P1‐013: Physical Activity In Young And Middle Adulthood Are Independently Linked To Later‐Life Memory Functioning

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152978/1/alzjjalz201906038.pd

Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.

Megakaryoblastic leukaemia is the commonest form of leukaemia occuring in Down syndrome infants. However, it’s subtype with translocation t(1;22)(p13;q13)is uncommon comprising <1% of all cases and reported to exclusively occur in infant without Down syndrome. It has a female predominance and carries apoor prognosis. We described this rare form of leukaemia in a 9-month-old girl who presented with bruises, massive hepatosplenomegaly and multiple cervical and inguinal lymphadenopathy. The blood film showed severe anaemia with ovalostomatocytosis, thrombocytopenia and mild leucocytosis. The bone marrow aspirate showed numerous blasts showing high nuclear-cytoplasmic ratio and agranular cytoplasm with cytoplasmic blebs. Peroxidase staining was negative. The immunophenotyping of the blasts showed positive expression of CD117, CD13, CD33 and CD61 which confirmed the diagnosis of acute megakaryoblastic leukaemia. Interestingly, the cytogenetic finding of translocation t(1;22) which is most common in acute megaloblastic leukaemia in infants without Down syndrome was found in this case. She received the AML trial 15 ADE protocol chemotherapy regime and developed severe neutropenic sepsis and respiratory distress requiring ventilatory support and granulocyte colony stimulating factor (G-CSF). She recovered wellmafter the first course of chemotherapy and was discharged. Unfortunately, she was not brought in for follow-up chemotherapy and presented a few months later with relapsed AML. She was re-started on ADE protocol and currently is on oral thioguanine for maintenance therapy

Pendekatan Konstruktif ASEAN – Myanmar : Sorotan Kajian Lepas

: Myanmar (Burma) as a member of the Association of Southeast Asian Nations (ASEAN) became the centre of regional attention when the United States (US) and the European Union (EU) imposed economic sanctions on the country. Myanmar\u27s membership is said to be hampering image and credibility of ASEAN. In addition, the Rohingya\u27s human rights issue has also affected Myanmar\u27s relations with regional Islamic states. However, ASEAN accepts Myanmar\u27s membership hoping its political system will be more social oriented and more democratic. In this light, this article poses a question. Has ASEAN\u27s constructive approach successfully democratized Myanmar? ASEAN utilizes the constructive approach towards Myanmar rather than isolating it in order to pave way for Myanmar\u27s democratization. This study employs library research and secondary data from other sources. The literature review shows that even though Myanmar\u27s political system is yet to be fully democratized, ASEAN\u27s constructive approach has indeed brought Myanmar closer to be more democratic compared to its more socialist system earlier on. The election and the release of Aung San Suu Kyi, the chairperson of the National League for Democracy (NLD) and main opposition leader in Myanmar in 2010, are the indicators of this progress. It is with the hope that this literature review will contribute to the accumulation of knowledge in the field of democracy research, democratization, and the role of ASEAN in the discipline of International Relations

Association of variants in the CP, ATOX1 and COMMD1 genes with Wilson disease symptoms in Latvia

Funding Information: This study was partially financed by a grant of Riga Stradins University, Department of Doctoral studies and grant of Roche Academy. Funding Information: Funding . This study was partially financed by a grant of Riga Stradiņš University, Department of Doctoral studies and grant of Roche Academy. Publisher Copyright: © 2019 Zarina A, Tolmane I, Krumina Z, Tutane AI, Gailite L, published by Sciendo.Wilson's disease (WD) is a copper metabolism disorder, caused by allelic variants in the ATP7B gene. Wilson's disease can be diagnosed by clinical symptoms, increased copper and decreased cerulopasmin levels, which could all also be by other genetic variants beyond the ATP7B gene, e.g., disturbed ceruloplasmin biosynthesis can be caused by pathogenic allelic variants of the CP gene. Copper metabolism in the organism is affected by several molecules, but pathogenic variants and related phenotypes are described with COMMD1 and ATOX1 genes. The aim of the study was to test other genes, CP, ATOX1 and COMMD1, for possible influence to the manifestation of WD. Patients were enrolled on the basis of Leipzig's diagnostic criteria, 64 unrelated patients with confirmed WD. Direct sequencing of promoter region of the CP gene and ATOX1 and COMMD1 gene exons was conducted. Statistically significant differences were found between the two variants in the CP gene and the ATP7B genotype (rs66508328 variant AA genotype and the rs11708215 variant GG genotype) were more common in WD patients with an unconfirmed ATP7B genotype. One allelic (intronic) variant was found in the ATOX1 gene without causing the functional changes of the gene. Three allelic variants were identified in the COMMD1 gene. No statistically significant differences were found between allele and genotype frequencies and the first clinical manifestations of WD. Different variants of the CP gene contributed to a WD-like phenotype in clinically confirmed WD patients with neurological symptoms and without identified pathogenic variants in the ATP7B gene. Allelic variants in the ATOX1 and COMMD1 genes do not modify the clinical manifestation of WD in Latvian patients.publishersversionPeer reviewe

Excellent educare tuition centre / Marsytah Shaari... [et al.]

Committing to the business domain expressly in education directly will help the Ministry Of Education to increase the education level or standard in Malaysia. Barrel to the government’s aspiration is to produce the educated and excellent younger for the new millennium era. That is why we come out with this business in order to overcome the barrel. Apart from that, in order to realize the government's encouragement, to increase the number of excellent students in our country, to increase the quality of education and to produce more expertise and professional in fieldwork, therefore we come out with this business. Based on the objectives of Excellent Educare Tuition Centre, we will provide a space for the USPR, PMR, SPM & STPM candidates and also for those are the former students (repeaters ), to improve their quality of studies. Besides that, we come out with the latest technology approach, meaning that our services are totally technology-oriented. The teachers will conduct the learning session using the projector and laptop. This will be the best way to attract student's attention and will avoid the feeling of the bore during the learning session. These actually comply with our target to establish the best learning condition for the student

Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138379/1/phar1968_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138379/2/phar1968.pd

Squamous cell carcinoma of the tongue in a patient with rothmund-thomson syndrome (Recq4 Mutation) - intolerance to radiotherapy

We report a case of squamous cell carcinoma of the base of the tongue in a 27 years old patient with Rothmund-Thomson syndrome (RTS). An abnormal DNA repair mechanism in some RTS patients predispose them to malignancy and influence the tolerance to radiotherapy