1,268 research outputs found
Different mechanics of snap-trapping in the two closely related carnivorous plants Dionaea muscipula and Aldrovanda vesiculosa
The carnivorous aquatic Waterwheel Plant (Aldrovanda vesiculosa L.) and the
closely related terrestrial Venus Flytrap (Dionaea muscipula SOL. EX J. ELLIS)
both feature elaborate snap-traps, which shut after reception of an external
mechanical stimulus by prey animals. Traditionally, Aldrovanda is considered as
a miniature, aquatic Dionaea, an assumption which was already established by
Charles Darwin. However, videos of snapping traps from both species suggest
completely different closure mechanisms. Indeed, the well-described snapping
mechanism in Dionaea comprises abrupt curvature inversion of the two trap
lobes, while the closing movement in Aldrovanda involves deformation of the
trap midrib but not of the lobes, which do not change curvature. In this paper,
we present the first detailed mechanical models for these plants, which are
based on the theory of thin solid membranes and explain this difference by
showing that the fast snapping of Aldrovanda is due to kinematic amplification
of the bending deformation of the midrib, while that of Dionaea unambiguously
relies on the buckling instability that affects the two lobes.Comment: accepted in Physical Review
Intestinal epithelial cell-intrinsic deletion of Setd7 identifies role for developmental pathways in immunity to helminth infection
The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems. Lysine methyltransferases are part of a family of novel attractive targets for drug discovery. SETD7 is a member of the Suppressor of variegation 3-9-Enhancer of zeste-Trithorax (SET) domain-containing family of lysine methyltransferases, and has been shown to methylate and alter the function of a wide variety of proteins in vitro. A few of these putative methylation targets have been shown to be important in resistance against pathogens. We therefore sought to study the role of SETD7 during parasitic infections. We find that Setd7-/- mice display increased resistance to infection with the helminth Trichuris muris but not Heligmosomoides polygyrus bakeri. Resistance to T. muris relies on an appropriate type 2 immune response that in turn prompts intestinal epithelial cells (IECs) to alter differentiation and proliferation kinetics. Here we show that SETD7 does not affect immune cell responses during infection. Instead, we found that IEC-specific deletion of Setd7 renders mice resistant to T. muris by controlling IEC turnover, an important aspect of anti-helminth immune responses. We further show that SETD7 controls IEC turnover by modulating developmental signaling pathways such as Hippo/YAP and Wnt/β-Catenin. We show that the Hippo pathway specifically is relevant during T. muris infection as verteporfin (a YAP inhibitor) treated mice became susceptible to T. muris. We conclude that SETD7 plays an important role in IEC biology during infection
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Emiritus hoogleraar Bestuurskunde aan de Rijksuniversiteit Leiden en beschermheer van de BI
Disaster displacement and zoonotic disease dynamics: The impact of structural and chronic drivers in Sindh, Pakistan
Projected increases in human and animal displacement driven by climate change, disasters and related environmental degradation will have significant implications to global health. Pathways for infectious disease transmission including zoonoses, diseases transmitted between animals and humans, are complex and non-linear. While forced migration is considered an important driver for the spread of zoonoses, actual disease dynamics remain under researched. This paper presents the findings of a case study investigating how disaster displacement affected zoonotic disease transmission risk following the 2010 ‘superfloods’ in Sindh province, Pakistan. We interviewed 30 key informants and 17 household members across 6 rural communities between March and November 2019, supported by observational studies and a review of secondary data. Results were analysed using the ecosocial theoretical framework. Buffalo, cattle and goats were often the only moveable asset, therefore livestock was an important consideration in determining displacement modality and destination location, and crowded locations were avoided to protect human and animal health. Meanwhile however, livestock was rarely included in the humanitarian response, resulting in communities and households fragmenting according to the availability of livestock provisions. We found that rather than a driver for disease, displacement acted as a process affecting community, household and individual zoonotic disease risk dynamics, based on available resources and social networks before, during and after displacement, rooted in the historical, political and socio-economic context. We conclude that in rural Sindh, disaster displaced populations’ risk of zoonoses is the result of changes in dynamics rooted in pre-existing structural and chronic inequalities, making people more or less vulnerable to disease through multiple interlinked pathways. Our findings have implications for policy makers and humanitarian responders assisting displaced populations dependent on livestock, with a call to integrate livestock support in humanitarian policies and responses for health, survival and recovery
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