T helper type 1-like response as well as depression in lymphocyte apoptosis, which may provide the basis of persistent activated T cell immune response and chronic inflammatory in Lyme borreliosis.Цель настоящей работы заключалась в определении взаимосвязи между особенностями пролиферации и апоптоза клеток в культурах лимфоцитов, стимулированных специфическим антигеном B. garinii, и развитием различных клинических исходов у больных иксодовым клещевым боррелиозом (ИКБ). Установлено, что стимуляция боррелиозным антигеном культур, полученных от больных хроническим ИКБ, приводит к развитию in vitro Т-хелперов типа 1 при одновременном подавлении апоптоза реактивных клеток, что может лежать в основе формирования персистентно активированного Т-клеточного иммунного ответа и хронического воспалительного процесса при этом заболевании