ASSESSMENT OF THE KNOWLEDGE, ATTITUDE, AND PRACTICE TOWARDS EXPIRED DRUG DISPOSAL AMONG THE COMMUNITY IN BEIRUT CITY, LEBANON

The global increase in pharmaceutical spending has led to enhanced international awareness of the unused and expired drug issues due to improper drug disposal\u27s harmful economic, environmental, and health effects. Consequently, the study was conducted to assess the knowledge, attitude, and practice toward expired drug disposal among the community in Beirut City, Lebanon. A cross-sectional, observational, questionnaire-based study was conducted. Data were analyzed using SPSS version 23. The fact that improper disposal of expired medicine affects the environment and health was acknowledged by 70.7% of the 450 participants. Even though 72.2% of the participants knew that the best method for drug disposal was medication disposal boxes, 50.4% did not know about the use of the drug take-back system. Expired drugs were present in 71.1% of the participants’ homes, and 78.9% of the participants discarded them in household garbage. In fact, 53.6% agreed that there is a lack of adequate information on the safe disposal of expired household medicines. This study revealed a lack of proper advice on the safe disposal of expired medicines. Consequently, the government should initiate feasible expired drug programs to educate the public. Improper disposal of expired drugs has a negative impact on the environment. The current study revealed that 78.9% of the participants discards expired drugs in an improper way. Accordingly, actions should be taken to save the planet

Mathematical Description of the Change in Properties of Casuarina Wood Upon Exposure to Gamma Radiation. 1. Changes in the Compressive and Tensile Strength

Casuarina cunninghamiana specimens were exposed to gamma-radiation doses ranging from 104 to 108 rad and tested in compression and tension parallel to grain. The percentage values of the irradiated specimens relative to that of the matched control (Y) were determined. The relationship between (Y) and log gamma radiation dose (X) was represented mathematically by the equation: Y = aXbcx. This equation described the change in compressive and tensile strength very well as was detected from the high correlation coefficients. Generally these properties increased slightly at low levels of radiation, reached a maximum, then decreased gradually thereafter. The reduction in tensile strength was more pronounced than in compressive strength.The threshold dose, i.e., the dose beyond which the properties began to decrease, was calculated. This dose ranged from 3.69 x 106 to 3.76 x 106 rad for compressive strength properties and from 1.51 x 106 to 1.70 x 106 rad for tensile strength properties. This indicated that irradiated casuarina wood had a greater resistance to compression than to tension

PHYTOCHEMICAL STUDY AND THE ANTIPROLIFERATIVE ACTIVITY OF INULA VULGARIS SPECIES GROWN IN LEBANON

Objective: Cancer represents the second leading cause of death after stroke and heart diseases. Plant extracts have long been used in traditional medicine for the prevention and treatment of many illnesses, including some types of cancer. The aim of this study was to evaluate the antiproliferative effects of ethyl acetate fractions of two Lebanese herbs: Inula viscosa (I. vis) and Inula vulgaris (I. vul).Methods: Plants were extracted with ethanol followed by ethyl acetate, then dried and tested on three cell lines including CaCO2, HepG2, and MCF7, to check for their viability and antiproliferative activity, using trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Proton (1H) and carbon (13C) nuclear magnetic resonance spectrometry (NMR) were used to identify the compounds that have been isolated from both Inula species.Results: The current findings were consistent for both trypan blue and MTT assays. The results showed that the most potent effect for I. vul was HepG2 (IC50 20 µg/ml, 27 µg/ml), and for I. vis on MCF7 (9 µg/ml, 15 µg/ml) and CaCO2 (12 µg/ml, 22 µg/ml) in the two mentioned assays respectively. However, insignificant differences were observed among the studied plants for each of the evaluated cells indicating comparable potencies. Quercetin, quercetin glycoside, and epicatechin derivatives were isolated by fractionation on column chromatography and identified using NMR spectroscopy.Conclusion: The antiproliferative activities of the two plants could be related to their content that is significant for high levels of secondary metabolites. The identification of those compounds is necessary to establish a relationship between their chemical structures and their activities

Food, flavouring and feed plant traditions in the Tyrrhenian sector of Basilicata, Italy

BACKGROUND: Research was carried out in the years 2002–2003 into food, flavouring and feed folk traditions of plants in the Tyrrhenian part of the Basilicata region (southern Italy). This area was colonized in ancient times by Greeks. Data was collected through field interviews, especially of farmers. METHODS: Field data were collected through structured interviews. The informants, numbered 49, belonged to families which had strong links with the traditional activities of the area. RESULTS: 61 taxa are cited, belonging to 26 botanical families, amongst which 44 used as food or flavouring and 22 for animal alimentation. Besides 7 taxa are involved in rituals especially connected with agriculture and plant growth. CONCLUSION: The preservation of some rituals especially concerning agricultural plants is noteworthy in the area, together with a certain degree of continuity in food uses. Knowledge and rediscovery of recipes in human and animal diet could represent an economic potential for the area

Multifaceted value profiles of forest owner categories in South Sweden: The river helge å catchment as a case study

Forest landscapes provide benefits from a wide range of goods, function and intangible values. But what are different forest owner categories\u27 profiles of economic use and non-use values? This study focuses on the complex forest ownership pattern of the River Helge å catchment including the Kristianstad Vattenrike Biosphere Reserve in southern Sweden. We made 89 telephone interviews with informants representing the four main forest owner categories. Our mapping included consumptive and non-consumptive direct use values, indirect use values, and non-use values such as natural and cultural heritage. While the value profiles of non-industrial forest land owners and municipalities included all value categories, the forest companies focused on wood production, and the Swedish Environmental Protection Agency on nature protection. We discuss the challenges of communicating different forest owners\u27 economic value profiles among stakeholders, the need for a broader suite of forest management systems, and fora for collaborative planning. © 2013 The Author(s)

TRP channels: a provocative rationalization for local Ca2+ control in arterial tone development

Arterial networks are controlled by the consolidated output of stimuli that set “how much” (magnitude) and “where” (distribution) blood flow is delivered. While notable changes in magnitude are tied to network wide responses, altered distribution often arises from focal changes in tone, whose mechanistic foundation remains unclear. We propose herein a framework of focal vasomotor contractility being controlled by pharmacomechanical coupling and the generation of Ca2+ waves via the sarcoplasmic reticulum. We argue the latter is sustained by receptor operated, transient receptor potential (TRP) channels through direct extracellular Ca2+ influx or indirect Na+ influx, reversing the Na+/Ca2+ exchanger. We view this focal regulatory mechanism as complementary, but not redundant with, electromechanical coupling in the precision tuning of blood flow delivery

Voicing interests and concerns: challenges for forest research

Forest research has to change in response to the increased interest of society in the management of forestland. The president and the vice president of IUFRO, the Assistant Director-General for Forestry in the FAO and the Past Director-General of CIFOR discuss key issues. IUFRO should become a clearing house for forest research and expertise. Research has to recognize that the culture of forestry has become a culture of conflict. More interdisciplinary and policy research should be added to the strong bio-physical sciences in forestry. It needs science to exploit the comparative advantages of local and larger-scale forest management and also needs science to bridge the gaps between the traditional and modern pools of knowledge and experienc