76 research outputs found
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers
Aryl hydrocarbon receptor (AHR) is the key transcription factor that controls animal development and various adaptive processes. The AHR\u27s target genes are involved in biodegradation of endogenous and exogenous toxins, regulation of immune response, organogenesis, and neurogenesis. Ligand binding is important for the activation of the AHR signaling pathway. Invertebrate AHR homologs are activated by endogenous ligands whereas vertebrate AHR can be activated by both endogenous and exogenous ligands (xenobiotics). Several studies using mammalian cultured cells have demonstrated that transcription of the AHR target genes can be activated by exogenous AHR ligands, but little is known about the effects of AHR in a living organism. Here, we examined the effects of human AHR and its ligands using transgenic Drosophila lines with an inducible human AhR gene. We found that exogenous AHR ligands can increase as well as decrease the transcription levels of the AHR target genes, including genes that control proliferation, motility, polarization, and programmed cell death. This suggests that AHR activation may affect the expression of gene networks that could be critical for cancer progression and metastasis. Importantly, we found that AHR target genes are also controlled by the enzymes that modify chromatin structure, in particular components of the epigenetic Polycomb Repressive complexes 1 and 2. Since exogenous AHR ligands (alternatively - xenobiotics) and small molecule inhibitors of epigenetic modifiers are often used as pharmaceutical anticancer drugs, our findings may have significant implications in designing new combinations of therapeutic treatments for oncological diseases. Β© Akishina et al
All-Russian Physical and Sports Complex "Ready for Work and Defense" as a Way to Improve Student Youth Health
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ Β«ΠΠΎΡΠΎΠ² ΠΊ ΡΡΡΠ΄Ρ ΠΈ ΠΎΠ±ΠΎΡΠΎΠ½Π΅Β» ΠΊΠ°ΠΊ ΠΎΠ΄ΠΈΠ½ ΠΈΠ· ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠ°ΡΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠΏΠΎΡΡΠ° Π² ΡΠ΅Π»ΠΎΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈΠ²Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΡΡΠ΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ ΠΊ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΠ΅, Π·Π΄ΠΎΡΠΎΠ²ΠΎΠΌΡ ΠΎΠ±ΡΠ°Π·Ρ ΠΆΠΈΠ·Π½ΠΈ
Π₯ΠΈΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π°Π·ΠΎΡΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠΌΠΈ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»Π°ΠΌΠΈ
Heterocyclic compounds have an extremely important practical application, since many heterocycles are the basis of the most valuable medicinal substances, both natural (vitamins, enzymes, alkaloids, etc.) and synthetic biologically active compounds. The work mainly considers the most relevant directions for various purposes drugs search by modifying known bioactive natural, organoelement and framework compounds with 1,2-azole, oxazole, oxadiazole, thiazole, triazole, pyridine, pyrimidine heterocycles over the past 10 years. Chemical modification makes it possible to increase the water solubility of the compounds, which is important when choosing the pathways for the most rational drug introduction into the body, to reduce the toxicity of the corresponding substances, to increase the breadth of the therapeutic action, and also to give new valuable medicinal properties, thus significantly expanding their application in medicine and agriculture.Π‘ΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ΄Π° ΠΈΠΌΠ΅ΡΡ ΠΈΡΠΊΠ»ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²Π°ΠΆΠ½ΠΎΠ΅ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅, ΡΠ°ΠΊ ΠΊΠ°ΠΊ ΠΌΠ½ΠΎΠ³ΠΈΠ΅ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»Ρ Π»Π΅ΠΆΠ°Ρ Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ» ΡΠ΅Π½Π½Π΅ΠΉΡΠΈΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΊΠ°ΠΊ ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ
(Π²ΠΈΡΠ°ΠΌΠΈΠ½Ρ, ΡΠ΅ΡΠΌΠ΅Π½ΡΡ, Π°Π»ΠΊΠ°Π»ΠΎΠΈΠ΄Ρ ΠΈ Π΄Ρ.), ΡΠ°ΠΊ ΠΈ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. Π ΡΠ°Π±ΠΎΡΠ΅ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π·Π° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ 10 Π»Π΅Ρ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΏΠΎΠΈΡΠΊΠ° Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠ³ΠΎ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΏΡΡΠ΅ΠΌ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
Π±ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ
, ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΊΠ°ΡΠΊΠ°ΡΠ½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ 1,2-Π°Π·ΠΎΠ»ΡΠ½ΡΠΌ, ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ½ΡΠΌ, ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»ΡΠ½ΡΠΌ, ΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΡΠΌ, ΡΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΡΠΌ, ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΡΠΌ, ΠΏΠΈΡΠΈΠΌΠΈΠ΄ΠΈΠ½ΠΎΠ²ΡΠΌ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»Π°ΠΌΠΈ. Π₯ΠΈΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠ²ΡΡΠΈΡΡ Π²ΠΎΠ΄ΠΎΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΡΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΆΠ½ΡΠΌ ΠΏΡΠΈ Π²ΡΠ±ΠΎΡΠ΅ ΠΏΡΡΠ΅ΠΉ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ, ΡΠΌΠ΅Π½ΡΡΠΈΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
Π²Π΅ΡΠ΅ΡΡΠ², ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΠΈΡΠΎΡΡ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈΠ΄Π°ΡΡ Π²Π΅ΡΠ΅ΡΡΠ²Π°ΠΌ Π½ΠΎΠ²ΡΠ΅ ΡΠ΅Π½Π½ΡΠ΅ Π»Π΅ΡΠ΅Π±Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π°, ΡΡΠΎ ΡΠ°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅ΡΠ΅ ΡΠ°ΡΡΠΈΡΠΈΡΡ ΠΈΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅ ΠΈ ΡΠ΅Π»ΡΡΠΊΠΎΠΌ Ρ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅
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Challenges in QCD matter physics --The scientific programme of the Compressed Baryonic Matter experiment at FAIR
Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sNN= 2.7--4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (ΞΌB> 500 MeV), effects of chiral symmetry, and the equation of state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2024, in the context of the worldwide efforts to explore high-density QCD matter
ΠΠΠΠΠΠΠΠΠΠΠΠΠΠ’ΠΠ«Π Π‘ΠΠ‘Π’ΠΠΠ« Π‘ Π’Π ΠΠ₯Π€ΠΠΠΠ«Π Π ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ
A review of scientific publications that describe systems with a three-phase splitting region is presented. Mechanisms of a three-phase splitting region formation are shown. All the suggested classifications of diagrams with a three-phase splitting region are presented. Methods for studying the evolution of a three-phase splitting region are described. Problems connected with the mathematical modeling of liquid - liquid - liquid equilibrium are considered. The ability of mixtures to form three-phase splitting regions and opportunities of separating such mixtures by special methods is analyzed. A list of known systems with three and more liquid phases is presented.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΎΠ±Π·ΠΎΡ Π½Π°ΡΡΠ½ΡΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌ Ρ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΡΠΌ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ, ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠ»Π°ΡΡΠΎΠ². Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΏΡΠΈΠΌΠ΅ΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ Π΄ΠΈΠ°Π³ΡΠ°ΠΌΠΌ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ ΠΌΠ½ΠΎΠ³ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΈ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ. Π’Π°ΠΊΠΆΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠΈΡ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ-ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ-ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠΌΠ΅ΡΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²ΡΠ²Π°ΡΡ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΌΠ΅ΡΠ΅ΠΉ ΡΠΊΡΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ, ΡΠΎΡΠ΅ΡΠ°ΡΡΠΈΠΌΠΈ ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈ ΡΠ°ΡΡΠ»Π°ΠΈΠ²Π°Π½ΠΈΠ΅. ΠΡΠΈΠ²Π΅Π΄Π΅Π½ ΡΠΏΠΈΡΠΎΠΊ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΡΠΈΡΡΠ΅ΠΌ Ρ ΡΡΠ΅ΠΌΡ ΠΈ Π±ΠΎΠ»Π΅Π΅ ΠΆΠΈΠ΄ΠΊΠΈΠΌΠΈ ΡΠ°Π·Π°ΠΌΠΈ
Π‘ΠΈΠ½ΡΠ΅Π· ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ ΡΠ»ΠΎΠΆΠ½ΡΡ ΡΡΠΈΡΠΎΠ² Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ
Nicotinic (3-pyridinecarboxylic) acid is one of the most important vitamins as well as substance with versatile physiological activity, since it plays significant role in the human organism. Nicotinic acid (niacin, vitamin PP, vitamin B3) is widely used in medicine as drug which has a vasodilating effect, prevents the accumulation of cholesterol and normalizes the heart function. Isonicotinic (4-pyridinecarboxylic) acid is used for the production of valuable anti-tuberculosis drugs, antidepressants, etc. However, nicotinic and isonicotinic acids have various side effects: skin hyperemia, pruritus, formation of stomach peptic ulcers, liver dysfunction and hyperglycemia. To reduce the severity of side effects, their slightly soluble salts, esters or amides are obtained. The synthesis of nicotinic and isonicotinic acid esters with vanillin benzaldehydes, cholesterol, 8-hydroxyquinoline, quinine and (4,5-dichloroisothiazol-3-yl)methanol is described. Esters were obtained by acylation of hydroxybenzaldehydes and alcohols with nicotinic and isonicotinic acid hydrochlorides in the presence of triethylamine in anhydrous methylene chloride. The IR- UV- and NMR spectra of the compounds obtained are presented.ΠΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΠΈΠ³ΡΠ°Π΅Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΡΠΎΠ»Ρ Π² ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°; ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΡΡΡ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅, Π° ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π½Π° Π΅Π΅ ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΡΠΎΡΡΠ΄ΠΎΡΠ°ΡΡΠΈΡΡΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅, ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°ΡΡ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π°, Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ΅ΡΠ΄ΡΠ°. ΠΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΡΡ (4-ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ) ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΡΡΡ Π΄Π»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π²Π΅ΡΡΠΌΠ° ΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ΄Π΅ΠΏΡΠ΅ΡΡΠ°Π½ΡΠΎΠ² ΠΈ Π΄Ρ. ΠΠ΄Π½Π°ΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°ΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ: Π³ΠΈΠΏΠ΅ΡΠ΅ΠΌΠΈΡ ΠΊΠΎΠΆΠΈ, Π·ΡΠ΄, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ·Π² ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ, Π³ΠΈΠΏΠ΅ΡΠ³Π»ΠΈΠΊΠ΅ΠΌΠΈΡ. ΠΠ»Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎΠ±ΠΎΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΡΡΡΡ ΠΈΡ
ΠΌΠ°Π»ΠΎΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΡΠ΅ ΡΠΎΠ»ΠΈ, ΡΡΠΈΡΡ, Π°ΠΌΠΈΠ΄Ρ. ΠΠΏΠΈΡΠ°Π½ ΡΠΈΠ½ΡΠ΅Π· ΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΡΠΈΡΠΎΠ² Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ Ρ Π±Π΅Π½Π·Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π°ΠΌΠΈ Π²Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ΄Π°, Π° ΡΠ°ΠΊΠΆΠ΅ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½ΠΎΠΌ, 8-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΡ
ΠΈΠ½ΠΎΠ»ΠΈΠ½ΠΎΠΌ, Ρ
ΠΈΠ½ΠΈΠ½ΠΎΠΌ ΠΈ (4,5-Π΄ΠΈΡ
Π»ΠΎΡΠΈΠ·ΠΎΡΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»)ΠΌΠ΅ΡΠ°Π½ΠΎΠ»ΠΎΠΌ. Π‘Π»ΠΎΠΆΠ½ΡΠ΅ ΡΡΠΈΡΡ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠΈΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ±Π΅Π½Π·Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄ΠΎΠ² ΠΈ ΡΠΏΠΈΡΡΠΎΠ² Π³ΠΈΠ΄ΡΠΎΡ
Π»ΠΎΡΠΈΠ΄Π°ΠΌΠΈ Ρ
Π»ΠΎΡΠ°Π½Π³ΠΈΠ΄ΡΠΈΠ΄ΠΎΠ² Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ·ΠΎΠ½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΡΠΈΡΡΠΈΠ»Π°ΠΌΠΈΠ½Π° Π² Π±Π΅Π·Π²ΠΎΠ΄Π½ΠΎΠΌ Ρ
Π»ΠΎΡΠΈΡΡΠΎΠΌ ΠΌΠ΅ΡΠΈΠ»Π΅Π½Π΅. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΠ- Π£Π€- ΠΈ Π―ΠΠ -ΡΠΏΠ΅ΠΊΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
Π‘ΠΈΠ½ΡΠ΅Π· ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ½ΡΡ ΠΈ ΠΈΠ·ΠΎΡΠΈΠ°Π·ΠΎΠ»ΡΠ½ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π°
Curcumin is a chemical compound with antioxidant properties as well as strong anti-inflammatory, antiviral, analgesic, antimicrobial and antitumor effect, contained in the tuberous rhizomes of the turmeric plant (Curcuma longa). Curcumin derivatives are being intensively studied as potential drugs β antitumor drugs for the treatment of certain forms of cancer. The presence of reactive functional groups makes curcumin a convenient starting compound for the further chemical modification. The esters of curcumin and 5-phenylisoxazole-3-carboxylic acid, 5-(p-tolyl)isoxazole-3-carboxylic acid, 4,5- dichloroisothiazole-3-carboxylic acid and adduct of 5-(p-tolyl)isoxazol-3-carbaldehyde with curcumin were synthesized. Esters were obtained by acylation of curcumin with heterocycle-containing carboxylic acid chloride in diethyl ether in the presence of triethylamine. The IR and NMR spectra of the obtained compounds are described.ΠΡΡΠΊΡΠΌΠΈΠ½ β Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π΅ΡΡ Π² ΠΊΠ»ΡΠ±Π½Π΅Π²ΠΈΠ΄Π½ΡΡ
ΠΊΠΎΡΠ½Π΅Π²ΠΈΡΠ°Ρ
ΡΠ°ΡΡΠ΅Π½ΠΈΡ ΠΊΡΡΠΊΡΠΌΠ° ΠΈ ΠΎΠ±Π»Π°Π΄Π°ΡΡΠ΅Π΅ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΠ΅Π΅ ΡΠΈΠ»ΡΠ½ΠΎΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅, ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠ΅, Π±ΠΎΠ»Π΅ΡΡΠΎΠ»ΡΡΡΠ΅Π΅, Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ΅ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ. ΠΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΡΡΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² β ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΡΠΎΡΠΌ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠ»Π°Π³ΠΎΠ΄Π°ΡΡ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΡ Π² Π΅Π³ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ΅Π°ΠΊΡΠΈΠΎΠ½Π½ΠΎΡΠΏΠΎΡΠΎΠ±Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΠΆΠΈΡΡ ΡΠ΄ΠΎΠ±Π½ΡΠΌ ΠΈ Π»Π΅Π³ΠΊΠΎΠ΄ΠΎΡΡΡΠΏΠ½ΡΠΌ ΠΈΡΡ
ΠΎΠ΄Π½ΡΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ΠΌ Π΄Π»Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ. ΠΠΏΠΈΡΠ°Π½ ΡΠΈΠ½ΡΠ΅Π· ΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΡΠΈΡΠΎΠ² ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° ΠΈ 5-ΡΠ΅Π½ΠΈΠ»ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ, 5-(Ρ-ΡΠΎΠ»ΠΈΠ»)ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ, 4,5-Π΄ΠΈΡ
Π»ΠΎΡΠΈΠ·ΠΎΡΠΈΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ ΠΈ Π°Π΄Π΄ΡΠΊΡΠ° 5-(Ρ-ΡΠΎΠ»ΠΈΠ»)ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»-3-ΠΊΠ°ΡΠ±Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π° Ρ ΠΊΡΡΠΊΡΠΌΠΈΠ½ΠΎΠΌ. Π‘Π»ΠΎΠΆΠ½ΡΠ΅ ΡΡΠΈΡΡ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΡΡΠΊΡΠΌΠΈΠ½Π° Ρ
Π»ΠΎΡΠ°Π½Π³ΠΈΠ΄ΡΠΈΠ΄Π°ΠΌΠΈ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Π² ΡΡΠ΅Π΄Π΅ Π΄ΠΈΡΡΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠΈΡΠ° Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΡΠΈΡΡΠΈΠ»Π°ΠΌΠΈΠ½Π°. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΠ- ΠΈ Π―ΠΠ -ΡΠΏΠ΅ΠΊΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
Feasibility studies of the time-like proton electromagnetic form factor measurements with PANDA at FAIR
The possibility of measuring the proton electromagnetic form factors in the
time-like region at FAIR with the \PANDA detector is discussed. Detailed
simulations on signal efficiency for the annihilation of into a
lepton pair as well as for the most important background channels have been
performed. It is shown that precision measurements of the differential cross
section of the reaction can be obtained in a wide
angular and kinematical range. The individual determination of the moduli of
the electric and magnetic proton form factors will be possible up to a value of
momentum transfer squared of (GeV/c). The total cross section will be measured up to (GeV/c).
The results obtained from simulated events are compared to the existing data.
Sensitivity to the two photons exchange mechanism is also investigated.Comment: 12 pages, 4 tables, 8 figures Revised, added details on simulations,
4 tables, 9 figure
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