SYNTHESIS, ELECTROCHEMICAL AND HETEROGENEOUS ELECTROCATALYTIC BEHAVIORS OF A NOVEL NON SYMMETRICAL COPPER(II) COMPLEX

We describe in this paper the synthesis of new unsymmetrical tetradentate copper(II) Schiff base complex, prepared from tridentate Schiff base ligand (HL) and pyridine molecule. This new copper complex was identified by various physicochemical characteristics such as elemental analysis (EA), FT-IR, UV-Vis, XPS analysis and thermogravimetry (TG/DTG). The electrochemical behavior of the copper(II) complex was investigated by cyclic voltammetry in N,N-dimethylformamide (DMF). These experiments have been allowed to obtain new conducting polymeric films, prepared by successive cycling at the suitable potentials. These polymeric films containing metallic centers were studied to evaluate their electrocatalytical performances in which copper (II) ions were used as electrocatalysts in the heterogeneous conditions for the electroreduction of 1,4-dibromobutane

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are poorly understood. Here, we utilized available gene expression data sets of selected brain regions of HD patients and controls for systematic interaction network filtering in order to predict disease-relevant, brain region-specific HTT interaction partners. Starting from a large protein-protein interaction (PPI) data set, a step-by-step computational filtering strategy facilitated the generation of a focused PPI network that directly or indirectly connects 13 proteins potentially dysregulated in HD with the disease protein HTT. This network enabled the discovery of the neuron-specific protein CRMP1 that targets aggregation-prone, N-terminal HTT fragments and suppresses their spontaneous self-assembly into proteotoxic structures in various models of HD. Experimental validation indicates that our network filtering procedure provides a simple but powerful strategy to identify disease-relevant proteins that influence misfolding and aggregation of polyQ disease proteins.DFG [SFB740, 740/2-11, SFB618, 618/3-09, SFB/TRR43 A7]; BMBF(NGFN-Plus) [01GS08169-73, 01GS08150, 01GS08108]; HDSA Coalition for the Cure; EU (EuroSpin) [Health-F2-2009-241498, HEALTH-F2-2009-242167]; Helmholtz Association (MSBN, HelMA) [HA-215]; FCT [IF/00881/2013]info:eu-repo/semantics/publishedVersio

QUBIC: The QU Bolometric Interferometer for Cosmology

One of the major challenges of modern cosmology is the detection of B-mode polarization anisotropies in the CMB. These originate from tensor fluctuations of the metric produced during the inflationary phase. Their detection would therefore constitute a major step towards understanding the primordial Universe. The expected level of these anisotropies is however so small that it requires a new generation of instruments with high sensitivity and extremely good control of systematic effects. We propose the QUBIC instrument based on the novel concept of bolometric interferometry, bringing together the sensitivity advantages of bolometric detectors with the systematics effects advantages of interferometry. Methods: The instrument will directly observe the sky through an array of entry horns whose signals will be combined together using an optical combiner. The whole set-up is located inside a cryostat. Polarization modulation will be achieved using a rotating half-wave plate and interference fringes will be imaged on two focal planes (separated by a polarizing grid) tiled with bolometers. We show that QUBIC can be considered as a synthetic imager, exactly similar to a usual imager but with a synthesized beam formed by the array of entry horns. Scanning the sky provides an additional modulation of the signal and improve the sky coverage shape. The usual techniques of map-making and power spectrum estimation can then be applied. We show that the sensitivity of such an instrument is comparable with that of an imager with the same number of horns. We anticipate a low level of beam-related systematics thanks to the fact that the synthesized beam is determined by the location of the primary horns. Other systematics should be under good control thanks to an autocalibration technique, specific to our concept, that will permit the accurate determination of most of the systematics parameters.Comment: 12 pages, 10 figures, submitted to Astronomy and Astrophysic

QUBIC: The QU Bolometric Interferometer for Cosmology

Context. One of the major challenges of modern cosmology is the detection of B-mode polarization anisotropies in the Cosmic Microwave Background. These originate from tensor fluctuations of the metric produced during the inflationary phase. Their detection would therefore constitute a major step towards understanding the primordial Universe. The expected level of these anisotropies is however so small that it requires a new generation of instruments with high sensitivity and extremely good control of systematic eects. Aims. We propose the QUBIC instrument based on the novel concept of bolometric interferometry, bringing together the sensitivity advantages of bolometric detectors with the systematics eects advantages of interferometry. Methods. The instrument will directly observe the sky through an array of entry horns whose signals will be combined together using an optical combiner. The whole set-up is located inside a cryostat. Polarization modulation will be achieved using a rotating half-wave plate and the images of the interference fringes will be formed on two focal planes (separated by a polarizing grid) tiled with bolometers. Results.We show that QUBIC can be considered as a synthetic imager, exactly similar to a usual imager but with a synthesized beam formed by the array of entry horns. Scanning the sky provides an additional modulation of the signal and improve the sky coverage shape. The usual techniques of map-making and power spectrum estimation can then be applied. We show that the sensitivity of such an instrument is comparable with that of an imager with the same number of horns. We anticipate a low level of beam-related systematics thanks to the fact that the synthesized beam is determined by the location of the primary horns. Other systematics should be under good control thanks to an autocalibration technique, specific to our concept, that will permit the accurate determination of most of the systematics parameters

QUBIC: the Q&U Bolometric Interferometer for Cosmology

The primordial B-mode polarisation of the Cosmic Microwave Background is the imprints of the gravitational wave background generated by inflation. Observing the B-mode is up to now the most direct way to constrain the physics of the primordial Universe, especially inflation. To detect these B-modes, high sensitivity is required as well as an exquisite control of systematics effects. To comply with these requirements, we propose a new instrument called QUBIC (Q and U Bolometric Interferometer for Cosmology) based on bolometric interferometry. The control of systematics is obtained with a close-packed interferometer while bolometers cooled to very low temperature allow for high sensitivity. We present the architecture of this new instrument, the status of the project and the self-calibration technique which allows accurate measurement of the instrumental systematic effects

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Effect of the Synthesis Route on the Structural, Morphological and Dielectric Properties of Bi4 (Ni2/3,Ta1/3)0.08Ti2.92O12 Aurivillius Phases

The effect of 8% of (Ni2+, Ta5+) content and the route of synthesis (i.e., conventional solid state reaction « CSS » and molten salt method « MS ») on micro-structural, morphological and dielectric properties of BIT ceramics have been investigated. X-ray diffraction (XRD) analysis revealed that the (Ni,Ta)- modified BIT ceramics have a pure orthorhombic three-layer Aurivillius type structure. Phase purity is obtained at 950°C by CSS reaction and by the MS method at 850°C. SEM/ EDX results confirms that the samples have a relatively dense pure, with micro-grains plate-like, structure typical for Aurivillius layered structures but strongly influenced by the crystallite size of both methods. The dielectric constant and the tangent loss of 8%-BNTT have been found to be decreasing by shifting the curie temperature to a high temperature, when we change the reaction from CSS to MS

Evaluation de l’efficacité de la kaolinite pour l’élimination des ions Cr(VI) et Cr(III) seuls et mélanges

National audienc

Reconciling image captioning and user’s comments for urban tourism

Abstract Image captioning as a process of assigning textual description to an image has gained momentum nowadays thanks to recent advances in deep learning related architectures and availability of associated tools. In the era of digital tourism, this offers a valuable framework to reconcile the widely available tourism images and user’s generated content. This paper presents a novel approach to perform such reconciliation in a way to benefit tourism industry. Especially, IMGUR online image sharing services has been employed to construct a novel database, referred Tourism48, which contains gallery tourism images from 48 countries together with their associated user’s comments. Google Cloud Vision API has been employed to perform image captioning of the underlined images, while similarity analysis has been employed to match user’s comments to the obtained captioning results. The outcomes can trigger the development of subsequent policy research in tourism industry and behavior analysis. Besides, the Tourism48 dataset has been made available for research community.

Evaluation de l’efficacité de la kaolinite pour l’élimination des ions Cr(VI) et Cr(III) seuls et mélanges

National audienc