Ein erweitertes Konzept für die Messung von Armut in der Bildungsforschung im Nationalen Bildungspanel (NEPS)

Dieses Papier stellt mit dem Verwirklichungschancenansatz von Amartya Sen einen umfassenden theoretischen Rahmen für eine multidimensionale Messung von Armut im Nationalen Bildungspanel (NEPS) vor. Es wird aufgezeigt, wie diese erweiterte Betrachtung von Armut genutzt werden kann um die Auswirkungen von Armut auf die individuelle Bildung aber auch den Einfluss von Bildung auf Armutslagen im Rahmen eines Multi-Kohorten- Sequenz-Designs zu untersuchen. Neben einem Überblick über den Ansatz sowie einer Aufarbeitung der bildungsbezogenen Forschungen stellt dieses Papier die bereits bestehende Operationalisierung von relevanten Konstrukten im NEPS sowie einen Vorschlag zur Erweiterung der erfassten Dimensionen um die verschiedenen Facetten individueller Verwirklichungschancen für verschiedene Befragungsgruppen dar. Es erarbeitet somit eine Grundlage, um erweiterte Aspekte von Armut zukünftig im Rahmen des NEPS besser abzubildenThis paper provides a comprehensive theoretical framework for a multidimensional measurement of poverty in the National Education Panel Study (NEPS), based on Amartya Sen's capability approach. It shows how the extended view of poverty can serve to examine the impact of poverty on an individual's education as well as the influence of education on poverty levels in a multicohort-sequence design. The paper provides an overview of the approach as well as a review of education-related research, an overview of the operationalization of relevant constructs in the NEPS, and a proposal to extend the dimensions measured up to now in order to better reflect the different facets of individual realization opportunities for different types of respondents. It thus provides a framework for better measuring different aspects of poverty in the NEPS in the futur

Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model

The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats

Brainhack: Developing a culture of open, inclusive, community-driven neuroscience

Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open, inclusive environment. This NeuroView describes the myriad benefits for participants and the research community and how Brainhacks complement conventional formats to augment scientific progress.Additional co-authors: Sofie Van Den Bossche, Xenia Kobeleva, Jon Haitz Legarreta, Samuel Guay, Selim Melvin Atay, Gael P. Varoquaux, Dorien C. Huijser, Malin S. Sandström, Peer Herholz, Samuel A. Nastase, AmanPreet Badhwar, Guillaume Dumas, Simon Schwab, Stefano Moia, Michael Dayan, Yasmine Bassil, Paula P. Brooks, Matteo Mancini, James M. Shine, David O’Connor, Xihe Xie, Davide Poggiali, Patrick Friedrich, Anibal S. Heinsfeld, Lydia Riedl, Roberto Toro, César Caballero-Gaudes, Anders Eklund, Kelly G. Garner, Christopher R. Nolan, Damion V. Demeter, Fernando A. Barrios, Junaid S. Merchant, Elizabeth A. McDevitt, Robert Oostenveld, R. Cameron Craddock, Ariel Rokem, Andrew Doyle, Satrajit S. Ghosh, Aki Nikolaidis, Olivia W. Stanley, Eneko Uruñuela, The Brainhack Communit

The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol

Bipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental disorders, the mechanisms underlying bipolar disorder at the neural network level still remain elusive. This has severe consequences for clinical practice, for instance by inadequate diagnoses or delayed treatments. The German research consortium BipoLife aims to shed light on the mechanisms underlying bipolar disorders. It was established in 2015 and incorporates ten university hospitals across Germany. Its research projects focus in particular on individuals at high risk of bipolar disorder, young patients in the early stages of the disease and patients with an unstable highly relapsing course and/or with acute suicidal ideation. Functional and structural magnetic resonance imaging (MRI) data was acquired across nine sites within three different studies. Obtaining neuroimaging data in a multicenter setting requires among others the harmonization of the acquisition protocol, the standardization of paradigms and the implementation of regular quality control procedures. The present article outlines the MRI imaging protocols, the acquisition parameters, the imaging paradigms, the neuroimaging quality assessment procedures and the number of recruited subjects. The careful implementation of a MRI study protocol as well as the adherence to well-defined quality assessment procedures is one key benchmark in the evaluation of the overall quality of large-scale multicenter imaging studies. This article contributes to the BipoLife project by outlining the rationale and the design of the MRI study protocol. It helps to set the necessary standards for follow-up analyses and provides the technical details for an in-depth understanding of follow-up publications

Brainhack: Developing a culture of open, inclusive, community-driven neuroscience

Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open, inclusive environment. This NeuroView describes the myriad benefits for participants and the research community and how Brainhacks complement conventional formats to augment scientific progress