Hydrous hydrazine decomposition for hydrogen production using of ir/ceo2: Effect of reaction parameters on the activity

In the present work, an Ir/CeO2 catalyst was prepared by the deposition–precipitation method and tested in the decomposition of hydrazine hydrate to hydrogen, which is very important in the development of hydrogen storage materials for fuel cells. The catalyst was characterised using different techniques, i.e., X‐ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), scanning electron microscopy (SEM) equipped with X‐ray detector (EDX) and inductively coupled plasma—mass spectroscopy (ICP‐MS). The effect of reaction conditions on the activity and selectivity of the material was evaluated in this study, modifying parameters such as temperature, the mass of the catalyst, stirring speed and concentration of base in order to find the optimal conditions of reaction, which allow performing the test in a kinetically limited regime

Immunogenicity comparison of interferon beta-1a preparations using the BALB/c mouse model: assessment of a new formulation for use in multiple sclerosis

The in vivo immunogenicity of a new interferon (IFN) beta-1a product (Rebif New Formulation; RNF) was compared with that of two approved recombinant human IFN beta-1a products (Rebif and Avonex). Immunogenic potential was assessed based on time to development of neutralizing antibodies (NAbs) and NAb titer. Female BALB/c mice (six in each group) received RNF, Rebif or Avonex (1.0 microg/mL subcutaneously three times weekly), and serum samples collected on Days 7, 21, and 35 (Study 1), or 28, 42, 49, and 60 (Study 2) were assayed for NAbs. In Study 1, no mice had NAbs at Day 7, but by Day 21 one mouse in the RNF group had NAbs, compared with three and four mice in the Rebif and Avonex groups, respectively. Results were similar in Study 2. All control mice were NAb negative; all actively treated mice had NAbs by day 35 or 42. Throughout Study 1, NAb titers were lowest in the RNF group and highest in the Avonex group, and at day 35, NAb titers were significantly lower in the RNF group than the Rebif group (p = 0.037). Results indicate that, on a gram-for-gram basis, RNF appears less immunogenic than Rebif or Avonex

The Outcome of Cholangitis After Percutaneous Biliary Drainage in Neoplastic Jaundice

The purpose of this paper is to evaluate factors affecting the outcome of cholangitis after PTBD in jaundiced cancer patients. Twenty nine patients with neoplastic jaundice (male/female ratio 13/16, median age 55 years) with full clinical data, were treated by PTBD and developed cholangitis at a median of 9 days later. Four patients (14%) died of biliary sepsis a median of one month after PTBD while the other 25 survived a median of 6 months, with one week median duration of cholangitis. The probability of the cholangitis resolving was analyzed by time to resolution and it was found that 50% and 100% of the recoveries occurred 5 and 9 months respectively from the onset of the complication

Long-term outcomes of a pilot CT screening for lung cancer

Background: Low-dose computed tomography (CT) screening can detect early stage lung cancer in high-risk populations. However, no data on repeated annual screening over more than 5 years are available, and the impact of screening on lung cancer mortality is controversial. Methods: We analysed outcomes in high-risk asymptomatic volunteers (smokers and former smokers, >50 years) enrolled in a pilot study over 1 year from June 2000, who received annual low-dose CT for 7 years. Cumulative lung cancer incidence and survival were represented by Kaplan 12Meier curves. Standardized incidence and mortality ratios were used to estimate risks relative to the general Italian and US population. Results: Compliance was 86% at the end of the seventh year in 1035 recruited volunteers (71% men, mean age 58 years). Lung cancer was diagnosed in 54 (5.3%); radical surgery was possible in 48/54 (87%); 39/54 (72%) had stage I disease. Five-year survival was 63% overall, 89% for stage I cases. During 6308 person-years of observation, 47 participants had died versus 75 expected in the Italian general population standardised for age and sex. Fourteen lung cancer deaths were registered versus 27 expected in a standardised US smoker population. Conclusions: Seventy percent of screening-diagnosed patients had stage I disease, and the survival of screen-detected cancer patients was high. Lung cancer mortality was favourable compared to age- and sex-matched population of US smokers, suggesting that mortality can be lowered by screening, although larger trials with longer follow-up are necessary to confirm these findings

The multiphase and magnetized neutral hydrogen seen by LOFAR

Faraday tomography of polarimetric observations at low frequency in the radio is a unique tool for studying the structure of the magneto-ionic diffuse interstellar medium (ISM) based on Faraday depth. LOFAR data below 200 MHz have revealed a plethora of features in polarization, whose origin remains unknown. Previous studies have highlighted the remarkable association of such features with tracers of the magnetized-neutral ISM, such as interstellar dust and atomic hydrogen (HI). However, the physical conditions responsible for the correlation between magneto-ionic and neutral media have not been clarified yet. In this Letter we further investigate the correlation between LOFAR data and the HI spectroscopic observations at 21 cm from the Effelsberg-Bonn HI Survey (EBHIS). We focus on the multiphase properties of the HI gas. We present the first statistical study on the morphological correlation between LOFAR tomographic data and the cold (CNM), lukewarm (LNM), and warm (WNM) neutral medium HI phases. We use the Regularized Optimization for Hyper-Spectral Analysis approach to decompose the HI phases based on a Gaussian decomposition of the HI spectra. We study four fields of view - Fields 3C196, A, B, and C - and find, in at least the first two, a significant correlation between the LOFAR and EBHIS data using the histograms of oriented gradients (HOG) feature. The absence of a correlation in Fields B and C is caused by a low signal-to- noise ratio in polarization. The observed HOG correlation in Fields 3C196 and A is associated with all HI phases and it is surprisingly dominant in the CNM and LNM phases. We discuss possible mechanisms that would explain the correlation between CNM, LNM, and WNM with polarized emission at Faraday depths up to 10 rad m-2. Our results show how the complex structure of the ionic medium seen by the LOFAR tomographic data is tightly related to phase transition in the diffuse and magnetized neutral ISM traced by HI spectroscopic data

ICM-SHOX. Paper I: Methodology overview and discovery of a baryon--dark matter velocity decoupling in the MACS J0018.5+1626 merger

Galaxy cluster mergers are rich sources of information to test cluster astrophysics and cosmology. However, cluster mergers produce complex projected signals that are difficult to interpret physically from individual observational probes. Multi-probe constraints on both the baryonic and dark matter cluster components are necessary to infer merger parameters that are otherwise degenerate. We present ICM-SHOX (Improved Constraints on Mergers with SZ, Hydrodynamical simulations, Optical, and X-ray), a systematic framework to jointly infer multiple merger parameters quantitatively via a pipeline that directly compares a novel combination of multi-probe observables to mock observables derived from hydrodynamical simulations. We report on a first application of the ICM-SHOX pipeline to the MACS J0018.5+1626 system, wherein we systematically examine simulated snapshots characterized by a wide range of initial parameters to constrain the MACS J0018.5+1626 merger parameters. We strongly constrain the observed epoch of MACS J0018.5+1626 to within $\approx -10$--$50$ Myr of the pericenter passage, and the observed viewing angle is inclined $\approx 25$--$38$ degrees from the merger axis. We obtain less precise constraints for the impact parameter ($\approx 100$--250 kpc), the mass ratio ($\approx 1.5$--$3.0$), and the initial relative velocity when the cluster components are separated by 3 Mpc ($\approx 1700$--3000 km s$^{-1}$). The primary and secondary cluster components initially (at 3 Mpc) have gas distributions that are moderately and strongly disturbed, respectively. We further discover a velocity space decoupling of the dark matter and baryonic distributions in MACS J0018.5+1626, which we attribute to the different collisional natures of the two distributions.Comment: 25 pages, 13 figures; submitted to Ap

Perfusion CT is a valuable diagnostic method for prostate cancer: a prospective study of 94 patients

Purpose: The aim of this study is to assess the usefulness of perfusion computer tomography (pCT) in prostate cancer (PCa) diagnostics. Copyright:Materials and Methods: 94 patients with biopsy-proven PCa were enrolled in the study. Dynamic pCT of the prostate gland was performed for 50 seconds after an intravenous injection of contrast medium. Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were computed in the suspected PCa area and in normal prostatic tissue.Results: PCa was visible in pCT in 90 of the 94 examined patients as a focal peripheral CT enhancement. When PCa was located in the peripheral zone (PZ), it was visible on perfusion maps, mostly showing an early peak followed by wash-out. The average values of all perfusion parameters were higher for tumour than for normal prostate tissue (p 7). In high-grade PCa, the mean BF value was significantly higher (p = 0.001) than the mean value of BF low- and medium-grade PCa (p = 0.011). Similar results were obtained regarding the mean values of BV; the more aggressive the cancer grade, the higher the mean BV value (p = 0.04).Conclusion: CT quantitative perfusion imaging allows PCa to be distinguished from normal prostate tissue. The highest values for BF and BV were observed in the most aggressive PCa grade

Immunogenicity of Therapeutic Proteins: The Use of Animal Models

Immunogenicity of therapeutic proteins lowers patient well-being and drastically increases therapeutic costs. Preventing immunogenicity is an important issue to consider when developing novel therapeutic proteins and applying them in the clinic. Animal models are increasingly used to study immunogenicity of therapeutic proteins. They are employed as predictive tools to assess different aspects of immunogenicity during drug development and have become vital in studying the mechanisms underlying immunogenicity of therapeutic proteins. However, the use of animal models needs critical evaluation. Because of species differences, predictive value of such models is limited, and mechanistic studies can be restricted. This review addresses the suitability of animal models for immunogenicity prediction and summarizes the insights in immunogenicity that they have given so far

Serum microrna biomarkers for detection of non-small cell lung cancer

Non small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality world-wide and the majority of cases are diagnosed at late stages of disease. There is currently no cost-effective screening test for NSCLC, and the development of such a test is a public health imperative. Recent studies have suggested that chest computed tomography screening of patients at high risk of lung cancer can increase survival from disease, however, the cost effectiveness of such screening has not been established. In this Phase I/II biomarker study we examined the feasibility of using serum miRNA as biomarkers of NSCLC using RT-qPCR to examine the expression of 180 miRNAs in sera from 30 treatment naive NSCLC patients and 20 healthy controls. Receiver operating characteristic curves (ROC) and area under the curve were used to identify differentially expressed miRNA pairs that could distinguish NSCLC from healthy controls. Selected miRNA candidates were further validated in sera from an additional 55 NSCLC patients and 75 healthy controls. Examination of miRNA expression levels in serum from a multi-institutional cohort of 50 subjects (30 NSCLC patients and 20 healthy controls) identified differentially expressed miRNAs. A combination of two differentially expressed miRNAs miR-15b and miR-27b, was able to discriminate NSCLC from healthy controls with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100% in the training set. Upon further testing on additional 130 subjects (55 NSCLC and 75 healthy controls), this miRNA pair predicted NSCLC with a specificity of 84% (95% CI 0.73-0.91), sensitivity of 100% (95% CI; 0.93-1.0), NPV of 100%, and PPV of 82%. These data provide evidence that serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of NSCLC. Further testing in a Phase III biomarker study in is necessary for validation of these results. © 2012 Hennessey et al