Teelt van herfstchrysanten

Mét de toegenomen belangstelling voor de teelt van snijbloemen in het algemeen, is ook de interesse voor de teelt van herfstchrysanten toegenomen. En ook nu is deze teelt favoriet als nateelt op tal van groentebedrijven. Er is echter in de loop der jaren veel veranderd; ook met betrekking tot de teelt van herfstchrysanten. De mogelijkheden in teelttechnisch opzicht zijn belangrijk vergroot, maar ook de eisen voor een goede kwaliteit zijn verscherpt. Deze teelthandleiding geeft onder andere informatie over de economische aspecten, de kasteelt, arbeid, teeltmethoden, gewasbescherming en bemesting

The chemical potential of the electron gas on a one dimensional lattice

The chemical potential of the electron gas on a one-dimensional lattice is determined within the discrete Hubbard model. The result will have applications in studies of transport properties of quasi one-dimensional organic conductors such as the Bechgaard salts.Comment: 4 pages,plain TeX,presented at the 9 National Congress of Yugoslav Physicists,held in May 1995.,and published in the proceedings.The author can be contacted at: [email protected]

Characterization of precipitation product errors across the United States using multiplicative triple collocation

Validation of precipitation estimates from various products is a challenging problem, since the true precipitation is unknown. However, with the increased availability of precipitation estimates from a wide range of instruments (satellite, ground-based radar, and gauge), it is now possible to apply the triple collocation (TC) technique to characterize the uncertainties in each of the products. Classical TC takes advantage of three collocated data products of the same variable and estimates the mean squared error of each, without requiring knowledge of the truth. In this study, triplets among NEXRAD-IV, TRMM 3B42RT, GPCP 1DD, and GPI products are used to quantify the associated spatial error characteristics across a central part of the continental US. Data are aggregated to biweekly accumulations from January 2002 through April 2014 across a 2° × 2° spatial grid. This is the first study of its kind to explore precipitation estimation errors using TC across the US. A multiplicative (logarithmic) error model is incorporated in the original TC formulation to relate the precipitation estimates to the unknown truth. For precipitation application, this is more realistic than the additive error model used in the original TC derivations, which is generally appropriate for existing applications such as in the case of wind vector components and soil moisture comparisons. This study provides error estimates of the precipitation products that can be incorporated into hydrological and meteorological models, especially those used in data assimilation. Physical interpretations of the error fields (related to topography, climate, etc.) are explored. The methodology presented in this study could be used to quantify the uncertainties associated with precipitation estimates from each of the constellations of GPM satellites. Such quantification is prerequisite to optimally merging these estimates

Burden of early, advanced and metastatic breast cancer in The Netherlands

BACKGROUND: The aim of this study was to estimate the total economic and health related burden of breast cancer in the Netherlands. METHODS: Data on incidence, prevalence, mortality and survival were extracted from the Dutch National Cancer Registry and were used to calculate the economic and health related burden of breast cancer for overall, DCIS (stage 0), early- (stage I), locally advanced- (stage II-III) and metastatic- (stage IV) breast cancer by age groups and by year (if applicable). RESULTS: The overall incidence of breast cancer increased from 103.4 up to 153.2 per 100,000 women between 1990 and 2014. The increase was driven by DCIS and early breast cancer as the incidence of locally advanced and metastatic breast cancer remained stable. Between 1990 and 2014, ten-year overall survival rates increased from 87% to 93% for early breast cancer, 41% to 62% for locally advanced- and from 6% to 9% for metastatic disease. Annually, breast cancer in the Netherlands is responsible for approximately 3100 deaths, 26,000 life years lost, 65,000 Disability Adjusted Life Years (DALYs) and an economic burden of €1.27 billion. CONCLUSIONS: This study provides a comprehensive assessment of the burden of breast cancer and subsequent trends over time in the Netherlands

Relationship between vegetation microwave optical depth and cross-polarized backscatter from multiyear Aquarius observations

Soil moisture retrieval algorithms based on passive microwave remote sensing observations need to account for vegetation attenuation and emission, which is generally parameterized as vegetation optical depth (VOD). This multisensor study tests a new method to retrieve VOD from cross-polarized radar backscattering coefficients. Three years of Aquarius/SAC-D data were used to establish a relationship between the cross-polarized backscattering coefficient σHV and VOD derived from a multitemporal passive dual-channel algorithm (VODMT). The dependence of the correspondence is analyzed for different land use classes. There are no systematic differences in the slope for woody versus nonwoody vegetation, resulting in a strong correlation (80% explained-variance) and a global linear relationship when all classes are combined. The relationship is stable over the years of observations. The comparison of the Aquarius-derived VODMT to Soil Moisture and Ocean Salinity's multi-angular VOD estimates shows similar spatial patterns and temporal behavior, evident in high correlations. However, VODMT has considerably higher mean values, but lower dynamic range globally. Most of the differences can be attributed to differences in instrument sampling. The main result of this study, a relationship between backscatter and VOD, will permit high-resolution mapping of VOD with synthetic aperture radar measurements. These maps allow future studies of scaling and heterogeneity effects of vegetation on soil moisture retrieval at the coarser scales of land microwave radiometry. The study shows that VOD based on passive measurements and predicted by active measurements are comparable globally and that the breakdown by land cover classification does not affect the relationship appreciably

Spillovers from Foreign Direct Investment in Central and Eastern Europe. An index for measuring a country’s potential to benefit from technology spillovers

In the paper, we construct a composite indicator to estimate the potential of four Central and Eastern European countries (the Czech Republic, Hungary, Poland and Slovakia) to benefit from productivity spillovers from foreign direct investment (FDI) in the manufacturing sector. Such transfers of technology are one of the main benefits of FDI for the host country, and should also be one of the main determinants of FDI incentives offered to investing multinationals by governments, but they are difficult to assess ex ante. For our composite index, we use six components to proxy the main channels and determinants of these spillovers. We have tried several weighting and aggregation methods, and we consider our results robust. According to the analysis of our results, between 2003 and 2007 all four countries were able to increase their potential to benefit from such spillovers, although there are large differences between them. The Czech Republic clearly has the most potential to benefit from productivity spillovers, while Poland has the least. The relative positions of Hungary and Slovakia depend to some extent on the exact weighting and aggregation method of the individual components of the index, but the differences are not large. These conclusions have important implication both the investment strategies of multinationals and government FDI policies

Carboplatin- and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell lines.

The interaction between moderate-dose radiation and cisplatin or carboplatin was studied in a cisplatin-sensitive (GLC4) and -resistant (GLC4-CDDP) human small-cell lung cancer cell line. Cellular toxicity was analysed under oxic conditions with the microculture tetrazolium assay. For the platinum and radiation toxicity with the clinically relevant dose ranges applied, this assay was used to obtain information on cell survival after the treatments. Apart from effects on cell survival effects on DNA were also investigated. Configurational DNA changes could be induced by platinum drugs and thereby these drugs might change the frequency of DNA double-strand breaks (dsbs). DNA fragmentation assayed with the clamped homogeneous electric field (CHEF) technique was used as a measure for dsbs in DNA. The radiosensitising effect of the platinum drugs was expressed as enhancement ratio (ER) calculated directly from survival levels of the initial slope of the curve. The highest ER for cisplatin in GLC4 was 1.39 and in GLC4-CDDP 1.38. These were all at 75% cell survival. Carboplatin showed increased enhancement with prolonged incubation up to 1.21 in GLC4 and was equally effective as cisplatin in GLC4-CDDP. According to isobologram analysis, prolonged incubation with both platinum drugs showed at least additivity with radiation for both cell lines at clinically achievable doses. GLC4-CDDP showed cross-resistance to radiation. The radiosensitising capacity of both lung cancer cell lines was not dependent on their platinum sensitivity. The formation of dsbs in DNA directly after radiation was not influenced by pretreatment of either drug in the sensitive or in the resistant cell line. Drug treatment resulted in decreased DNA extractability in control as well as in irradiated cells. Modest enhancement ratio for radiosensitisation by platinum drugs cannot be explained on the level of dsb formation in DNA in both cell lines. Interaction of radiation with the clinically less toxic carboplatin can be improved by prolonged low-dose carboplatin exposure before irradiation and is as potent as cisplatin in the resistant lung cancer cell line. This suggests an advantage in combining radiation and carboplatin in lung cancer patients

Mechanism of hyperthermic potentiation of cisplatin action in cisplatin-sensitive and -resistant tumour cells.

In this study, the mechanism(s) by which heat increases cis-diamminedichloroplatinum (cisplatin, cDDP) sensitivity in cDDP-sensitive and -resistant cell lines of murine as well as human origin were investigated. Heating cells at 43 degrees C during cDDP exposure was found to increase drug accumulation significantly in the cDDP-resistant cell lines but had little effect on drug accumulation in the cDDP-sensitive cell lines. DNA adduct formation, however, was significantly increased in all cell lines studied. Furthermore, ongoing formation of platinum (Pt)-DNA adducts after the end of cDDP treatment was enhanced and/or adduct removal was decreased in heated cells, resulting in relatively more DNA damage remaining at 24 h after the end of cDDP exposure. Correlation plots with survival revealed weak correlations with cellular Pt accumulation (r2 = 0.59) and initial Pt-DNA adduct formation (r2 = 0.64). Strong correlations, however, were found with Pt-DNA adducts at 6 h (r2 = 0.97) and 24 h (r2 = 0.89) after the incubation with the drug. In conclusion, the mechanism by which heat sensitizes cells for cDDP action seems to be the sum of multiple factors, which comprise heat effects on accumulation, adduct formation and adduct processing. This mechanism did not seem to differ between cDDP-sensitive and -resistant cells, emphasizing the potential of hyperthermia to reduce cDDP resistance