37 research outputs found
Contents of heavy metals in fructicose epiphytic lichens of Karelia as indicator of atmospheric transport of pollutants
Results of studies of heavy metals contents in fruticose epiphytic lichens in Karelia are presented and the influence of different sources on the elemental composition of lichens has been estimated. It has been shown, that long-range atmospheric transport influences strongly the accumulation of Pb, Zn, Cd, Sb. For Al, Fe and Co lithogenic source is the main one. In the Northern Karelia atmospheric transport of Cu, Co and Ni from metallurgic enterprises of the Murmansk Region is important source of these elements
Application of repetitively pulsed X-ray radiation in experimental oncology
Development of new technologies in the field of radiation required new approaches and strategies for their application. Power radiation when one continued pulsed divided to serial pulses with different specific repetition rate could provide more complicated and expressed reaction of the biological objects. We used different normal and tumor cell lines in vivo and in vitro to compare efficacy of different pulse repetition rate of X-ray radiation when the total absorbed dose didnβt exceed 1 Gy. We observed strong dependent of tumor cell reaction to repetition rate. Using this parameter we can stimulate or inhibit tumor growth up to 90% compare to control group. Irradiation of tumor-bearing mice inhibited growth of primary tumor up to 60% with the total absorbed dose 0.4 Gy. Moreover same experimental conditions allowed to reduce number of metastasis in mouse lung at 70%. That resulted in longer survival of experimental animals compare to control group. Thus we can conclude that pulsed radiation with nanosecond pulse duration has a potential for application in oncology
Effect of nanosecond repetitive pulsed microwave exposure on proliferation of bone marrow cells
The purpose was to study the proliferative activity of bone marrow mononuclear cells (BMNCs) of rats after irradiated by nanosecond repetitive pulsed microwave (RPM). It was found that the irradiated by nanosecond microwave pulses can affect the BMNCs proliferation in vitro. It is important that both stimulation and inhibition of proliferation were observed after exposure. The effect depended on the pulse repetition frequency. The amount of BMNCs increased after exposure to pulse repetition frequency of 13 Hz up to 30% in comparison with a control cells and up to 51% in comparison with a falseirradiated cells. In contrast, there was inhibition up to 40% of BMNCs after exposure to a frequency of 8 Hz, in comparison with a control group
Macrophage and tumor cell responses to repetitive pulsed X-ray radiation
To study a response of tumor cells and macrophages to the repetitive pulsed low-dose X-ray radiation. Methods. Tumor growth and lung metastasis of mice with an injected Lewis lung carcinoma were analysed, using C57Bl6. Monocytes were isolated from a human blood, using CD14+ magnetic beads. IL6, IL1-betta, and TNF-alpha were determined by ELISA. For macrophage phenotyping, a confocal microscopy was applied. "Sinus-150" was used for the generation of pulsed X-ray radiation (the absorbed dose was below 0.1 Gy, the pulse repetition frequency was 10 pulse/sec). The irradiation of mice by 0.1 Gy pulsed X-rays significantly inhibited the growth of primary tumor and reduced the number of metastatic colonies in the lung. Furthermore, the changes in macrophage phenotype and cytokine secretion were observed after repetitive pulsed X-ray radiation. Conclusion. Macrophages and tumor cells had a different response to a low-dose pulsed X-ray radiation. An activation of the immune system through changes of a macrophage phenotype can result in a significant antitumor effect of the low-dose repetitive pulsed X-ray radiation
C-fos expression and cell proliferation in mice after exposure to nanosecond repetitively-pulsed X-rays
Π ΡΡΠ°ΡΡΠ΅ ΡΠΊΠ°Π·Π°Π½ΠΎ Rostov, Vladimir V
Π Π°Π·Π»ΠΈΡΠΈΡ ΡΡΠ΅ΠΊΡΠΎΠ² ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎ-ΠΏΠ΅ΡΠΈΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ Π² ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π»ΠΈΠ½ΠΈΠΈ MOLT-4 ΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
Effects of ionizing radiation registered in cells after low dose irradiation are still poorly understood. Thus, the aim of this study was to analyze effects of pulsed X-rays on level of radiation-induced DNA double-strand breaks and their repair kinetics in cancer and normalhuman cells in vitro. Analysis of radiation-induced Ξ³H2AX and 53BP1 repair foci in MOLT-4 cells with lymphoblastic origin was used for assessment of DNA double-strand breaks (DSB) in these cells. Number of residual radiation-induced Ξ³H2AX and 53BP1 foci at 18 hafter irradiation depended on frequency of X-ray pulses: at 8 pulses per second effect was highest in MOLT-4 cells and lowest in peripheral blood lymphocytes. It suggests that pulsed X-rays with various frequencies could be used for target influence on cancer cells being lessdeleterious for normal human cells.Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΈ, ΡΠΏΠΎΡΠΎΠ±Π½ΡΠ΅ Π³Π΅Π½Π΅ΡΠΈΡΠΎΠ²Π°ΡΡ ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎ-ΠΏΠ΅ΡΠΈΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠ΅ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΠ΅ (ΠΠΠ Π) Π² Π½Π°Π½ΠΎΡΠ΅ΠΊΡΠ½Π΄Π½ΠΎΠΌ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ°ΡΡΠΎΡΡ ΠΏΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΡ ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² ΠΈ Π΄ΠΎΠ·Ρ Π·Π° ΠΈΠΌΠΏΡΠ»ΡΡ. Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°Π» Π°Π½Π°Π»ΠΈΠ· Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠΠ Π Π½Π° ΡΡΠΎΠ²Π΅Π½Ρ Π΄Π²ΡΠ½ΠΈΡΠ΅Π²ΡΡ
ΡΠ°Π·ΡΡΠ²ΠΎΠ² ΠΠΠ Π² ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
in vitro. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠΎΠ²Π½Ρ Π΄Π²ΡΠ½ΠΈΡΠ΅Π²ΡΡ
ΡΠ°Π·ΡΡΠ²ΠΎΠ² ΠΠΠ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΡ
ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΡΡ ΠΌΠ΅ΡΠΎΠ΄ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΡΡ
ΡΠΎΠΊΡΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΠΠ Ξ³H2AX ΠΈ 53BP1 Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ Π»ΠΈΠ½ΠΈΠΈ MOLT-4, ΠΈΠΌΠ΅ΡΡΠ΅ΠΉ Π»ΠΈΠΌΡΠΎΠ±Π»Π°ΡΡΠ½ΠΎΠ΅ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅, ΠΏΠΎΡΠ»Π΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠΠ Π Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
in vitro. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΎΠΊΡΡΠΎΠ² Ξ³H2AX ΠΈ 53BP1 ΡΠ΅ΡΠ΅Π· 18 Ρ ΠΏΠΎΡΠ»Π΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΡΠ²Π»ΡΡΡΠΈΠΉΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠΌ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΠΠΠ, Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
Π»ΠΈΠ½ΠΈΠΈ MOLT-4 ΠΎΡΠΌΠ΅ΡΠ°Π»ΡΡ ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΠΠ Π Ρ ΡΠ°ΡΡΠΎΡΠΎΠΉ ΠΏΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΡ ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² 8 ΠΈΠΌΠΏ./Ρ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΉ ΡΠ°Π½Π΅Π΅ Π² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ
Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ Π½Π°ΠΈΠΌΠ΅Π½ΡΡΠ΅Π΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π΄Π²ΡΠ½ΠΈΡΠ΅Π²ΡΡ
ΡΠ°Π·ΡΡΠ²ΠΎΠ² ΠΠΠ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΊΠ°Π·ΡΠ²Π°ΡΡ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ Π Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΡΠ°ΡΡΠΎΡΠ°ΠΌΠΈ ΠΏΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΡ ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² ΠΌΠΎΠΆΠ΅Ρ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡΡΠ΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ Π½Π° ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ, Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π°Ρ ΠΏΡΠΈ ΡΡΠΎΠΌ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» Ρ Π΄ΠΎΠ½ΠΎΡΠΎΠ² ΡΠΎ ΡΠΌΠ΅ΡΡΡΡ ΠΌΠΎΠ·Π³Π° ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅ΡΠ°Π΄ΠΊΠ΅ ΠΏΠΎΡΠ΅ΠΊ
Objective. The objective of this study is to develop a therapeutic strategy for protecting grafts in order to improve the efficiency of kidney transplantation (KT) using polyclonal antibodies (pAbs) through elimination of activated forms of neutrophils, chemo- and cytokines from the donorβs bloodstream, and a decrease in the level of expression of adhesion molecules on the renal vascular endothelium at the pre-transplant stage.Materials and methods. In 2017, we developed and for the first time applied a therapeutic strategy for ischemia-reperfusion injury (IRI) in a brain-dead donor (BDD). Given the limited time interval after brain death has been diagnosed, Timoglobulin (Sanofi Genzyme, France) was administered to the donor at a dose of 8 mg/kg intravenously for 6 hours. Before drug administration and immediately before the start of cold perfusion, a complete blood count and renal transplant biopsy were performed. The study group included 10 BDDs (mean age 39.3 Β± 4.4 years) who received anti-thymocyte globulin (ATG). The comparison group included 10 BDDs (mean age 38.5 Β± 4.3 years) who did not undergo the new strategy. Donor kidneys were transplanted to 40 recipients (average age 47.5 Β± 4.3 years), who were also divided into 2 groups, depending on the graft received (with and without ATG). At the organ donation center, a biobank of specimens from donors of various categories, including those using the IRI therapeutic strategy and recipients for retrospective assessment of the effectiveness of pAbs, was formed.Results. Clinical blood test results show that in the ATG group, there was stable leukopenia (neutropenia and lymphopenia) of 1.46 Β± 0.18x109/l. Fifteen (75%) recipients of kidneys obtained from donors with ATG had immediate graft function; in the control group β 10 (50%) recipients.Conclusion. Data obtained testify to the prospects of implementing the proposed strategy in clinical practice, which will improve the quality of the resulting grafts and their suitability for subsequent transplantation, prolong graft functioning due to elimination of leukocytes as a factor of IRI, prevention of early allograft nephropathy, increase in the donor pool by using expanded criteria donors (ECDs).Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»Π°ΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Π° ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠΎΠ·Π½ΠΎΠΉ Π·Π°ΡΠΈΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² Π΄Π»Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠ΅ΡΠ°Π΄ΠΊΠΈ ΠΏΠΎΡΠ΅ΠΊ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΏΠΎΠ»ΠΈΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΡΠ΅Π» (ΠΠΠΠ’) Π·Π° ΡΡΠ΅Ρ ΡΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΠΈ ΠΈΠ· ΠΊΡΠΎΠ²ΠΎΡΠΎΠΊΠ° Π΄ΠΎΠ½ΠΎΡΠ° Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΡΠΌ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ², Ρ
Π΅ΠΌΠΎ- ΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ², ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ» Π°Π΄Π³Π΅Π·ΠΈΠΈ Π½Π° ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΏΠΎΡΠ΅ΠΊ Π½Π° ΠΏΡΠ΅Π΄ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΡΡΠ°ΠΏΠ΅.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π 2017 Π³ΠΎΠ΄Ρ Π½Π°ΠΌΠΈ Π±ΡΠ» ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΈ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ ΠΏΡΠΎΡΠΎΠΊΠΎΠ» Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈ-ΡΠ΅ΠΏΠ΅ΡΡΡΠ·ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ (ΠΠ Π) Ρ Π΄ΠΎΠ½ΠΎΡΠ° Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Β«ΡΠΌΠ΅ΡΡΡ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°Β» (ΠΠ‘Π). Π£ΡΠΈΡΡΠ²Π°Ρ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΡΠΉ Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π» ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠΌΠ΅ΡΡΠΈ ΠΌΠΎΠ·Π³Π°, ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ Β«Π’ΠΈΠΌΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½Β» (Sanofi Genzyme, Π€ΡΠ°Π½ΡΠΈΡ) Π²Π²ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ Π΄ΠΎΠ½ΠΎΡΠ° Π² Π΄ΠΎΠ·Π΅ 8 ΠΌΠ³/ΠΊΠ³ Π²Π½ΡΡΡΠΈΠ²Π΅Π½Π½ΠΎ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 6 ΡΠ°ΡΠΎΠ². ΠΠ΅ΡΠ΅Π΄ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΈ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎ ΠΏΠ΅ΡΠ΅Π΄ Π½Π°ΡΠ°Π»ΠΎΠΌ Ρ
ΠΎΠ»ΠΎΠ΄ΠΎΠ²ΠΎΠΉ ΠΏΠ΅ΡΡΡΠ·ΠΈΠΈ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΡΡ ΡΠ°Π·Π²Π΅ΡΠ½ΡΡΡΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΊΡΠΎΠ²ΠΈ ΠΈ Π±ΠΈΠΎΠΏΡΠΈΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ² ΠΏΠΎΡΠ΅ΠΊ. Π ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ Π³ΡΡΠΏΠΏΡ Π±ΡΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 10 ΠΠ‘Π (ΡΡ. Π²ΠΎΠ·ΡΠ°ΡΡ β 39,3 Β± 4,4 Π³ΠΎΠ΄Π°), ΠΊΠΎΡΠΎΡΡΠΌ Π²Π²ΠΎΠ΄ΠΈΠ»ΡΡ Π°Π½ΡΠΈΡΠΈΠΌΠΎΡΠΈΡΠ°ΡΠ½ΡΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ (ΠΠ’Π), Π³ΡΡΠΏΠΏΠΎΠΉ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Π±ΡΠ»ΠΈ 10 ΠΠ‘Π (ΡΡ. Π²ΠΎΠ·ΡΠ°ΡΡ β 38,5 Β± 4,3 Π³ΠΎΠ΄Π°) Π±Π΅Π· ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Π°. ΠΠΎΠ½ΠΎΡΡΠΊΠΈΠ΅ ΠΏΠΎΡΠΊΠΈ Π±ΡΠ»ΠΈ ΠΏΠ΅ΡΠ΅ΡΠ°ΠΆΠ΅Π½Ρ 40 ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ°ΠΌ (ΡΡ. Π²ΠΎΠ·ΡΠ°ΡΡ β 47,5 Β± 4,3 Π³ΠΎΠ΄Π°), ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° 2 Π³ΡΡΠΏΠΏΡ, Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ° (Ρ ΠΠ’Π ΠΈ Π±Π΅Π· ΠΠ’Π). Π ΡΠ΅Π½ΡΡΠ΅ ΠΎΡΠ³Π°Π½Π½ΠΎΠ³ΠΎ Π΄ΠΎΠ½ΠΎΡΡΡΠ²Π° ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ Π±ΠΈΠΎΠ±Π°Π½ΠΊ ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΎΡ Π΄ΠΎΠ½ΠΎΡΠΎΠ² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΉ, Π² Ρ. Ρ. Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Π° ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΠ Π, ΠΈ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² Π΄Π»Ρ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΠΠΠ’.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΡΠΎΠ²ΠΈ, Π² Π³ΡΡΠΏΠΏΠ΅ Ρ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΠΠ’Π Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ ΡΡΡΠΎΠΉΡΠΈΠ²Π°Ρ Π»Π΅ΠΉΠΊΠΎΠΏΠ΅Π½ΠΈΡ (Π½Π΅ΠΉΡΡΠΎΠΏΠ΅Π½ΠΈΡ ΠΈ Π»ΠΈΠΌΡΠΎΠΏΠ΅Π½ΠΈΡ) 1,46 Β± 0,18 Γ 109/Π». Π£ 15 (75%) ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΡΠ΅ΠΊ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΎΡ Π΄ΠΎΠ½ΠΎΡΠΎΠ² Ρ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΠΠ’Π, Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ Π½Π΅ΠΌΠ΅Π΄Π»Π΅Π½Π½Π°Ρ ΡΡΠ½ΠΊΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ°, Π² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ β Ρ 10 (50%) ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ².ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Π° Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΡΠ»ΡΡΡΠΈΡΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌΡΡ
ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΎΠ², ΠΈΡ
ΠΏΡΠΈΠ³ΠΎΠ΄Π½ΠΎΡΡΡ ΠΊ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΉ ΠΏΠ΅ΡΠ΅ΡΠ°Π΄ΠΊΠ΅, ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΡΠΎΠΊ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ° Π·Π° ΡΡΠ΅Ρ ΡΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΠΈ Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠΎΠ² ΠΊΠ°ΠΊ ΡΠ°ΠΊΡΠΎΡΠ° Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΠ Π, ΠΏΡΠ΅Π΄ΡΠΏΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ°Π½Π½Π΅ΠΉ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π½Π΅ΡΡΠΎΠΏΠ°ΡΠΈΠΈ, ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ Β«Π΄ΠΎΠ½ΠΎΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ»Π°Β» Π·Π° ΡΡΠ΅Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΎΠ½ΠΎΡΠΎΠ² Ρ ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΡΠΌΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌΠΈ (ΠΠ Π)
ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π°Π½ΠΎΡΠ΅ΠΊΡΠ½Π΄Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎ-ΠΏΠ΅ΡΠΈΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΈΠΊΡΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ Π½Π° ΠΏΡΠΎΡΠ΅ΡΡΡ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ
The effects of pulse periodic microwaves (10 GHz, duration of pulse 100 ns, pulse repetition frequency 4β19 pps, peak power density 40β1 520 W/cm2 ) on the reparative regeneration of full-thickness skin wounds on mice was investigated. This effect depends on the pulse repetition frequency and peak power density.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎ-ΠΏΠ΅ΡΠΈΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΈΠΊΡΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ (10 ΠΠΡ, Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² 100 Π½Ρ, ΡΠ°ΡΡΠΎΡΠ° ΠΏΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΡ 4β19 ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² Π² ΡΠ΅ΠΊΡΠ½Π΄Ρ, ΠΏΠΈΠΊΠΎΠ²Π°Ρ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΏΠΎΡΠΎΠΊΠ° ΠΌΠΎΡΠ½ΠΎΡΡΠΈ 40β1 520 ΠΡ/ΡΠΌ2 ) Π½Π° ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΡΡ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΠΏΠΎΠ»Π½ΠΎΡΠ»ΠΎΠΉΠ½ΠΎΠΉ ΠΊΠΎΠΆΠ½ΠΎΠΉ ΡΠ°Π½Ρ Ρ ΠΌΡΡΠ΅ΠΉ. ΠΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΠΎΠΆΠ΅Ρ ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°ΡΡ Π·Π°ΠΆΠΈΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠ°Π½. ΠΠ°Π½Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΠ°ΡΡΠΎΡΡ ΠΏΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΡ ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² ΠΈ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΠΏΠΈΠΊΠΎΠ²ΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΏΠΎΡΠΎΠΊΠ° ΠΌΠΎΡΠ½ΠΎΡΡΠΈ