Andi Selle dalam Pergolakan Bersenjata di Sulawesi Selatan (1950-1964)

This paper describes the background, role and impact of the involvement of Andi Selle in the throes of armed in South Sulawesi. This research is a descriptive-analytic nature by using the historical method through phases of heuristics, critique, interpretation, and historiography. The involvement of Andi Selle in the throes of armed caused by internal conflict on TNI. Andi Selle was involved in a series of conflicts with several parties from the time of independence until the period before independence. The upheaval affects ethnic hatred caused by acts of violence and the monopoly of trade in the region committed soldiers, so that hurt the people of Mandar

Pembelajaran Sejarah SMA Negeri 1 Berau Berbasis Situs Peninggalan Belanda di Teluk Bayur

The use of the Dutch heritage site in Teluk Bayur as a learning resource is intended to improve history learning at SMAN 1 Berau and also to enrich history learning resources. The purpose of this study was to describe the historical learning process at SMAN 1 Berau by utilizing the Dutch heritage site in Teluk Bayur and the teacher’s obstacles in the process of utilizing the Dutch heritage site as a learning resource. The type of research used ia a qualitative approach. The result of this study show how the learning process at SMAN 1 Berau runs according to the existing curriculum and the use of Dutch heritage sites as a learning resource makes students have a high enthusiasm for learning, and students can add social attitudes toward historical sites in the environment

Laparoscopic left hemicolectomy for colo-colonic intussusception caused by sigmoid colon cancer

INTRODUCTION Adult intussusception is uncommon and is usually associated with carcinoma. Traditionally, an open technique with en bloc resection has been used to manage these. OBJECTIVE We present a case of colo-colonic intussusception caused by a sigmoid colonic tumour that was treated with am laparoscopic left colectomy and primary anastomosis. CASE REPORT An 80-year-old woman presented to the ER with bowel changes and abdominal pain that had been present for two weeks. She denied having lost weight and had no obstructive symptoms. She was discovered to be stable, apyretic, and cachectic. She was diagnosed with colo-colonic intussusception after a CT scan and colonoscopy, which was most likely caused by sigmoid colon cancer. During laparoscopic exploration, the intussusception was discovered. As a result, the bowel was removed via en bloc left hemicolectomy with primary anastomosis. Pathology of the resected specimen revealed a moderately differentiated adenocarcinoma (pT3N1aM0). The postoperative course of the patient was uneventful, and she was discharged on the sixth postoperative day. CONCLUSION Despite the fact that an open conventional method is the most commonly used, laparoscopic colectomy is expected to be an effective treatment strategy for adult colo-colonic intussusceptions caused by malignancy

Perianal Merkel cell carcinoma - a rare case report

INTRODUCTION Merkel cell carcinoma is a rare, aggressive neuroendocrine skin cancer that primarily affects elderly men in sun-exposed areas such as the extremities. To the best of our knowledge, this is the first case of a perianal MCC. OBJECTIVE We present a young male with perianal Merkel cell carcinoma. CASE REPORT A previously healthy 35-year-old man presented with left perianal a mass. Initially, his symptoms were attributed to a cold perianal abscess. He was referred to our center due to persistent swelling. The mass was 4x4cm in size and 3cm away from the anal verge; it was firm, nontender and not mobile in relation to the underlying musculature; it grew rapidly and ulcerated in a few weeks. Following biopsies of the lesion, it was discovered to be a neuroendocrine carcinoma that stained CK20- positive, indicating it was a Merkel cell carcinoma. A thorough metastatic work-up, which included a chest x-ray, CT scan, and MRI, revealed evidence of widespread metastatic disease. A multidisciplinary team meeting was held to discuss the case, and palliative chemoradiotherapy was scheduled for the patient. However, he died before receiving palliative care. CONCLUSION MCC is a rare, aggressive carcinoma that typically appears in areas that are exposed to the sun. A colorectal surgeon should consider MCC as a differential diagnosis when faced with a rapidly growing, painless lesion in the perianal region. Early detection and treatment may lead to a higher rate of patient survival. However, because MCC is uncommon, more research is required to develop treatment protocols for metastatic disease

CULTURAL SIGNIFICANCE OF THE NONDOI RITUAL IN SHAPING THE IDENTITY OF EAST KALIMANTAN, INDONESIA’S NEW CAPITAL CITY

The Indonesian governmentâs decision to relocate the capital to East Kalimantan carries implications for the indigenous Paser people, raising concerns about the potential diminishment of their rich cultural heritage, including the Nondoi ritual. This qualitative research focuses on understanding the construction of the Paser community identity, explicitly emphasizing the Nondoi ritual deeply rooted in ancestral traditions. This study used an ethnographic method to unveil key characteristics within Paserese society through observations and interviews with traditional leaders, community figures, and mulung (shaman). The findings demonstrate that the Nondoi ritual, enriched with religious, spiritual, noble, social, and morally moderate values, plays a pivotal role in expressing and preserving the identity of the Paser community. As East Kalimantan becomes the new capital, the Nondoi ritual is a vital cultural force strenghtening the Paserese identity amidst evolving socio-cultural landscapes

KRAS mutation status is associated with distinct clinical and molecular features in Malaysian stage IV colorectal patients

Aim: The purpose of this study was to estimate the prevalence of KRAS mutations in stage IV colorectal cancer in Malaysians and to investigate the associations of KRAS mutations with clinicopathological characteristics Method: All patients with stage IV colorectal cancer who underwent resection of the primary tumour between January 2017 and December 2021 were included in the single-center retrospective study. KRAS mutation status was determined. A multiple logistic regression model was used to analyse patient characteristics and tumour location Results: 41 patients (51% of whom were men) with an average age of 63 ± 13 years. The most common tumours were left-sided colon cancers (50%). The most common histological subtype was adenocarcinoma (95%). Thirty-two patients (78%) had LN metastasis. Twenty-nine patients (71%) had single-organ metastasis. The lung was the most common metastatic site (66%). KRAS mutation was found in 19 ( 46% ) of patients (63% in codon 12, 15% in codon 13, 15% in codon 61, and 7% in codon 117). KRAS mutation was found to be associated with rectal cancer in multivariable logistic regression analyses (odds ratio [OR] 6.8; confidence interval [CI] 1.41 to 33.2; p = 0.017). Conclusion: In t his study, K RAS mutations were found in 46% of patients with stage IV colorectal cancer. However, according to literature, the right-sided colon has a higher prevalence of mutated KRAS. In our study, the rectum was associated with a high KRAS mutation

PERANAN ANDI SELLE DALAM PERGOLAKAN BERSENJATA DI SULAWESI SELATAN (1950-1964).

Abstrak Tujuan penelitian ini adalah (i) untuk meneliti, mengungkapkan dan menjelaskan latar belakang keterlibatan Andi Selle dalam Pergolakan bersenjata di Sulawesi Selatan. (ii) Meneliti, mengungkapkan dan menjelaskan peranan Andi Selle dalam Pergolakan Bersenjata di Sulawesi Selatan (iii) Menjelaskan dampak yang ditimbulkan Andi Selle dalam pergolakan bersenjata di Sulawesi Selatan. Penelitian ini bersifat deskriptif analisis dengan menggunakan metode historis, melalui tahapan: heurisitik, kritik, interpretasi, dan historiografi. Penelitian ini berpijak pada arsip-arsip serta sumber yang berfokus kelampauan sesuai tinggalan zaman yang sesuai. Hasil penelitian ini menunjukkan bahwa, (i) keterlibatan Andi Selle dalam pergolakan bersenjata disebabkan oleh konflik internal dalam tubuh TNI, kebencian Andi Selle terhadap etnis Jawa serta kondisi pembangunan yang tidak seimbangan antara Jawa dan Sulawesi. Selain itu, pasukan TNI yang berasal dari Jawa dianggap terlibat dan memiliki hubungan dengan PKI. (ii) Pergolakan bersenjata yang melibatkan Andi Selle berlangsung dalam beberapa periode. Dalam periode sebelum kemerdekaan, Andi Selle berjuang melawan penjajah Belanda. Dalam periode kemerdekaan Andi Selle terlibat dalam seragkaian konflik dengan beberapa pihak termasuk Kahar Muzakkar dan pihak Kodam XIV Hasanuddin. (iii) akibat yang ditimbulkan dari pergolakan tersebut ialah adanya kebencian etnis yang disebabkan oleh tekanan-tekanan yang dilakukan oleh anak buahnya. Hal ini berhubungan dengan monopoli perdagangan yang dilakukan di wilayah Mandar, serta kegiatan lain seperti tindak kekerasan prajuritnya dianggap melukai hati rakyat Mandar. Pasca dilakukan operasi tumpas untuk membersihkan sisa-sisa kekacauan yang ditimbulkan dari pergolakan ini, kegiatan sehari-hari masyarakat berangsur-angsur berjalan dengan normal. Kata Kunci: Andi Selle, Pergolakan Bersenjata, Sulawesi Selatan