Hygro-thermo-chemo-mechanical coupled discrete model for the self-healing in Ultra High Performance Concrete

Reliable durability predictions and design for advanced cement-based materials cannot disregard the modelling of their inherent self-healing capability. A discrete meso-scale model to simulate the recovery in water tightness, stiffness and strength induced by the (stimulated) autogenous healing of cracks for Ultra High Performance Concrete is presented. In this paper the model is implemented into the numerical framework of the Multiphysics-Lattice Discrete Particle Model (M-LDPM), resulting from the coupling of the Hygro-Thermo-Chemical (HTC) model and Lattice Discrete Particle Model (LDPM). Consistently with experimental evidence, the development of the self-repairing process is modelled as consisting of two independent stages: (a) the healing of matrix cracks, affecting both moisture permeability and fracture strength in the cracked state, and (b) the recovery in terms of fibre bridging action, relying on the adhesion between the healing products and the walls of the tunnel cracks which form during the fibre debonding process. This research activity is framed into the Horizon 2020 project ReSHEALience (GA 760824)

Numerical modelling via a coupled discrete approach of the autogenous healing for Fibre-Reinforced Cementitious Composites (FRCCs)

Aiming to predict long-term performance of advanced cement-based materials and design more durable structures, a reliable modelling of the autogenous healing of cementitious materials is crucial. A dis-crete model for the regain in terms of water tightness, stiffness and strength induced by the autogenous and/or “stimulate" autogenous healing was recently proposed for ordinary plain concrete. The modelling proposal stemmed from the coupling of two models, namely the Hygro-Thermo-Chemical (HTC) model, on one side,and the Lattice Discrete Particle Model (LDPM), on the other side, resulting in the Multiphysics-Lattice Discrete Particle Model (M-LDPM). Being this approach not customised only for ordinary concrete, but for the whole broad category of cementitious materials, in this paper, its application to Fibre-Reinforced Cementitious Composites is presented. To accurately simulate what has been experimentally observed so far, the mechanical model is updated to also include the self-healing of the tunnel cracks at the fibre-matrix interfaces. Therefore,the self-repairing process is modelled to develop on two independent stages: (a) matrix cracks healing, and(b) fibre bridging action restoring. This research activity is part of the modelling tasks framed into the project ReSHEALience, funded from the European Union’s Horizon 2020 Research and Innovation Programme

Prevalence of HBV-genotypes in immigrants affected by HBV-related chronic active hepatitis

BACKGROUND: The genetic heterogeneity of the HBV genome has been established and eight genotypes can be classified according to the criterion of >8% differences in the complete nucleotide sequence of the viral genome. AIMS: To evaluate the prevalence of HBV-infection in a population of immigrants and to determine in patients with detectable serum HBV-DNA the HBV-genotypes. METHODS: Between January 2005 and December 2005 a total of 556 immigrants were tested for HBsAg. In HBsAg positive patients the biochemical and virological activity of infection and the possible presence of co-infections (HCV, HDV, HIV) were evaluated. In patients with detectable serum HBV DNA, the HBV-genotype was determined by INNOLiPA. RESULTS: Among the 556 subjects tested, 60 (10.7%) resulted HBsAg positive. All were men, and 42 (70%) come from Africa, 10 (16.6%) from Asia and 9 (14.4%) from East-Europe. 28/60 (46.6%) patients presented normal ALT levels (<40 IU/L) and undetectable serum HBV DNA (<100 copies/mL in real-time PCR), while 32 (53.4%) patients had ALT levels above laboratory normal values and detectable serum HBV DNA. Genotype distribution was as follow: genotype E, 16 (50%), genotype D, 9 (28.1%), genotype A, 7 (21.9%). CONCLUSION: Our study evidences a moderate prevalence of HBV-infection in immigrants, particularly in sub-Saharan African people, and the potentiality of migratory flow in the introduction of genotype non-D hepatitis B virus, potentially characterized by a different natural history and, possibly, a different response to antiviral treatment

Heart rate variability reduction is related to a high amount of visceral adiposity in healthy young women

Several heart rate variability (HRV) studies show abnormalities in autonomic nervous control in obese and overweight subjects. However, some of the results appear to be controversial. Here we investigate the HRV profile in seventy adult normotensive women and its association with general and visceral adiposity. Specifically, we recorded the electrocardiographic (ECG) activity in subjects during a supine resting state for five minutes in a quiet room late in the morning. Total fat mass (TFM) and visceral adipose tissue (VAT) were instead estimated using dual-energy X-ray absorptiometry (DXA). Finally, we used simple a linear regression analysis of frequency and time-domain parameters to study the relationship between HRV and adiposity. Our data showed an overall reduction of the HRV related to an increase of TFM although this regression appeared significant only for high frequencies (HF). When the linear regression was applied between HRV variables and VAT, the slope of the line increases, thus unveiling a statistically significant relation (i.e. the more VAT, the lower HRV). Finally, a control analysis showed that age does not alter the relation between HRV and VAT when used as a confounding factor in multiple regression. To conclude, these findings point to abnormal activity of the autonomic nervous system (ANS) in subjects with an excess of VAT and represent a starting point to determine a non-invasive index of cardiac wellness for clinical and nutritional application

A comparative study on trichoderma harzianum and a combination of candida/bacillus as tools for the bioremediation of table olive processing water

A comparative study was performed on Trichoderma harzianum and a combination of Candida boidinii/Bacillus pumilus to reduce the polluting effect of TOPW (Table Olive Processing Water) from the Spanish style. A 2k fractional design was used to study the effect of pH (6–11 for the fungus and 6–9 for Candida/Bacillus), temperature (10–35◦C) and duration (7–14 days for Candida/Bacillus and 14–21 days for T. harzianum), and the effect on phenol reduction, COD and color was evaluated. The experiments were also performed on diluted TOPW (dilution ratio 1:1). Generally, Trichoderma removed higher amounts of phenols and reduced COD more than the combination Candida/Bacillus, thus confirming the higher efficiency of filamentous fungi reported in the literature. The dilution of TOPW had an effect only on COD reduction; however, the effect was mild, at least for T. harzianum (4%), while yield increase was 9% for Bacillus/Candida. pH acted in a different way on phenol removal and COD reduction; an increase of pH caused a reduction of efficiency for COD, while the effect was positive for phenols

Prospectus, August 28, 1989

https://spark.parkland.edu/prospectus_1989/1017/thumbnail.jp

Effects of mixed of a ketogenic diet in overweight and obese women with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a commonly occurring endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Often comorbid with insulin resistance, dyslipidemia, and obesity, it also carries significant risk for the development of cardiovascular and metabolic sequelae, including diabetes and metabolic syndrome. The relationship between central obesity and the development of insulin resistance is widely verified. Adipose tissue excess and the coexistent dysregulation of adipocyte functions directly contribute to the pathogenesis of the metabolic complications observed in women with PCOS. In the light of these evidence, the most therapeutic option prescribed to obese women with PCOS, regardless of the phenotype e from the severity of clinical expression, is lifestyle correction by diet and physical activity. The aim of this study is to evaluate the beneficial effects of ketogenic diet in 17 obese women with PCOS. Our results showed that the ketogenic diet inducing therapeutic ketosis, improves the anthropometric and many biochemical parameters such as LH, FSH, SHBG, insulin sensitivity and HOMA index. In addition, it induces a reduction in androgenic production, whereas the contextual reduction of fat mass reduced the acyclic production of estrogens deriving from the aromatization in the adipose tissue of the androgenic excess, with an improvement of the LH/FSH ratio. This is the first study on the effects of the ketogenic diet on PCOS, however, further studies are needed to elucidate the mechanism underlying ketogenic diet effects

Prospectus, February 28, 1990

https://spark.parkland.edu/prospectus_1990/1006/thumbnail.jp

Prospectus, January 16, 1990

https://spark.parkland.edu/prospectus_1990/1000/thumbnail.jp