45 research outputs found
Dust exposure and the impact on hospital readmission of farming and wood industry workers for asthma and chronic obstructive pulmonary disease (COPD)
Objectives It is still not well established how occupational air pollutants affect the prognosis of asthma or chronic obstructive pulmonary disease (COPD). This study uses nationwide Danish registers and quantitative dust industry exposure matrices (IEM) for the farming and wood industries to estimate whether previous year dust exposure level impacts hospital readmissions for workers diagnosed with asthma or COPD. Methods We identified all individuals with a first diagnosis of either asthma (769 individuals) or COPD (342 individuals) between 1997 and 2007 and followed them until the next hospital admission for asthma or COPD, emigration, death or 31 December 2007. We included only individuals who worked in either the wood or farming industries at least one year during follow-up. We used logistic regression analysis to investigate associations between dust exposure level in the previous year and hospital readmission, adjusting for sex, age, time since first diagnosis, socioeconomic status, and labor force participation. Results Asthma readmissions for individuals with low and high dust exposure were increased [adjusted rate ratio (RR adj) 2.52, 95% confidence interval (CI) 1.45-4.40] and RR adj2.64 (95% CI 1.52-4.60), respectively. For COPD readmission, the risk estimates were RR adj1.36 (95% CI 0.57-3.23) for low and RR adj1.20 (95% CI 0.49-2.95) for high exposure level in the previous year. For asthma readmission, stratified analyses by type of dust exposure during follow-up showed increased risks for both wood dust [RR adj2.67 (95% CI 1.35-5.26) high exposure level] and farming dust [RR adj3.59 (95% CI 1.11-11.59) high exposure level]. No clear associations were seen for COPD readmissions. Conclusions This study indicates that exposure to wood or farm dust in the previous year increases the risk of hospital readmission for individuals with asthma but not for those with COPD
A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)
A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)
Objectives To study exposure-response relations
between cumulative organic dust exposure and incident
chronic obstructive pulmonary disease (COPD) among
subjects employed in the Danish farming and wood
industry.
Methods We studied exposure-response relations
between cumulative organic dust exposure and incident
COPD (1997–2013) among individuals born during
1950–1977 in Denmark ever employed in the farming
or wood industry (n=1 75 409). Industry-specific
employment history (1964–2007), combined with
time-dependent farming and wood industry-specific
exposure matrices defined cumulative exposure. We used
logistic regression analysis with discrete survival function
adjusting for age, sex and calendar year. Adjustment for
smoking status was explored in a subgroup of 4023 with
smoking information available.
Results Cumulative organic dust exposure was inversely
associated with COPD (adjusted rate ratios (RRadj
(95% CIs) of 0.90 (0.82 to 0.99), 0.76 (0.69 to 0.84) and
0.52 (0.47 to 0.58) for intermediate-low, intermediatehigh and high exposure quartiles, respectively, compared
with the lowest exposure quartile). Lagging exposure 10
years was not consistently suggestive of an association
between cumulative exposure and COPD; RRadj (95% CI):
1.05 (0.94 to 1.16), 0
Selection of reliable biomarkers from PCR array analyses using relative distance computational model: Methodology and proof-of-concept study
10.1371/journal.pone.0083954PLoS ONE812-POLN
Spatial extent and historical context of North Sea oxygen depletion in August 2010
Prompted by recent observations of seasonal low dissolved oxygen from two moorings in the North Sea, a hydrographic survey in August 2010 mapped the spatial extent of summer oxygen depletion. Typical near-bed dissolved oxygen saturations in the stratified regions of the North Sea were 75–80 % while the well-mixed regions of the southern North Sea reached 90 %. Two regions of strong thermal stratification, the area between the Dooley and Central North Sea Currents and the area known as the Oyster Grounds, had oxygen saturations as low as 65 and 70 % (200 and 180 µmol dm-3) respectively. Low dissolved oxygen was apparent in regions characterised by low advection, high stratification, elevated organic matter production from the spring bloom and a deep chlorophyll maximum. Historical data over the last century from the International Council for the Exploration of the Sea oceanographic database highlight an increase in seasonal oxygen depletion and a warming over the past 20 years. The 2010 survey is consistent with, and reinforces, the signal of recent depleted oxygen at key locations seen in the (albeit sparse) historical data
Patients with persistent medically unexplained symptoms in general practice: characteristics and quality of care
<p>Abstract</p> <p>Background</p> <p>Medically unexplained physical symptoms (MUPS) are common in general practice (GP), and are even more problematic as they become persistent. The present study examines the relationship between persistent MUPS in general practice on the one hand and quality of life, social conditions, and coping on the other hand. Additionally, it is examined how patients with persistent MUPS evaluate the quality of GP-care.</p> <p>Methods</p> <p>Data were used from a representative survey of morbidity in Dutch general practice, in which data from the electronic medical records were extracted. A random sample of patients participated in an extensive health interview and completed self-reported measures on social isolation, coping and the quality of GP-care. Patients with persistent MUPS (N = 192) were compared with general practice patients not meeting the criteria for persistent MUPS (N = 7.314), and with a group of patients that visited the GP in comparable rates for medical diagnoses (N = 2.265). Multiple logistic regression analyses were used to control for relevant socio-demographic variables and chronic diseases.</p> <p>Results</p> <p>After adjustment for demographics and chronic diseases, patients with persistent MUPS reported more psychological distress, more functional impairment, more social isolation, and they evaluated the quality of GP-care less positive than the other two patient groups. Although the majority of MUPS patients were positive about the quality of GP-care, they more often felt that they were not taken seriously or not involved in treatment decisions, and more often reported that the GP did not take sufficient time. The three groups did not differ with respect to the statement that the GP unnecessarily explains physical problems as psychological ones.</p> <p>Conclusion</p> <p>Strengthening MUPS patients' social network and encouraging social activities may be a meaningful intervention in which the GP may play a stimulating role. To further improve MUPS patients' satisfaction with GP-care, GPs may pay extra attention to taking sufficient time when treating MUPS patients, taking the problems seriously, and involving them in treatment decisions.</p
From Newton's bucket to rotating polygons: experiments on surface instabilities in swirling flows
AbstractWe present an experimental study of ‘polygons’ forming on the free surface of a swirling water flow in a partially filled cylindrical container. In our set-up, we rotate the bottom plate and the cylinder wall with separate motors. We thereby vary rotation rate and shear strength independently and move from a rigidly rotating ‘Newton’s bucket’ flow to one where bottom and cylinder wall are rotating oppositely and the surface is strongly turbulent but flat on average. Between those two extremes, we find polygonal states for which the rotational symmetry is spontaneously broken. We investigate the phase diagram spanned by the two rotational frequencies at a given water filling height and find polygons in a regime, where the two frequencies are sufficiently different and, predominantly, when they have opposite signs. In addition to the extension of the family of polygons found with the stationary cylinder, we find a new family of smaller polygons for larger rotation rates of the cylinder, opposite to that of the bottom plate. Further, we find a ‘monogon’, a figure with one corner, roughly an eccentric circle rotating in the same sense as the cylinder. The case where only the bottom plate is rotating is compared with the results of Jansson et al. (Phys. Rev. Lett., vol. 96, 2006, art. 174502), where the same size of cylinder was used, and although the overall structure of the phase diagram spanned by water height and rotational frequency is the same, many details are different. To test the effect of small experimental defects, such as misalignment of the bottom plate, we investigate whether the rotating polygons are phase locked with the bottom plate, and although we find cases where the frequency ratio of figure and bottom plate is nearly rational, we do not find phase locking. Finally, we show that the system has a surprising multistability and excitability, and we note that this can cause quantitative differences between the phase diagrams obtained in comparable experiments.</jats:p