A CASE REPORT: DRUG INTERACTION BETWEEN LINEZOLID AND DOPAMINE

Linezolid is a weak, non-selective inhibitor of monoamine oxidase (MAO). It can inhibit the breakdown of the tyramine by MAO in the gut and can also potentiate the effect of tyramine at nerve endings, thereby causing an increase in blood pressure. We encountered a neonate who developed acute hypertensive episode after simultaneous administration of dopamine and linezolid. A 25 w preterm neonate was admitted in NICU (Neonatal Intensive Care Unit) with complaints of Patent Ductus Arteriosus and respiratory infection. Linezolid infusion 6.5 mg every 8 h over 30 min (7 am, 3pm, 11 pm) was added after confirmation of gram-positive cocci (Staphylococcus epidermis) growth. Inj. Dopamine 20 mcg/kg/min was started for derangement in blood pressure 52/28 mm Hg (Mean blood pressure 43) at 5 pm. The baby developed acute hypertensive episode at 5.30 pm for which dopamine was withdrawn immediately. The half-life of Linezolid is 5.6 h in preterm baby, and that of Dopamine is 2 min. Since the probability of peak concentration for both the administered drugs was around the same time period, the baby developed acute hypertensive episode. So the combination of Linezolid with Dopamine should be avoided if possible or the dosage interval has to be extended to minimize the adverse reaction.Â

SCIENTIFIC WRITING AS AN ART: AN OVERVIEW

Writing well is an art that takes time to be perfect, but if you don't try it, you won't nail it. The value of writing should never be underestimated, as writing well improves your work [1]. If the writing is clear, it can turn bad science into good science and makes more impactful and valuable [1]. Writing helps the speaker to express the issue before audience very easier. There are various types of writing such as articles, journals, literature review etc [3]. The scientific writing should be simple, objective and concise. Writing depends on the reader's needs (for a normal reader technical terms mathematical expressions has never suited well) [2]. Various types of manuscripts are used in scientific writing. One of the key developers in scientific publications is the adoption of the IMRAD's [Introduction, Methods, Results and Discussion] structure [5]. Apart from this other form is TAKAR (Title, Abstract, Keywords, Acknowledgements, and References) [5]. Approaches made by writers for in the design of the contents are about various forms in more than one journal [4]. In case of reference also various styles are used, such as Vancouver's style, the Harvard system. Writing is a most important factor to criticize and evaluate the publications [9]. Writing process should not intend to be sane, effective. Writing is a decision making process and Writers designs in different ways for their scientific work [7]. All written communications are affected by a larger context or situation [8]. This article helps the reviewers to know about the different writing methods its rhythm and styles

Effective Disaster Management by Efficient Usage of Resources

Disaster Management can be merely defined as the organization and management of resources and responsibilities for dealing with all humanitarian aspects of crises, in specific preparedness, rejoinder and recapture in order to diminish the influence of disasters. But the affects of the disaster increases only when the information about the disaster is unknown and when the resources for the disaster management is not correctly used. Now there are several methods for forecast the disaster, But there are no any effective methods for handling the resources needed for both managing the disaster and also for rehabilitation purpose. Thus this paper proposes an application used for managing the disaster and handling the rehabilitation process. This application which deals with almost all the resources those are required for the management of disaster. This proposed application which is based on java programming language. This project also has a great scope of enhancement in future

PROPRANOLOL HYDROCHLORIDE TOPICAL GEL FOR THE TREATMENT OF INFANTILE HEMANGIOMA

Objective: To formulate and evaluate propranolol hydrochloride topical gel for overcoming the limitations and low oral bioavailability associated with conventional therapy. Methods: The propranolol hydrochloride topical gels were prepared by the cold mechanical method. The preliminary evaluation and further characterisation studies was conducted to find the optimised formulation. The in vitro release and ex vivo permeation studies were investigated. The histopathological studies and stability studies was also assessed. Results: The propranolol hydrochloride topical gel was successfully prepared. The in vitro release of optimized topical propranolol hydrochloride gel formulation (G2) showed the highest cumulative percentage drug release that is, 95.55%±0.15 after 7.5 h. (G2) the formulation showed a higher flux value of 4.61μg/cm2/h. The histopathological study using pig skin revealed that the optimized formulation was found to be safe for topical application. Conclusion: The formulated topical gel containing propranolol Hydrochloride seems to be a promising dosage form for enhanced skin delivery of propranolol hydrochloride in treating Infantile Hemangioma

Oral mucosal diseases in anxiety and depression patients: Hospital based observational study from south India

Objectives: The objective of this study was to evaluate the prevalence of different Oral Mucosal diseases in Anxiety and Depression patients. Material and Methods: A hospital based observational Study was conducted in the department of Psychiatry and department of Oral Medicine and Radiology. Patients who were diagnosed with Anxiety or Depression by the psy - chiatrists using Hamilton Anxiety and Depression scale were subjected to complete oral examination to check for oral diseases like Oral Lichen Planus (OLP), Recurrent Aphthous Stomatitis (RAS), and Burning Mouth Syndrome (BMS). Equal number of control group subjects were also included. Results: In this study statistically significant increase in the oral diseases in patients with anxiety and depression than the control group was recorded. Oral diseases were significantly higher in anxiety patients (20.86%) than in depression (9.04%) and control group patients (5.17%). In anxiety patients, the prevalence of RAS was 12%, OLP was 5.7%, and BMS was 2.87%. In depression patients, the prevalence of RAS was 4.02%, OLP was 2.01% and BMS was 3.01%. In control group the prevalence was 2.2%, 1.33% and 1.62% in RAS, OLP and BMS respecti - vely. RAS and OLP were significantly higher in the younger age group (18-49) and BMS was seen between the age group of 50-77 years in both study and control groups. Conclusions: The results of the present study showed a positive association between psychological alterations and changes in the oral mucosa, particularly conditions like OLP, RAS and BMS. Thus psychogenic factors like anxiety and depression may act as a risk factor that could influence the initiation and development of oral mucosal diseases. Hence psychological management should be taken into consideration when treating patients with these oral diseases

Time Based Self-Destruction System for Secure Data Sharing in Cloud

Abstract -Cloud computing is often touted as the future of business and enterprise technology where people are subjected to post their personal information like passwords, account number and different vital data. The shared data in a dynamic environment remains in cloud for indefinite period of time and the sensitive information stored may be misused by a miscreant or even by service providers. As a result sensitive and confidential data is at risk from outsider and insider attacks. Thus security and privacy becomes a major issue. In our proposed system, a self-destructing module can be used to automatically clear the data and their copies after a user-specified time. After time expiration, the multicloud feature enables the user to retain the shared data from the user cloud while it is deleted from the shared cloud. By using AES-256 and triple DES algorithm such a system can be developed and hence it reduces the time taken to upload and download file as compared to the native system

GPS phase scintillation at high latitudes during geomagnetic storms of 7-17 March 2012, part 2: interhemispheric comparison

During the ascending phase of solar cycle 24, a series of interplanetary coronal mass ejections (ICMEs) in the period 7–17 March 2012 caused geomagnetic storms that strongly affected high-latitude ionosphere in the Northern and Southern Hemisphere. GPS phase scintillation was observed at northern and southern high latitudes by arrays of GPS ionospheric scintillation and TEC monitors (GISTMs) and geodetic-quality GPS receivers sampling at 1 Hz. Mapped as a function of magnetic latitude and magnetic local time (MLT), the scintillation was observed in the ionospheric cusp, the tongue of ionization fragmented into patches, sun-aligned arcs in the polar cap, and nightside auroral oval and subauroral latitudes. Complementing a companion paper (Prikryl et al., 2015a) that focuses on the high latitude ionospheric response to variable solar wind in the North American sector, interhemispheric comparison reveals commonalities as well as differences and asymmetries between the northern and southern high latitudes, as a consequence of the coupling between the solar wind and magnetosphere. The interhemispheric asymmetries are caused by the dawn–dusk component of the interplanetary magnetic field controlling the MLT of the cusp entry of the storm enhanced density plasma into the polar cap and the orientation relative to the noon–midnight meridian of the tongue of ionization

Mitigating Phytophthora foot rot and slow decline diseases of black pepper through the deployment of bacterial antagonists

Field trial was conducted at ICAR-IISR Experimental Farm, Peruvannamuzhi, Kozhikode district, Kerala, during 2008-2013 using IPM modules. Planting materials of black pepper were produced by raising two node runners cuttings treated with chemicals and bioagents. A plot having non-living standards in 3 x 2 m spacing was selected. Pits of 50 cm3 were made and buffered with lime and cow dung. Planting was done with three month old rooted plants where roots were primed with respective bacterium/chemical. The experiment was in RCBD with eight treatments viz., Pseudomonas aeruginosa (Bp 35) + Phorate, P. putida (Bp 25) + Phorate, P. fluorescence (IISR 6)  (later identified as P.aeruginosa) + Phorate, Bacillus megaterium (Bp 17) + Metalaxyl Mz, Curtobacterium luteum (TC10) + Metalaxyl Mz, P. aeruginosa (IISR 853) + Metalaxyl Mz and Phorate + Metalaxyl Mz (chemical check) and an absolute control having no treatments.  The differential treatments were imposed at planting in May and subsequent application in September and thereafter every year. Initial two years, plants were maintained weed free by plastic mulching. Commonly, shade and irrigation were provided during summer in the first two years and thereafter only mulching and irrigation were continued. All the plants were sprayed with ZnSO4 (0.25%), DAP (0.5%) and MgSO4 (0.25%) during May and September from second year onwards. For controlling ‘Pollu’ beetle (Longitarsus nigripennis) and anthracnose (Colletotrichum gloeosporioides), quinalphos (0.075%) + Bordeaux mixture (1%) was sprayed twice during September and November. Soil biological properties and pathogen population were monitored regularly. No foot rot incidence due to Phytophthora spp. could be noticed in any of the treatments till the end of the experimental period. However, nematode infection, manifested as yellowing of the vines, as well as nematode population showed a gradual increase. Among the treatments, C. luteum (TC 10) with Metalaxyl- Mz showed significant reduction in nematode population and also showed better performance in growth and yield