Color dielectric model with two scalar fields

SU(2) Yang-Mills theory coupled in a non-minimal way to two scalar fields is discussed. For the massless scalar fields a family of finite energy solutions generated by an external, static electric charge is found. Additionally, there is a single solution which can be interpreted as confining one. Similar solutions have been obtained in the magnetic sector. In case of massive scalar fields the Coulomb problem is investigated. We find that asymptotic behavior of the fields can also, for some values of the parameter of the model, give confinement of the electric charge. Quite interesting one glueball--meson coupling gives the linear confining potential. Finally, it is shown that for one non-dynamical scalar field we derive the color dielectric generalization of the Pagels--Tomboulis model.Comment: 20 pages, LaTeX, Accepted for publication in Eur. Phys. J.

Non-abelian color dielectric - towards the effective model of the low energy QCD

Lattice motivated triplet color scalar field theory is analyzed. We consider non-minimal as well as covariant derivative coupling with SU(2) gauge fields. Field configurations generated by external electric sources are presented. Moreover non-Abelian magnetic monopoles are found. Dependence on the spatial coordinates in the obtained solutions is identical as in the usual Abelian case. We show also that after a decomposition of the fields a modified Faddeev-Niemi action can be obtained. It contains explicit O(3) symmetry breaking term parameterized by the condensate of an isoscalar field. Due to that Goldstone bosons observed in the original Faddeev-Niemi model are removed.Comment: 19 page

The electromagnetic dipole operator effect on B -> Xs gamma at O(alpha_s^2)

The flavor-changing electromagnetic dipole operator O_7 gives the dominant contribution to the B -> Xs gamma decay rate. We calculate two-loop QCD corrections to its matrix element together with the corresponding bremsstrahlung contributions. The optical theorem is applied, and the relevant imaginary parts of three-loop diagrams are computed following the lines of our recent t -> Xb W calculation. The complete result allows us to test the validity of the naive non-abelianization (NNA) approximation that has been previously applied to estimate the NNLO QCD correction to Gamma(B -> Xs gamma)/Gamma(B -> Xu e nu). When both decay widths are normalized to m^5_{b,R} in the same renormalization scheme R, the calculated O(alpha_s^2) correction is sizeable (~ 6%), and the NNA estimate is about 1/3 too large. On the other hand, when the ratio of the decay widths is written as S*(m_b(m_b)/m_{b,pole})^2, the calculated O(alpha_s^2) correction to S is at the level of 1% for both the complete and the NNA results.Comment: Corrected pi^2 terms in the description of intermediate steps in Section II. Final results unchange

Venture Capital and Business Angels and the Creation of Innovative Firms in Poland

The article also points out that conditions fostering further development of the described types of entrepreneurship and innovation financing and a dynamic environment generating innovative capacity should be created.W artykule zasygnalizowano również potrzebę kreowania uwarunkowań sprzyjających rozwojowi opisanych form finansowania przedsiębiorczości, innowacyjności i dynamicznego otoczenia generującego zdolności innowacyjne

Chemometric approach to characterization of the selected grape seed oils based on their fatty acids composition and FTIR spectroscopy

Addressing the issues arising from the production and trade of low-quality foods necessitates developing new quality control methods. Cooking oils, especially those produced from the grape seeds, are an example of food products that often suffer from questionable quality due to various adulterations and low-quality fruits used for their production. Among many methods allowing for fast and efficient food quality control, the combination of experimental and advanced mathematical approaches seems most reliable. In this work a method for grape seed oils compositional characterization based on the infrared (FTIR) spectroscopy and fatty acids profile is reported. Also, the relevant parameters of oils are characterized using a combination of standard techniques such as the Principal Component Analysis, k-Means, and Gaussian Mixture Model (GMM) fitting parameters. Two different approaches to perform unsupervised clustering using GMM were investigated. The first approach relies on the profile of fatty acids, while the second is FT-IR spectroscopy-based. The GMM fitting parameters in both approaches were compared. The results obtained from both approaches are consistent and complementary and provide the tools to address the characterization and clustering issues in grape seed oils.O

Confinement from new global defect structures

We investigate confinement from new global defect structures in three spatial dimensions. The global defects arise in models described by a single real scalar field, governed by special scalar potentials. They appear as electrically, magnetically or dyonically charged structures. We show that they induce confinement, when they are solutions of effective QCD-like field theories in which the vacua are regarded as color dielectric media with an anti-screening property. As expected, in three spatial dimensions the monopole-like global defects generate the Coulomb potential as part of several confining potentials.Comment: RevTex4, 7 pages, 1 figure. Version to appear in Eur. Phys. J.

A novel, pan-PDE inhibitor exerts anti-fibrotic effects in human lung fibroblasts via inhibition of TGF-β\beta signaling and activation of cAMP/PKA signaling

Phosphodiesterase (PDE) inhibitors are currently a widespread and extensively studied group of anti-inflammatory and anti-fibrotic compounds which may find use in the treatment of numerous lung diseases, including asthma and chronic obstructive pulmonary disease. Several PDE inhibitors are currently in clinical development, and some of them, e.g., roflumilast, are already recommended for clinical use. Due to numerous reports indicating that elevated intracellular cAMP levels may contribute to the alleviation of inflammation and airway fibrosis, new and effective PDE inhibitors are constantly being sought. Recently, a group of 7,8-disubstituted purine-2,6-dione derivatives, representing a novel and prominent pan-PDE inhibitors has been synthesized. Some of them were reported to modulate transient receptor potential ankyrin 1 (TRPA1) ion channels as well. In this study, we investigated the effect of selected derivatives (832-a pan-PDE inhibitor, 869-a TRPA1 modulator, and 145-a pan-PDE inhibitor and a weak TRPA1 modulator) on cellular responses related to airway remodeling using MRC-5 human lung fibroblasts. Compound 145 exerted the most considerable effect in limiting fibroblast to myofibroblasts transition (FMT) as well as proliferation, migration, and contraction. The effect of this compound appeared to depend mainly on its strong PDE inhibitory properties, and not on its effects on TRPA1 modulation. The strong anti-remodeling effects of 145 required activation of the cAMP/protein kinase A (PKA)/cAMP response element-binding protein (CREB) pathway leading to inhibition of transforming growth factor type β1 (TGF-β1) and Smad-dependent signaling in MRC-5 cells. These data suggest that the TGF-β pathway is a major target for PDE inhibitors leading to inhibitory effects on cell responses involved in airway remodeling. These potent, pan-PDE inhibitors from the group of 7,8-disubstituted purine-2,6-dione derivatives, thus represent promising anti-remodeling drug candidates for further research

Norditerpenoids with selective anti-cholinesterase activity from the roots of Perovskia atriplicifolia Benth

Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related conditions. The current study was inspired by previous data on anticholinesterase properties of diterpenoids from Perovskia atriplicifolia and other Lamiaceae species. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by the three new natural compounds-(1R,15R)-1-acetoxycryptotanshinone (1), (1R)-1-acetoxytanshinone IIA (2), and (15R)-1-oxoaegyptinone A (3)-as well as, new for this genus, isograndifoliol (4) were assessed. Three of these compounds exhibited profound inhibition of butyrylcholinesterase (BChE) and much weaker inhibition of acetylcholinesterase (AChE). All compounds (1-4) selectively inhibited BChE (IC(50) = 2.4, 7.9, 50.8, and 0.9 µM, respectively), whereas only compounds 3 and 4 moderately inhibited AChE (IC(50) 329.8 µM and 342.9 µM). Molecular docking and in silico toxicology prediction studies were also performed on the active compounds. Natural oxygenated norditerpenoids from the traditional Central Asian medicinal plant P. atriplicifolia are selective BChE inhibitors. Their high potential makes them useful candidate molecules for further investigation as lead compounds in the development of a natural drug against dementia caused by neurodegenerative diseases