17 research outputs found
Colour Sensor White Balance Influence on White-Light Interferometer Resolution
Impact of a sensor color balance on white-light fullfieldoptical coherence tomography (FF-OCT)resolution is investigated in the paper. Full width athalf magnitude (FWHM) of a coherence pulse wascalculated for various white balance (WB) settings.Simulated dependence of FWHM on WB of asensor and experimental data are shown in thepaper. The minimum interference pulse width canbe achieved by the proper color balance coefficientschoice. And in this case the pulse is narrower thaneither one registered by colour image sensor withWB based on light source emission spectrum or bymonochrome image sensor
Durability increase of mining dump trucks through the use of protective coatings of the body
The share of trucking in the total cost of open-cast mining is 50% or more. Therefore, reducing transportation costs is one of the tasks of increasing the technical and economic indicators of an open development method, which is an urgent task. Performance dump truck is estimated either by the volume of transported rock mass (in cubic meter or tons), or the value of cargo turnover (ton-kilometers). However, these indicators do not take into account the percentage of adhering rock that is transported uselessly and reduces productivity. The paper proposes methods for protecting the body of a mining dump truck from clay rocks adhering. Detail the method of protection with the help of vibration using metal structure is considered. A mathematical model of the stress-strain state of a two-layer beam is proposed. The dependence of the stress in the body on the stiffness of the elastic supports and impact energy when using a rubber lining is shown. Β© 2020 IOP Publishing Ltd. All rights reserved
Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response
We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apoptosis and DNA double-strand breaks, antiapoptotic gene expression and cell cycle inhibition confirm this hypothesis. We have demonstrated that treatment of mesenchymal stem cells (MSCs) with low doses of IR (10βcGy) leads to cell death of part of cell population and release of oxidized cfDNA. cfDNA has the ability to penetrate into the cytoplasm of other cells. Oxidized cfDNA, like low doses of IR, induces oxidative stress, ROS production, ROS-induced oxidative modifications of nuclear DNA, DNA breaks, arrest of the cell cycle, activation of DNA reparation and antioxidant response, and inhibition of apoptosis. The MSCs pretreated with low dose of irradiation or oxidized cfDNA were equally effective in induction of adaptive response to challenge further dose of radiation. Our studies suggest that oxidized cfDNA is a signaling molecule in the stress signaling that mediates radiation-induced bystander effects and that it is an important component of the development of radioadaptive responses to low doses of IR
ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Ρ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΎΠ² Π»ΠΈΠΊΠ²ΠΈΠ΄Π°ΡΠΈΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΉ Π°Π²Π°ΡΠΈΠΈ Π½Π° Π§Π΅ΡΠ½ΠΎΠ±ΡΠ»ΡΡΠΊΠΎΠΉ ΠΠΠ‘ ΠΈ ΠΆΠΈΡΠ΅Π»Π΅ΠΉ ΡΠ΅Π²Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ·Π»Π° Π³. Π’ΠΎΠΌΡΠΊΠ°
A clinical, electroneuromyographic (ENMG) and pathomorphological investigation of 19 eliminators of accident consequences (EAC) in Chernobyl APP in 1986 and 27 Tomsk region inhabitants living in the accident area that has taken place at radiochemical plant of Siberian Chemical Complex in 1993 has been made with the aim of the influence study of low ionizing radiation levels on the peripheral nervous system. Symptoms of sensory polyneuropathy prevailed in both groups clinically. Mixed affection type has been found at EAC by ENGM method, affection of myelinic nerve fibre membrane has been found at people living in accident trace area. Morphofunctional changes in skin allow considering the role of immune system in mechanisms of neuroglial and neuronal damages, distant by time.Π‘ ΡΠ΅Π»ΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΉ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ°Π»ΡΡ
ΡΡΠΎΠ²Π½Π΅ΠΉ ΠΈΠΎΠ½ΠΈΠ·ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ Π½Π° ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΡΡ Π½Π΅ΡΠ²Π½ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅, ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π΅ΠΉΡΠΎΠΌΠΈΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ (ΠΠΠΠ) ΠΈ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ 19 Π»ΠΈΠΊΠ²ΠΈΠ΄Π°ΡΠΎΡΠΎΠ² ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΉ Π°Π²Π°ΡΠΈΠΈ (ΠΠΠ) Π½Π° Π§Π΅ΡΠ½ΠΎΠ±ΡΠ»ΡΡΠΊΠΎΠΉ ΠΠΠ‘ Π² 1986 Π³. ΠΈ 27 ΠΆΠΈΡΠ΅Π»Π΅ΠΉ Π’ΠΎΠΌΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΉΠΎΠ½Π°, ΠΏΡΠΎΠΆΠΈΠ²Π°ΡΡΠΈΡ
Π² Π·ΠΎΠ½Π΅ Π°Π²Π°ΡΠΈΠΈ, ΠΏΡΠΎΠΈΠ·ΠΎΡΠ΅Π΄ΡΠ΅ΠΉ Π½Π° ΡΠ°Π΄ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ Π·Π°Π²ΠΎΠ΄Π΅ Π‘ΠΈΠ±ΠΈΡΡΠΊΠΎΠ³ΠΎ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠ° Π² 1993 Π³. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π»ΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΡ ΡΠ΅Π½ΡΠΎΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΠ½Π΅Π²ΡΠΎΠΏΠ°ΡΠΈΠΈ. ΠΠΠΠ-ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Ρ ΠΠΠ Π²ΡΡΠ²Π»Π΅Π½ ΡΠΌΠ΅ΡΠ°Π½Π½ΡΠΉ ΡΠΈΠΏ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ, Ρ ΠΏΡΠΎΠΆΠΈΠ²Π°ΡΡΠΈΡ
Π² Π·ΠΎΠ½Π΅ Π°Π²Π°ΡΠΈΠΉΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅Π΄Π° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΌΠΈΠ΅Π»ΠΈΠ½ΠΎΠ²ΡΡ
ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΠΊ Π½Π΅ΡΠ²Π½ΠΎΠ³ΠΎ Π²ΠΎΠ»ΠΎΠΊΠ½Π°. ΠΠΎΡΡΠΎΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΊΠΎΠΆΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ ΡΠΎΠ»Ρ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
Π²ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Π³Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΈ Π½Π΅ΠΉΡΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ
Peculiarities of blood supply of inferior angle of scapula from the system of thoracodorsal angiosom
At the current stage of development of the reconstructive-plastic surgery, to remove combined soft-tissueβbone defects, a combined thoracodorsal flap is used most often. This flap includes, as a bone fragment, the lateral edge of scapula, which is supplied with blood by the arterial branch surrounding the scapula. However, our investigations of the blood supply of thoracodorsal flap from the system of thoracodorsal angiosom indicate that the inferior angle of scapula is supplied directly from the system of thoracodorsal artery. Based on the results obtained, we concluded that the inferior angle of scapula is supplied by the branch of the thoracodorsal artery, which has a length of (54.0 Β± 11.8) mm and a diameter of (1.3 Β± 0.3) mm and can be included in the combined thoracodorsal flap
Effects of Different Optical Properties of Head Tissues on Near-Infrared Spectroscopy Using Monte Carlo Simulations
In near-infrared spectroscopy (NIRS), it is crucial to have an accurate and realistic model of photon transport in the adult head for obtaining accurate brain oxygenation values. There are several studies on the influence of thickness, the morphology of extracerebral layers, and source-detector distance on the sensitivity of NIRS to the brain. However, the optical properties of the different layers vary between different publications. How is the performance of NIRS affected when the real optical properties differ from the assumed ones?We aim to investigate the influence of variation in scattering and absorption in a five-layered head model (scalp, skull, CSF, grey and white matter). We performed Monte Carlo simulations focusing on a five-layered slab mesh. The range of optical properties is based on a review of the published literature. We assessed the effect on light propagation by measuring the difference in the mean partial path lengths, attenuation, and the number of the detected photons between the different optical properties performing Monte Carlo simulations. For changes in the reduced scattering, we found that the upper layers tend to have a negative impact. In contrast, changes in lower layers tend to impact the brain's influence metrics positively. Furthermore, for small source-detector distances, the relative percentage difference between lower and higher values is greater than larger distances. Conclusions: We conclude that the assumption of different optical properties has a substantial effect on the sensitivity to the brain. This means that it is important to determine the correct optical properties for NIRS measurements in vitro and in vivo
Dual mode diffraction phase microscopy for quantitative functional assessment of biological cells
Abstract
A diffraction phase microscopy approach with a combined use of transmission and reflection imaging modes has been developed and applied for non-invasive quantitative assessment of the refractive index of red blood cells (RBCs). We present the theoretical background of signal formation for both imaging modes, accompanied by the results of experimental studies. We demonstrate that simultaneous use of the two modes has great potential for accurate assessment of the refractive index of biological cells, and we perform a reconstruction of spatial distribution of the refractive index of RBC in 3D